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Optometry (2009) 80, 447-453

Clinician versus potential acuity test predictions of visual


outcome after cataract surgery
Marta Vianya-Estopa, Ph.D.,a William A. Douthwaite, Ph.D.,a Charlotte L. Funnell,
FRCOphth,b and David B. Elliott, Ph.D.a

a
University of Bradford, Department of Optometry, West Yorkshire; and bLeeds Teaching Hospitals Trust, Ophthalmology
Department, St. James’s University Hospital, West Yorkshire, United Kingdom.

KEYWORDS Abstract
Potential vision test; BACKGROUND: The aim of this study was to compare the ability of potential vision tests and clinical
Cataract; judgement to predict postoperative visual acuity after uneventful cataract surgery.
Super-illuminated METHODS: Sixty-two subjects (median, 74.5 years) were included in the study. Preoperative measure-
pinhole; ments included a clinical judgement prediction (based on case history and ocular examination alone), 2
Potential Acuity Meter; super-illuminated pinhole techniques (distance and near), Potential Acuity Meter and interferometer.
Laser interferometer Postoperative visual acuity was used as the outcome measure to evaluate the accuracy of the preoper-
ative predictions.
RESULTS: Subjects were categorized as follows: (a) moderate cataract (N 5 25); (b) moderate cataract
and comorbidity (N 5 18), and (c) advanced cataract (N 5 19). Preoperative predictions within 2 lines
of the postoperative visual acuity were as follows (a, b, and c respectively): clinical judgement (92%,
72%, 58%), super-illuminated pinhole distance (96%, 100%, 21%), super-illuminated pinhole near
(92%, 78%, 26%), Potential Acuity Meter (72%, 67%, 21%), and interferometer (56%, 61%, 37%).
CONCLUSIONS: Based on the preoperative predictions above, none of the potential vision tests was
useful compared with the clinical judgement in the advanced cataract group. The super-illuminated
pinhole (distance) provided additional information beyond clinical judgement in the moderate cataract
subgroup. The Potential Acuity Meter and interferometer were inaccurate even in the presence of mod-
erate cataract, and this and other recent findings suggest they should no longer be considered adequate
for potential vision assessment.
Optometry 2009;80:447-453

Clinicians usually predict the likely visual outcome to be contribution of ocular comorbidity to the subject’s
achieved after cataract surgery based on history and ocular decreased sight, particularly when both cataract and reti-
examination. However, it is not always easy to establish the nal/neural disease coexist. Schein et al. reported that 63%
of subjects predicted by ophthalmologic judgement to
obtain a visual acuity (VA) of 20/40 or worse after cataract
surgery (the level at which surgery is often considered to be
Conflict of interest: None of the authors have a financial or proprietary ‘‘unsuccessful’’),1 actually achieved a VA of 20/30 or bet-
interest in any method or material mentioned in this study. ter.2 Conversely, overestimation of the visual outcome
Corresponding author: Marta Vianya-Estopa, Ph.D., University of
Bradford, Department of Optometry, Bradford BD7 1DP, West Yorkshire,
will undoubtedly result in patient disappointment and
United Kingdom. should be avoided whenever possible. Mavroforou and
E-mail: martavianya@hotmail.com Michalodimitrakis3 reported that the most common cause

1529-1839/09/$ -see front matter Ó 2009 American Optometric Association. All rights reserved.
doi:10.1016/j.optm.2008.11.011
448 Optometry, Vol 80, No 8, August 2009

