Ysun Kristine M. Espino Ms. Anita D.

Urbi, RN, MAN, PhD

G3A Clinical Instructor
DRUG STUDY
Name of Drug Action Indication Adverse Effect Nursing Responsibility

Generic Name: Blocks dopamine Management of severely ill CNS: Drowsiness,

receptors in the brain, schizophrenics who are sedation seizures,  Assess for hallucinations,
 Clozapine depresses the RAS; unresponsive to standard dizziness, syncope, mental status, dementia,
anticholinergic, antipsychotic drugs. headache, tremor, bipolar disorder (initially
Brand Name: antihistaminic (H1), disturbed sleep, and throughout therapy)
and alpha-adrenergic Reduction of the risk of nightmares,  Obtain complete health
 Clozaril blocking activity may recurrent suicidal behavior restlessness, agitation, history, especially
contribute to some of in patients with increase salivation, psychological, neurologic
Classification: its therapeutic (and schizophrenia or sweating, tardive and blood disease:
adverse) and actions. schizoaffective disorder dyskinesia, neuroleptic including blood studies:
 Antipsychotic/Dopami (not orally disintegrating
Clozapine produces malignant syndrome. CBC, WBC with
nergic blocker tablet)
fewer extrapyramidal differential, electrolytes,
effects than other CV: Tachycardia, BUN, creatinine, liver
Contraindication hypotension,
Dosage: antipsychotics. enzymes.
hypertension, ECG  Do not let client engage
Contraindicated with
 100mg tab bid allergy to clozapine, CNS
changes, potentially in any hazardous activity
fatal myocarditis. until response to the drug
depression, comatose
Route of Administration: states, history of seizure is known. Drowsiness
GI: nausea, vomiting
disorders, lactation, and sedation are
 Orally
therapy with other drugs common adverse effects.
that cause bone marrow  Let client rise slowly to
depression prevent orthostatic
hypotension
 Report immediately any
of the following:
unexplained fatigue,
especially with activity;
shortness of breath,
sudden weight gain or
edema.
Ysun Kristine M. Espino Ms. Anita D. Urbi, RN, MAN, PhD
G3A Clinical Instructor
DRUG STUDY
Name of Drug Action Indication Adverse Effect Nursing Responsibility

Generic Name: Interferes with cell Treatment of infections EENT:  Determine previous
wall replication of caused by pneumococci, occasionally, laryngeal exposure and
 Cloxacillin susceptible Group A beta-hemolytic edema sensitivity to penicillin
organisms, the cell streptococci, and penicillin and cephalosporins
Brand Name: wall, rendered G sensitive staphylococci. Skin: and other allergic
osmotically unstable, urticaria, skin reactions of any kind
 Avastoph swell, bursts from Prophylaxis: rashes, before treatment is
osmotic pressure; Staphylococcal infection exfoliative initiated.
Classification resists the during major dermatitis, rash  Monitor for S&S of
penicillinase action cardiovascular and anaphylactoid reaction
 Anti-infective, orthopedic surgery.
that inactivates GI: (see Appendix G) or
Antibiotic
penicillin. GI disturbances, other signs or
Contraindication
nausea, symptoms of
Dosage: History of hypersensitivity vomiting, hypersensitivity
to penicillin and epigastric distr reaction (see
 150 mg every 6hrs cephalosporins. Severe ess, Appendix F) as with
pneumonia, emphysema, d i a r r h e other penicillin.
Route of Administration: bacteremia, pericarditis, a a n d  Take medication
meningitis and purulent flatulence, antibiot around the clock, do
 Orally
and septic arthritis during i c - associated pseudo not miss a dose, and
the acute stage. Sub- membranous colitis continue taking the
conjunctival infections medication until it is
GU: finished.
Interstitial nephritis and  Report to physician
vasculitis the onset of
hypersensitivity
Hematologic: reaction and super
eosinophilia, infections.
agranulocytosis,  Check with physician
anemia, if GI adverse effects
thrombocytopenia,
t r a n s i e n t r (nausea, vomiting,
i s e i n diarrhea) appear.
transminases  Instruct patient to take
a n d alkaline the drug with one full
phosphatase glass of water

Other:
Hypersensitivity
reactions, serum
sickness-like reactions,
fever
Ysun Kristine M. Espino Ms. Anita D. Urbi, RN, MAN, PhD
G3A Clinical Instructor
DRUG STUDY
Name of Drug Action Indication Adverse Effect Nursing Responsibility

Generic Name: Azithromycin is a Treatment of lower Mild to moderate  Culture site of infection
bacteriostatic drug respiratory infections: nausea, vomiting, before therapy.
 Azithromycin acts by inhibiting Acute bacterial abdominal pain,  Administer on an empty
stomach 1 hr before or
protein synthesis. It exacerbations of COPD dyspepsia, flatulence,
2–3 hrs after meals.
Brand Name: binds reversibly to due to Haemophilus diarrhea, cramping; Food affects the
50S ribosomal influenzae, Moraxella angioedema, cholestatic absorption of this drug.
 Zithromax subunits of sensitive catarrhalis, Streptococcus jaundice; dizziness,  Prepare Zmax by adding
microorganism. pneumoniae; community- headache, vertigo, 60 mL water to bottle,
Classification: Azithromycin acquired pneumonia due somnolence; transient shake well.
interferes with to S. pneumoniae, H. elevations of liver  Counsel patients being
 Macrolide treated for STDs about
transpeptidation and influenzae enzyme values.
 Antibiotic appropriate precautions
translocation thus
there is inhibition of and additional therapy
Dosage:
protein synthesis and
Contraindication
 500mg OD hence inhibition of cell
growth. Contraindicated with
Route of Administration: hypersensitivity to
azithromycin,
 PO
erythromycin, or any
macrolide antibiotic.

Use cautiously with

gonorrhea or syphilis,
pseudomembranous
colitis, hepatic or renal
impairment, lactation.