Beruflich Dokumente
Kultur Dokumente
EMBRYOLOGY
1. What maternal disease is associated with anencephaly? (p 475) ___________________________
______________________________________________________________________________
3. Which branchial arches form the posterior 1/3 of the tongue? (p 477) _______________________
7. Which substances cross the blood-brain barrier quickly? Which substances cross it slowly? (p 480)
______________________________________________________________________________
______________________________________________________________________________
9. From which four areas does the brain's vomiting center, coordinated by nucleus tractus solitarius in
the medulla, receive information? (p 481) ______________________________________________
______________________________________________________________________________
10. Ascending sensory information from the body reaches the __________ (VPL / VPM) of the thalamus,
and sensory information from the face reaches the ____________ (VPL / VPM). (p 482)
11. Decreases in the activity of tuberoinfundibular pathway lead to increases in what secretory protein?
(p 482) _________________________________________________________________________
12. The direct pathway utilizes the ____ receptor and __________ movement. The indirect pathway
utilizes the___ receptor and ____________ movement. (p 484)
13. How does loss of dopamine in Parkinson disease affect the excitatory pathway? How does it affect
the inhibitory pathway? (p 484) ____________________________________________________
______________________________________________________________________________
15. What is the major vascular territory covered by the ACA? MCA? PCA? (pp 485-487) ___________
______________________________________________________________________________
17. What structures pass through the superior orbital fissure? (p 489) __________________________
18. Fill in the following chart describing the cranial nerves. (pp 489, 490)
III Oculomotor
IV Trochlear
V Trigeminal
VI Abducens
VII Facial
VIII Vestibulocochlear
IX Glossopharyngeal
X Vagus
XI Accessory
XII Hypoglossal
20. If there is a lesion in CNs V and VII, which reflexes are impaired? (p 490) ____________________
22. Which spinal nerves exit the intervertebral foramina above the corresponding vertebra? Which spinal
nerves exit the foramina below the corresponding vertebra? (p 491) ________________________
______________________________________________________________________________
24. Match these commonly tested reflexes to their nerve roots. (p 494)
_____ A. Achilles 1. C5
_____ B. Biceps 2. C7
_____ C. Patella 3. L4
_____ D. Triceps 4. S1
NEUROPATHOLOGY
25. Match the area of a brain lesion with its clinical effect(s). (p 495)
_____ A. Anterograde amnesia 1. Amygdala
_____ B. Contralateral hemiballismus 2. Basal ganglia
_____ C. Deficits in concentration, orientation, and judgment 3. Cerebellar hemisphere
_____ D. Eyes look away from side of lesion 4. Cerebellar vermis
_____ E. Eyes look toward side of lesion 5. Frontal eye fields
_____ F. Intention tremor and limb ataxia 6. Frontal lobe
_____ G. Internuclear ophthalmoplegia 7. Hippocampus
_____ H. Klüver-Bucy syndrome 8. Mammillary bodies
_____ I. Parinaud syndrome 9. Medial longitudinal fasiculus
_____ J. Reduced levels of arousal and wakefulness 10. Midbrain
_____ K. Tremor at rest, chorea, or athetosis 11. PPRF
_____ L. Truncal ataxia and dysarthria 12. Subthalamic nucleus
_____ M. Wernicke-Korsakoff syndrome 13. Dorsal midbrain
27. Which three brain regions are most susceptible to hypoxia? (p 496) ______________________
______________________________________________________________________________
28. A 50-year-old woman presents to the emergency department with a headache and numbness on the
right side. Her speech is difficult to understand, and her mouth droops when talking. Noncontrast CT
of the head shows bright areas. Should tPA be administered? Why or why not? (p 496) ________
______________________________________________________________________________
29. What are the causes of neonatal intraventricular hemorrhage? (p 496) ________________________
______________________________________________________________________________
30. On CT, an epidural hematoma _______________ (does/does not) cross suture lines, but a subdural
hematoma _______________ (does/does not) cross suture lines. (p 497)
