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4 authors, including:
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a
University of Bradford, Department of Optometry, West Yorkshire; and bLeeds Teaching Hospitals Trust, Ophthalmology
Department, St. James’s University Hospital, West Yorkshire, United Kingdom.
KEYWORDS Abstract
Potential vision test; BACKGROUND: The aim of this study was to compare the ability of potential vision tests and clinical
Cataract; judgement to predict postoperative visual acuity after uneventful cataract surgery.
Super-illuminated METHODS: Sixty-two subjects (median, 74.5 years) were included in the study. Preoperative measure-
pinhole; ments included a clinical judgement prediction (based on case history and ocular examination alone), 2
Potential Acuity Meter; super-illuminated pinhole techniques (distance and near), Potential Acuity Meter and interferometer.
Laser interferometer Postoperative visual acuity was used as the outcome measure to evaluate the accuracy of the preoper-
ative predictions.
RESULTS: Subjects were categorized as follows: (a) moderate cataract (N 5 25); (b) moderate cataract
and comorbidity (N 5 18), and (c) advanced cataract (N 5 19). Preoperative predictions within 2 lines
of the postoperative visual acuity were as follows (a, b, and c respectively): clinical judgement (92%,
72%, 58%), super-illuminated pinhole distance (96%, 100%, 21%), super-illuminated pinhole near
(92%, 78%, 26%), Potential Acuity Meter (72%, 67%, 21%), and interferometer (56%, 61%, 37%).
CONCLUSIONS: Based on the preoperative predictions above, none of the potential vision tests was
useful compared with the clinical judgement in the advanced cataract group. The super-illuminated
pinhole (distance) provided additional information beyond clinical judgement in the moderate cataract
subgroup. The Potential Acuity Meter and interferometer were inaccurate even in the presence of mod-
erate cataract, and this and other recent findings suggest they should no longer be considered adequate
for potential vision assessment.
Optometry 2009;80:447-453
Clinicians usually predict the likely visual outcome to be contribution of ocular comorbidity to the subject’s
achieved after cataract surgery based on history and ocular decreased sight, particularly when both cataract and reti-
examination. However, it is not always easy to establish the nal/neural disease coexist. Schein et al. reported that 63%
of subjects predicted by ophthalmologic judgement to
obtain a visual acuity (VA) of 20/40 or worse after cataract
surgery (the level at which surgery is often considered to be
Conflict of interest: None of the authors have a financial or proprietary ‘‘unsuccessful’’),1 actually achieved a VA of 20/30 or bet-
interest in any method or material mentioned in this study. ter.2 Conversely, overestimation of the visual outcome
Corresponding author: Marta Vianya-Estopa, Ph.D., University of
Bradford, Department of Optometry, Bradford BD7 1DP, West Yorkshire,
will undoubtedly result in patient disappointment and
United Kingdom. should be avoided whenever possible. Mavroforou and
E-mail: martavianya@hotmail.com Michalodimitrakis3 reported that the most common cause
1529-1839/09/$ -see front matter Ó 2009 American Optometric Association. All rights reserved.
doi:10.1016/j.optm.2008.11.011
448 Optometry, Vol 80, No 8, August 2009
of patient litigation after cataract surgery (in the United Leeds, United Kingdom. The exclusion criteria for this
States) was poor visual outcome in patients who had cata- study included:
ract and macular disease before cataract surgery. Subjects unable to speak English
Potential vision tests (PVTs) were developed initially in Subjects with any physical or mental disability that
the early 1980s in an attempt to improve the prediction of the would make it arduous to perform the tests
visual performance after cataract surgery.4,5 However, a ma- Upper age limit 90 years
jor review conducted by the Agency for Health Care Policy Three subjects had postoperative complications (includ-
and Research in 1993 concluded that there was insufficient ing malposition of intraocular lens, intraocular lens ex-
evidence to establish whether PVTs increased the accuracy change, and central retinal vein occlusion) and were
of the preoperative visual outcome prediction over and above excluded from the study because the preoperative predic-
history and ocular examination alone.6 As a result, clinical tions only apply to the visual result of an uneventful
guidelines for the management of adult cataracts typically surgery. One subject decided not to undertake the surgical
do not include PVTs as part of the preoperative ophthalmic procedure, and 8 subjects were lost at the follow-up visit.
