PKSolver 2.

0 Compartmental Analysis of Plasma Data after Intravenous Bolus Input

Time Unit h
Conc Unit μg/ml Analyst lapcy
Dose 1 Date 2018-10-27
Dose Unit mg Time 18:49:04

Time Conc ln(Conc) Conc_pre Residual Weight Parameter Unit

0.5 49 3.8918203 49.0055565 -0.0055565 1 C0 μg/ml
1 33.6 3.51452607 33.5856737 0.01432631 1 k10 1/h
1.5 23 3.13549422 23.0177465 -0.0177465 1
2 15.8 2.76000994 15.775079 0.02492103 1 Parameter Unit
2.5 10.8 2.37954613 10.8113588 -0.0113588 1 t1/2 h
3 7.4 2.00148 7.40950201 -0.009502 1 V (mg)/(μg/ml)
CL (mg)/(μg/ml)/h
AUC 0-t μg/ml*h
AUC 0-inf μg/ml*h
AUMC μg/ml*h^2
MRT h
Vss mg/(μg/ml)

Diagnostics Value
r obs-pre 0.9999994413
SS 0.0013914249
WSS 0.0013914249
R^2 0.9999996894
WR^2 0.9999996894
SE 0.0186509042
AIC -35.46456168
SC -35.88104274

60

Observed
50 Predicted

40
Concentration (μg/ml)

30

20

10

0
0 0.5 1 1.5 2 2.5 3 3.5
Time (h)
10

0
0 0.5 1 1.5 2 2.5 3 3.5
Time (h)
 Value Time Conc_Pre
71.50502885 0.5 49.0055565
0.755668183 0.52525253 48.0792725
0.55050505 47.1704968
Value 0.57575758 46.2788984
0.917263948 0.6010101 45.4041527
0.01398503 0.62626263 44.5459411
0.010568042 0.65151515 43.703951
84.81967123 0.67676768 42.8778759
94.62490344 0.7020202 42.067415
125.2201767 0.72727273 41.2722731
1.323332148 0.75252525 40.4921606
0.01398503 0.77777778 39.7267936
0.8030303 38.9758932
0.82828283 38.239186
0.85353535 37.5164038
0.87878788 36.8072833
0.9040404 36.1115663
0.92929293 35.4289996
0.95454545 34.7593344
0.97979798 34.102327
1.00505051 33.4577381
1.03030303 32.8253329
1.05555556 32.2048812
1.08080808 31.5961571
1.10606061 30.9989388
1.13131313 30.4130089
1.15656566 29.8381541
1.18181818 29.2741649
1.20707071 28.720836
1.23232323 28.1779659
1.25757576 27.645357
1.28282828 27.1228152
1.30808081 26.6101503
1.33333333 26.1071756
1.35858586 25.6137079
1.38383838 25.1295676
1.40909091 24.6545783
1.43434343 24.188567
1.45959596 23.7313641
1.48484848 23.2828031
1.51010101 22.8427206
1.53535354 22.4109564
1.56060606 21.9873532
1.58585859 21.5717568
1.61111111 21.1640159
1.63636364 20.7639819
1.66161616 20.3715092
1.68686869 19.9864548
1.71212121 19.6086786
1.73737374 19.238043
1.76262626 18.874413
1.78787879 18.5176562
1.81313131 18.1676427
1.83838384 17.8242449
1.86363636 17.487338
1.88888889 17.1567991
1.91414141 16.832508
1.93939394 16.5143465
1.96464646 16.2021987
1.98989899 15.8959511
2.01515152 15.595492
2.04040404 15.3007121
2.06565657 15.0115039
2.09090909 14.7277623
2.11616162 14.4493839
2.14141414 14.1762673
2.16666667 13.908313
2.19191919 13.6454235
2.21717172 13.387503
2.24242424 13.1344576
2.26767677 12.8861952
2.29292929 12.6426253
2.31818182 12.4036594
2.34343434 12.1692102
2.36868687 11.9391925
2.39393939 11.7135226
2.41919192 11.4921181
2.44444444 11.2748986
2.46969697 11.0617848
2.49494949 10.8526993
2.52020202 10.6475658
2.54545455 10.4463096
2.57070707 10.2488575
2.5959596 10.0551376
2.62121212 9.86507932
2.64646465 9.67861343
2.67171717 9.49567204
2.6969697 9.31618854
2.72222222 9.14009757
2.74747475 8.967335
2.77272727 8.79783792
2.7979798 8.63154461
2.82323232 8.46839451
2.84848485 8.30832821
2.87373737 8.15128743
2.8989899 7.99721496
2.92424242 7.84605471
2.94949495 7.69775164
2.97474747 7.55225173
3 7.40950201
PKSolver 2.0 Compartmental Analysis of Plasma Data after Intravenous Bolus Input