31. Lesions in PICA or AICA may result in vomiting, vertigo, nystagmus and ipsilateral Horner syndrome.
The two can be distinguished because _________ lesions cause loss of pain and temperature in the
face and limbs, whereas _________ lesions cause paralysis of the face and pain/temperature loss
in the face only. ________ lesions cause decreased corneal reflex, whereas _______ lesions cause
loss of gag reflex, as well as dysphagia and hoarseness. (p 498)
32. A 44-year-old patient is unconscious after a serious car accident with visible head trauma. A scan of
his brain shows multiple lesions involving the white matter tracts. What injury has the patient likely
suffered, and what is his prognosis? (p 499) ____________________________________________
______________________________________________________________________________
33. Fluent aphasia with impaired comprehension describes _________ (Broca/Wernicke) aphasia,
whereas nonfluent aphasia with intact comprehension describes _________ (Broca/Wernicke)
aphasia. (p 500)
34. For each case, identify the type of seizure and its first-line treatment. (pp 501, 528)
A. A teenage boy suddenly stiffens, falls down, and experiences rhythmic jerking of his extremities
lasting 1 minute. _____________________________________________________________
B. A 7-year-old boy is having “behavioral problems” at school. He “spaces out” during class. EEG
shows a 3-Hz spike-and-wave pattern. ___________________________________________
C. A 45-year-old man who suffered a concussion from a car accident has episodes of jerky
movements of his left arm that he cannot control. He remembers the incident itself, but had
blacked out afterward. ________________________________________________________
35. What are the main symptoms of a migraine? What mnemonic can you use to remember them?
(p 502) ________________________________________________________________________
______________________________________________________________________________
______________________________________________________________________________
A. Athetosis __________________________________________________________________
B. Chorea ___________________________________________________________________
C. Dystonia __________________________________________________________________
D. Myoclonus ________________________________________________________________
37. What are the cardinal features of Parkinson disease? (p 504) ____________________________
______________________________________________________________________________
38. Match the type of dementia with its most defining histologic characteristic. (pp 504-505)
39. What are risk factors for development of idiopathic intracranial hypertension (pseudotumor cerebri)?
(p 505) _______________________________________________________________________
_____________________________________________________________________________
40. What are the symptoms of normal pressure hydrocephalus? (p 506) _______________________
______________________________________________________________________________
41. Which disorder presents with increased IgG and myelin basic protein in the CSF? (p 507) ______
______________________________________________________________________________
42. "Locked-in syndrome" is a potential consequence of which demyelinating disorder? (p 508) ______
______________________________________________________________________________
43. For each case, identify the most likely neurocutaneous disorder. (p 509)
A. A 6-month-old presents with her first seizure. Wood’s lamp examination shows several areas
of hypopigmentation over her trunk and extremities. ________________________________
B. A 6-month-old has a port-wine stain over his left eye and cheek, extending to the tip of his
nose, with a sharp drop-off to normal-toned skin on the right side of his face. _____________
__________________________________________________________________________
C. A 6-month-old has congestive heart failure. Imaging shows a cavernous hemangioma in the
liver. ______________________________________________________________________
D. A 6-month-old has multiple hyperpigmented brown macules scattered over the trunk and up-
per extremities. _____________________________________________________________
44. For each case, identify the most likely brain tumor. (pp 510-512)
A. A 49-year-old man presents with a 2-month history of morning headaches. CT of the head
shows a heterogeneous-appearing mass with irregular borders crossing the corpus callosum.
