Step 2 CS Differential Diagnoses

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1. Headache Migraine 8. Fatigue Depression

Cluster headache PTSD
Temporal Arteritis Colon Cancer
Sinusitis Hypothyroid
Tension Headache Obstructive Sleep Apnea (OSA)
SAH Diabetes Mellitus (DM)
Pseudotumor Cerebri Sleep deprivation
Trigeminal Neuralgia
9. Night sweats TB
Meningitis
HIV
Ref Error
lymphoma
2. Confusion/Memory Alzheimer's Leukemia
Loss Vascular Dementia (Vascular Multi Hyperthyroid
Infarct Dementia)
10. Insomnia Stress
Normal Pressure Hydrocephalus
OSA
Creutzfeld-Jakob
MDD
SDH
Hypoglycemia 11. Sore throat Mono
Depression with Pseudo Dementia HIV
Hypothyroidism Pharyngitis
Vit B12 deficiency 12. Cough/SOB Asthma
3. Depression Bereavement COPD
MDD Pneumonia
Bipolar I Atypical pneumonia
Bipolar II Lung Cancer
TB
4. Psychosis Schizophrenia
CHF
Substance induced
HIV
Schizoaffective
ACE inhibitors
Brief Psychotic Disorder
Paroxysmal Nocturnal Dysnea
Psychosis sec. medical
Narcolepsy 13. Chest pain MI
Seizure SSA - pulm infarction
GERD
5. Dizziness Meniere's disease
Angina
Orthostatic hypotension
Pericarditis
Drugs vs fluids
Costochodritis
Benign Positional Vertigo
PE
Vestibular Neuronitis
Aortic dissection
Labyrinthitis
Cocaine induced
6. LOC Seizure, grand mal
14. Palpitations Cardiac
Vasovagal
Hyperthyroid
Cardiac arrhythmia
Panic
Drug/orthostatic
Pheo
Convulsive syncope
Carcinoid
Aortic stenosis
Angina
7. Numbness/Weakness TIA
15. Weight loss Hyperthyroid
Stroke
Cancer
Guillain Barre
HIV
MS
Diet
DM peripheral
Drugs
Myasthenia Gravis
Anorexia
Todds Paralysis
Malabsorption
16. Weight gain Smoking cessation 22. Blood in Colon Cancer
Drugs (Lithium) Stool Ulcerative Colitis
Hypothyroid Diverticulosis
Cushings Hemorrhoids
PCOS Crohns
DM Angiodysplasia
Atypical depression Ischemic Bowel
Familial Dysentery
Pregnancy
23. Hematuria Bladder Cancer
17. Dysphagia Esophageal cancer PKD
Plummer-Vinson Renal cell carcinoma
Achalasia Nephrolithiasis
Esophagitis Glomerulonephritis
Pyelonephritis
18. Nausea/Vomiting Pregnancy
Coagulatuib disorder
Gastritis
Hypercalcemia 24. Other BPH
DM Urinary Sx Prostate CA
UTI Urethritis
Infection - Gatroenteroritis Acute Pyelonephritis
Obstruction Bladder stone
19. Abdominal Pain Pancreatic Cancer 25. Erectile Drugs
Acute Pancreatitis Dysfunction HTN
Acute Cholecystitis DM
Ascending Cholangitis Psychogenic
Acute Hepatitis Peyronie's disease (induratio penis plastica
PUD (IPP) or chronic inflammation of the tunica
Perforated ulcer albuginea (CITA)) - connective tissue disorder
Splenic rupture involving the growth of fibrous plaques
Intestinal Obstruction
26. Amenorrhea Pregnancy
Mesenteric Ischemia
PCOS
Ovarian Torsion
Prolactinoma
Diverticulitis
Menopause
Appendicitis
Sheehan's
IBS
Anorexia
PID
Anxiety
Ca Stomach
Asherman's
Func. Dyspepsia
Hypothyroid
20. Constipation/Diarrhea Colorectal Cancer
27. Vaginal Dysfunctional Uterine Bleeding
Low-Fiber Diet
Bleeding Endometrial Cancer
IBS
Cervical Cancer
Infectious Diarrhea
Spontaneous Abortion
C Diff colitis
Ectopic Pregnancy/Rupture
Travelers Diarrhea
Trauma
Lactose intolerance
Endometrial Hyperplasia
Crohn's
Molar Pregnancy
UC
Ruptured Uterine Pregnancy
21. Upper GI Bleed PUD
28. Vaginal Bacterial Vaginosis
Gastritis
Discharge Vaginitis (trich vs candida)
Varices
Cervicitis
Mallory Weiss
Cancer
29. Dyspareunia (painful intercourse) Atrophic vaginitis 34. Behavioral problems ADHD
Endometriosis Adjustment
Cervicitis disorder
Depression ODD
Domestic Abuse Childhood BPD
Vaginismus Substance abuse
PID Age appropriate
Abuse behavior
Depression
35. Colorectal Cancer (CRC) Anal fissure
Vulvo vaginitis
Associations/DDX Hemorrhoid
Vulvo dynia
Diverticulosis
30. Abuse Domestic Violence MI
Osteogenesis Imperfecta Angiodysplasia
Substance abuse Upper GIB
Rape IBD
Consensual violent sex
36. Ulcerative Colitis (UC) Associations/DDX Crohn's
31. Joint/Limb pain RA Proctitis
SLE Anal fissure
Domestic Violence Hemorrhoid
Carpal Tunnel Diverticulosis
Psoriatic Arthritis Dysentery
Fracture
37. Divertivulosis Associations/ DDX Anal fissure
dislocation
Hemorrhoid
OA
Angiodysplasia
Septic Arthitis
CRC
Stress Frac
inflammation 38. Myocardial Infarction (MI) GERD
PVD Associations/DDX Angina
DVT Costochondritis
MI Aortic dissection
Rhabdomyolysis Pericarditis
PE
32. Lower Back Pain Disk herniation
Pneumothorax
Lumbar muscle strain
Lumbar spinal stenosis 39. Sickle Cell Crisis Associations/DDX PNA
Malingering PE
Ankylosing Spondylitis MI
Cancer Pneumothorax
AAA Aortic dissection

