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UMDNS information
This Product Comparison covers the following device terms and product codes as listed in ECRI’s Universal Medical Device
Nomenclature System™ (UMDNS™):
9 Scanning Systems, Gamma Camera, Mobile [16-891]
9 Scanning Systems, Gamma Camera, Planar Image [16-892]
9 Scanning Systems, Gamma Camera, Single Photon Emission Tomography [18-444]
Table of Contents
Scope of this Product Comparison ...............................................................................................................................3
Purpose..........................................................................................................................................................................3
Principles of operation..................................................................................................................................................4
Mobile gamma cameras ...........................................................................................................................................6
SPECT ......................................................................................................................................................................6
Image processing......................................................................................................................................................7
Reported problems........................................................................................................................................................7
Purchase considerations...............................................................................................................................................9
ECRI recommendations...........................................................................................................................................9
Other considerations................................................................................................................................................9
Cost containment ...................................................................................................................................................10
Present Value/Life-Cycle Cost Analysis...........................................................................................................10
Stage of development..................................................................................................................................................12
Bibliography................................................................................................................................................................13
Standards and guidelines...........................................................................................................................................14
Citations from other ECRI publications ....................................................................................................................15
Supplier information ..................................................................................................................................................16
About the chart specifications....................................................................................................................................19
Chart A: Mobile Gamma Cameras.............................................................................................................................22
Chart B: Stationary Gamma Cameras ......................................................................................................................25
Scanning Systems, Gamma Camera
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September 2005
Scanning Systems, Gamma Camera
Purpose
Gamma cameras are used to produce
images of the radiation generated by
radiopharmaceuticals within a patient’s
body in order to examine organ anatomy
and function and to visualize bone
abnormalities. The wide variety of
radiopharmaceuticals and procedures
used allows evaluation of almost every
organ system. In addition to producing a
conventional planar image (a two-
dimensional [2-D] image of the three-
dimensional [3-D] radiopharmaceutical
distribution within a patient’s body), most
stationary gamma camera systems can
also produce whole-body images (single head-to-toe skeletal profiles) and tomographic images (cross-
sectional slices of the body acquired at various angles around the patient and displayed as a
computer-reconstructed image).
SPECT is most commonly used for whole-body bone imaging, brain-perfusion studies, and cardiac
imaging; 30% of SPECT procedures are cardiac studies. Through sequential image acquisition, the
gamma camera can image blood flow to various organs, including the brain, lungs, liver, kidneys,
and bones. It also helps physicians detect and identify lesions, such as cysts, tumors, hematomas,
and infarcted tissue, as well as areas of altered osteogenesis and abnormalities of the cortex and
white matter. In addition, the gamma camera can work in tandem with a computer to evaluate
cardiac function and perfusion—for example, SPECT gamma cameras can perform myocardial
perfusion imaging with thallium-201 and technetium-99m. SPECT is also used to detect femoral
head avascular necrosis, knee osteoarthritis, metastatic liver disease, temporomandibular joint
abnormalities, and deep-seated small hemangiomas, as well as to assess bone metabolism in
hyperparathyroidism and thyrotoxicosis. Such techniques reduce the need for interventional
radiography, thereby circumventing its associated morbidity. Brain SPECT is being used in the
prognosis of strokes, acquired immunodeficiency syndrome (AIDS) dementia complex, psychiatric
diseases, and Parkinson’s disease. One study indicates that FDG-SPECT is as effective as PET in
detecting myocardial viability and diagnosing certain malignant tumors (Martin et al. 1995).
Mobile gamma camera images facilitate the assessment of cardiac function and perfusion in
patients with impending myocardial infarction (MI), as well as in those who have suffered acute MI.
Bedside evaluation of these and other critically ill patients greatly reduces the need to transport
them by stretcher to a stationary gamma camera system.
Principles of operation
The gamma camera detects and counts photons emanating from a target organ and maps
individual scintillation events in a spatial configuration that creates an image of the organ. Static
images display data acquired at a specific point during an exam, and dynamic images display a
change in data measurements over time. A gamma camera system is composed of a collimator, a
thallium-activated sodium iodide (NaI[Tl]) crystal detector, photomultiplier tubes (PMTs), electronic
circuitry to determine the location and magnitude of scintillation events, an imaging computer, and
an operator console. An integral computer and/or a separate image-acquisition, processing, and
display workstation is also used. Whole-body imaging requires either a track-mounted movable
detector that passes over the patient or a patient table that moves beneath a stationary detector.
SPECT systems require a mechanical gantry to support and rotate the camera head and collimators
in a circular, body-contour, or elliptical orbit. Noncircular orbits allow the camera head to be closer
to the body, thereby improving spatial resolution. Recently, at least one manufacturer began
marketing a chair-based cardiac system, in which the patient sits in an upright position rather than
lying on a table.
