Beruflich Dokumente
Kultur Dokumente
Human Vaccines & Immunotherapeutics 9:5, 1158–1162; Publish Date 2013; © 2013 Landes Bioscience
Keywords: adverse events, immune thrombocytopenic purpura, MMR, platelets, vaccine safety, vaccine
defective immune regulation of genetic origin may play a role in MMR were based on only one or two vaccine-exposed cases, they
the pathogenesis of the disease.9 suggested that these findings could only be considered a hypoth-
esis rather than conclusive evidence, and suggested the need for
Risk of ITP after Vaccination further studies to clarify the question.13
There are few and not always reliable data concerning the abso- MMR Vaccine-Associated ITP
lute risk of developing ITP in children receiving any type of vac-
cine. Reports from surveillance systems are subject to substantial The development of ITP after the administration of a live attenu-
reporting bias as reporting depends on the vaccination schedule ated measles vaccine was first described by Oski and Naiman in
used in each country: for example, there are limited data regard- 1966.14 Since then, a number of reports have clearly demonstrated
ing hepatitis B vaccine (HB) because it is not universally recom- that all of the live, attenuated viruses in the MMR vaccine can
mended for children in some industrialized countries. Moreover, cause ITP whether administered alone or in combination.15-24