a-, 1. a prefix meaning ‘before’ from Latin, ante. 2. a prefix meaning ‘without,’ ‘lack of,’ ‘not,’ from Greek a: aphasia. A, α. See alpha. A68, symbol for a protein found in the brain tissue of patients with Alzheimer’s disease. It is also found in the developing normal brains of fetuses and infants but begins to disappear by the age of 2 years. It is a major subunit of paired helical filaments and derivatized forms of tau protein. See also tau protein. AA, 1. abbreviation for achievement age. 2. abbreviation for Alcoholics Anonymous. 3. abbreviation for amplitude of accommodation. 4. abbreviation for anesthesiologist assistant. 5. abbreviation for amino acid. 6. abbreviation for anterior apical. 7. abbreviation for aortic arch. 8. abbreviation for arm-ankle (pulse rate). AAA, 1. abbreviation for American Association of Anatomists. 2. abbreviation for acquired aplastic anemia. 3. abbreviation for abdominal aortic aneurysm. āa, aa, AA, (in prescriptions) abbreviation for ana, indicating an equal amount of each ingredient to be compounded. AAAI, abbreviation for American Academy of Allergy and Immunology. AACE, 1. abbreviation for American Association of Clinical Endocrinologists; 2. abbreviation for Association for the Advancement of Computing in Education. AACN, 1. abbreviation for American Association of Colleges of Nursing. 2. abbreviation for American Association of Critical Care Nurses. AAFP, abbreviation for American Academy of Family Physicians. AAI, abbreviation for ankle-arm index. See ankle-brachial index. AAIN, abbreviation for American Association of Industrial Nurses. AAL, abbreviation for anterior axillary line. AAMC, abbreviation for American Association of Medical Colleges. AAMI, abbreviation for Association for the Advancement of Medical Instrumentation. AAN, abbreviation for American Academy of Nursing. AANA, abbreviation for American Association of Nurse Anesthetists. AANN, 1. abbreviation for American Association of Neuroscience Nurses. 2. abbreviation for American Association of Neurological Nurses. AAO–HNS, abbreviation for American Academy of Otolaryngology– Head and Neck Surgery. AAOMS, abbreviation for American Association of Oral and Maxillofacial Surgeons. AAPA, abbreviation for American Academy of Physician Assistants. Aaron’s sign [Charles D. Aaron, American physician, 1866– 1951], a clinical sign in acute appendicitis indicated by referred pain or feeling of distress in the epigastric or precordial region when continuous firm pressure is applied over McBurney’s point. See also McBurney’s point. AARP, a voluntary U.S. organization of older persons, who may or may not be retired, with the goal of improving the welfare of persons over 50 years of age. Among other actions, the group seeks out lower cost car, travel, and health insurance for its members. The AARP advocates for older individuals on legislative, consumer, education, and legal issues. Formerly called American Association of Retired Persons. Aarskog’s syndrome /ärs′kog/ [Dagfinn Charles Aarskog, Norwegian pediatrician, b. 1928], an X-linked syndrome characterized by wide-set eyes, anteverted nostrils, broad upper lip, peculiar scrotal “shawl” above the penis, and small hands. Also called faciodigitogenital syndrome, faciogenital dysplasia. AART, abbreviation for American Association for Respiratory Therapy. Aase’s syndrome /äz/ [Jon Morton Aase, American pediatrician, b. 1936], a familial syndrome characterized by mild growth retardation, hypoplastic anemia, variable leukocytopenia, triphalangeal thumbs, narrow shoulders, and late closure of fontanels, and occasionally by cleft lip, cleft palate, retinopathy, and web neck. A recessive mode of inheritance has been suggested. AAUP, abbreviation for American Association of University Professors. AAV, abbreviation for adenoassociated virus. Ab, abbreviation for antibody. ab-, abs-, prefixes meaning ‘from, off, away from’: abstract, abnormal. abacavir, an antiviral that is a nucleoside reverse transcriptase inhibitor. n indication: It is prescribed in combination with other antiretroviral agents for HIV-1 infection. n contraindication: Known hypersensitivity to this drug prohibits its use. n adverse effects: Hypersensitivity reactions occur in approximately 5% of patients, and can be fatal. Other lifethreatening adverse effects include granulocytopenia, anemia, and lactic acidosis. Common side effects include fever, headache, malaise, insomnia, nausea, vomiting, diarrhea, anorexia, and rash. abacterial /ab′aktir′ē·əl/, any atmosphere or condition free of bacteria; literally, without bacteria. abaissement /ä′bāsmäN′/ [Fr, a lowering], 1. a falling or depressing. 2. (in ophthalmology) the displacement of a lens. abalienation /abāl′yənā′shən/, a state of physical deterioration or mental decay. —abalienate, v., abalienated, adj. Ab amyloid, an abnormal peptide, varying from 40 to 43 amino acids in length and found in aggregates in the cerebrovascular walls and the cores of the plaques in Alzheimer’s disease. It is derived from a large transmembrane glycoprotein, amyloid precursor protein. It is postulated to be neurotoxic. A band, in muscle tissue, the area between two I bands of a sarcomere, marked by partial overlapping of actin and myosin filaments and appearing dark. Compare I band. abandonment of care /əban′dənment/, 1. (in law) wrongful cessation of the provision of care to a patient by a health care provider, usually a physician or a nurse. 2. unilateral