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Testofen® - Gencor https://www.gencorpacific.com/featured-ingredients/testofen

Benefits and market opportunity

Testofen® is a fenugreek extract standardized for 50% Fenuside™.

Fenugreek contains over 100 phytochemical constituents, including Furostanol Saponins and Steroidal Saponins, and has
multiple health applications. However, Testofen is a unique extract of fenugreek standardized to a proprietary matrix of saponin
glycosides that Gencor has named Fenuside. These constituents in Testofen can support healthy sexual desire and vitality*,
muscle mass, free testosterone levels in men, and help reduce normal symptoms of Andropause in men.*

Supplementing diets with products containing Testofen, and regular resistance exercise, can help men maintain healthy levels of
free testosterone that are already within the normal range, which, in turn, supports multiple bodily functions.

Incorporate Testofen in product formulations designed to support healthy sexual function and performance in adult
males.*

Clinical research
Both animal and human clinical studies have been conducted on Testofen®.

Animal study

Study results: The 2010 study of Testofen on the reproductive systems of rats demonstrated that Testofen supported an
increase in the weight of the ani-levator muscle, which led to support for muscle mass and body weight.*

Citation: Urmila Aswar et.al, 2010. Effect of Furostanol Glycosides from Trigonella foenum –graecum on the reproductive system
of Male Albino Rats. Phytotherapy Research, 24, 1482–1488.

Human study on adult male sexual desire

Study result: A six-week double-blind, randomized, placebo-controlled clinical study was conducted in Australia in 2009 on 60
healthy adult males. A formulation containing Testofen as a major ingredient showed a statistically significant increase in the
sexual function, performance and satisfaction of the active group.* Study used the DISF-SR index. In addition, the study also
found self-reported satisfaction in quality of life measures such as perceived muscle strength, energy levels, and well-being,
although these were not analyzed for significance.*

Citation: Steels, E., Rao, A. and Vitetta, L., 2011. Physiological Aspects of Male Libido Enhanced by Standardized Trigonella
foenum-graecum Extract and Mineral Formulation. Phytotherapy Research, Vol. 25, 1294–1300. doi: 10.1002/ptr.3360

Human study on free testosterone and performance*

Study Results: A double-blind, randomized, placebo-controlled human clinical study of 60 subjects was conducted using
Testofen as the sole ingredient. The active group demonstrated the following mainly statistically significant results:

Significant anabolic activity as evidenced by BUN reduction (p<0.05) compared to placebo*

Significant support for free testosterone (p<0.05) compared to placebo group*
Immune support (p<0.003) compared to placebo group*
Significant support for Serum Creatinine levels (p<0.02) compared to placebo group signifying support for Creatine uptake and
recycling in muscle cells*
Significant support for prolactin (p<0.04) compared to placebo group, however, this increase is within physiological limits for
men*
Significant decrease in body fat compared to baseline*
Supports maintenance of muscle size despite maintaining overall weight and reduction of body fat* (although not significant)

Citation: Wankhede S, Mohan V, Thakurdesai P, Beneficial effects of fenugreek glycoside supplementation in male subjects
during resistance training: a randomized controlled pilot study, Journal of Sport and Health Science (2015), doi:
10.1016/j.jshs.2014.09.005.

Human study on Andropause

A study was conducted in Australia and aimed to assess the effectiveness of Testofen on symptoms of Andropause. This 12
week, single-site, double-blind, randomized, short-duration human clinical trial was conducted on 120 male subjects, aged 40-75,
who reported having symptoms of Andropause (male menopause), and were otherwise considered to be healthy.

Participants were given a clinically-validated questionnaire (AMS), which was comprised of seventeen questions in three sub-
scales (Psychological, Somatic, and Sexual). This questionnaire helped gauge the level of severity of Andropause symptoms. In
addition, this study also used the DISF-SR to measure the parameters.

Testofen was shown to significantly reduce normal symptoms of Andropause in the active treatment group at weeks 6 & 12 in the
total AMS score and all sub-domains (except psychological sub-score), compared to the placebo.

Overall, Testofen was shown to effectively reduce the normal symptoms of Andropause and improve sexual health by significantly
increasing arousal, sexual desire, sexual activity,and free and total testosterone levels.

Citation: Rao, Amanda, et al., Testofen, a specialised Trigonella foenum-graecum seed extract reduces age-related symptoms of
androgen decrease, increases testosterone levels and improves sexual function in healthy aging males in a double-blind
randomised clinical study (2016).

http://www.tandfonline.com/doi/full/10.3109/13685538.2015.1135323 (http://www.tandfonline.com/doi/full/10.3109
/13685538.2015.1135323)

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Testofen® - Gencor https://www.gencorpacific.com/featured-ingredients/testofen

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* These statements have not been evaluated by the Food and Drug Administration.
This product is not intended to diagnose, treat, cure or prevent any disease.

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