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Platelet-Rich Plasma
Preparation System in
Medical Aesthetics
Platelet-Rich Plasma (PRP)
PLT-Haemostasis
Wound Healing
Growth Factors in PRP
Sports Medicine
Orthopaedics
Aesthetic
Dermatology PRP Wound Care
“Vampire face lift”
Dental Surgery
Hair Loss
PRP in Aesthetics
• PRP Benefits:
• Improved skin texture and tone (silkiness)
• Refinement of signs of aging (lines, spots)
• Reduction of dark circles
• Hydration
• Reduction of scars (acne, stretch marks)
• Gradual increase in skin thickness and vitality
PRP Applications in Aesthetics
• Eliminating RBC, which may inhibit proliferation and induce apoptosis (1)
1. Blood Cells Inhibit Proliferation and Stimulate Apoptosis in Human Lung Fibroblasts In Vitro. Scand J Immunol. 2004
2. Peripheral Blood Mononuclear Cells Enhance the Anabolic Effects of Platelet-Rich Plasma on Anterior Cruciate Ligament Fibroblasts. J Orthop Res. 2013
- PRP vs. Whole Blood (WB)
WB
PRP
~90% PLT yield
- Performance Evaluation (1)
* “Mycells”, “Tropocells” and “Cellenis” are commercial names of Estar’s PRP Systems.
Platelet and growth factor concentrations in activated platelet-rich plasma: a comparison of seven commercial
separation systems Kushida S. et al J Artif Organs 2014
- Literature Review
• Aesthetic Dermatology
• Hair Loss
• Plastic Surgery (Striae Distensae)
• Orthopaedics (Jumper’s knee)
• Wound Healing
• Basic Science
- in Aesthetics (1)
Study objective
To evaluate the efficacy of PRP facial skin treatment through objective parameters, such as
hydration rate and transepidermal water loss.
Design
37 female patients were treated with 4 cc of PRP at the lower part of the face. Control
group consisted of 2 patients, which received saline.
Biometric Parameters tested
Skin hydration, anisotropy, TEWL, Cutaneous micro-relief, Pigmentation, luminance,
temperature
Follow up:
Three follow up visits at 21-28d, 90d and 120d.
Outcome:
3 weeks post treatment a good anti-ageing effect was evidenced (24% improvement),
which increased with time (33%) . The positive effect of one treatment lasted up to ten
months.
Amgar et al, 2011 - Clinical Aspect of Treatment
Zones of injection and (A) Before (B) 1 month after (C) 3 months later
measurement
120
in Aesthetics (2)
for Hair Growth
Methods
The scalp was first traumatized with a 1.5 mm microneedling roller, followed by two 10 ml PRP
injections at 3 months intervals
Results
At 3 months an increase in hair density of 18.8% was observed, as well as a decrease in the
average of caliber (-2%), as the new hairs are thin. At 9 months the density increased in 29% and
the caliber in 5%.
for Striae Distensae
Methods
19 patients. 3 sessions of intradermal RF combined with PRP at intervals of 4 weeks
Outcome
5.3% achieved excellent improvement; 36.8% - marked improvement; 31.6% - moderate
improvement and 26.3% - mild improvement.
in Orthopaedics
Methods: RCT L1. 46 athletes with jumper’s randomized into 2 groups: 2 PRP
injections (over 2 weeks under US (PRP group), and 3 sessions of focused extracor-poreal shock
wave therapy (ESWT group).
Results: The PRP group showed significantly better improvement than the
ESWT group in VISA-P, VAS scores at 6- and 12-m follow-up, and modified
Blazina scale score at 12-m follow-up.
Methods:
PRP-treated human skin fibroblasts in vitro.
Outcome:
Increase in expression of G1 cell cycle regulators and type I collagen, thereby accelerating the wound healing
process.
Unique Features - Summary
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