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Gosset et al.
Tree-In-Bud Pattern
Residents’ Section
Pattern of the Month
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Residents
DOI:10.2214/AJR.09.3401
1
All authors: Department of Radiology, Beth Israel
Deaconess Medical Center, Harvard Medical School, 330
Brookline Ave., Boston, MA 02215. Address correspond
ence to R. L. Eisenberg (rleisenb@bidmc.harvard.edu).
WEB
This is a Web exclusive article.
viral, parasitic), congenital disorders (cystic fibrosis, Kartagener syndrome), idiopathic disor-
ders (obliterative bronchiolitis, panbronchiolitis), aspiration or inhalation of foreign substances,
immunologic abnormalities, connective tissue disorders, and peripheral pulmonary vascular
disease (neoplastic pulmonary emboli) (Table 1). Additional imaging findings combined with
history and clinical presentation can suggest the appropriate diagnosis.
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Infections
Bacterial Infection
The classic cause of the tree-in-bud pattern is postprimary tuberculosis (Fig. 3), a condition
that develops in approximately 5% of patients with primary infection and is frequently associ-
ated with malnutrition and immune suppression. Occasionally, it may reflect reinfection with
new organisms. The tree-in-bud pattern suggests active and contagious disease, especially
when associated with adjacent cavitary disease within the lungs.
The most common CT findings are centrilobular nodules and branching linear and nodular
opacities. This tree-in-bud pattern is due to the presence of caseation necrosis and granuloma-
tous inflammation within and surrounding the terminal and respiratory bronchioles and al-
veolar ducts, reflecting endobronchial spread of tuberculosis. Other common findings include
cavitary nodules, lobular consolidation, interlobular thickening, and bronchovascular distor-
tion. Pleural effusion and enlarged lymph nodes with central low attenuation due to caseous
necrosis also can be seen. After antituberculous therapy is begun, most of the centrilobular
and branching opacities disappear within 5 months. However, bronchovascular distortion, fi-
brosis, emphysema, and bronchiectasis increase on follow-up CT.
Atypical mycobacteria may produce a pattern indistinguishable from that of tuberculosis,
although without any upper lobe predominance (Fig. 4). This is also seen with Mycobacteri-
um avium-intracellulare or M. avium complex, notably in immunologically compromised
individuals with HIV. Bronchiolitis due to Staphylococcus aureus and Haemophilus influen-
zae also may manifest as the peripheral tree-in-bud pattern.
Fungal Infection
Invasive airway aspergillosis causing bronchiolitis occurs most commonly in neutropenic
patients and individuals who are immunologically suppressed with AIDS. Fungal hyphae are
often found in the airway lumen. Other clinical manifestations of this condition are broncho-
pneumonia (peribronchial distribution of consolidation) and tracheobronchitis (bronchiectasis
A B
Fig. 3—Tuberculosis.
A and B, Peripheral tree-in-bud opacities (circle, A) combine to produce more peripheral centrilobular nodules
(circle, B).
A B
Fig. 4—Atypical mycobacterial infection.
A and B, Maximum-intensity-projection images in transverse (A) and coronal (B) planes show generalized tree-
in-bud opacities.
and thickening of the trachea or bronchi), which are often bilateral. Invasive airway aspergil-
losis should be suggested when the tree-in-bud pattern occurs in combination with a consoli-
dation accompanied by a halo of ground-glass opacity in a patient with leukemia.
Viral Infection
Cytomegalovirus infection, which typically occurs in immunologically compromised indi-
viduals, can cause bronchiolitis with centrilobular nodules and thickening of the bronchovas-
cular bundles that produce the tree-in-bud pattern. This pattern may have a patchy and unilat-
eral or bilateral and asymmetric distribution and may progress to areas of ground-glass opac-
ity and consolidation. There may be poorly defined nodules with the CT halo sign. In infants
and young children, the tree-in-bud pattern is most commonly caused by bronchial wall
thickening and dilatation related to respiratory syncytial virus.
Congenital Disorders
Cystic Fibrosis
Cystic fibrosis is an autosomal-recessive hereditary disorder involving the exocrine glands,
resulting in the production of abnormal secretions by the salivary and sweat glands, pancreas,
large bowel, deferent ducts, and tracheobronchial tree. A block in the transport of chloride
into the bronchial lumen and the excessive resorption of sodium leads to the production of
thick and dry mucus, resulting in decreased clearance of mucus and eventually mucous plug-
ging in small and large airways and subsequent bacterial infection.