__________________________________________________________________________
C. A 4-year-old boy presents with a 1-month history of morning headaches, abnormal gait, and
dysmetria. Imaging shows an appearance in the posterior fossa. ______________________
E. A 36-year-old woman presents with amenorrhea and “problems with peripheral vision.” _____
___________________________________________________________________________
45. Using the following chart, compare and contrast the characteristics of upper and lower motor neuron
lesions. (p 513)
46. For each lesion in the image, identify the motor deficit and associated diseases. (p 514)
A. ____________________________________________________________________________
B. ____________________________________________________________________________
C. ____________________________________________________________________________
D. ____________________________________________________________________________
E. ____________________________________________________________________________
F. ____________________________________________________________________________
G. ____________________________________________________________________________
47. With a lesion in CN X, the uvula deviates _______________ (toward/away from) the side of the
lesion. (p 516)
48. With a lesion in CN XI, the head turns ________ (toward/away from) the side of the lesion. (p 516)
49. With a lesion in CN XII, the tongue deviates _______________ (toward/away from) the side of the
lesion. (p 516)
OTOLOGY
50. In a patient with _______________ (conductive/sensorineural) hearing loss, the Weber test localizes
to the affected ear, while in a patient with _______________ (conductive/sensorineural) hearing loss
the Weber test localizes to the unaffected ear. (p 517)
51. Presbycusis results in hearing loss of what types of sound frequencies first? (p 517) ___________
52. A patient with central vertigo presents with _______________ (delayed/immediate) nystagmus,
nystagmus. (p 518)
OPHTHALMOLOGY
53. Where is the obstruction in open/wide-angle glaucoma? Where is the obstruction in closed/narrow-
angle glaucoma? Which one is painful? (p 520) ________________________________________
______________________________________________________________________________
54. When a patient is diagnosed with hypertensive retinopathy, under what conditions must the blood
55. Horner syndrome is associated with which three symptoms? (p 524) _______________________
______________________________________________________________________________
56. Referring to the image, which cranial nerve and muscle are tested with each movement? (p 524)
57. Identify the type of visual field defects in the image. (p 526)
58. What structures pass through the cavernous sinus? (p 526) ______________________________
______________________________________________________________________________
59. Horizontal diplopia develops in a 26-year-old woman with multiple sclerosis. Examination reveals
she cannot adduct her left eye past midline and has a left-beating nystagmus in her right eye when
looking to the right. However, her left eye can adduct during convergence. Where is the lesion most
likely located? (p 527) ____________________________________________________________
PHARMACOLOGY
60. Match the drug with its indication for use. (pp 528-529, 534-535)
_____ A. Acute status epilepticus 1. Diazepam
_____ B. Absence seizures 2. Ethosuximide
_____ C. Chronic pain 3. Methadone
_____ D. Closed- and narrow-angle glaucoma 4. Phenobarbital
_____ E. Induction of anesthesia 5. Pilocarpine
_____ F. Insomnia 6. Thiopental
_____ G. Opiate dependency 7. Tramadol
_____ H. Seizure prophylaxis in neonates 8. Zolpidem
61. Describe the mechanism of action for each drug commonly used to treat Parkinson disease. (p 531)
A. Benztropine ________________________________________________________________
B. Bromocriptine ______________________________________________________________
C. L-dopa/carbidopa ____________________________________________________________
D. Selegiline __________________________________________________________________
62. Anesthetics with low blood and lipid solubility have __________ (fast/slow) induction, whereas
anesthetics with high blood and lipid solubility have __________ (fast/slow) induction. (p 532)
63. What are the two clinical uses of dantrolene? (p 534) ____________________________________
Answers
EMBRYOLOGY
1. Maternal diabetes (type 1).
2. “Cape-like” bilateral loss of pain and temperature sensation in upper extremities while fine touch is
preserved.
7. Nonpolar/lipid-soluble substances cross rapidly (via diffusion); glucose and amino acids cross slowly
(by carrier-mediated transport).
9. The chemoreceptor trigger zone (CTZ, located within area postrema in 4th ventricle), GI tract (via
vagus nerve), vestibular system, and CNS.
11. Prolactin.
13. Loss of dopamine inhibits the excitatory pathway and disinhibits (or excites) the inhibitory pathway.
14. pCO2
15. The ACA supplies the medial surface of the brain, which covers the leg area of the motor and sensory
cortices. The MCA supplies the motor and sensory cortex of the face and arm. The PCA supplies
the occipital cortex.
18.
20. The corneal and lacrimation reflexes are impaired if a lesion occurs in CNs V and VII.
22. Nerves C1-C7 exit above the corresponding vertebra; the others exit below the corresponding
vertebrae.