Two energy-matter interactions
are important to conventional
gamma camera imaging: the
photoelectric effect and Compton
scattering. In photoelectric
interactions, an incident
(incoming) photon with slightly
more energy than the binding
energy of a k-shell electron
encounters one of these electrons
and ejects it from its orbit; because
all its energy is imparted to the
orbital electron, the photon is
absorbed. The ejected
photoelectron possesses kinetic
energy equal to the energy from
the incident photon minus the
energy required to eject the
electron from its orbit. The resultant vacancy in the k-shell is filled by an l- or m-shell electron,
which emits energy in the form of an x-ray photon. The energy of radiation produced by the
movement of electrons within an atom is characteristic of each element and is therefore called
characteristic radiation.
Compton scattering results from a collision between a high-energy incident photon and a loosely
held outer-shell electron. The incident photon transfers some of its energy to the electron, which is
ejected from its orbit by the collision. Because incident photons cannot transfer all their energy to
the orbiting electron, Compton scattering always produces an ion pair—a positive ion and the ejected
negative electron (called a recoil electron)—and always results in the formation of a scatter photon.
An incident photon frequently initiates a chain of Compton reactions and photoelectric absorption
events, which result in the sequential degradation of photon energy.
Because gamma photons cannot be focused using lenses, as light can, a collimator is used to
selectively absorb scattered radiation; only photons traveling along the desired path are allowed to
pass through to the detector. The collimator is usually made of a heavy-metal absorber such as lead,
with some tungsten or platinum parts. The basic types used in conventional gamma camera imaging
are pinhole, parallel-hole, diverging, and converging collimators.
The pinhole collimator, which works much like a pinhole camera, is a lead cone with a small
aperture at the tip. Gamma rays passing through the pinhole produce an inverted image that can be
magnified or minified, depending on the length of the cone and the distance of the organ from the
aperture. Pinhole collimators are best suited for magnification imaging of small, thin structures,
such as the thyroid. Most have a removable aperture insert that allows changes in aperture size; a
smaller aperture produces sharper images but also reduces sensitivity and increases imaging time.
The parallel-hole collimator, which
is the most widely used, is a piece of
lead up to a few inches thick
containing many parallel holes
perpendicular to the collimator
surface. The projected image is the
same size as the source distribution
onto the detector. Gamma rays
leaving the organ almost
perpendicular to the collimator face
pass through to the detector; all other
rays are absorbed by the walls (septa)
of the collimator holes. The use of
high-energy radionuclides requires
thicker septa to absorb unwanted
photons and to keep photons from
crossing from one hole to the next;
however, thicker septa are not as efficient because they allow fewer photons to pass. Collimators
used specifically with low-energy radionuclides have lead foil septa that are only a few tenths of a
millimeter thick and thus are very fragile. Hole length and diameter also affect performance:
collimators with long, narrow holes provide better resolution but sacrifice efficiency. Septal materials
with high atomic numbers and high density provide the best results. Lead is by far the most popular
material because of its cost and availability, although tungsten, tantalum, and gold have some
limited research applications. For maximum versatility, gamma cameras usually come equipped
with several parallel-hole collimators, including a low-energy all-purpose (LEAP) collimator for
imaging photons of up to 150 keV, as well as low-energy high-resolution (LEHR) and medium-energy
all-purpose (MEAP) collimators for imaging photons of up to 1 MeV.
The diverging collimator has angled holes that diverge from a point 40 to 50 cm behind the
collimator. A minified image of source distribution is projected onto the detector. Particularly useful
when imaging large organs with a standard field-of-view (FOV) detector (e.g., lung scanning with a
portable gamma camera), the diverging collimator effectively increases the diameter of the detector
FOV by approximately one-third.
The converging collimator has angled holes that converge at a point 40 to 50 cm in front of the
collimator. The image is magnified but not inverted, provided that the organ is between the
collimator face and the convergence point. At the convergence point, images are reduced; beyond it,
they are not magnified but inverted. Some gamma cameras have a single collimator with a
removable center insert that allows both diverging and converging collimation. Specialty collimators,
such as seven-pinhole, rotating slant-hole, fan beam, and coded-aperture collimators, are also
available; most are used primarily for tomographic cardiac imaging.
The collimator projects radiation from the organ to be imaged onto the NaI(Tl) crystal, which
converts incoming gamma ray photons into visible light energy. The scintillation process involves a
series of Compton collisions in the NaI(Tl) crystal, each producing a scattered photon of lesser energy
and a Compton recoil electron that excites the NaI(Tl) electrons in its path and causes them to
scintillate (produce a flash of light) at an intensity proportional to the energy of the incident photon.
The scattered photon interacts with another crystal atom, produces another scattered photon and
recoil electron, and causes more scintillations until the photons lose enough energy to be
photoelectrically absorbed. Lower-energy photons undergo fewer interactions before absorption and
produce fewer scintillations.