Chronic infection and inflammatory reactions cause lung damage. The most common CT
findings include bronchial wall thickening, bronchiectasis or bronchiolectasis, mucous plug-
ging, and air trapping on expiratory scanning. Large amounts of bronchiolar secretions can
produce the tree-in-bud pattern, which predominantly tends to affect the upper lobes in the
early stage of the disease.
Kartagener Syndrome
Kartagener syndrome is one of the dyskinetic cilia syndromes, a set of autosomal-recessive
disorders in which inherited abnormalities in ciliary structure and function result in abnormal
mucociliary clearance and chronic infection. It is characterized by the clinical triad of situs
inversus, sinusitis, and bronchiectasis. Symptoms of recurrent bronchitis, pneumonia, and
sinusitis often date from childhood. In men, the syndrome may be associated with immotile
spermatozoa and infertility.
The typical chest CT findings in Kartagener syndrome include bilateral bronchiectasis
with a basal predominance. Airway damage can extend to the smaller airways, causing bron-
chiolectasis, air trapping, and centrilobular opacities producing the tree-in-bud pattern.
Idiopathic Disorders
Obliterative Bronchiolitis
Obliterative bronchiolitis, also known as constrictive bronchiolitis, is an irreversible fibro-
sis of small airway walls that narrows or obliterates the lumen, leading to chronic airway
obstruction. The most common causes include infection (viral, bacterial, mycoplasma), inha-
lation of toxic fumes, drug treatment (penicillamine or gold), collagen vascular disease (rheu-
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matoid arthritis, especially after the therapies mentioned), chronic lung transplant rejection,
and bone marrow transplantation with chronic graft-versus-host disease. Nevertheless, oblit-
erative bronchiolitis is often idiopathic. Patients usually present with shortness of breath and
evidence of airway obstruction. CT findings include bronchial wall thickening, central and
peripheral bronchiectasis, mosaic perfusion, and air trapping on expiratory CT scans (the
most sensitive sign). Centrilobular nodules from luminal impaction produce the tree-in-bud
pattern (Fig. 5).
Diffuse Panbronchiolitis
Diffuse panbronchiolitis is a progressive inflammatory disease of unknown cause that has
been reported almost exclusively in Japan and Eastern Asia. It represents a transmural infil-
tration of lymphocytes and plasma cells, with mucus and neutrophils filling the lumen of af-
fected bronchioles. Most affected individuals are nonsmokers and have chronic sinusitis. The
natural history of the disease is progressive respiratory failure leading to cor pulmonale and
ultimately death. In addition to thick-walled bronchioles filled with mucus and producing the
tree-in-bud pattern, there may be nodules, bronchiectasis, large cystic opacities accompanied
by dilated proximal bronchi, and mosaic perfusion or air trapping.
Immunologic Disorders
Allergic bronchopulmonary aspergillosis is a hyperimmune response to airway coloniza-
tion with Aspergillus species commonly seen in patients with asthma and cystic fibrosis. The
fungus proliferates in the proximal bronchi, acting as an antigenic stimulus for the production
of IgE and IgG antibodies. The inflammatory reaction results in damage to the bronchial wall,
central bronchiectasis, and the formation of mucous plugs that contain fungus and inflamma-
tory cells, producing the finger-in-glove sign of large airway impaction that tends to have
upper lobe predominance and can be seen on chest radiographs. Involvement of the small
airways causes the tree-in-bud pattern (Fig. 7). Indirect signs of small airways disease include
a mosaic pattern of lung attenuation and air trapping on expiratory scanning.
A B
Fig. 7—Allergic bronchopulmonary aspergillosis.
A and B, Peripheral tree-in-bud opacities (arrows, A) can often be accompanied by more proximal airway
abnormalities, such as mucous plugging (arrows, B).
A lymphoid interstitial infiltrate in the walls of the small airways (follicular bronchiolitis) may
cause small centrilobular nodules and the tree-in-bud pattern (Fig. 8). More extensive lympho-
cytic infiltrations may be associated with lymphoid interstitial pneumonia (LIP), with ground-
glass opacities, consolidation, septal thickening mimicking the lymphangitic spread of carcinoma,
and cystic air spaces. This condition progresses to fibrosis in about one third of patients.
Sjögren Syndrome
Sjögren syndrome consists of the clinical triad of keratoconjunctivitis sicca, xerostomia,
and recurrent swelling of the parotid gland. The most common thoracic manifestations in-
clude LIP (more common than in rheumatoid arthritis), follicular bronchiolitis, interstitial
pneumonia, organized pneumonia, tracheobronchial gland inflammation, and pleuritis with
or without effusion. As with rheumatoid arthritis, lymphoid interstitial infiltrate in the walls
of the small airways may produce the tree-in-bud pattern.
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