Week 1

Introduction to Chemistry
1. Show the Lewis-Dot structure. Do you notice anything in common?

2. Consider the following bonds:

3. Draw Lewis Structures for:

 4. Complete the following table

Week 2
Chemical Reactions
1. Using solubility guidelines, predict whether each of the following compounds
is soluble or insoluble in water:

2. Will precipitation occur when the following aqueous solutions are mixed? If so,
write a balanced chemical equation for the reaction.

3. Many proteins are dependent on zinc ions for their activity. A researcher
preparing a solution of protein and zinc starts by dissolving 3.25mg of zinc
chloride in water with a total volume of 250mL.

4. A solution of glucose with a volume 3.27𝝁𝑳 and a concentration of 1.45mmol/L

is diluted to a total final volume of 6.59𝝁𝑳. Determine the concentration of the
resulting solution
 5. A nurse wants to prepare a 1.0% (m/v) silver nitrate solution from 24mL of a
3.0% (m/v) stock solution of silver nitrate. How much water should be added to
the 24mL of stock solution?
6. Consider separate solutions of NaOH and KCl made by dissolving 100.0g of
each solute in 250mL of solution. Calculate the concentration of each solution.

Measurements in Chemistry
1. What is the mass of 1 mole of carbon?
2. What is the mass of 1 mole of silicon?
3. What is the mass of 0.1 mole of ethanol (𝑪𝟐 𝑯𝟔 𝑶)?
4. How many moles in 24 g carbon?
5. How many moles in 100 g CO2?
6. Bone and dental implants are often coated with calcium phosphate. If a coating
procedure can deposit 0.115 mol of pure calcium phosphate, what is the mass
of the coating?
7. How much sulfur by mass is in the amino acid cysteine? (𝑪𝟑 𝑯𝟔 𝑵𝑶𝟐 𝑺)

8. A sample of chlorophyll, 𝑪𝟓𝟓 𝑯𝟕𝟐 𝑴𝒈𝑵𝟒 𝑶𝟓 , was found to have 0.0011g of

magnesium. What mass of carbon was present in the sample?

Week 3
Reaction rates and equilibrium
1. Which of the following statements about activation energy is correct?
a. It is the same for all reactions
b. It is low for reactions that take place rapidly
c. It is the maximum energy a reacting molecule may possess
2. Calculate K for the reaction between the general reactions 𝑨𝟐 and 𝑩𝟐 . The
equilibrium concentrations are as follows:
 3. Carbon dioxide and hydrogen gas are allowed to react until equilibrium is
established as follows as follows: 𝑪𝑶𝟐(𝒈) + 𝑯𝟐(𝒈) ↔ 𝑯𝟐 𝑶𝒈 + 𝑪𝑶𝒈 . Which of the
following changes will cause the equilibrium position to shift to the right?
a. Increase in the concentration of hydrogen gas
b. Decrease in the concentration of CO
c. Decrease in the concentration of CO2
d. More than one correct response
e. No correct response

Week 4
Acid, Bases and buffers
1. Lactic acid has a pKa of 3.86. Is it more or less acidic than acetic acid (pKa =
4.76)
2. Calculate the pH of a solution in which 0.1mol of acetic acid and 0.2mol of
sodium acetate were made up to a total volume of 1L given 𝑲𝒂 (𝑪𝑯𝟑 𝑪𝑶𝑶𝑯) =
𝟏. 𝟕𝟔 × 𝟏𝟎−𝟓 .

Week 5
Redox Reactions
1. Determine the oxidation state for N in the following.
a. HNO3
b. N2O
c. NO2
d. NaNO2

Thermodynamics
1. What would an endothermic energy diagram look like? What would an
exergonic energy diagram look like?
2. The conversion of glucose, 𝑪𝟔 𝑯𝟏𝟐 𝑶𝟔 , to pyruvic acid, 𝑪𝟑 𝑯𝟒 𝑶𝟑 , is an important
step in the citric acid cycle:
 3. Use the Gibbs free energy equation to show that glucose and ATP will
spontaneously react.
𝑮𝒍𝒖𝒄𝒐𝒔𝒆 + 𝑨𝑻𝑷 → 𝑮𝟔𝑷 + 𝑨𝑫𝑷, ∆𝑮𝟐 =?
You will need the following information:
𝑨𝑻𝑷 + 𝑯𝟐 𝑶 → 𝑨𝑫𝑷 + 𝑷𝒊 , ∆𝑮𝟐 = −𝟑𝟎. 𝟓𝒌𝑱/𝒎𝒐𝒍
𝑮𝒍𝒖𝒄𝒐𝒔𝒆 + 𝑷𝒊 → 𝑮𝟔𝑷 + 𝑯𝟐 𝑶, ∆𝑮𝟐 = +𝟏𝟑. 𝟖𝒌𝑱/𝒎𝒐𝒍

