ADVERSE NURSING

DRUG ACTION INDICATION

CONTRAINDICATION EFFECTS CONSIDERATIONS
DRUG STUDY

Salbutamol 1 neb Relaxes smooth muscles by To prevent and Hypersensitivity to CNS: dizziness, ● Stay alert for
q 4° stimulating beta2- relieve drug excitement, hypersensitivity
receptors, thereby causing bronchospasm in headache, reactions and
bronchodilation and patients with hyperactivity, paradoxical
vasodilation reversible insomnia bronchospasm. Stop
obstructive airway drug immediately if
disease CV: these occur.
hypertension,
palpitations, ● Advise patient to limit
tachycardia, intake of caffeine-
chest pain containing foods and
CLASSIFICATION: beverages and to avoid
Sympathomimeti EENT: herbs unless prescriber
c conjunctivitis, approves.
dry and irritated
(beta2-adrenergic throat, ● As appropriate, review
agonist) pharyngitis all other significant and
life-threatening adverse
GI: nausea, reactions and
vomiting, interactions, especially
anorexia, those related to the
heartburn, GI drugs, foods, and herbs.
distress, dry
mouth

Metabolic:
hypokalemia

Musculoskeletal:
muscle cramps

Respiratory:
cough, dyspnea,
wheezing,
paradoxical
bronchospasm

Skin: pallor,
urticaria, rash,
angioedema,
flushing,
 NURSING
DRUG ACTION INDICATION CONTRAINDICATION ADVERSE EFFECTS
CONSIDERATIONS

Hydrocortisone Suppresses Replacement CNS: headache,

● Hypersensitivity to drug, alcohol,
40mg IV q 6° inflammatory therapy in bisulfites, or tartrazine (with some nervousness, ● Urge patient/SO
and immune adrenocortical depression, euphoria, to immediately
products)
responses, insufficiency; personality changes, report unusual
mainly by hypercalcemia psychoses, vertigo, weight gain, face or
● Systemic fungal infections
inhibiting due to cancer; paresthesia, leg swelling,
migration of arthritis; insomnia, epigastric burning,
● Concurrent use of other
CLASSIFICATION: leukocytes collagen restlessness, conus vomitingof blood, b
immunosuppressant
and diseases; medullaris syndrome, lack tarry stools,
Corticosteroids
Short-acting phagocytes dermatologic meningitis, increased fever, prolonged
corticosteroid and diseases; intracranial pressure, sore throat, cold or
● Concurrent administration of live
decreasing autoimmune seizures other infection, or
virus vaccines
inflammatory and worsening of
mediators hematologic CV: hypotension, symptoms.
disorders; hypertension,
trichinosis; thrombophlebitis,
ulcerative heart failure, shock, ● As appropriate,
colitis; fat embolism, review all other
multiple thromboembolism, significant and life-
sclerosis; arrhythmias threatening
proctitis; adverse
nephrotic EENT: cataracts, reactions and
syndrome; glaucoma, increased interactions,
aspiration intraocular pressure, especially those
pneumonia epistaxis, nasal related to the
congestion, drugs, tests, herbs,
perforated nasal and behaviors
septum, dysphonia,
hoarseness,
nasopharyngeal or
oropharyngeal fungal
infections

GI: nausea, vomiting,

esophageal
candidiasis or ulcer,
abdominal distention,
dry mouth, rectal
bleeding, peptic
ulceration,
pancreatitis

Hematologic: purpura

Metabolic: sodium
and fluid retention,
hypokalemia,
hypocalcemia,
hyperglycemia,
hypercholesterolemia
, growth retardation,
diabetes mellitus,
cushingoid
appearance

Musculoskeletal:
osteoporosis, aseptic
joint necrosis,muscle
pain or weakness,
steroid myopathy,
loss of muscle mass,
tendon rupture,
spontaneous fractures
Respiratory: cough,
wheezing, rebound
congestion,
bronchospasm

Skin: rash, pruritus,

urticaria, contact
dermatitis, bruising,
petechiae, striae,
acneiform lesions,
skin fragility and
thinness, angioedema

Other: altered taste;

anosmia; appetite
changes; weight gain;
facial edema;
increased
susceptibility to
infection; masking or
aggravation of
infection; adhesive
arachnoiditis;
injection site pain,
burning, or atrophy;
immunosuppression;
hypersensitivity
reactions including
anaphylaxis
 NURSING
DRUG ACTION INDICATION CONTRAINDICATION ADVERSE EFFECTS
CONSIDERATIONS

Cefuroxime 350mg Interferes with bacterial Moderate to CNS: headache,

● Hypersensitivity to
IV q 8° cell-wall synthesis and severe infections, cephalosporins or hyperactivity, ● Monitor
division by binding to cell including those of hypertonia, seizures neurologic status,
penicillins
wall, causing cell to die. skin, bone, joints, particularly
Active against urinary or GI: nausea, for signs of
● Carnitine deficiency
gram-negative and gram- respiratory tract, vomiting, diarrhea, impending
positive gynecologic abdominal pain, seizures
CLASSIFICATION: bacteria, with expanded infections dyspepsia,
activity against gram- pseudomembranou ● Monitor
Second generation negative bacteria s colitis temperature;
cephalosporin watch for signs and
GU: hematuria, symptoms of
renal dysfunction, superinfection.
acute renal failure
● Advise patient
Hematologic: to immediately
hemolytic anemia, report
aplastic anemia, rash or bleeding
hemorrhage tendency.

Hepatic: hepatic ● Advise patient to

dysfunction report CNS
changes.
Metabolic:
hyperglycemia As appropriate,
review all other
Skin: toxic significant
epidermal and life-
 threatening
necrolysis, adverse
erythema reactions and
interactions.
Other: allergic
reaction, drug fever,
superinfection,
anaphylaxis