Time Unit h
Conc Unit μg/ml Analyst lapcy
Dose 5000 Date 2018-10-27
Dose Unit mg Time 22:09:38

Time Conc ln(Conc) Conc_pre Residual Weight Parameter Unit

0.25 320 5.768321 317.982294 2.01770567 1 C0 μg/ml
0.5 270 5.59842196 272.378561 -2.3785607 1 k10 1/h
1 200 5.29831737 199.854018 0.14598157 1
2 106 4.66343909 107.595179 -1.5951793 1 Parameter Unit
3 60 4.09434456 57.9258936 2.07410642 1 t1/2 h
4 32 3.4657359 31.1854971 0.81450294 1 V (mg)/(μg/ml)
5 17 2.83321334 16.7893004 0.21069962 1 CL (mg)/(μg/ml)/h
6 9 2.19722458 9.03883644 -0.0388364 1 AUC 0-t μg/ml*h
AUC 0-inf μg/ml*h
350 AUMC μg/ml*h^2
MRT h
Observed Vss mg/(μg/ml)
300
Predicted
Diagnostics Value
250 r obs-pre 0.9999181184
SS 17.305829947
Concentration (μg/ml)

WSS 17.305829947
200 R^2 0.9999252545
WR^2 0.9999252545
150
SE 1.6983241714
AIC 26.808347487
SC 26.967230571
100

50

0
0 1 2 3 4 5 6 7
Time (h)

1000

Observed
Predicted

100
Concentration (μg/ml)

10

1
Concentrat
10

1
0 1 2 3 4 5 6 7
Time (h)

