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although the study did not substantiate their optimistic quent, they were no more severe on the high-dose
expectations for the high-dosage ‘#{176} regimens. Staff reported one patient who was confused,
In our treatment setting, high-potency neuroleptics possibly secondary to medication. The one case of seri-
were used routinely in doses of 60 to 100 mg. daily; the ous toxicity was a 30-year-old man who had been
dosage was increased when psychotic symptoms were treated for more than ten years with neuroleptics. He
uncontrolled. We studied the outcome of high-dosage developed agranulocytosis after receiving chlorproma-
patients treated over a three-year period, from July zine, 3900 mg., and fluphenazine decanoate, 100 mg.
1973 to June 1976; their hospital treatment included a He recovered without incident.
course of neuroleptic therapy above an arbitrarily cho- We were unable to confirm any remarkable benefits
sen cutoff of 100 mg. daily of a high-potency neurolep- from high-dose neuroleptic treatment. The results are
tic-fluphenazine, haloperidol, trifluoperazine, or no better than those that one might expect from con-
thiothixene-or 2000 mg. of chlorpromazine. ventional chemotherapy. The doses we used are some-
Treatment was determined by residents under super- what higher than those reported by McClelland and by
vision of a staff psychiatrist and included chemother- Prien, but considerably lower than those used by Rifkin
apy; individual, group, and family therapy on a crisis- or reported in the world literature. No study has shown
oriented model; and milieu and recreational therapy. that patients do less well on high-dose treatment than
Referrals were from the community; the patients were on standard-dose regimens. Davis has suggested that
generally acutely psychotic. The average stay was about aggressive chemotherapy in the acute situation may
three weeks. hasten remission of symptoms and thus lower cumula-
Discharge summaries for all patients seen on the tive exposure to neuroleptics and risk of tardive dyski-
service during the three years were used to identify 11
schizophrenic patients who had been treated with high- The dose range from 100 to 500 mg. daily of high-
dose chemotherapy. The patients’ medical records were potency neuroleptics may yet be a fruitful area for
examined to ascertain diagnosis, drug treatment, out- controlled studies. I suspect that the doses reported
come, and disposition. In some instances, patients were here are not rare in today’s treatment settings. Con-
included when they were receiving combinations whose trolled evaluation of outcome is greatly needed. Nei-
total, in equivalents, was clearly above the cutoff (for then drug-induced extrapyramidal symptoms nor other
example, fluphenazine, 70 mg. per day, with fluphena- major toxicity appears to be an impediment to the
zine decanoate, 150 mg. per week). All doses reported design of such studies, although the literature and this
were oral. Additional medications were used as needed. clinical report would suggest that any optimism should
Response to treatment was recorded as improved, ques- be cautious.
tionably improved, or unimproved. J M. Davis, “Overview:
11 Maintenance Therapy in Psychiatry: I.
A total of 681 patients were treated with neuroleptics Schizophrenia,” AmericanJournal ofPsychiatry, Vol. 132, December
during the period. Of those, 31, or 4.5 per cent, were 1975, pp. 1237-1245.
treated during 35 admissions with 42 courses of high-
dose therapy. The therapy ranged from five days to six
weeks, although in nearly every instance there was a A LOOK AT THE PROFESSIONALIZATION
period before or after when patients received the same OF THE MENTAL HEALTH VOLUNTEER
drug at lower doses. Some patients had more than one
course of treatment during an admission. Carl Fellner, M.D.
After 12 of the courses patients were seen as im- Mary Holscher, MEd.
proved, after five they were seen as questionably im-
proved, and after 25 they were rated as unimproved. UVolunteer work-an important part of health care
Drugs used included haloperidol, 100 to 350 mg. ; flu- delivery systems-is especially important in mental
phenazine, 100 to 180 mg. ; chlorpromazine, 2000 to health. While volunteers in the general medical field
4000 mg. ; thiothixene, 100 to 225 mg. ; and tn- may do rather peripheral work in well-circumscribed
fluoperazine, 100 to 120 mg. Because of the uncon- areas that are not essential for the provision of medical
trolled nature of patient selection, drug assignment, services, those in mental health have moved into more
and evaluation, no statistical manipulations of the data central positions and often participate in almost all
were deemed appropriate, and comparisons between phases of care. In addition, volunteers have helped
the groups or drugs cannot be made. On discharge, 13 establish and staff independent lay services such as
admissions were seen as improved, six as questionably crisis intervention centers, rap centers, and suicide pre-
improved, and 16 as unimproved. Seven of the un- vention centers.
improved patients were discharged to the state hospital There are, of course, many reasons for the greater
for further treatment.
Dr. Fellner is professor of psychiatry and behavioral sciences at the
University of Washington, at Harborview Medical Center, 325 9th
10 H. A. McClelland et al., “Very High Dose Fluphenazine Deca- Avenue, Seattle, Washington 98104. Ms. Holscher, a Ph.D. can-
noate: A Controlled Trial in Chronic Schizophrenia,” Archives of didate, is on the faculty of the graduate psychology program at
General Psychiatry, Vol. 33, December 1976, pp. 1435-1439. Antioch College West in Seattle.