NEUROPATHOLOGY
25. A-7, B-12, C-6, D-11, E-5, F-3, G-9, H-1, I-13, J-10, K-2, L-4, M-8.
28. This patient has had a stroke, and the bright areas on noncontrast CT indicate hemorrhage. Thus
tPA should not be administered.
29. Reduced glial fiber support and impaired autoregulation of blood pressure in premature infants.
32. The patient likely has suffered a diffuse axonal injury. He likely has a devastating neurologic injury,
and may be in a coma or persistent vegetative state.
34. A. Generalized tonic-clonic (grand mal) seizures. Treat with phenytoin, carbamazepine, or
valproic acid.
C. Simple partial seizures with secondary generalization. Virtually any antiepileptic drug can be
used; the most common are phenytoin, carbamazepine, levetiracetam, and valproic acid.
35. The main symptoms of migraines are unilateral, pulsating pain with nausea, photophobia, or
phonophobia. This pain is usually disruptive to everyday activity. The mnemonic that one can use to
remember these symptoms are POUND (Pulsatile, One-day duration, Unilateral, Nausea, Disabling).
37. Remember TRAPS: Tremor at rest, cogwheel Rigidity, Akinesia, Postural instability, Shuffling gait.
39. Risk factors for idiopathic intracranial hypertension (ICH) include female gender, Tetracyclines,
Obesity, vitamin A excess, and Danazol (female TOAD).
B. Sturge-Weber syndrome.
C. Cavernous hemangiomas can occur in isolation, but are associated with von Hippel-Lindau
disease.
D. Neurofibromatosis type 1.
B. Meningioma.
C. Medulloblastoma.
D. Craniopharyngioma.
45.
Atrophy – +
Babinski reflex + –
Fasciculation – +
Reflexes ↑ ↓
Spastic paralysis + –
Tone ↑ ↓
Weakness + +
46. A. Lower motor neuron lesions only, attributable to destruction of anterior horns; spinal muscular
atrophy.
C. Combination of upper and lower motor neuron deficits with no sensory deficit; amyotrophic
lateral sclerosis.
D. Complete occlusion of anterior spinal artery with sparing of dorsal columns and tract of
Lissauer.
G. Demyelination of dorsal columns, lateral corticospinal tracts, and spinocerebellar tracts; vitamin
B12 deficiency
47. The uvula deviates away from the side of the CN X lesion.
48. There is weakness turning the head away from the CN XI lesion.
49. The tongue deviates toward the side of the CN XII lesion.
OTOLOGY
50. Conductive, sensorineural.
OPHTHALMOLOGY
53. Open/wide-angle glaucoma is due to obstructed outflow. Closed/narrow-angle glaucoma is due to
obstructed flow between iris and lens. Closed/narrow-angle glaucoma is painful.
54. The presence of papilledema would require blood pressure to be lowered immediately.
56. Line A-B (SR-SO): assesses CN III—all but the superior oblique and the lateral rectus.
57.
58. CN III, CN IV, CN V1, CN V2, CN VI, sympathetic fibers, internal carotid artery.
59. The medial longitudinal fasciculus. Her left eye can adduct during convergence but not during right
lateral gaze because the oculomotor nerve itself works perfectly, but the connection between the
abducens nuclei and the oculomotor nuclei is impeded. The “message” to look right does not reach
the left medial rectus, causing the right eye to beat leftward because of the dysconjugate image. (If
you are still confused, now would be an excellent time to review INO.)
PHARMACOLOGY
60. A-1, B-2, C-7, D-5, E-6, F-8, G-3, H-4.
61. A. Inhibits acetylcholine, which preferentially excites the inhibitory pathway over the excitatory
pathway. The net effect of acetylcholine is inhibition of the thalamus.
C. Inhibits peripheral breakdown of L-dopa, which crosses the blood-brain barrier and is
converted to dopamine in the brain. The net effect is an increase of dopamine in the brain
milieu.