Residual Plot
3

1
Residual (μg/ml)

0
0 1 2 3 4 5 6 7

-1

-2

-3
Time (h)
 Value Time Conc_Pre
371.2213591 0.25 317.982294
0.619211348 0.30808081 306.749486
0.36616162 295.913479
Value 0.42424242 285.460258
1.119403227 0.48232323 275.376299
13.46905257 0.54040404 265.648558
8.340190193 0.59848485 256.264453
584.9093754 0.65656566 247.211843
599.506712 0.71464646 238.47902
968.177851 0.77272727 230.054686
1.614957484 0.83080808 221.927943
13.46905257 0.88888889 214.08828
0.9469697 206.525555
1.00505051 199.229985
1.06313131 192.192133
1.12121212 185.402896
1.17929293 178.853489
1.23737374 172.535443
1.29545455 166.440583
1.35353535 160.561025
1.41161616 154.889165
1.46969697 149.417664
1.52777778 144.139446
1.58585859 139.047682
1.64393939 134.135786
1.7020202 129.397404
1.76010101 124.826406
1.81818182 120.41688
1.87626263 116.163122
1.93434343 112.059629
1.99242424 108.101093
2.05050505 104.282394
2.10858586 100.598591
2.16666667 97.0449189
2.22474747 93.6167816
2.28282828 90.3097441
2.34090909 87.1195285
2.3989899 84.0420082
2.45707071 81.0732021
2.51515152 78.2092698
2.57323232 75.4465067
2.63131313 72.781339
2.68939394 70.210319
2.74747475 67.7301209
2.80555556 65.3375365
2.86363636 63.0294708
2.92171717 60.8029381
2.97979798 58.6550583
3.03787879 56.5830529
3.0959596 54.5842416
3.1540404 52.6560389
3.21212121 50.7959504
3.27020202 49.0015701
3.32828283 47.2705767
3.38636364 45.6007311
3.44444444 43.9898732
3.50252525 42.4359193
3.56060606 40.9368593
3.61868687 39.4907539
3.67676768 38.0957326
3.73484848 36.7499908
3.79292929 35.4517877
3.8510101 34.1994439
3.90909091 32.9913396
3.96717172 31.8259118
4.02525253 30.7016531
4.08333333 29.6171091
4.14141414 28.5708769
4.19949495 27.5616031
4.25757576 26.5879822
4.31565657 25.6487547
4.37373737 24.7427057
4.43181818 23.8686631
4.48989899 23.0254963
4.5479798 22.2121145
4.60606061 21.4274657
4.66414141 20.6705348
4.72222222 19.9403427
4.78030303 19.2359449
4.83838384 18.5564301
4.89646465 17.9009193
4.95454545 17.2685646
5.01262626 16.658548
5.07070707 16.0700804
5.12878788 15.5024005
5.18686869 14.9547741
5.24494949 14.4264928
5.3030303 13.9168731
5.36111111 13.4252559
5.41919192 12.9510052
5.47727273 12.4935075
5.53535354 12.0521711
5.59343434 11.626425
5.65151515 11.2157184
5.70959596 10.8195202
5.76767677 10.4373178
5.82575758 10.0686168
5.88383838 9.71294026
5.94191919 9.36982809
6 9.03883644
PKSolver 2.0 Compartmental Analysis of Plasma Data after Extravascular Input

Time Unit h
Conc Unit μg/ml Analyst lapcy
Dose 37.5 Date 2018-10-27
Dose Unit mg Time 22:12:50

Time Conc ln(Conc) Conc_pre Residual Weight Parameter Unit

0.8 1.8 0.58778666 1.79924871 0.00075129 1 A μg/ml
2 1.1 0.09531018 1.10386187 -0.0038619 1 ka 1/h
4 0.5 -0.6931472 0.4889757 0.0110243 1 k10 1/h
5 0.32 -1.1394343 0.32544196 -0.005442 1
7 0.14 -1.9661129 0.14416043 -0.0041604 1 Parameter Unit
10 0.04 -3.2188758 0.04250156 -0.0025016 1 t1/2ka h
t1/2k10 h
V/F (mg)/(μg/ml)
CL/F (mg)/(μg/ml)/h
Tmax h
Cmax μg/ml
AUC 0-t μg/ml*h
AUC 0-inf μg/ml*h
2.5 AUMC μg/ml*h^2
MRT h
Observed
Predicted Diagnostics Value
2
r obs-pre 0.9999597983
SS 0.0001901957
WSS 0.0001901957
Concentration (μg/ml)

1.5 R^2 0.9999605698

WR^2 0.9999605698
SE 0.0079623219
AIC -45.40474178
1 SC -46.02946337

0.5

10

0
Observed
0 2 4 6 8 10 12
Time (h)
Predicted
Concentration (μg/ml)

1
0 2 4 6 8 10 12
Time (h)
Conc

1
0 2 4 6 8 10 12
Time (h)

