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D N A: T h e M a s t e r
M o l e c u l e of Life
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CONTENTS
Curriculum Standards 1
Student Preparation 2
Pre-test 2
Student Objectives 3
Follow-Up Discussion 4
Answer Key 5
Video Quiz 11
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duplicate, in whole or in part, this teacher’s guide and the blackline master handouts
that accompany it for the purpose of teaching in conjunction with this video,
DNA: The Master Molecule of Life ™.This right is restricted only for use with this video
program. Any reproduction or duplication in whole or in part of this guide and the
blackline master handouts for any purpose other than for use with this video
program is prohibited.
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CLASSROOM/LIBRARY VIEWING CLEARANCE
This program is for instructional use. The cost of each program
includes public performance rights as long as no admission charge is
made. Public performance rights are defined as viewing of a video in
the course of face-to-face teaching activities in a classroom, library,
or similar setting devoted to instruction.
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1
CURRICULUM STA N DA R D S
The design of this program was guided by the curriculum standards
of the States of Texas, California and Illinois. The American
Association for the Advancement of Science recommendations for
improving biological science content were followed throughout this
series: "Biology: The Science of Life". In accordance with these guide-
lines we have attempted to help students:
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It is also suggested that the video presentation take place before the
entire group under your supervision. The lesson activities grow out
of the context of the video; therefore, the presentation should be a
common experience for all students.You should also duplicate selected
"hand out" materials from the blackline masters included in this guide.
Set up a "Learning Center" with diagrams and models that depict
DNA, RNA and proteins.
STUDENT PREPARATION
Before viewing DNA: The Master Molecule of Life
PRETEST
An optional pretest is provided (Blackline Master 1). This test will
help you determine the level of student comprehension prior to
participating in this lesson. An Answer Key appears on page 5 of
this Teachers Guide.
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STUDENT OBJECTIVES
After viewing the video and participating in the follow-up activities
students should be able to:
1. Explain the chemical basis of the genetic code.
2. Describe the relationship between genetic code words and
amino acids.
3. Describe the relationship between the linear order of code words
in a gene and the order of amino acids in a protein.
4. Explain the role of messenger RNA.
5. Explain the role of transfer RNA.
6. Compare and contrast Replication, Transcription and Translation.
7. Discuss the importance of proteins in living cells.
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FOLLOW-UP DISCUSSION
It is recommended that you involve students in a discussion
immediately after viewing the video:
2. Discuss how the proteins called enzymes carry out the actual
work of regulating the activities of the cell.
3. DNA fingerprinting
4. Genetic engineering
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ANSWER KEY
Blackline Master 1, Pre-test
1. True
2. False, it is the same in every organism.
3. False, it is based on the 4 different subunits of DNA.
4. False, all genetic code words are three letters long.
5. True
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C I
L B
E 1 C O D O N
2 U S
2 T R A N S L A T I O N
R M
1 A E
3 A M I N O A C I D S S
A S
C C
R 4 R E P L I C A T I O N
O I
M P
5
O 5 T H R E E G
L I E
E O N
C 6 N U C L E O T I D E
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BRIEF REVIEW
Let's briefly review how DNA stores instructions: The DNA mole-
cule of a single chromosome can be thought of as one book from the
cell's library of instructions. A chromosome can contain thousands
of genetic code sentences or genes that determine the order amino
acids will appear in proteins. Such sentences are written using genetic
code words ...all of which are just three letters long. These words
are codes for any of 20 different amino acids and, of course, the
letters with which the words are written are the four nucleotide
subunits of DNA.
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11
CONCLUSION
As we have just learned DNA performs an essential role in the lives
of all living things. It stores huge amounts of information in the
unique biological language called the genetic code. DNA's genetic
information is transcribed into messenger RNA which carries it to the
ribosomes where, with the help of transfer RNA, new proteins are
made that perform thousands of tasks inside of cells. But DNA is
even more amazing because it can make exact copies of itself. As a
result genes and the instructions they hold are passed on; not just
from old cells to new cells but from one generation to the next.