Because light produced by scintillation is scattered within the crystal, thin crystals provide better
resolution by bringing the light flashes closer to the PMTs. However, thin crystals absorb fewer
gamma-ray photons; therefore, the number of scintillations is reduced. The crystals of most units are
9.5 mm (3/8 in) thick; however, cameras equipped for coincidence imaging have thicker crystals,
typically 15.9 mm (5/8 in) thick. Crystal dimensions range from 25 × 25 cm (10 × 10 in) to 52 × 64 cm
(20.5 × 25 in). Because sodium iodide (NaI) absorbs water, a hermetically sealed aluminum housing
covers the sides and front of the crystal. The back is sealed by a clear Lucite light pipe or is optically
coupled directly to the face of the PMTs.
The light pulse created by the incident photon is converted into a measurable electrical signal by
the PMT array, which can be composed of 37 to 150 PMTs arranged hexagonally (although several
manufacturers use rectangular arrays). Each PMT has a preamplifier, a simple circuit that allows
the PMT to be tuned so that each yields the same output for a given scintillation intensity, ensuring
uniform detector performance throughout the entire FOV. Several cameras have an automatic
tuning option that electronically balances PMT output from a single control on the operator console.
The light photons strike the photocathode in the PMT and form photoelectrons that are then
directed through a series of 10 to 12 dynodes, which boost the signal. The output is sent to a
position-encoding circuit, which determines the 2-D location of the scintillation event and encodes
this position as four signals: x, x-, y, and y-. These signals are combined to form two signals that are
transmitted to a summation amplifier. All the light pulses viewed by the PMTs are summed into one
pulse, which is transmitted to a pulse height analyzer (PHA) that accepts only those pulses within a
predetermined range of energies. These pulses are used to generate an image.
In mobile gamma cameras, the system components are configured in one of two ways. In one
configuration, the detector and wheeled detector stand are separate from the data processing
console, which is also mounted on wheels; each component is manually pushed to the patient’s
bedside and interconnected by coaxial or fiberoptic cable. In another configuration, the detector,
detector stand, and data processing console are integrated into a single, motor-driven, wheeled unit
powered by rechargeable batteries. Either a chain drive or a friction wheel mechanism delivers
power to the system’s wheels. Images stored by these systems can be transferred to a workstation
via disk or Ethernet connection at a later time.
The principles of operation and image acquisition for mobile cameras are identical to those for
stationary models.
SPECT
Apart from some basic models and those intended only for whole-body studies, most stationary
and some mobile gamma cameras can perform SPECT, a nuclear medicine technique used to create a
3-D representation of the distribution of an administered radiopharmaceutical. SPECT cameras
detect only radionuclides that produce a cascaded emission of single photons; the technology is thus
distinguished from PET, which uses radionuclides that simultaneously produce two high-energy
photons 180° from each other. (See the Product Comparison titled SCANNING SYSTEMS, POSITRON
EMISSION TOMOGRAPHY.)
FDG, a radiopharmaceutical used for PET studies, is also used as an imaging agent for SPECT.
FDG-SPECT, also called 511 keV or positron-emitting SPECT, has been used with dual- or triple-
head SPECT systems fitted with specially designed high-energy collimators that optimize relative
resolution and sensitivity. However, now that PET imaging is widely available, FDG-SPECT is
rarely used.
SPECT systems can be configured with one, two, or three camera heads. Single-head gamma
camera systems have one detector mounted on a specialized mechanical gantry that automatically
rotates the camera 360° around the patient. SPECT systems acquire data in a series of projections at
increments of ≥2°. (In limited-angle systems, the camera is moved a limited number of times, usually
six.) From the sequence of projections, an image is reconstructed by an algorithm in what is called
filtered-back projection: after nontarget data is mathematically removed or suppressed (filtered) for
each view, the reconstructed, 3-D image is derived from back projection, which composites the
multiangled, 2-D views and projects them onto a computer matrix. The projection data is combined
to produce transverse (also called axial or transaxial) slices; sagittal and coronal image slices can
also be produced through mathematical manipulation of the data.
SPECT systems with multiple camera heads are also available. In a dual-head system, two 180°-
opposed camera heads are used, and acquisition time is reduced by half, with no loss of sensitivity; a
triple-head SPECT system further improves sensitivity (Patton 2000). Some suppliers also offer
variable-angle dual-head systems for improved positioning during cardiac, brain, and whole-body
imaging. One supplier offers a triple-head system with the detectors electronically grouped in pairs
for coincidence imaging. Combining this configuration with improved signal processing improves
sensitivity significantly. Imaging times can be decreased by using another SPECT configuration—a
ring of detectors completely surrounding the patient. Although multiple camera heads reduce
acquisition time, they do not significantly shorten procedure/exam time because of factors such as
patient preparation and data processing.