Residual Plot
0.012

0.01

0.008

0.006
Residual (μg/ml)

0.004

0.002

0
0 2 4 6 8 10 12
-0.002

-0.004

-0.006

-0.008
Time (h)
 Value Time Conc_Pre
2.491966457 0 0
22.61944393 0.1010101 2.13789494
0.407128658 0.2020202 2.26938663
0.3030303 2.20010651
Value 0.4040404 2.11371937
0.030643865 0.50505051 2.02878721
1.702526134 0.60606061 1.94707077
15.32417739 0.70707071 1.8686257
6.238911781 0.80808081 1.79333904
0.180865248 0.90909091 1.72108547
2.273393626 1.01010101 1.65174296
5.906270166 1.11111111 1.58519427
6.010663609 1.21212121 1.52132681
15.02927824 1.31313131 1.46003258
2.500435762 1.41414141 1.40120789
1.51515152 1.34475325
1.61616162 1.29057316
1.71717172 1.23857599
1.81818182 1.18867378
1.91919192 1.14078213
2.02020202 1.09482004
2.12121212 1.05070976
2.22222222 1.00837668
2.32323232 0.9677492
2.42424242 0.9287586
2.52525253 0.89133893
2.62626263 0.8554269
2.72727273 0.82096176
2.82828283 0.78788523
2.92929293 0.75614134
3.03030303 0.72567642
3.13131313 0.69643893
3.23232323 0.66837941
3.33333333 0.64145042
3.43434343 0.61560639
3.53535354 0.59080362
3.63636364 0.56700015
3.73737374 0.54415572
3.83838384 0.5222317
3.93939394 0.50119099
4.04040404 0.48099802
4.14141414 0.46161861
4.24242424 0.44302001
4.34343434 0.42517074
4.44444444 0.40804061
4.54545455 0.39160067
4.64646465 0.37582308
4.74747475 0.36068117
4.84848485 0.34614934
4.94949495 0.33220298
5.05050505 0.31881853
5.15151515 0.30597334
5.25252525 0.29364568
5.35353535 0.2818147
5.45454545 0.27046039
5.55555556 0.25956354
5.65656566 0.24910573
5.75757576 0.23906927
5.85858586 0.22943717
5.95959596 0.22019315
6.06060606 0.21132157
6.16161616 0.20280743
6.26262626 0.19463632
6.36363636 0.18679443
6.46464646 0.17926848
6.56565657 0.17204576
6.66666667 0.16511404
6.76767677 0.15846159
6.86868687 0.15207718
6.96969697 0.14594999
7.07070707 0.14006967
7.17171717 0.13442626
7.27272727 0.12901023
7.37373737 0.12381241
7.47474747 0.11882401
7.57575758 0.11403659
7.67676768 0.10944206
7.77777778 0.10503264
7.87878788 0.10080088
7.97979798 0.09673961
8.08080808 0.09284198
8.18181818 0.08910137
8.28282828 0.08551148
8.38383838 0.08206623
8.48484848 0.07875978
8.58585859 0.07558655
8.68686869 0.07254117
8.78787879 0.06961848
8.88888889 0.06681356
8.98989899 0.06412164
9.09090909 0.06153818
9.19191919 0.05905881
9.29292929 0.05667933
9.39393939 0.05439572
9.49494949 0.05220412
9.5959596 0.05010081
9.6969697 0.04808225
9.7979798 0.04614502
9.8989899 0.04428584
10 0.04250156
PKSolver 2.0 Compartmental Analysis of Plasma Data after Extravascular Input

Time Unit h
Conc Unit μg/ml Analyst lapcy
Dose 200 Date 2018-10-27
Dose Unit mg Time 22:14:16

Time Conc ln(Conc) Conc_pre Residual Weight Parameter Unit

0.5 6.8 1.91692261 6.76597434 0.03402566 1 A μg/ml
1 6.2 1.82454929 6.18459598 0.01540402 1 ka 1/h
2 5.1 1.62924054 5.16741343 -0.0674134 1 k10 1/h
3 4.3 1.45861502 4.31752723 -0.0175272 1
6 2.55 0.93609336 2.51837681 0.03162319 1 Parameter Unit
12 0.88 -0.1278334 0.85682468 0.02317532 1 t1/2ka h
t1/2k10 h
V/F (mg)/(μg/ml)
CL/F (mg)/(μg/ml)/h
Tmax h
Cmax μg/ml
AUC 0-t μg/ml*h
AUC 0-inf μg/ml*h
AUMC μg/ml*h^2
MRT h

