PMID- 26182337

OWN - NLM
STAT- MEDLINE
DCOM- 20160510
LR - 20150810
IS - 1532-432X (Electronic)
IS - 0363-0269 (Linking)
VI - 39
IP - 4
DP - 2015
TI - Aging in Sickle Cell Disease: Co-morbidities and New Issues in Management.
PG - 221-4
LID - 10.3109/03630269.2015.1040493 [doi]
AB - Availability of hydroxyurea (HU) coupled with early therapeutic interventions
has
increased the life expectancy of patients with sickle cell disease. Hence,
the
sickle cell community needs to be aware of common diseases of aging that
survivors are predisposed to. We chose to investigate the sickle cell
disease-related complications as well as non sickle cell disease-related
medical
problems of aging in 45 sickle cell patients over the age of 40 years. The
most
frequent chronic complications of sickle cell disease were elevated tricuspid
regurgitant jet velocity on echocardiogram, chronic renal disease, iron
overload
and leg ulcers. Medical co-morbidities in this patient group included
hypertension, diabetes mellitus (DM), hypercholesterolemia and symptomatic
coronary artery disease (CAD). In our cohort, only 38.0% had a primary care
doctor. Only 11.0% over age 50 had a screening colonoscopy, and of the women,
42.0% had a screening mammography. Medical co-morbidities and lack of health
maintenance in older sickle cell patients are likely to impact overall health
and
mortality. Aging patients with sickle cell disease may benefit from a primary
medical home for age appropriate comprehensive health care.
FAU - Sandhu, Manpreet K
AU - Sandhu MK
AD - Department of Hematology/Oncology, Newark Beth Israel Medical Center ,
Newark,
New Jersey , USA.
FAU - Cohen, Alice
AU - Cohen A
LA - eng
PT - Journal Article
DEP - 20150716
PL - England
TA - Hemoglobin
JT - Hemoglobin
JID - 7705865
SB - IM
MH - Adult
MH - Aged
MH - Anemia, Sickle Cell/blood/complications/*epidemiology
MH - Cardiovascular Diseases/epidemiology/etiology
MH - Comorbidity
MH - Disease Management
MH - Female
MH - Hematologic Tests
MH - Humans
MH - *Life Expectancy
MH - Male
MH - Middle Aged
MH - Prevalence
MH - Renal Insufficiency, Chronic/epidemiology/etiology
OTO - NOTNLM
OT - Aging
OT - hemoglobinopathies
OT - sickle cell disease
EDAT- 2015/07/17 06:00
MHDA- 2016/05/11 06:00
CRDT- 2015/07/17 06:00
PHST- 2015/07/17 06:00 [entrez]
PHST- 2015/07/17 06:00 [pubmed]
PHST- 2016/05/11 06:00 [medline]
AID - 10.3109/03630269.2015.1040493 [doi]
PST - ppublish
SO - Hemoglobin. 2015;39(4):221-4. doi: 10.3109/03630269.2015.1040493. Epub 2015
Jul
16.