Beruflich Dokumente
Kultur Dokumente
DOI 10.1007/s00381-011-1541-7
S. Oi (*) S. Nomura
Health Sciences Asia Executive Dean Office, Department of Neurosurgery, Yamaguchi University,
Japan International University, 1-1-1 Minamiogushi,
2-18-1 Nakoji, Amagasaki, Ube, Yamaguchi, Japan
Hyogo 661-8530, Japan
e-mail: shizambroi@aol.com T. Miwa
Department of Neurosurgery, Jikei University,
T. Inagaki 3-25-8 Nishi-Shinbashi,
Department of Neurosurgery, Kansai Medical University, Minato-ku, Tokyo, Japan
10-15, Fumizono,
Moriguchi, Osaka, Japan T. Araki
Department of Neurosurgery,
M. Shinoda National Center for Child Health and Development,
Department of Neurosurgery, St. Luke’s International Hospital, 2-10-1 Okura,
9-1 Akashi-cho, Setagaya-ku, Tokyo, Japan
Chuo-ku, Tokyo, Japan
S. Ito
S. Takahashi Department of Neurosurgery,
Department of Neurosurgery, Keio University, Kanagawa Children’s Medical Center,
35 Shinano machi, 2-138-4 Mutsugawa, Minami-ku,
Shinjuku-ku, Tokyo, Japan Yokohama, Kanagawa, Japan
Saitama Children's Medical Center, Sizuoka Children's Pacchionian body, a major player in CSF absorption in
Hospital, Tsukuba University, Tokyo Jikei University, and major CSF pathway does not appear until infancy. In
Miyagi Children's Hospital. The total number of patients infancy, pacchionian body gradually appears and starts to
and the detailed information obtained was 107 (Fig. 1). acquire function of CSF absorption.
Fifty-five patients were diagnosed in utero (51.4%). The CSF pathways of fetus, neonates, and infants are mainly
period of diagnosis was from 16 to 37 weeks of gestation consisted of minor CSF pathway. Major CSF pathway starts
(mean, 26.1 week). Remaining 52 patients were diagnosed to develop gradually from infancy. In animals, birds,
after birth. The timing of diagnosis was from 0 day to rodents, and mammals like Macaca fuscata, the develop-
12 month after birth (mean, 59.1 day). In one case, father ment of pacchionian body is not observed and CSF
has the history of hydrocephalus. Three cases had the circulation is mainly consisted of minor CSF pathways.
chromosomal abnormalities. Two cases had gene abnor- We herein propose a hypothesis that the CSF dynamics
malities. The cause of hydrocephalus varied (Fig. 2). develop in the theory of evolution from the immature brain,
Myeloschisis and post-hemorrhagic hydrocephalus are the as in the animals with the minor CSF pathway predomi-
most common cause of hydrocephalus in this series. It was nance, towards matured adult human brain together with
almost the same incidence of previously reported Japanese completion of the major CSF pathway: the “evolution
congenital hydrocephalus study. Eighty-four patients were theory in CSF dynamics” [5] (Fig. 6).
operated with reservoir placement, shunt placement and/or We also herein propose a new aspect of classification for
neuroendoscopic surgery (78.5%). Seventy-four patients hydrocephalus with special reference to the CSF circulation in
out of 84 required shunt placement. Shunt repair was the minor CSF pathway, i.e., “minor pathway hydrocephalus”.
performed in 24 out of 74 cases (28.6%), so far (Fig. 3). The high incidence of “failure to arrest hydrocephalus” by
The DQ was also measured. There is a tendency that the neuroendoscopic ventriculostomy in fetal, neonatal, and
patients with epilepsy have low DQ compared with the infantile periods was explicable by the specific CSF dynam-
patients without epilepsy. Slow progressive or arrested ics, in which the major CSF pathway has not developed and
hydrocephalus patients have high DQ (Figs. 4 and 5). the minor pathway has a significant role [8].
Findings of ventriculo-cisternography in a patient with
Cerebrospinal fluid and its circulation in fetus and neonates non-communicating hydrocephalus due to aqueduct stenosis
treated by endoscopic third ventriculostomy (ETV) in
In adults, CSF is generated by filtration or secretion from combination with EAP: after outlet of third ventricle was
ventricular colloid plexus or blood vessels, and is absorbed released and aqueduct was re-canalized, congestion of
in venous sinus via pacchionian body or blood vessels in contrast enhanced material inside ventricles and around
subarachnoid space. CSF is generated approximately 500 to ventricular ependymal is observed even 4 days after operation.