Diagnostics Value
8 r obs-pre 0.9998523721
Observed SS 0.0077839256
7 Predicted WSS 0.0077839256
R^2 0.9999429569
WR^2 0.9999429569
6
SE 0.0509376271
AIC -23.13416699
Concentration (μg/ml)

5 SC -23.75888858

3
10
2
Observed
1 Predicted

0
Concentration (μg/ml)

0 2 4 6 Time (h) 8 10 12 14

1
0 2 4 6 8 10 12 14
Time (h)
Conc

1
0 2 4 6 8 10 12 14
Time (h)

Residual Plot
0.04

0.02

0
Residual (μg/ml)

0 2 4 6 8 10 12 14

-0.02

-0.04

-0.06

-0.08
Time (h)
 Value Time Conc_Pre
7.402006439 0 0
32.12907734 0.12121212 7.09186272
0.179689422 0.24242424 7.08342232
0.36363636 6.93374792
Value 0.48484848 6.78441977
0.021573828 0.60606061 6.6382503
3.857473483 0.72727273 6.49522887
27.17166482 0.84848485 6.35528882
4.882460747 0.96969697 6.21836379
0.162328206 1.09090909 6.08438881
7.149010885 1.21212121 5.95330033
36.19458635 1.33333333 5.82503616
40.96295093 1.45454545 5.69953545
229.240238 1.57575758 5.57673866
5.596282318 1.6969697 5.45658753
1.81818182 5.33902506
1.93939394 5.22399549
2.06060606 5.11144423
2.18181818 5.00131789
2.3030303 4.89356423
2.42424242 4.78813213
2.54545455 4.68497157
2.66666667 4.58403361
2.78787879 4.48527037
2.90909091 4.38863498
3.03030303 4.29408161
3.15151515 4.20156539
3.27272727 4.11104244
3.39393939 4.02246982
3.51515152 3.93580549
3.63636364 3.85100835
3.75757576 3.76803817
3.87878788 3.68685559
4 3.60742209
4.12121212 3.52969999
4.24242424 3.45365242
4.36363636 3.3792433
4.48484848 3.30643732
4.60606061 3.23519995
4.72727273 3.1654974
4.84848485 3.09729659
4.96969697 3.03056517
5.09090909 2.96527149
5.21212121 2.90138455
5.33333333 2.83887407
5.45454545 2.77771038
5.57575758 2.71786446
5.6969697 2.65930793
5.81818182 2.602013
5.93939394 2.54595249
6.06060606 2.49109981
6.18181818 2.43742893
6.3030303 2.3849144
6.42424242 2.33353129
6.54545455 2.28325524
6.66666667 2.23406238
6.78787879 2.18592939
6.90909091 2.13883342
7.03030303 2.09275215
7.15151515 2.04766369
7.27272727 2.00354667
7.39393939 1.96038015
7.51515152 1.91814365
7.63636364 1.87681715
7.75757576 1.83638102
7.87878788 1.7968161
8 1.7581036
8.12121212 1.72022516
8.24242424 1.68316282
8.36363636 1.64689899
8.48484848 1.61141646
8.60606061 1.57669841
8.72727273 1.54272836
8.84848485 1.5094902
8.96969697 1.47696815
9.09090909 1.44514679
9.21212121 1.41401103
9.33333333 1.38354609
9.45454545 1.35373751
9.57575758 1.32457117
9.6969697 1.29603321
9.81818182 1.26811011
9.93939394 1.24078861
10.0606061 1.21405575
10.1818182 1.18789886
10.3030303 1.16230551
10.4242424 1.13726358
10.5454545 1.11276118
10.6666667 1.08878668
10.7878788 1.06532871
10.9090909 1.04237615
11.030303 1.0199181
11.1515152 0.99794391
11.2727273 0.97644315
11.3939394 0.95540563
11.5151515 0.93482137
11.6363636 0.91468059
11.7575758 0.89497375
11.8787879 0.8756915
12 0.85682468
PKSolver 2.0 Compartmental Analysis of Plasma Data after Intravenous Bolus Input