Week 7
Introduction to Organic Chemistry
1. Name the following alkane:

2. Name the following alkane

3. Name the following alkane:

4. Name the following cycloalkane:

 5. Name the following cycloalkane:

6. Draw 2-methylhexanol
7. Draw 3-ethylheptanoic acid
8. Name the following:

9. Name the following:

10. Name the following:

11. Name the following:

12. Draw 1,3-dichlorocyclopentane

13. Draw 1-bromobut-2-ene

Isomers
1. Draw the constitutional isomers for the molecular formula 𝑪𝟓 𝑯𝟏𝟐

Week 8
Chemistry of alkanes, alkenes
1. Draw the mirror image of the following. Which are superimposable?
2. Which of the following pairs of molecules are enantiomers?

3. How many stereoisomers are possible for the following molecules?

4. Rank the following in decreasing priority (highest first)

5. Assign the stereochemistry for the chiral centre (R or S)?

6. What is the correct name for the following structure?

7. Which of the following compounds exist as cis-trans isomers?

8. Which of the following compounds show cis-trans isomerism?

9. Which of alkenes have E configurations?

 10. What is the correct name for the following alkene?

Week 9
Chemistry of alcohols, amines and related compounds
1. Using Markovnikov’s rule, what will be the product?

2. Using Zaitsev’s rule, what will be the major product?

Week 10
Chemistry of Aldehydes and Ketones
1. Complete the following reactions:
 2. Draw the hemiacetal and acetal formed for each pair of reagents shown in the
presence of an acid catalyst.

3. From which parent aldehyde/ketone and alcohol do the following arise from?

4. From which parent aldehyde/ketone and alcohol do the following arise from?

Week 11
Chemistry of Carboxylic Acids and Esters
1. Draw the products from the following reactions.
a.

b.

2. Draw the products from the following reactions.

a.
 b.

3. Draw the products of the following reactions.

a.

b.

4. True or false, the following structure is representative of an L-aldohexose.

5. Which of the following are L-sugars?

 6. What is the relationship between the following compounds?
a. Anomers
b. Diastereomers
c. Enantiomers
d. Identical structures

Chemistry of Carbohydrates
1. True or false: The sugar below undergoes mutarotation in neutral aqueous
solution.

2. Which of the following are non-reducing monosaccharides?

3. True or false: The disaccharide shown below is a reducing sugar.

 4. Complete the following reaction by providing the reagent needed.

a. NaBH4
b. H+/CH3OH
c. H+/H2O
d. NaBH4/H+
e. Ag+/NH4OH

Week 12
Chemistry of amino acids, peptides and proteins
1. Classify the following amino acids as non-polar, polar, acidic or basic.
a.

b.

c.

2. Draw alanine as zwitterion and draw the molecule when 1mol of alanine is in
the presence of each of the following:

a. 1mol of NaOH
b. 1mol of HCl
3. What would be the predominant form of lysine in water at pH 14

4. At pH 10, what is the overall charge on the following molecule?

5. Which of the pH conditions below would give this heptapeptide an overall

charge of 2+?

a. The cyclic structure means that the system will always be isoelectronic
b. pH = 3
c. Neutral pH
d. pH = 10
e. The system will always be charged as it is a zwitterion
6. Draw the individual amino acids that make up this dipeptide.

7. Draw the individual amino acids that make up this tetrapeptide.

8. What is the total charge on each of the following amino acids in a pH of 14?
a. Threonine

b. Aspartic acid

9. At pH 1, what is the overall charge on the following molecule?

 10. Draw the structure of the amino acids that would be formed upon base
catalysed hydrolysis of the amide bonds in the following tripeptide.

Week 13
Chemistry of nucleic acids
1. What is the difference between a nucleotide and a nucleoside?
2. Which is an incorrect statement concerning the DNA double helix?
a. The sugar-phosphate backbone is on the outside
b. The two strands are identical but proceed in opposite directions
c. Hydrogen bonding holds together the two strands
d. Only purine-pyrimidine base pairs can be accommodated
e. The sugar-phosphate backbone is completely regular
3. The base content of a particular DNA molecule is 36% thymine. What is the
percentage of cytosine in the molecule?
4. What is the complementary DNA for 5’-ACCGTTAAT-3’

Chemistry of lipids
1. Draw the products of the saponification of this triglyceride.

2. How many molecules of hydrogen gas will react with one molecule of the
triglyceride below?

3. True or false: The greater degree of unsaturation in a fatty acid, the higher its
melting point
Resources
Solubility Table

Electronegativity Values