VIDEO QUIZ
1. True of False? The four subunits of DNA are used as the "letters"
of the genetic code alphabet.
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1
Name
DNA: The Master Molecule of Life
PRE-TEST
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Name
DNA: The Master Molecule of Life
VO C A B U LA RY WORKSHEET
Adenine: A nitrogen containing base found in one of the Cytosine: A nitrogen containing base in a nucleotide
nucleotide subunits of DNA. Adenine is the "A" of the subunit of DNA. Cytosine is the "C" of the genetic
genetic code alphabet. code alphabet.
Amino Acid: The subunits that are chemically bonded Deoxyribonucleic Acid (DNA): A long molecule shaped
together in proteins. The order of amino acids in a protein like a twisted ladder(double helix). The plans for running
is what gives it the ability to do its job. and reproducing cells are chemically stored in the DNA.
DNA is found mostly in the nucleus but small amounts of
Anticodon: The three letter word of a transfer RNA that
DNA are found in mitochondia and chloroplasts.
corresponds to the amino acid it carries. The anticodon
matches up with the codon of the messenger–RNA. Deoxyribose: The sugar part of a a DNA nucleotide subunit.
Bacteria: Simple, one-celled, organisms that lack a nucleus Double Helix: The double spiral shape of the DNA molecule.
belonging to the kingdom Monera. Enzymes: Proteins that control the rates of chemical reac-
Cell Division: The process that results in two cells being tions in cells. Most proteins in a cell are enzymes. Digestive
formed from one cell. Cell reproduction. enzymes such as pepsin and trypsin are produced by
specialized cells. These enzymes are exported from cells
Chemical: Chemicals are substances made from combi-
to break down food in the digestive tract.
nations of different elements.
Gene: A region of a DNA molecule that stores the instruc-
Chemical Bonds: The way in which atoms are joined to
tions for making a particular protein. Genes are also known
one another: For example, in water an atom of oxygen is
as the units of making a particular protein. Genes are also
joined to two atoms of hydrogen by chemical bonds.
known as the units of heredity.
The subatomic particles called electrons are responsible
for creating chemical bonds. Genetic Code: The chemical language of the cell. DNA
stores its instructions in the genetic code.
Chemical Reactions: Events in which chemical bonds are
broken, rearranged and reformed. Matter is changed by Genetic Code Word: Three DNA nucleotide subunits in a
chemical reactions: This is what happens when chemical row, such as AAA or AGA, that represent amino acids.
compounds react with one another and new compounds Genetic Transcription: The process of copying a gene into
are formed. messenger-RNA.
Chromatin: Chromatin is made up of the tangled, thread- Guanine: A nitrogen–containing base found in a nucleotide
like, coils of chromosomes. Chromatin contains DNA plus subunit of DNA that is the "G" of the genetic code alphabet.
certain proteins.
Heredity: Characteristics that are passed on from
Chromosomes: Chromosomes are worm-shaped struc- parents to their offspring. Genes are called the "units
tures that develop from chromatin before cells divide. of heredity”.
Chromosomes contain DNA and protein. Human body
cells have two full sets of 23 different chromosomes. Hereditary: Passed on from one generation to the next.
Codon: A code word of messenger RNA that represents Hydrogen Bond: A type of weak chemical bond. Hydrogen
an amino acid. bonds exist between the two strands of the DNA molecule
and between the messenger RNA codons and the transfer
Complementary: Two parts of a jigsaw puzzle fit together RNA anticodons.
to make a whole: Therefore they are called complementary
parts. DNA has two complementary strands because they Molecule: A combination of two or more atoms bonded
are exact opposites of one another. together by strong chemical bonds (covalent bonds).