Time Unit h
Conc Unit μg/ml Analyst lapcy
Dose 100 Date 2018-10-27
Dose Unit mg Time 22:16:07

Time Conc ln(Conc) Conc_pre Residual Weight Parameter Unit

0.5 5.4 1.68639895 5.42846213 -0.0284621 1 C0 μg/ml
1 4 1.38629436 4.06974186 -0.0697419 1 k10 1/h
1.5 3.3 1.19392247 3.05110332 0.24889668 1
2 2.2 0.78845736 2.28742554 -0.0874255 1 Parameter Unit
3 1.2 0.18232156 1.28566277 -0.0856628 1 t1/2 h
4 0.71 -0.3424903 0.72261533 -0.0126153 1 V (mg)/(μg/ml)
6 0.22 -1.5141277 0.22827974 -0.0082797 1 CL (mg)/(μg/ml)/h
AUC 0-t μg/ml*h
AUC 0-inf μg/ml*h
AUMC μg/ml*h^2
MRT h
Vss mg/(μg/ml)

Diagnostics Value
r obs-pre 0.9980859352
SS 0.0828326129
WSS 0.0828326129
R^2 0.9986827398
WR^2 0.9986827398
SE 0.1287110041
AIC -13.43653394
6 SC -13.54471364

Observed
5 Predicted

4
Concentration (μg/ml)

310

Observed
2
Predicted

1
Concentration (μg/ml)

01
0 1 2 3 4 5 6 7
Time (h)

0.1
0 1 2 3 4 5 6 7
Concent

0.1
0 1 2 3 4 5 6 7
Time (h)