evaluation.7,8 Since this major review, several newer tech- Thus, 62 subjects (median age, 74.5 years; range, 50 to 89
niques have been developed.9-16 In most cases, developers years) were included in this study. A total of 38 subjects
of PVTs have reported the value of newer techniques by com- were listed for first-eye cataract surgery. Informed consent
paring them with standard PVTs, such as the Potential Acuity was obtained in each case, and the study gained approval
Meter.12,17 In addition, it is important to compare the results from the Hospital Ethical Committee and followed the
of PVTs with clinical judgement to determine whether they Declaration of Helsinki for research involving human
provide any additional useful information. subjects. The decision to perform cataract surgery was
Pinhole tests have been suggested previously as PVTs, independent of the findings of this study.
given their resistance to moderate/dense cataract and sensi- The 62 cataract subjects were divided into 3 groups as
tivity to macular disease.18 However, there is variation in the suggested by the Agency for Health Care Policy and
design of these tests ranging from the simple pinhole,19 to the Research:6 25 subjects with moderate cataract, 19 with ad-
illuminated pinhole at near12,18,20 and retro-illuminated pin- vanced cataract, and 18 with moderate cataract and comor-
hole at distance18,10 (either at 3.2 m or at 1 m). Techniques bid eye disease (see Table 1). Advanced cataract was
have also varied in the type of VA charts used (including re- defined as a Lens Opacity Classification System (LOCS)
versed contrast polarity,10,18 Snellen12,20 and logMAR de- III21 grading for nuclear opalescence, nuclear color, and
signs10,18) and the luminance levels used10,20 (ranging from cortical opacity R5.0 and/or a posterior subcapsular opac-
1200 cd/m2 at 1 m to 1464 cd/m2 at 40 cm). Perhaps, not sur- ity R3.0. All other cataracts listed for cataract surgery were
prisingly, Potential Acuity Meter predictions were found to classified as moderate and had nuclear opalescence R2.0
be more accurate than a conventional pinhole (81% versus (range, 2.0 to 4.8), nuclear color R1.7 (range, 1.7 to 4.9),
40% within 2 lines of best-corrected VA).19 The most likely and/or cortical opacity R0.1 (range, 0.1 to 4.2), and/or a
explanation for this is the lack of decreased retinal illumina- posterior subcapsular opacity R0.1 (range, 0.1 to 2.5). Sub-
tion with the Potential Acuity Meter. Conversely, the predic- jects in the moderate cataract and comorbidity subgroup
tions obtained with an illuminated pinhole at near were found presented with the following ocular comorbidities: 9 with
to be more accurate than the Potential Acuity Meter for a dry age-related macular degeneration, 6 with glaucoma,
range of cataract severities associated with a VA of better and 1 each with amblyopia, wet age-related macular degen-
than 20/50 to worse than 20/200 (for example, 100% versus eration, and an epiretinal membrane. All clinical diagnoses
47% for the 20/60 to 20/100 subgroup).12 were made before surgical intervention and were confirmed
This study was undertaken to compare the predictive postoperatively when a clear view of the fundus could be
ability of 2 versions of the super-illuminated pinhole obtained. The clinical diagnoses of 8 subjects in the ad-
(distance and near), the standard PVTs of the Potential vanced cataract included dry age-related macular disease
Acuity Meter and interferometer, and clinical judgement (3 cases), glaucoma (2 cases), amblyopia (2 cases) and
based on history and ocular examination alone. The aim epi-retinal membrane (1 case). The predictive ability of
was to assess whether PVTs should be used in clinical PVTs and clinical judgement in the advanced cataract
practice to guide clinicians when there is uncertainty over only and advanced cataract with comorbidity subjects pro-
the likely visual benefit of cataract surgery. vided very similar results, and so the 2 groups were
combined.