Recently introduced diagnostic-quality hybrid SPECT/CT systems have propelled the technology
into a number of new research and clinical arenas, allowing anatomic information to be seen
simultaneously with metabolic information. The first hybrid SPECT/CT systems combined SPECT
with a nondiagnostic CT scanner, but the coupling of SPECT technology with today’s high-powered
high-speed CT scanners has widened the range of clinical applications and enhanced anatomic
mapping and localization. Increased speed and improved attenuation correction are advantages of
the new SPECT/CT systems. Anatomic maps derived from CT images can be used to correct likely
photon attenuation and improve diagnostic accuracy of the images.
Image processing
System software allows a variety of image-processing protocols, many of which are user defined.
Some of the more popular general software applications provided by manufacturers are image
smoothing, normalization, and interpolation; image addition or subtraction; background subtraction;
contrast enhancement; cyclic display of sequential images (cine); region-of-interest construction and
display; curve or histogram construction and display; and creation of alphanumeric overlays. Cardiac
applications include first-pass acquisition; multigated acquisition; automatic edge detection;
determination of end-systolic and end-diastolic volumes, stroke volume, cardiac output, global
ejection fraction, regional ejection fraction, and pulmonary transit time; shunt quantification;
thallium perfusion profiles; and rest/exercise thallium image comparison.
Electrocardiographic synchronizers are often offered as optional equipment for gamma cameras.
They are used in gated-acquisition studies to synchronize image collection with the cardiac cycle
defined by electrocardiogram R waves. The beginning of the R wave triggers the synchronizer to
signal the start of data collection. The computer divides the interval between R waves into equal
subdivisions, usually between 16 and 32. During each cardiac cycle, data is stored in the
corresponding subdivisions so that a composite image of the cycle can be developed; a number of
quantitative and qualitative assessments are then possible.
Reported problems
Gamma camera systems have certain limitations in image linearity, image uniformity, intrinsic
and extrinsic spatial resolution, and efficiency.
Because of limitations in detector electronics, straight-line objects may appear curved: areas
directly in front of the PMTs are subject to pincushion distortion (inward bowing of lines), whereas
areas between the tubes undergo barrel distortion (outward bowing), neither of which is usually
clinically significant. Image intensity can also vary—for example, pincushion distortion tends to
concentrate signals in the center of the PMT, resulting in areas of increased intensity at each PMT
location.
Improperly balanced PMTs and imperfections inherent in the NaI(Tl) crystal can also contribute
to field nonuniformity. Edge packing occurs when scintillation photons near the edge of the crystal
reflect off the inside of the aluminum housing into the outer-edge PMTs, resulting in a FOV outlined
by a ring of increased intensity. Some cameras eliminate this ring by electronically creating an iris
that masks edge packing but reduces the FOV by a few centimeters.
Optical problems can occur if hydrated spots—small white spots caused by water absorption—
develop on the surface of the NaI(Tl) crystal; these spots scatter or absorb light and cause a loss of
light in some scintillation events. Off-peak testing can reveal these defects in aged crystals.
Variations in spatial resolution are usually caused by statistical fluctuations in the distribution of
light photons between PMTs. These fluctuations can be as great as one standard deviation from one
scintillation to the next. Intrinsic spatial resolution also depends in part on crystal thickness; thicker
crystals allow photons to spread out before reaching the PMTs. In addition, lower-energy gamma
rays produce fewer photons, causing greater statistical fluctuations and therefore decreased spatial
resolution.
Extrinsic spatial resolution is a function of collimator and detector resolution and, surprisingly, is
less than either one alone. Because collimator resolution decreases with increasing distance from the
source, extrinsic resolution also decreases. Differences in resolution between gamma cameras,
although detectable on bar-phantom performance checks, are seldom clinically significant.
A gamma camera cannot efficiently detect high-energy gamma photons because they pass through
the thin crystal before being absorbed and produce fewer scintillations. Detector efficiency is also
limited by dead time (a period of a few microseconds during which a scintillation is processed and no
other scintillations can be recorded) and pulse pileup, both of which can be clinically significant in
high-count-rate dynamic studies, such as first-pass cardiac function analysis.
SPECT image quality can be limited by Compton scatter and attenuation of the radiation beam as
it travels through the patient. The patient’s body size and anatomic structure (e.g., amount of soft
tissue, chest or breast size) affect the degree of scatter and attenuation. Compton scatter reduces the
contrast in SPECT images. Advanced scatter correction techniques have been introduced to
minimize the effect of Compton scatter on data acquisition. Attenuation is caused by the weakening
of the radiation beam produced by the radiopharmaceutical as it passes through the patient’s body.
Attenuation correction techniques to reduce or eliminate artifacts have also been introduced. These
techniques use hardware that transmits a controlled radiation beam to the detector(s) during data
acquisition. The signals produced from the control beam and the radiation beam produced by the
radiopharmaceutical are integrated, and patient-specific attenuation is calculated. These
attenuation correction techniques can increase diagnostic specificity, and possibly sensitivity, of
SPECT studies and are required for cardiac imaging.