of patient litigation after cataract surgery (in the United Leeds, United Kingdom. The exclusion criteria for this
States) was poor visual outcome in patients who had cata- study included:
ract and macular disease before cataract surgery.  Subjects unable to speak English
Potential vision tests (PVTs) were developed initially in  Subjects with any physical or mental disability that
the early 1980s in an attempt to improve the prediction of the would make it arduous to perform the tests
visual performance after cataract surgery.4,5 However, a ma-  Upper age limit 90 years
jor review conducted by the Agency for Health Care Policy Three subjects had postoperative complications (includ-
and Research in 1993 concluded that there was insufficient ing malposition of intraocular lens, intraocular lens ex-
evidence to establish whether PVTs increased the accuracy change, and central retinal vein occlusion) and were
of the preoperative visual outcome prediction over and above excluded from the study because the preoperative predic-
history and ocular examination alone.6 As a result, clinical tions only apply to the visual result of an uneventful
guidelines for the management of adult cataracts typically surgery. One subject decided not to undertake the surgical
do not include PVTs as part of the preoperative ophthalmic procedure, and 8 subjects were lost at the follow-up visit.
evaluation.7,8 Since this major review, several newer tech- Thus, 62 subjects (median age, 74.5 years; range, 50 to 89
niques have been developed.9-16 In most cases, developers years) were included in this study. A total of 38 subjects
of PVTs have reported the value of newer techniques by com- were listed for first-eye cataract surgery. Informed consent
paring them with standard PVTs, such as the Potential Acuity was obtained in each case, and the study gained approval
Meter.12,17 In addition, it is important to compare the results from the Hospital Ethical Committee and followed the
of PVTs with clinical judgement to determine whether they Declaration of Helsinki for research involving human
provide any additional useful information. subjects. The decision to perform cataract surgery was
Pinhole tests have been suggested previously as PVTs, independent of the findings of this study.
given their resistance to moderate/dense cataract and sensi- The 62 cataract subjects were divided into 3 groups as
tivity to macular disease.18 However, there is variation in the suggested by the Agency for Health Care Policy and
design of these tests ranging from the simple pinhole,19 to the Research:6 25 subjects with moderate cataract, 19 with ad-
illuminated pinhole at near12,18,20 and retro-illuminated pin- vanced cataract, and 18 with moderate cataract and comor-
hole at distance18,10 (either at 3.2 m or at 1 m). Techniques bid eye disease (see Table 1). Advanced cataract was
have also varied in the type of VA charts used (including re- defined as a Lens Opacity Classification System (LOCS)
versed contrast polarity,10,18 Snellen12,20 and logMAR de- III21 grading for nuclear opalescence, nuclear color, and
signs10,18) and the luminance levels used10,20 (ranging from cortical opacity R5.0 and/or a posterior subcapsular opac-
1200 cd/m2 at 1 m to 1464 cd/m2 at 40 cm). Perhaps, not sur- ity R3.0. All other cataracts listed for cataract surgery were
prisingly, Potential Acuity Meter predictions were found to classified as moderate and had nuclear opalescence R2.0
be more accurate than a conventional pinhole (81% versus (range, 2.0 to 4.8), nuclear color R1.7 (range, 1.7 to 4.9),
40% within 2 lines of best-corrected VA).19 The most likely and/or cortical opacity R0.1 (range, 0.1 to 4.2), and/or a
explanation for this is the lack of decreased retinal illumina- posterior subcapsular opacity R0.1 (range, 0.1 to 2.5). Sub-
tion with the Potential Acuity Meter. Conversely, the predic- jects in the moderate cataract and comorbidity subgroup
tions obtained with an illuminated pinhole at near were found presented with the following ocular comorbidities: 9 with
to be more accurate than the Potential Acuity Meter for a dry age-related macular degeneration, 6 with glaucoma,
range of cataract severities associated with a VA of better and 1 each with amblyopia, wet age-related macular degen-
than 20/50 to worse than 20/200 (for example, 100% versus eration, and an epiretinal membrane. All clinical diagnoses
47% for the 20/60 to 20/100 subgroup).12 were made before surgical intervention and were confirmed
This study was undertaken to compare the predictive postoperatively when a clear view of the fundus could be
ability of 2 versions of the super-illuminated pinhole obtained. The clinical diagnoses of 8 subjects in the ad-
(distance and near), the standard PVTs of the Potential vanced cataract included dry age-related macular disease
Acuity Meter and interferometer, and clinical judgement (3 cases), glaucoma (2 cases), amblyopia (2 cases) and
based on history and ocular examination alone. The aim epi-retinal membrane (1 case). The predictive ability of
was to assess whether PVTs should be used in clinical PVTs and clinical judgement in the advanced cataract
practice to guide clinicians when there is uncertainty over only and advanced cataract with comorbidity subjects pro-
the likely visual benefit of cataract surgery. vided very similar results, and so the 2 groups were
combined.

Methods
Procedures
Subjects
Subjects were examined a median of 3 weeks (range, 1 to
An unselected sample of 74 subjects with age-related 13 weeks) before surgical intervention and a median of 11
cataract was recruited from the cataract surgery waiting weeks (range, 10 to 20 weeks) after the cataract surgery. In
list at the Leeds Teaching Hospitals Trust, Eye Department, the preoperative visit, PVT measurements were taken in a
Vianya-Estopa et al
Table 1 Demographic characteristics of the 62 subjects assessed preoperatively and postoperatively including mean (6SD) for the preoperative predictions of VA and the

