The challenges of respiratory motor system recovery following cervical spinal cord injury.

Author information

1Department of Neurosciences, MetroHealth Medical Center, Case Western Reserve University School
of Medicine, Cleveland, OH, USA.

2Department of Neurosciences, MetroHealth Medical Center, Case Western Reserve University School
of Medicine, Cleveland, OH, USA. Electronic address: warren.alilain@case.edu.

Abstract

High cervical spinal cord injury (SCI) typically results in partial paralysis of the diaphragm due to intrusion
of descending inspiratory drive at the level of the phrenic nucleus. The degree to which such paralysis
occurs depends on the type, force, level, and extent of trauma produced. While endogenous recovery
and plasticity may occur, the resulting respiratory complications can lead to morbidity and death.
However, it has been shown that through modification of intrinsic motor neuron properties, or altering
the environment localized at the site of SCI, functional recovery and plasticity of the respiratory motor
system can be facilitated. The present review emphasizes these factors and correlates it to the
treatment of SCI at the level of the somatic nervous system. Despite these promising therapies,
functional respiratory motor system recovery following cervical SCI is often minimal. This review thus
focuses on possible directions for the field, with emphasis on combinatorial treatment.

© 2014 Elsevier B.V. All rights reserved.

http://www.ncbi.nlm.nih.gov/pubmed/25194199

terjemahan

Tantangan pemulihan sistem motor pernapasan setelah cedera sumsum tulang belakang serviks.

penulis informasi
1Jurusan dari ilmu saraf, MetroHealth Medical Center, Case Western Reserve University School of
Medicine, Cleveland, OH, USA.

2Department dari ilmu saraf, MetroHealth Medical Center, Case Western Reserve University School of
Medicine, Cleveland, OH, USA. Alamat Elektronik: warren.alilain@case.edu.

Abstrak

Serviks cedera tulang belakang Tinggi (SCI) biasanya menghasilkan kelumpuhan parsial diafragma akibat
intrusi turun berkendara inspirasi pada tingkat inti frenikus. Sejauh mana kelumpuhan tersebut terjadi
tergantung pada jenis, kekuatan, tingkat, dan tingkat trauma yang dihasilkan. Sementara pemulihan
endogen dan plastisitas dapat terjadi, komplikasi pernapasan yang dihasilkan dapat menyebabkan
morbiditas dan kematian. Namun, telah terbukti bahwa melalui modifikasi intrinsik sifat neuron motorik,
atau mengubah lingkungan lokal di lokasi SCI, pemulihan fungsional dan plastisitas sistem motorik
pernapasan dapat difasilitasi. Tinjauan ini menekankan faktor-faktor ini dan menghubungkannya ke
pengobatan SCI pada tingkat sistem saraf somatik. Meskipun ini terapi yang menjanjikan, pemulihan
sistem motor pernapasan fungsional berikut SCI serviks sering minimal. Ulasan ini sehingga berfokus
pada kemungkinan arah untuk lapangan, dengan penekanan pada pengobatan kombinasi.

© 2014 Elsevier B.V. All rights reserved.

http://www.ncbi.nlm.nih.gov/pubmed/25194199