33. Child with fever Sepsis 40. Gastroesophageal Reflux Disorder Esophagitis
Meningitis (GERD) Associations/DDX PUD
Pneumonia Esophageal
UTI spasm
OM MI
URI Angina
Viral exanthem 41. Angina Associations/DDX Esophageal
Gastroenteritis spasm
Volvulus Esophagitis
Intussueption
42. Pericarditis Associations/DDX Aortic dissection
Food poisoning
MI
Costochondritis
GERD
Esophageal
rupture
43. Costochondritis Associations/ DDX PNA 53. Atypical Pneumonia (aPNA) Reactive Airway Disease
MI Associations/DDX (RAD)
PE URI-associated
Pericarditis (postinfectious) cough
Muscle strain Postnasal drip
GERD
44. Pulmonary Embolism (PE) PNA
Associations/DDX Costochondritis 54. Lung Cancer Associations/DDX TB
MI Abscess
CHF COPD
Aortic Vasculitis
dissection Interstitial lung disease
CHF
45. Aortic Dissection Associations/DDX MI
Pericarditis 55. COPD Exacerbation Lung cancer
Esophageal Associations/DDX PNA
rupture URI
Esophageal CHF
spasm
56. Tuberculosis (TB) PNA (incl PCP)
GERD
Associations/DDX Abscess
Pancreatitis
Vasculitis
Fat emboli
Lymphoma
46. Neonatal Sepsis Associations/ DDX Meningitis Metastatic cancer
PNA HIV/AIDS
UTI Sarcoidosis
47. Acute Otitis Media (AOM) URI
PNA (incl PCP)
Associations/DDX Meningitis
Bronchitis
UTI
CHF
48. Measles Associations/DDX Rubella Asthma
Roseola Acute HIV
Fifth disease
57. Congestive Heart Failure (CHF) Cardiac valvular disease
Varicella
Associations/DDX GERD
Scarlet fever
Pulmonary fibrosis
Meningitis
COPD
49. Gastroenteritis Associations/ DDX Food poisoning Postnasal drip
UTI
58. Migraine Associations/DDX Tension
URI
Cluster
Volvulus
Pseudotumor
Intussusception
Trigeminal neuralgia
50. Asthma Associations/DDX GERD CNS vasculitis
Bronchitis Partial seizure
Pneumonitis Intracranial neoplasm
Foreign body
59. Cluster Headache Migraine
51. Chronic Obstructive Pulmonary Disease Bronchiectasis Associations/DDX Tension
(COPD) Associations/DDX Lung Ca Sinusitis
TB Pseudotumor
52. Pneumonia (PNA) Associations/DDX COPD Trigeminal neuralgia
exacerbation Brain tumor
Lung abscess
Lung cancer
TB
Pericarditis