600 ml a day. The total amount of CSF in the subarachnoid
space is known to be approximately 10% of cranial volume. Proposal of classification of fetal hydrocephalus and
CSF is totally replaced thrice to four times a day. congenital hydrocephalus Classification of hydrocephalus
There are two types of CSF pathway; those are major is in variety. Congenital and acquired hydrocephalus is
CSF pathway (consisted of ventricular system and sub- usually classified independently based on the timing of
arachnoid space) and minor CSF pathway (consisted of onset in conjunction with co-existing disease or its
brain and spinal parenchyma, vascular system, nerve root pathophysiology. From their pathophysiological aspects,
sheath, and pia matter) hydrocephalus is classified as communicating–non-commu-
In pediatric populations, circulation velocity of CSF is faster nicating or high pressure—normal pressure based on the
than adult, and CSF replacement interval is shorter than adult. changes in CSF dynamics.
Most frequently discussed controversy in the field of
hydrocephalus is controversy in their classification. Classifi-
cation of hydrocephalus such as normal pressure hydroceph-
alus, arrested hydrocephalus, or external hydrocephalus
should be considered from their chronological change.
Hydrocephalus is a pathological state that may change
chronologically.
In the definition of communicating/non-communicating
hydrocephalus by Dandy, communicating hydrocephalus is
the form of hydrocephalus in which the injected dye could
Fig. 1 Graph showed the distribution of the patient; approximately be detected from the spinal subarachnoid space, and in non-
51.4% of the patients were diagnosed in utero communicating hydrocephalus dye did not reach the spinal
1566 Childs Nerv Syst (2011) 27:1563–1570
subarachnoid space [1]. The concept is different from the Some classifications that describe specific forms of
concept of obstructive/non-obstructive hydrocephalus by hydrocephalus such as longstanding overt ventriculomegaly
Russell [10]. In the definition of Russell, the obstruction in in adult (LOVA), hydrocephalus-parkinsonism complex, or
obstructive hydrocephalus can be at any region in the major hydromyelic hydrocephalus have been proposed. It has not
CSF pathway including the ventricular system and entire been elucidated until now whether these types of hydro-
cistern/subarachnoid space, so that the cause or condition cephalus existed in pediatric populations or not [7, 9].
for non-obstructive hydrocephalus is limited to either CSF As for LOVA, it is estimated that the states of “pre-LOVA”
overproduction by choroid plexus papilloma or CSF that is presented as merely enlargement of head circumference
malabsorption due to sinus thrombosis. Nowadays, the without neurological abnormality may exist before it has
two classifications are sometimes used with confusion. become clinically relevant LOVA. Multicenter study of
The term “normal pressure hydrocephalus (NPH)” was pediatric hydrocephalus in Japan recently revealed the
firstly proposed by Hakim and Adams in 1964 and 1965. existence of pre-LOVA but the pathophysiology of pre-LOVA
They defined this type of hydrocephalus as a syndrome has not been fully determined yet. Patients with pre-LOVA are
with surgically treatable specific clinical features such as considered to show normal DQ and intelligence quotient (IQ).
dementia, urinary incontinence, and gait disturbance [6]. From these findings, to classify hydrocephalus in fetus and
They named the clinical entity as NPH from its pathophys- neonates, it is important to pay attention to when hydroceph-
iological aspects, but nowadays, recent research revealed alus occurs and how it would change chronologically. We
that the intracranial pressure in patients with NPH is not recommend using PCCH that focuses on the timing of onset of
always uniformly normal pressure. On the other hand, hydrocephalus and their chronological change [2].
intracranial pressure in pediatric and neonatal population is There exists hydrocephalus which can be classified to
physiologically lower than in adults. It is controversial multi-categorical subtypes. To explain the features of
whether or not pathophysiological states like NPH exist in
pediatric populations or not.
irreversible change would be occur to brain parenchyma. tissues, and colloid plexus. On the contrary, major causes of
Especially in smaller children, the neurosurgeon should pay obstruction in abdominal side are greater omentum and cystic
attention not to miss the timing of surgery. change of tissues. Clinical manifestation of shunt malfunction
ETV is only effective in patients with non-communicating varies depending on pathophysiology of hydrocephalus and
hydrocephalus. In pediatric patients who are less than 1 year patients' age. To diagnose shunt malfunction with only
old, CSF circulation mainly depends on minor CSF pathway. flushing device compression findings is difficult. Shunt
ETV is useful only in patients whose CSF circulation mainly malfunction is not always presented with ventricular en-
depends on major CSF pathway; however, some specialists do largement. In those patients continuous ICP evaluation is
not recommend performing ETV to this patient population extremely useful. Shunt obstruction should be treated by
(Fig. 7). shunt reconstruction as soon as possible. Number of shunt
Main principle of treating patients with hydrocephalus is reconstructions does not affect prognosis.
