DRUG MECHANISM OF ACTION INDICATION & ADVERSE REACTION NSG.

CONSIDERATION
CONTRAINDICATION

GENERIC NAME : Bacteriostatic: Competitively Treatment of acute CNS: Headache, peripheral ASSESSMENT
sulfisoxazole antagonizes PABA, an infections caused by neuropathy, mental depression, History: Allergy to
BRAND NAME: essential component of folic susceptible organisms: UTIs, seizures, ataxia, hallucinations, sulfo0namides,
Gantrisin acid synthesis in chancroid, inclusion tinnitus, vertigo, insomnia, sulfunylureas,thiazides;impaire
CLASSIFICATION: susceptible gram-negative conjunctivitis, trachoma, hearing loss, drowsiness, d renal or hepatic function;
Antibiotic and gram-positive bacteria, nocardiosis, toxoplasmosis transient lesions, of posterior G6PD deficiency; porphyria;
Sulfunamide preventing cell replication. (with pyrimethamine), malaria spinal column, transverse pregnancy; lactation.
DOSAGE & (as adjunctive therapy for myelitis Physical: skin color,lesions;
FREQUENCY: chloroquine-resistant strains Dermatologic: Photosensitivity culture of infection;
ADULTS of P. falciparum), acure otitis cyanosis, petechiae, alopecia orientation, reflexes, affect,
Loading dose, 2-4g PO. media (due to H. influenza GI: Nausea, emesis, peripheral sensssation.
Maintenance 4-8 g/day when used with penicillin or abdominal pains diarrhea, INTERVENTIONS
P0 in four to six divided erythromycin) bloody diarrhea, anorexia, Arrange for culture and
doses. Conjunctivitis, corneal ulcer, pancreatitis, stomatitis, sensitivity tests of infection
CDC-recommended superficial ocular infections impaired folic acid absorption before therapy
treatment of sexually due to susceptible Hematologic: Agranulocytosis, Administer oral drug on an
transmitted diseases- microorganisms. aplastic anemia, empty stomach, 1hr before or
lymphogranuloma  CDC recommended for thrombocytopenia, leukopenia, 2 hr after meals, with a full
venereum: As an treatment of sexually hemolytic anemia, glass of water.
alternative regimen to transmitted diseases. hypoprothrombinemia, Monitor CBC , differential,
doxycycline, 500 mg P0 Unlabeled use: methemoglobinemia, and urinalysis before and
qid for 21 days. Chemoprophylaxis for megaloblastic anemia periodically during therapy.
Treatment of recurrent otitis media. Hypersensitivity: Stevens- TEACHING POINTS
uncomplicated erethral, Johnson syndrome, generalized Complete full course of
endocervical, or rectal Contraindicated with allergy skin eruptions, epidermal therapy.Take the drug on an
Chlamydia trachomatis to sulfonamides, sulfonyureas, necrolysis, urticaria, serum empty stomach.
infections: As an thiazides; pregnancy sickness, pruritus.arthralgia, Drink up to 2-3 liters of
alternative regimen to (teratogenic may cause allergic myocarditis, transient water daily.
doxy cycline or kernicterus); lactation (risk of pulmonary changes with This drug is specific ti this
tetracycline (if kernicterus, diarrhea, eosinophilia, decreased disease. Do not self-treat any
erythromycin is not rash);patients <2mo of age pulmonary function. other infection.
tolerated),500 mg PO qid except in congenital Report blood in urine; rash
for 10 days toxoplasmosis as an adjunct ringing in the ears; difficulty
PEDIATRIS PATIENTS>2 mo with pyrimethamine. breathing ;fever; sore
Initial dose, 75 mg/kg •Use cautiously with impaired throat ;chills.
PO. Maintenance dose, renal function.
150 mg/kg/day PO in 4-6
divided doses with a
TIFFANY VALDEZ
minimum dose of 6 g/kg.
BSN-II
BLK-4