Clinical Research
postoperative measurement of VA

Age Preoperative Predictions of postoperative VA* (mean 6 SD) Postoperative


LOCS III (median; VA (mean 6 VA (mean 6
(mean 6 SD) range; yrs) SD; logMAR) CJ SPHd SPHn PAM LI SD; logMAR)
Moderate NO 3.2 6 0.8 73.0; 50 – 83 0.22 6 0.14 0.04 6 0.08 0.11 6 0.07 0.07 6 0.10 0.11 6 0.11 0.16 6 0.15 20.02 6 0.07
cataract NC 3.2 6 0.9
(N 5 25) C 2.1 6 1.6
P 0.4 6 0.7

Moderate NO 3.0 6 0.7 78.0; 63 – 89 0.37 6 0.23 0.18 6 0.16 0.19 6 0.12 0.18 6 0.11 0.21 6 0.13 0.24 6 0.18 0.20 6 0.33
cataract NC 3.2 6 0.6
& co- C 2.4 6 1.6
morbidity P 0.6 6 0.7
(N 5 18)

Advanced NO 4.6 6 1.3 73.0, 56 – 85 0.88 6 0.54 0.19 6 0.11 0.27 6 0.13 0.25 6 0.22 0.27 6 0.19 0.35 6 0.46 0.02 6 0.11
cataract NC 4.9 6 1.5
(N 5 19) C 1.1 6 1.6
P 2.3 6 2.2

NO, nuclear opalescence; NC, nuclear color; C, cortical; P, posterior capsular opacity; LogMAR, logarithm of the minimum angle of resolution; CJ, clinician judgment; SPHd, super-illuminated pinhole
distance; SPHn, super-illuminated pinhole near; PAM, Potential Acuity Meter; LI, laser interferometer.
* The mean of the predictions of postoperative VA was calculated for those subjects able to obtain a score with all PVTs (25 in the moderate, 17 in the moderate and comorbidity, and 13 in the advanced
cataract subgroup).

449
450 Optometry, Vol 80, No 8, August 2009

interferometer used following the standard procedure23


Table 2 The accuracy of PVT predictions given as a with the gratings presented at 4 random orientations: hori-
percentage of PVT preoperative predictions within 2 logMAR
zontal, vertical, or oblique (45 to the right or the left). The
lines of the postoperative VA measurement in the 3 ocular
subgroups compared with the clinical judgment prediction in highest spatial frequency at which the orientation of the
62 subjects fringe pattern could be correctly identified on 2 separate
occasions gave a measure of the retinal/neural resolution.
Moderate Moderate cataract Advanced Oblique orientations were not used at threshold level. The
cataract & co-morbidity cataract super-illuminated pinhole at near was based on the test de-
(N 5 25) (N 5 18) (N 5 19) scribed by Melki et al.12 The test measured logMAR near
CJ 92% 72% 58% VA using an ETDRS logMAR reading card held at 40 cm
SPHd 96% 100% 21% and illuminated by an external light source with the subject
SPHn 92% 78% 26% looking through a multiperforated pinhole (5 apertures of
PAM 72% 67% 21% 1 mm). The external light source was moved by the exam-
LI 56% 61% 37% iner onto the section of the chart that was being read by the
CJ, clinical judgment; SPHd, super-illuminated pinhole distance; subject to give a luminance around 1,300 cd/m2. A super-
SPHn, super-illuminated pinhole near; PAM, Potential Acuity Meter; illuminated pinhole at distance was also used. It consisted
LI, laser interferometer.
of measuring distance VA using a reversed polarity (white
letters on a black background) ETDRS logMAR chart,
with the subject looking through a multiperforated pinhole.
random order in the surgical eye after instillation of 1.0% The letters were seen by retroillumination (luminance 500
tropicamide and 2.5% phenylephrine. The cataracts were cd/m2) in a darkened room at a working distance of 3.2 m.
graded using the Lens Opacity Classification System III.21 To evaluate whether any of the PVTs provided information
The LOCS III is a widely used classification system based beyond that obtained by history and ocular examination
on a set of standard photographs that are used as a reference alone, the PVT predictions were compared with a clinical