aiming to arrest hydrocephalus considering normal physi- Clinical manifestation of shunt infection varies accord-
ological function of CSF. In this context, endoscopic ing to types of shunt surgery. Typical signs of shunt
surgical ablation of colloid plexus aiming to the reduction infection after VA shunt are fever and cough, and sign of
of CSF production may result in impairment of CSF flow, shunt infection after VP shunt is abdominal pain. When the
thus its usability remains to be controversial for now. signs and symptoms of meningitis presents, a diagnosis of
shunt infection is definitive; however, only one third of all
Complication of shunt surgery: concepts and classifica- the patients with shunt infection present the sign of
tion Complication of shunt surgery can be classified into meningitis while around 80% of the patients present fever.
four major categories: those are shunt malfunction, As many as two thirds of shunt infection occur within
infection, over drainage, and surgical complication. 4 months from shunt surgery; however, more than 20% of
One of the factors that greatly affects surgical outcome is shunt infection may occur after more than 1 year from
shunt management after operation. Chronological change in shunt surgery. A flare or swelling of the skin along with
physiology of hydrocephalus should be stressed in the shunt tube tract should be regarded as the sign of infection.
management of shunt system. Increased cell counts and protein level in conjunction with
A great variety of complications associated with shunt decreased glucose level in CSF is the typical findings for
system including shunt closure or infection have been shunt infection. Sometimes, CSF culture would be exam-
reported so for. Complications associated with shunt ined in an attempt of identify pathogenic bacteria. In cases
systems or surgical procedures have been also documented in which infection is localized at the site of wound or shunt
so far. tube tract, CSF findings can be within normal limit.
Obstruction of shunt device is known to be caused by the Shunt tube in patients suffering from shunt infection
following reasons. Major causes of obstruction in ventricular should be removed, and external ventricular drainage
side are connective tissue, inflammatory tissues, necrotic should be placed instead. Keep ICP within normal range
Fig. 7 Showed the case in which the ETV did not improved the patient's condition
Childs Nerv Syst (2011) 27:1563–1570 1569
with ventricular drainage, administrate antibiotics, and wait From these findings, we think that McHC classification
until infection disappears. After infection disappears, based on PCCH stage can predict prognosis of pediatric
ventricular drainage should be removed and shunt recon- patientswith hydrocephalus (from the result of prospective
struction should be done. study of COE top 10 Japan).
Subdural hematoma after shunt surgery: CSF over In hydrocephalus patients without brain anomaly, progno-
drainage after shunt placement sometimes results in slit ses are not always pessimistic, and patients can show DQ over
ventricle syndrome. In this situation, deterioration of brain 80 with adequate treatment timing and proper management
compliance resulted in laceration of brain surface vein and after surgery. As noted, our present data shows that there is no
may cause subdural hematoma. In patients with slit statistical significant difference in the prognosis of patients
ventricle syndrome, ICP may raise without ventricular with communicating hydrocephalus and those of patients with
enlargement. In these situations, surgeries that can decrease non-communicating hydrocephalus. Underlining lesion of
the amount of drained CSF should be considered. hydrocephalus and existence of convulsion are proved to be
Pathophysiology of isolated fourth ventricle syndrome is statistically significant prognostic factors.
considered to be aqueduct stenosis after shunt placement in
patients with obstruction of outlet of fourth ventricle. There Shunt malfunction In terms of mechanical obstruction,
are various opinions in terms of functional aqueduct major causes of obstruction in ventricular side of VP shunt
stenosis in this clinical entity (Fig. 8). are connective tissue, inflammatory tissues, and colloid
plexus. On the contrary, major causes of obstruction in
Prognosis of fetal/congenital hydrocephalus Both patients abdominal side of VP shunt are connective tissue, inflam-
and therapeutic factors define prognosis of hydrocephalus. matory tissue, necrotic tissue, and fibrous tissue. Even if
Recent data shows that the frequency of super high IQ there is no obstruction inside the shunt tube, bending,
patients is statistically higher in patients after hydrocepha- laceration, or relative shortening (according to growth) of
lus treatment. As for prognosis of hydrocephalus, prognosis shunt tube can cause shunt malfunction. Ventricular end of
of simple hydrocephalus is usually good. On the contrary, shunt tube should be placed apart from colloid plexus.
DQ in patients with syndromic hydrocephalus remains to be Factors such as patients' age or underlining lesion for
poor. Progressive ventricular enlargement and existence of hydrocephalus also affect shunt closure. In immature brain,
convulsion are shown to be negative prognostic factors. shunt obstruction occurs more frequently. Shunt obstruction
Fig. 8 The heavily-T2-weighted fast-spine-echo MR image demon- expanded ventriculomegaly and macrocephalus with more severely
strated severe triventricular hydrocephalus, likely due to aqueductal comparessed/thinning brain mantle suggesting a fact of rapid
stenosis, at 27 weeks in gestational age (a, c, e). The fetal MR images progression of fetal hydrocephalus before birth [4]
follow up at 33-weeks gestational age (b, d, f) disclosed more
1570 Childs Nerv Syst (2011) 27:1563–1570
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