Defects in collimators can cause sensitivity loss, longer acquisition times, errors in image
reconstruction, and image artifacts. Collimators should be checked for proper angulation, sensitivity
contrast, and center-of-rotation offset variations.
Quality-control procedures should be established for planar and SPECT imaging systems to
ensure proper operation and creation of the highest-quality images possible for the equipment used.
Daily tests should include energy peaking and intrinsic uniformity; intrinsic sensitivity and
resolution/linearity should be tested weekly. In addition, center-of-rotation, uniformity correction,
and motion correction testing should be performed for SPECT systems. For further information, see
the American Society of Nuclear Cardiology 2001 guideline article cited below (see Bibliography).
To obtain optimal image quality, hospitals should carefully select the appropriate imaging
protocol or test, patient position, and collimator.
The crystal and the detector assembly of a mobile gamma camera can be damaged during
transport through hospital corridors.
Purchase considerations
ECRI recommendations
Included in the accompanying comparison charts are ECRI’s recommendations for minimum
performance requirements for gamma cameras. Whole-body gamma cameras are general-purpose
imagers that typically use detectors with a relatively large FOV. They are commonly used for both
large and small organ studies. Some have SPECT, FDG-SPECT, and coincidence imaging
capabilities.
Dedicated gamma cameras are designed for particular studies, including PET/SPECT brain, small
parts (thyroid, mammographic), cardiac, and neurologic applications. The detectors are generally
smaller with a small FOV.
Mobile gamma cameras are unlike stationary whole-body gamma cameras; they typically use
smaller detectors with a reduced field of view. They are commonly used for small organ studies
including the thyroid and heart.
Other considerations
ECRI recommends that buyers consider the number of nuclear medicine studies that will be
performed before deciding on a specific system configuration. Multihead systems allow faster
acquisition times and better image resolution than single-head systems. However, the cost of a dual-
head or triple-head system can be double or triple that of a single-head system. In addition,
purchasers should keep in mind that, although multihead cameras have faster acquisition times,
their use will not necessarily result in a significantly greater throughput because other factors, such
as patient preparation time, remain unchanged.
Purchasers should also consider the clinical applications for which the new system will be used.
For example, a dual-head camera is ideal for single-pass whole-body bone scanning and general
SPECT. However, for cardiac SPECT, a dual-head camera with opposing detectors offers little
advantage over a single-head camera, since SPECT data is typically acquired in a 180° arc, with
most of the data acquired by one detector. A variable-angle dual-head camera, which allows the
detectors to be positioned at 90°, 101°, or 180° relative to each other, offers a more efficient
configuration for hospitals planning to perform a wide range of studies. Whole-body bone scans and
general SPECT studies can be performed with the detectors positioned at 180°, and cardiac scans
and certain other procedures can be performed with the detectors positioned at 90° or 101°. Triple-
head cameras are more commonly used for brain and cardiac SPECT; they can collect all image data
for a heart scan in about one-third the time of a single-head camera and are well suited for nuclear
medicine departments that conduct numerous stress thallium or cardiac studies.
Most cameras have a 51 × 38 cm (20 × 15 in) rectangular large field of view (LFOV), and some
provide an ultralarge 61 × 38 cm (24 × 15 in) FOV. LFOV cameras cover larger areas of the body
and acquire a complete study in less time, thereby increasing patient throughput.
Hospitals planning to purchase more than one gamma camera or purchase additional cameras for
a nuclear medicine department should consider whether the new equipment can interface with their
existing nuclear medicine computers and other cameras and can therefore be integrated into one
comprehensive network. In addition, hospitals should consider purchasing multiple systems from
one supplier. Standardizing equipment can make staff training easier, simplify servicing and parts
acquisition, and provide greater bargaining leverage when negotiating the purchase of new
equipment and/or service-contract costs.
Other purchase considerations include the dimensions and weight of the system and humidity and
temperature requirements.
Many gamma camera scanning systems incorporate the American College of Radiology/National
Electrical Manufacturers Association Digital Imaging and Communications in Medicine (DICOM)
3.0 Standard into their scanning systems. The purpose of this standard is to allow digital images
produced by any medical device to be stored and transferred through picture archiving and
communication systems or other means, regardless of the device supplier. Despite DICOM, buyers
must ensure that a gamma camera can share data with existing computer systems. When
purchasing a mobile gamma camera system, buyers should pay careful attention to selecting optional
features, the type and number of which can greatly affect the final purchase price. For instance, an
onboard computer can significantly increase the cost of a system.
Cost containment
Because gamma cameras entail ongoing maintenance and operational costs, the initial acquisition
cost does not accurately reflect the total cost of ownership. Therefore, a purchase decision should be
based on issues such as life-cycle cost (LCC), local service support, discount rates and non-price-
related benefits offered by the supplier, and standardization with existing equipment in the
department or hospital (i.e., purchasing all gamma cameras and computers from one supplier).