Methods
Procedures
Subjects
Subjects were examined a median of 3 weeks (range, 1 to
An unselected sample of 74 subjects with age-related 13 weeks) before surgical intervention and a median of 11
cataract was recruited from the cataract surgery waiting weeks (range, 10 to 20 weeks) after the cataract surgery. In
list at the Leeds Teaching Hospitals Trust, Eye Department, the preoperative visit, PVT measurements were taken in a
Vianya-Estopa et al
Table 1 Demographic characteristics of the 62 subjects assessed preoperatively and postoperatively including mean (6SD) for the preoperative predictions of VA and the
Clinical Research
postoperative measurement of VA
Moderate NO 3.0 6 0.7 78.0; 63 – 89 0.37 6 0.23 0.18 6 0.16 0.19 6 0.12 0.18 6 0.11 0.21 6 0.13 0.24 6 0.18 0.20 6 0.33
cataract NC 3.2 6 0.6
& co- C 2.4 6 1.6
morbidity P 0.6 6 0.7
(N 5 18)
Advanced NO 4.6 6 1.3 73.0, 56 – 85 0.88 6 0.54 0.19 6 0.11 0.27 6 0.13 0.25 6 0.22 0.27 6 0.19 0.35 6 0.46 0.02 6 0.11
cataract NC 4.9 6 1.5
(N 5 19) C 1.1 6 1.6
P 2.3 6 2.2
NO, nuclear opalescence; NC, nuclear color; C, cortical; P, posterior capsular opacity; LogMAR, logarithm of the minimum angle of resolution; CJ, clinician judgment; SPHd, super-illuminated pinhole
distance; SPHn, super-illuminated pinhole near; PAM, Potential Acuity Meter; LI, laser interferometer.
* The mean of the predictions of postoperative VA was calculated for those subjects able to obtain a score with all PVTs (25 in the moderate, 17 in the moderate and comorbidity, and 13 in the advanced
cataract subgroup).
449
450 Optometry, Vol 80, No 8, August 2009
the value of the 4 PVTs over and above clinical judgment in within 2 logMAR lines of the postoperative VA for the
subjects with moderate cataract (with and without comorbid- 62 subjects. It can be seen that the super-illuminated pin-
ity). PVTs were used as predictors, and the postoperative VA hole distance test provided a similar prediction to clinical
measurement was used as the outcome variable. Clinical judgement in the presence of moderate cataract and a better
judgement was used as a forced first step, as it is the standard prediction than clinical judgement in the presence of mod-
judgement of potential vision in the decision-making process erate cataract with comorbidity. Hierarchical regression
for cataract surgery assessment. Subsequent to clinical analysis confirmed that the super-illuminated pinhole dis-
judgement being forced as a first step, all PVTs were consid- tance test provided additional improvement in VA predic-
ered for inclusion into the regression model. Thus, for a PVT tion compared with the clinical judgement alone in the
to be of clinical value, it must provide significant additional moderate cataract and moderate cataract with comorbidity
information about postoperative visual acuity beyond clini- groups. This suggests that super-illuminated pinhole dis-
cal judgement. Stepwise regression indicated that 46% of tance may be used as a confirmatory test when the clinician
the postoperative VA data could be correctly predicted by is uncertain of the contribution of retinal/neural disease to
clinical judgement alone. The hierarchical stepwise regres- the existing disability in moderate cataracts. del Romo
sion then indicated that 74% of the postoperative VA data et al.10 also noted that an enhanced pinhole technique pro-
could be predicted by the super-illuminated pinhole distance vided information beyond that obtained by clinical judge-
procedure combined with the clinical judgement. This means ment in the presence of moderate cataract and ocular
that super-illuminated pinhole distance provides extra infor- comorbidity in 12 subjects attending for first eye cataract
mation beyond clinical judgement to help predict the postop- surgery (83% versus 50% within 2 logMAR lines).