to classify lens opacities at the slit lamp or in standardized judgement. The clinical judgement required the ophthal-
lens photographs. Pupil dilation is required before LOCS mologist to choose a predicted postoperative VA from a
III grading of the lens opacities. Grading using LOCS III range, which followed a logMAR line progression (20/13,
involves the assessment and estimation of 4 features: 20/17, 20/20, 20/25, 20/30, 20/40, 20/50, 20/60, 20/80,
nuclear opacification (i.e., brightness of scatter from the 20/100, 20/120, 20/160, 20/200, 20/250, and 20/400). The
nuclear region), nuclear color (i.e., brunescence), and the clinical judgement was performed prospectively by the
extent of cortical and posterior subcapsular opacities. ophthalmic surgeon undertaking the operation on the day
Nuclear opalescence and nuclear color are graded against of the surgery using information from the case history
6 photographs on a decimal scale of 0.1 to 6.9 (in 0.1 steps), and ocular examination alone and with no input from the
and cortical and posterior subcapsular opacity are each PVT results. In total, the clinical judgement was completed
graded against 5 photographs on a scale of 0.1 to 5.9 (in by 8 experienced cataract surgeons.
0.1 steps). The final LOCS III scale comprises the values
given to each of these 4 features. Higher grade scores indi-
cate greater severity of opacification. Results
Subjective refraction, measurement of optimal VA, and
slit lamp biomicroscopy of the fundus were performed in Table 1 presents LOCS III categories and mean (6SD) data
the pre- and postoperative visits. The postoperative VA for age, pre- and postoperative VA and PVT, and clinical
represented the visual performance measurement against judgement predictions of postoperative VA in the 3 ocular
which the preoperative predictions could be compared. All subgroups. Only those subjects able to obtain a result with
PVT tests, pre- and postoperative VAS, and LOCS III each of the PVTwere included in the calculation of the means
assessment were made by one clinician. Information from (6SD). The accuracy of the preoperative clinical judgement
PVT results was not available at the postoperative visits to prediction was further compared with the 4 PVT predictions
limit potential bias. in terms of the percentage of subjects who achieved the post-
Distance VA was measured at 3.2 m under monocular operative VA result within 10 letters (i.e., 2 logMAR lines) of
conditions using an early treatment diabetic retinopathy the predicted VA (see Table 2). Table 2 indicates that the pre-
study (ETDRS) logMAR chart (mean luminance 200 cd/m2), dictive ability of all PVTs under investigation was severely
using a by-letter scoring system (0.02 log units per letter) diminished in the advanced cataract subgroup where clinical
and a termination rule of no letters called correctly on a judgement offered the most accurate predictions. However,
line.22 The standard Potential Acuity Meter (Mentor Inc., some of the PVTs provide predictions as good as or better
Norwell, Massachusetts) procedure5 was used, and Snellen than clinical judgement with moderate cataracts (see Table
VA was determined as the smallest line at which the major- 2). The question is whether any PVT provides additional in-
ity of letters were correctly identified. The Rodenstock Ret- formation beyond that provided by clinical judgement alone.
inometer (Rodenstock, London, United Kingdom) was the Hierarchical stepwise regression analysis was used to assess
Vianya-Estopa et al Clinical Research 451