An LCC analysis can be used to compare high-cost alternatives and/or to determine the positive or
negative economic value of a single alternative. For example, hospitals can use LCC analysis
techniques to examine the cost-effectiveness of leasing or renting equipment versus purchasing the
equipment outright. Because it examines the cash-flow impact of initial acquisition costs and
operating costs over a period of time, LCC analysis is most useful for comparing alternatives with
different cash flows and for revealing the total costs of equipment ownership. One LCC technique—
present value (PV) analysis—is especially useful because it accounts for inflation and for the time
value of money (i.e., money received today is worth more than money received at a later date).
Conducting a PV/LCC analysis often demonstrates that the cost of ownership includes more than
just the initial acquisition cost and that a small increase in initial acquisition cost may produce
significant savings in long-term operating costs. The PV is calculated using the annual cash outflow,
the dollar discount factor (the cost of capital), and the lifetime of the equipment (in years) in a
mathematical equation.
The following represents a sample six-year PV/LCC analysis for a dual-detector digital gamma
camera with an integral computer.
Assumptions
• Operating costs are considered for years 1 through 6
• Dollar discount factor is 6.25%
• Inflation rate is 6% for a full service contract
• Inflation rate is 4% for disposables
• Operating and ownership costs are for 1 gamma camera, with 2,000 procedures/year in
years 1 and 2 and 2,200 procedures/year in years 3 through 6
• Staff costs are for 2 full-time nuclear medicine technologists (years 1 through 6) and 1
part-time technologist (years 3 through 6), including salary, benefits, payroll expenses,
and continuing education
Capital Costs
• Gamma camera and computer = $600,000
• Coincidence imaging in year 2 = $350,000
• Hardware and software upgrade for attenuation correction algorithm in year 2 =
$55,000
Total Capital Costs = $600,000 initially; $405,000 in year 2
• Cost for accessories, such as syringes, film, and optical disks, at $15/procedure =
$30,000/year in years 1 and 2 and $33,000/year in years 3 through 6
• Cost for radiopharmaceuticals at $250/dose = $500,000/year in years 1 and 2 and
$550,000/year in years 3 through 6
Total Operating Costs = $640,000 in year 1; $689,000 in year 2;
$762,000/year in years 3 through 6
PV = ($5,124,582)
Other factors not included in the above analysis that should be considered for budgetary planning
include the following:
• Costs associated with software upgrades
• Cost of utilities
• Cost of other accessories, such as phantoms and patient monitoring equipment
• Contributions to overhead
• Reimbursements received from third-party payers for standard procedures
As illustrated by the above sample PV/LCC analysis, the initial acquisition cost is only a fraction
of the total cost of operation over six years. Therefore, before making a purchase decision based
solely on the acquisition cost of a gamma camera, buyers should consider operating costs over the
lifetime of the equipment.
For further information on PV/LCC analysis, customized analyses, and purchase decision support,
readers should contact ECRI’s SELECT™ Group.
When deciding whether to upgrade current gamma cameras to obtain PET-like images, hospitals
should consider the following costs:
• Up to $350,000 for a coincidence upgrade to a dual-detector gamma camera
• $750,000 to $900,000 for a new dual-detector gamma camera that performs SPECT and
coincidence imaging
Hospitals can purchase service contracts or service on a time-and-materials basis from the
supplier. Service may also be available from a third-party organization. The decision to purchase a
service contract should be carefully considered and can be justified for several reasons. Most
suppliers provide routine software updates, which enhance the system’s performance, at no charge to
service contract customers. Furthermore, software updates are often cumulative; that is, previous
software revisions may be required in order to install and operate a new performance feature.
Purchasing a service contract also ensures that preventive maintenance will be performed at regular
intervals, thereby eliminating the possibility of unexpected maintenance costs. Also, many suppliers
do not extend system performance and uptime guarantees beyond the length of the warranty unless
the system is covered by a service contract.
ECRI recommends that, to maximize bargaining leverage, hospitals negotiate pricing for service
contracts before the system is purchased. Depending on the added cost and the contract conditions,
hospitals may want to negotiate for coverage of the crystal(s) to be included in the service contract. A
few suppliers offer “no questions asked” crystal coverage, while other suppliers will cover the crystal
only under certain conditions.
Additional service-contract discounts may be negotiable for multiple-year agreements or for
service contracts that are bundled with contracts on other systems in the department or hospital.
Service contracts should include a guarantee of at least two preventive maintenance inspections per
year, a guarantee of at least 95% uptime, and specified response time to service requests.
In addition, given the current highly competitive nuclear medicine market, hospitals should
negotiate for a significant discount—some suppliers may discount up to 40%. The actual discount
received will depend on the hospital’s negotiating skills and/or previous experience with the supplier,
the system configuration and options to be purchased, and the extent of concessions granted by the
supplier, such as extended warranties, fixed prices for annual service contracts, and guaranteed on-
site service response. Buyers should make sure that applications training is included in the purchase
price of the system. Some suppliers offer more extensive on- or off-site training programs for an
additional cost.