erative VA. However, the hierarchical stepwise regression In contrast, in the presence of advanced cataract, the
then indicated that none of the other PVTs provided signifi- predictions obtained with the clinical judgement were
cant additional information beyond that provided by the clin- superior to those found using any of the PVTs (see Table
ical judgement alone in subjects with moderate cataract (with 2). Previous investigators have also reported less accurate
or without ocular comorbidity). Clinically, one may expect predictions in the presence of increasingly advanced media
that PVTs may be used particularly in the preoperative as- opacities with the Potential Acuity Meter,6,26,27 the laser in-
sessment of cataract patients when clinicians suspect the terferometer,6,23,28-30 and enhanced pinhole techniques.12,20
presence of retinal/neural abnormalities. Thus, we repeated Recent reports suggest that the critical flicker/fusion fre-
the hierarchical regression analysis in subjects with moderate quency technique shows promising capabilities as a PVT
cataract and ocular comorbidity only. In this scenario, the in the presence of advanced cataract.10,14,31
clinical judgement accounted for 52% of the postoperative In this investigation, the super-illuminated pinhole dis-
VA data and clinical judgment, and super-illuminated pin- tance predictions were superior to the ones obtained with
hole distance accounted for 90% of the postoperative VA the super-illuminated pinhole near. The factors influencing
data. None of the others PVTs gave significant additional in- the pinhole measurement are pinhole diameter, test chart
formation to that provided by clinical judgment. illuminance, and the refractive status of the eye. Given that
the same multiperforated pinhole and optimal refractive
correction for the viewing distance was used in both tests,
Discussion the chart illuminance and chart contrast polarity remain as
the only factors responsible for the difference in predictive
A comparison of the means (6SD) obtained with the clinical ability between the tests. External illumination of the letter
judgement and the PVTs against the postoperative VA result chart may be less satisfactory than the retroillumination
indicates that with the exception of the interferometer, all used in the super-illuminated pinhole distance test. It would
PVTs and the clinical judgement underestimate the postop- also appear that a chart in reversed contrast polarity (white
erative VA by less than 1.5 lines of letters in the presence of letters on a black background) is preferable.
moderate cataract. Table 1 also indicates a larger underesti- Ten subjects (6 moderate cataract and comorbidity and 4
mation of postoperative VA with all PVTs and the clinical advanced cataract) were predicted by clinical judgement to
judgement in the presence of advanced cataract. It is worth achieve a postoperative VA of 20/40 or worse (the level of
noting that, despite poor penetration of even moderate cata- outcome often deemed ‘‘unsuccessful’’), but 50% of them
ract, the interferometer increased its predictive ability in achieved a postoperative VA of 20/30 or better after the
the presence of moderate cataract and comorbidity. It has surgery, similar to the findings of Schein et al.2 Underesti-
been shown previously that the interferometer (and to a lesser mations of the retinal/neural function may result in surgical
extent Potential Acuity Meter) overestimate the visual result delays or even discouragement toward undertaking the sur-
in the presence of clear media and macular abnormalities. gery. The latter is supported by the high prevalence
This suggests that the overoptimistic predictions obtained (w19%) of patients found in low-vision clinic populations
in the presence of retinal abnormalities can compensate for presenting with both age-related macular degeneration and
the poor cataract penetration in some cases.18,24,25 cataracts.32
Table 2 illustrates the percentage of preoperative PVT The clinical information provided by the VA measure-
predictions and clinical judgement predictions that fell ments and clinical examination after first-eye surgery may
452 Optometry, Vol 80, No 8, August 2009
have contributed to the correct clinical predictions for the super-illuminated pinhole distance technique may pro-
second-eye cataract in this study. A higher percentage of vide additional information beyond the clinical judgement.
correct clinical judgment predictions were found after Finally, and based on the outputs of this study, we encour-
second-eye surgery compared with first eye: 100% versus age those involved in the development of computerized eye
88% (moderate cataract group), 88% versus 60% (moderate charts to further develop a simple super-illuminated pinhole
cataract and comorbidity) and 71% versus 50% (advanced distance strategy that, combined with a pinhole, could be
cataract). This indicates that PVTs may be more beneficial used to provide accurate predictions of postoperative visual
in the decision-making process of cataract surgery in outcome.
subjects presenting for first-eye cataract surgery. In view
of these results, future studies of PVTs are encouraged to
focus their investigations primarily in first-eye cataract Acknowledgments
surgery subjects with and without ocular comorbidity.
The authors thank the consultants and staff of the Eye
Department of Leeds Teaching Hospitals Trust for their
Conclusions and clinical implications assistance.
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