Cytoplasm: All the protoplasm located outside the nucleus. continued
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2a
Name
DNA: The Master Molecule of Life
Macromolecule: A very large molecule made from thou- Sugar-Phosphate Bonds: Strong (covalent) bonds between
sands of atoms. DNA, messenger RNA and proteins are the deoxyribose sugar of one nucleotide and the phosphate
all examples of macromolecules. group of the adjoining nucleotide is what forms the "back-
bone" of the DNA molecule.
Messenger RNA (m-RNA): Messenger RNA carries instruc-
tions for making proteins from the nucleus to a ribosome. Terminator Codons: Every messenger RNA message ends
with one of three different "terminator" codons: UAG, UAA
Nitrogenous Bases: The nitrogen containing bases of the
or UGA. Since there are no transfer RNAs with anticodons
DNA nucleotide subunits whose chemical names are
to match these messenger RNA codons protein synthesis
Adenine, Thymine, Cytosine, and Guanine.
stops whenever a terminator codon is reached.
Nuclear: Refers to the nucleus.
Thymine: A nitrogen containing base found in one of the
Nucleic Acids: DNA or RNA nucleus (Plural: Nuclei) nucleotide subunits of DNA. Thymine is the "T" of the
A rounded structure located in the cytoplasm. The nucleus genetic code alphabet.
is the cell's control center because it is where most of the
Transfer RNA (t-RNA): A small RNA molecule that can pick
DNA is located.
up amino acids. By matching the transfer RNA anticodon to
Nucleolus (New-klee-oh-lus): "Little Nucleus" The area of the messenger RNA codon the amino acid is put into the
the nucleus where ribosomes are made. Cells can have protein chain correctly.
more than one nucleolus.
Translation: The process of making proteins using the
Nucleotide Subunit: The Subunits that make up DNA. instructions of messenger RNA molecule.
Each nucleotide has a phosphate group, a deoxyribose
Uracil: A nitrogen–containing base used in RNA molecules
sugar group and a nitrogen–containing base; either
instead of Thymine.
Adenine, Thymine, Cytosine or Guanine.
Organelles: "Little Organs". Structures in the cytoplasm
such as mitochondria, ribosomes, chloroplasts, and Golgi VO C A B U LA RY ACTIVITY
bodies where different tasks are performed in the cell.
From the vocabulary list find the correct word to fill
Proteins: Molecules made up of long chains of amino
in the blanks.
acids(polypeptides). Proteins build living material, fight dis-
ease, and help transport things out of the cell. The impor-
tant class of proteins called enzymes act to control the 1. are proteins that control the
rates of chemical reactions. Most proteins are enzymes. rates of chemical reactions.
Replication of DNA: The process that occurs when DNA
makes an exact copy of itself before cell division. 2. Two or more atoms strongly bonded together
is called a
Ribosomes: The organelles where proteins are assembled.
3. Instructions from DNA are carried to ribosomes by
Ribonucleic Acid: A type of nucleic acid that contains the
sugar ribose instead of deoxyribose, has one strand and molecules of
that has the base Uracil instead of Thymine.
4. Amino acids are picked up by special RNA
Ribose: A sugar group found in RNA nucleotide subunits. molecules called
Structural Formula: A diagram used by chemists that
shows how atoms are arranged in molecules. 5. The process of making something from simple
subunits is called
Synthesis: To make complex substances from simpler parts.
Proteins are synthesized from amino acid subunits. DNA is
synthesized from nucleotide subunits.
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Name
DNA: The Master Molecule of Life
CROSSWORD PUZZLE
3
Across:
4
1. A messenger-RNA code word
is called a .
Down: 4
1. The DNA molecule is called a
because it is
very large.
5
is the process by which 5
DNA is copied into messenger RNA.
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Name
DNA: The Master Molecule of Life
PRE-TEST
1. Messenger RNA–
3. Anticodon–
4. Transfer RNA–
5. Proteins–
6. Ribosome–
7. Amino acid–
8. Nucleotide Subunit–
9. Macromolecule–
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Name
DNA: The Master Molecule of Life
VIDEO QUIZ
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