To aid in installation planning, two facilities in the United Kingdom have applied virtual-reality
techniques to planning a gamma camera suite before purchase and installation. A virtual-reality
computer system was used to model existing and new gamma camera rooms to identify design
problems (e.g., restricted bed access and camera movements due to equipment placement). The study
(Penrose et al. 1996) suggests that virtual reality can be used successfully for planning and
installation of gamma camera suites, as well as for nuclear medicine pharmacies and magnetic
resonance imaging suites.
Stage of development
The Anger scintillation camera was developed in the 1950s and introduced commercially in the
1960s. In the late 1980s, multihead SPECT cameras were introduced, and in early 1994, an FDG
imaging agent for SPECT was introduced. Other significant developments include decreased imaging
times, faster and more powerful computers, new radiopharmaceuticals, new collimators for
ultrahigh-resolution imaging, variable-angle capabilities, and digital features.
Many suppliers are now marketing digital gamma cameras that perform analog-to-digital
conversion, either within each PMT or immediately after the signal leaves the PMT. By digitizing
the signal at this point, signal averaging, which affects image resolution, can be computer controlled.
Because digital detection provides more precise event-positioning information, detector performance
characteristics, such as maximum count rate, intrinsic spatial resolution, intrinsic energy resolution,
intrinsic uniformity, and system sensitivity, are improved. Software-controlled operation of digital
cameras also improves system reliability and allows use of remote diagnostics for servicing.
A number of manufacturers have recently received FDA clearance to market small handheld
gamma cameras. One manufacturer has introduced a mobile camera that uses new solid-state
detectors constructed of cadmium zinc telluride (CZT) that replace the crystal/PMT structure
currently used in other cameras. The solid-state CZT detectors directly convert gamma rays to
electrical pulses. The entire system is approximately the size of an ultrasound scanner. The smaller
detector head has a 20 × 20 cm (7.9 × 7.9 in) FOV for organ-specific imaging, although whole-body
data can be acquired by scanning sections. Another solid-state camera system converts the energy of
the gamma rays into an electronic signal by utilizing silicon photodiodes, rather than PMTs, coupled
to segmented cesium iodide scintillators.
Clinical applications research is focused on breast cancer imaging and expanded cardiology,
oncology, and neurology applications. Scintimammography, a technique that uses a gamma camera
to image the breasts of a patient injected with technetium-99m-sestamibi (a radioisotope
traditionally used for cardiac imaging), has been introduced as an adjunct to conventional
mammography. Initial research suggests that scintimammography may be useful for imaging
patients who have dense breasts, who have had breast surgery, or who have radiotherapy-altered
breasts. Because the radioisotope identifies malignancies, scintimammography may also prove useful
for targeting malignant tumors, thereby reducing the need for biopsy. (See the Product Comparison
titled RADIOGRAPHIC UNITS, MAMMOGRAPHIC; STEREOTACTIC SYSTEMS, BIOPSY,
MAMMOGRAPHIC for more information on mammography.)
Many suppliers are pursuing chair-based cardiac systems, which can cause less patient movement
artifact and improve patient comfort by imaging in an upright position. Other research into cardiac
and brain SPECT is focused on the development of new imaging agents, including
radiopharmaceuticals, monoclonal antibodies, and peptides, as well as on new applications of dual-
isotope imaging with multihead cameras. Monoclonal antibodies, which may prove useful for early
detection and staging of tumors and ovarian, colorectal, prostate, and lung cancers, have not been
used clinically on a regular basis. Peptide imaging agents are under development for tumor,
thrombus, atherosclerotic plaque, and infection imaging and are more promising because they are
safer and less expensive than monoclonal antibodies. Also, some evidence exists that SPECT may
improve diagnostic accuracy for Alzheimer’s disease.
Because hybrid systems provide users with more clinical options than conventional systems and
purchasing a hybrid system cost less than purchasing separate systems for each modality,
diagnostic-quality SPECT/CT systems are expected to see enhanced market interest. Additional
efforts focused on evaluating the effectiveness of FDG-SPECT and continued developments in
radiopharmaceuticals, as well as expanding applications, should increase the attractiveness of
multihead SPECT.
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programmable electrical medical systems. IEC 60601-1-4 (2000-04). 1996 (revised 2000).
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volume curves and EF values that appear to be lower than expected and not rely solely on these EF
values for diagnostic purposes. Source: FDA Enforcement Rep 2004 Oct 27; Manufacturer.
