Andrographis paniculata, The Herbal Medicine Stops

Plaques Accumulated in Neurons and Production of

Inmature Neurons That Cause Alzheimer's disease,
Scientists Say

Kyle J. Norton, Master of Nutrition

Herbal Andrographolide may process a neural protective effect in prevention of

early onset of Alzheimer's disease, a common type of dementia, a study
suggested.

Alzheimer's disease (AD) is a chronic neuro degenerative disease that is

irreversible and starts slowly and worsens over time, affecting patients thinking
ability and memory, correlated with major reductions of neurons to the
respective target areas. The disease is named after German physician Alois
Alzheimer.

Some researchers suggested that the disease is caused by prolonged period of

plaques excessive accumulation in the brain cells, leading to brain cells
degeneration and death.

People with Alzheimer's disease may experience the decline of cognitive and
functional abilities, change of motions and moods and behavior, particularly, in
reducing quality of life due to disability in physical activity.

According to the statistic provided by the Alzheimer.Net, approximately, 44

million people have Alzheimer’s or a related dementia worldwide. The disease
is most common in the North America and Western Europe.

Alzheimer’s disease is the 6th leading cause of death in the United States.

In US, Alzheimer’s cost the United States taxpayer $259 billion in 2017.

Andrographis paniculata is also known as Andrographis is a herbaceous plant,

genus Andrographis, belonging to the family Acanthaceae, native to India and
Sri Lanka.

The herb has been used in traditional Siddha and Ayurvedic in treating common
cold, flu, upper respiratory infections, infectious diseases, diarrhea, dysentery,
cholera, pneumonia,....
According to the joint study lead by the Pontificia Universidad Catolica de
Chile, oral administrated natural product (Andrographolide, ANDRO) isolated
from Andrographis paniculata in species Octodon degus (degu) exhibited the
recovery of spatial memory and learning performance, through regulated
phosphorylated tau protein and amyloid beta aggregate maturation in cell
survival in inducing Alzheimer's disease.

Dr., the lead author in the joint study said, "(Andrographolide, ANDRO)
inhibited) neural damage associated with aging processes and the
behavioral and neuropathological hallmarks of aging-related diseases such
as AD"

Additionally, Andrographolide also displayed the inhibitory activity of against

forming of amyloid beta (Aβ)42 through suppression of NF-κB, a protein
that regulates cell survival and function of microglia in activated response
to brain damage and immunological stimuli together with the reduction in the
production of pro inflammatory cytokines.

In animal study, mice treated with Andrographolide increased neural

progenitor cell proliferation and decreased the number of immature
neurons in the hippocampus, in compared to age-matched control mice.

Moreover, ANDRO increased the number of newborn dentate granule neurons

in various parts of the brain.

The study also found that the efficacy that reduces symptoms and protects
against the early onset of AD is the results of the stimulation of
neurogenesis in the hippocampus.

Taking together, Andrographis paniculata is surely consisted as a therapeutic

potential to protect the development of Alzheimer's disease through various
mechanisms, however, intake of large amount daily should be taken with care.

However, additional data collection on large example size and multi centers
studies performed with human consumption of the whole food during the
course of the disease will be necessary to complete the picture of Andrographis
paniculata anti Alzheimer's disease possibilities.

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Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers
have been written and published on line, including world wide health, ezine
articles, article base, healthblogs, selfgrowth, best before it's news, the karate
GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ
by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington
Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as
international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Andrographolide Activates Keap1/Nrf2/ARE/HO-1 Pathway in HT22 Cells
and Suppresses Microglial Activation by Aβ42 through Nrf2-Related
Inflammatory Response by Seo JY1, Pyo E1, An JP1, Kim J1, Sung SH1, Oh
WK1.(PubMed)
(2) Andrographolide recovers cognitive impairment in a natural model of
Alzheimer's disease (Octodon degus) by Rivera DS1, Lindsay C2, Codocedo
JF2, Morel I3, Pinto C2, Cisternas P4, Bozinovic F5, Inestrosa NC6.(PubMed)
(3) Andrographolide Stimulates Neurogenesis in the Adult Hippocampus by
Varela-Nallar L1, Arredondo SB1, Tapia-Rojas C2, Hancke J3, Inestrosa NC4.
(PubMed)