the value of the 4 PVTs over and above clinical judgment in within 2 logMAR lines of the postoperative VA for the
subjects with moderate cataract (with and without comorbid- 62 subjects. It can be seen that the super-illuminated pin-
ity). PVTs were used as predictors, and the postoperative VA hole distance test provided a similar prediction to clinical
measurement was used as the outcome variable. Clinical judgement in the presence of moderate cataract and a better
judgement was used as a forced first step, as it is the standard prediction than clinical judgement in the presence of mod-
judgement of potential vision in the decision-making process erate cataract with comorbidity. Hierarchical regression
for cataract surgery assessment. Subsequent to clinical analysis confirmed that the super-illuminated pinhole dis-
judgement being forced as a first step, all PVTs were consid- tance test provided additional improvement in VA predic-
ered for inclusion into the regression model. Thus, for a PVT tion compared with the clinical judgement alone in the
to be of clinical value, it must provide significant additional moderate cataract and moderate cataract with comorbidity
information about postoperative visual acuity beyond clini- groups. This suggests that super-illuminated pinhole dis-
cal judgement. Stepwise regression indicated that 46% of tance may be used as a confirmatory test when the clinician
the postoperative VA data could be correctly predicted by is uncertain of the contribution of retinal/neural disease to
clinical judgement alone. The hierarchical stepwise regres- the existing disability in moderate cataracts. del Romo
sion then indicated that 74% of the postoperative VA data et al.10 also noted that an enhanced pinhole technique pro-
could be predicted by the super-illuminated pinhole distance vided information beyond that obtained by clinical judge-
procedure combined with the clinical judgement. This means ment in the presence of moderate cataract and ocular
that super-illuminated pinhole distance provides extra infor- comorbidity in 12 subjects attending for first eye cataract
mation beyond clinical judgement to help predict the postop- surgery (83% versus 50% within 2 logMAR lines).
erative VA. However, the hierarchical stepwise regression In contrast, in the presence of advanced cataract, the
then indicated that none of the other PVTs provided signifi- predictions obtained with the clinical judgement were
cant additional information beyond that provided by the clin- superior to those found using any of the PVTs (see Table
ical judgement alone in subjects with moderate cataract (with 2). Previous investigators have also reported less accurate
or without ocular comorbidity). Clinically, one may expect predictions in the presence of increasingly advanced media
that PVTs may be used particularly in the preoperative as- opacities with the Potential Acuity Meter,6,26,27 the laser in-
sessment of cataract patients when clinicians suspect the terferometer,6,23,28-30 and enhanced pinhole techniques.12,20
presence of retinal/neural abnormalities. Thus, we repeated Recent reports suggest that the critical flicker/fusion fre-
the hierarchical regression analysis in subjects with moderate quency technique shows promising capabilities as a PVT
cataract and ocular comorbidity only. In this scenario, the in the presence of advanced cataract.10,14,31
clinical judgement accounted for 52% of the postoperative In this investigation, the super-illuminated pinhole dis-
VA data and clinical judgment, and super-illuminated pin- tance predictions were superior to the ones obtained with
hole distance accounted for 90% of the postoperative VA the super-illuminated pinhole near. The factors influencing
data. None of the others PVTs gave significant additional in- the pinhole measurement are pinhole diameter, test chart
formation to that provided by clinical judgment. illuminance, and the refractive status of the eye. Given that
the same multiperforated pinhole and optimal refractive
correction for the viewing distance was used in both tests,
Discussion the chart illuminance and chart contrast polarity remain as
the only factors responsible for the difference in predictive
A comparison of the means (6SD) obtained with the clinical ability between the tests. External illumination of the letter
judgement and the PVTs against the postoperative VA result chart may be less satisfactory than the retroillumination
indicates that with the exception of the interferometer, all used in the super-illuminated pinhole distance test. It would
PVTs and the clinical judgement underestimate the postop- also appear that a chart in reversed contrast polarity (white
erative VA by less than 1.5 lines of letters in the presence of letters on a black background) is preferable.
moderate cataract. Table 1 also indicates a larger underesti- Ten subjects (6 moderate cataract and comorbidity and 4
mation of postoperative VA with all PVTs and the clinical advanced cataract) were predicted by clinical judgement to
judgement in the presence of advanced cataract. It is worth achieve a postoperative VA of 20/40 or worse (the level of
noting that, despite poor penetration of even moderate cata- outcome often deemed ‘‘unsuccessful’’), but 50% of them
ract, the interferometer increased its predictive ability in achieved a postoperative VA of 20/30 or better after the
the presence of moderate cataract and comorbidity. It has surgery, similar to the findings of Schein et al.2 Underesti-
been shown previously that the interferometer (and to a lesser mations of the retinal/neural function may result in surgical
extent Potential Acuity Meter) overestimate the visual result delays or even discouragement toward undertaking the sur-
in the presence of clear media and macular abnormalities. gery. The latter is supported by the high prevalence
This suggests that the overoptimistic predictions obtained (w19%) of patients found in low-vision clinic populations
in the presence of retinal abnormalities can compensate for presenting with both age-related macular degeneration and
the poor cataract penetration in some cases.18,24,25 cataracts.32
Table 2 illustrates the percentage of preoperative PVT The clinical information provided by the VA measure-
predictions and clinical judgement predictions that fell ments and clinical examination after first-eye surgery may
452 Optometry, Vol 80, No 8, August 2009

have contributed to the correct clinical predictions for the super-illuminated pinhole distance technique may pro-
second-eye cataract in this study. A higher percentage of vide additional information beyond the clinical judgement.
correct clinical judgment predictions were found after Finally, and based on the outputs of this study, we encour-
second-eye surgery compared with first eye: 100% versus age those involved in the development of computerized eye
88% (moderate cataract group), 88% versus 60% (moderate charts to further develop a simple super-illuminated pinhole
cataract and comorbidity) and 71% versus 50% (advanced distance strategy that, combined with a pinhole, could be
cataract). This indicates that PVTs may be more beneficial used to provide accurate predictions of postoperative visual
in the decision-making process of cataract surgery in outcome.
subjects presenting for first-eye cataract surgery. In view
of these results, future studies of PVTs are encouraged to
focus their investigations primarily in first-eye cataract Acknowledgments
surgery subjects with and without ocular comorbidity.
The authors thank the consultants and staff of the Eye
Department of Leeds Teaching Hospitals Trust for their
Conclusions and clinical implications assistance.

All the evaluated PVTs were found to be adversely affected


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