D6158 FDA has designated this Class II Recall Nos. Z-0029/0030-2 complete for certain Siemens
Medical Solutions E.CAM gantry emission-imaging computed tomography systems and AccuSync 7
electrocardiogram gating devices/monitors. The above monitors, which are used as accessories to
E.CAM emission-imaging computed tomography systems, may generate electrocardiogram patterns
and traces when not connected to the patient. The manufacturer initiated a field correction by
Service Bulletin FM1-281 dated September 30, 1999. The firm states that no affected product
remains on the market. No further action is required of customers. Source: FDA Enforcement Rep
2001 Oct 24; Manufacturer.
Supplier information
Chart A: Mobile Gamma Cameras
Digirad
Digirad Corp [328751]
13950 Stowe Dr
Poway, CA 92064-8803
Phone: (800) 947-6134 Fax: (858) 726-1700
Internet: http://www.digirad.com
E-mail: info@digirad.com
Gamma Medica
Gamma Medica Inc [370899]
19355 Business Center Dr Suite 8
Northridge, CA 91324
Phone: (818) 709-2468 (877) 426-2633 Fax: (818) 709-2464
Internet: http://www.gammamedica.com
E-mail: info@gammamedica.com
Philips Medical Systems (Asia Pacific), Cardiac & Monitoring Systems Div [398048]
24/Fl Cityplaza One 1111 King’s Road
Taikoo Shing
People’s Republic of China
Phone: 852 31977777 Fax: 852 25069261
Internet: http://www.medical.philips.com
Philips Medical Systems (Europe), Cardiac & Monitoring Systems Div [398047]
Herrenberger Strasse 124
D-71034 Boeblingen
Germany
Phone: 49 (7031) 4641552 Fax: 49 (7031) 4644096
Internet: http://www.medical.philips.com
E-mail: pmscc@philips.com
Australia
Phone: 61 (2) 98876000 Fax: 61 (2) 98874866
Internet: http://www.medical.toshiba.com.au
E-mail: intouch@toshiba-tap.com
Note: The following company did not provide us with any product information in time for
publication. Its address is listed as a service to our readers.
Collimators: The following abbreviations are used to describe the collimators offered with the
gamma camera. Acronyms not defined below may be proprietary collimators specific to a certain
manufacturer.
Abbreviations
511 keV — Collimators for 511 keV (FDG- MEAP — Medium-energy all-purpose
SPECT) imaging
MEGP — Medium-energy general-purpose
FB — Fan beam, a specialized converging
MEHR — Medium-energy high-resolution
collimator
MELP — Medium-energy low-penetration
HE — High energy
SHEGP — Superhigh-energy general-purpose
HEGP — High-energy general-purpose
UHE — Ultrahigh-energy
HEHR — High-energy high-resolution
UHEHR — Ultrahigh-energy high-resolution
HR — High resolution
UHGP — Ultrahigh general-purpose
LEAP — Low-energy all-purpose
UHR — Ultrahigh resolution
LEFB — Low-energy fan beam
VXGP — Vertex general-purpose
LEGP — Low-energy general-purpose
VXHR — Vertex high-resolution
LEHR — Low-energy high-resolution
VXUR — Vertex ultrahigh-resolution
LEHS — Low-energy high-sensitivity
WRME — Wide-range medium-energy
LEUHR — Low-energy ultrahigh-resolution
LEUHS — Low-energy ultrahigh-sensitivity
List price, std configuration: Some of the pricing information in these charts has been derived from
list prices reported to ECRI’s in-house information services by healthcare institutions and by
suppliers. A footnote identifies these prices. In these instances, suppliers have declined to provide
HPCS directly with prices and may not have confirmed the information. These prices are estimates
and may not reflect discounts, options, special packages, and multiple-unit sales. They are provided
for the convenience of our readers.
Other abbreviations:
ADC — Analog-to-digital converter ETL — ETL Testing Laboratories
ARO — After receipt of order FDA — U.S. Food and Drug Administration
BTU — British thermal unit FDG — Fluorodeoxyglucose
B/W — Black and white FOV — Field of view
CD-R — Recordable compact disc FWHM — Full width at half maximum—the
measure of the width of a point or line spread
CD-RW — Rewritable compact disc
function across points 50% down each side
CE mark — Conformite Europeane mark from the peak
CFOV — Central field of view FWTM — Full width at tenth maximum—the
measure of the width of a point or line spread
cps — Counts per second
function across points 90% down each side
CPU — Central processing unit from the peak
DICOM — Digital Imaging and GMP — Good Manufacturing Practices
Communications in Medicine 3.0 standard
HIS — Hospital information system
ECG — Electrocardiogram
Note: The data in the charts derive from suppliers’ specifications and have not been verified
through independent testing by ECRI or any other agency. Because test methods vary, different
products’ specifications are not always comparable. Moreover, products and specifications are subject
to frequent changes. ECRI is not responsible for the quality or validity of the information presented
or for any adverse consequences of acting on such information.
When reading the charts, keep in mind that, unless otherwise noted, the list price does not reflect
supplier discounts. And although we try to indicate which features and characteristics are standard
and which are not, some may be optional, at additional cost.
For those models whose prices were supplied to us in currencies other than U.S. dollars, we have
also listed the conversion to U.S. dollars to facilitate comparison among models. However, keep in
mind that exchange rates change often.