Residual Plot
0.3

0.25

0.2

0.15
Residual (μg/ml)

0.1

0.05

0
0 1 2 3 4 5 6 7
-0.05

-0.1

-0.15
Time (h)
 Value Time Conc_Pre
7.240803497 0.5 5.42846213
0.576152607 0.55555556 5.25745673
0.61111111 5.09183828
Value 0.66666667 4.93143708
1.203061779 0.72222222 4.77608878
13.81062199 0.77777778 4.6256342
7.957025865 0.83333333 4.47991919
12.17129571 0.88888889 4.33879444
12.56750973 0.94444444 4.20211534
21.81281414 1 4.06974186
1.735651263 1.05555556 3.94153837
13.81062199 1.11111111 3.81737349
1.16666667 3.69712
1.22222222 3.5806547
1.27777778 3.46785824
1.33333333 3.35861506
1.38888889 3.25281321
1.44444444 3.1503443
1.5 3.05110332
1.55555556 2.9549886
1.61111111 2.86190164
1.66666667 2.77174708
1.72222222 2.68443253
1.77777778 2.59986853
1.83333333 2.51796844
1.88888889 2.43864833
1.94444444 2.36182693
2 2.28742554
2.05555556 2.21536791
2.11111111 2.14558021
2.16666667 2.07799094
2.22222222 2.01253084
2.27777778 1.94913284
2.33333333 1.88773198
2.38888889 1.82826535
2.44444444 1.77067201
2.5 1.71489296
2.55555556 1.66087104
2.61111111 1.60855089
2.66666667 1.55787892
2.72222222 1.50880319
2.77777778 1.46127344
2.83333333 1.41524094
2.88888889 1.37065855
2.94444444 1.32748057
 3 1.28566277
3.05555556 1.2451623
3.11111111 1.20593766
3.16666667 1.16794866
3.22222222 1.13115637
3.27777778 1.0955231
3.33333333 1.06101234
3.38888889 1.02758872
3.44444444 0.995218
3.5 0.96386702
3.55555556 0.93350363
3.61111111 0.90409675
3.66666667 0.87561623
3.72222222 0.84803289
3.77777778 0.82131847
3.83333333 0.7954456
3.88888889 0.77038777
3.94444444 0.7461193
4 0.72261533
4.05555556 0.69985177
4.11111111 0.6778053
4.16666667 0.65645333
4.22222222 0.63577398
4.27777778 0.61574606
4.33333333 0.59634906
4.38888889 0.57756309
4.44444444 0.55936891
4.5 0.54174788
4.55555556 0.52468194
4.61111111 0.5081536
4.66666667 0.49214594
4.72222222 0.47664254
4.77777778 0.46162752
4.83333333 0.4470855
4.88888889 0.43300158
4.94444444 0.41936133
5 0.40615076
5.05555556 0.39335635
5.11111111 0.38096498
5.16666667 0.36896397
5.22222222 0.357341
5.27777778 0.34608418
5.33333333 0.33518196
5.38888889 0.32462318
5.44444444 0.31439703
5.5 0.30449301
5.55555556 0.29490098
5.61111111 0.28561112
5.66666667 0.2766139
5.72222222 0.26790012
5.77777778 0.25946083
5.83333333 0.25128739
5.88888889 0.24337142
5.94444444 0.23570483
6 0.22827974
PKSolver 2.0 Compartmental Analysis of Plasma Data after Extravascular Input

Time Unit h
Conc Unit μg/ml Analyst lapcy
Dose 250 Date 2018-10-27
Dose Unit mg Time 22:17:48

Time Conc ln(Conc) Conc_pre Residual Weight Parameter Unit

0.25 29.6 3.38777436 29.599794 0.00020602 1 A μg/ml
0.5 28 3.33220451 28.0309916 -0.0309916 1 ka 1/h
1 25 3.21887582 25.0118689 -0.0118689 1 k10 1/h
2 20 2.99573227 19.9138829 0.08611712 1
4 12.6 2.53369681 12.6233772 -0.0233772 1 Parameter Unit
6 8 2.07944154 8.00193776 -0.0019378 1 t1/2ka h
8 5 1.60943791 5.07241501 -0.072415 1 t1/2k10 h
12 2.1 0.74193734 2.0382338 0.0617662 1 V/F (mg)/(μg/ml)
CL/F (mg)/(μg/ml)/h
Tmax h
Cmax μg/ml
AUC 0-t μg/ml*h
AUC 0-inf μg/ml*h
AUMC μg/ml*h^2
MRT h

Diagnostics Value
r obs-pre 0.9999888951
35 SS 0.0181267953
WSS 0.0181267953
Observed R^2 0.9999938288
30 WR^2 0.9999938288
Predicted
SE 0.0602109547
25 AIC -26.08291225
SC -25.84458763
Concentration (μg/ml)

20

15

10
100

5 Observed
Predicted

0
0 2 4 6 8 10 12 14
Concentration (μg/ml)

Time (h)

10

1
 10

Concentrat

1
0 2 4 6 8 10 12 14
Time (h)

Residual Plot
0.1

0.08

0.06

0.04
Residual (μg/ml)

0.02

0
0 2 4 6 8 10 12 14
-0.02

-0.04

-0.06

-0.08

-0.1
Time (h)
 Value Time Conc_Pre
31.4149475 0 0
24.14628061 0.12121212 28.8760818
0.227933347 0.24242424 29.6360106
0.36363636 28.9112837
Value 0.48484848 28.1278864
0.028706168 0.60606061 27.361636
3.041008213 0.72727273 26.616041
8.033832019 0.84848485 25.8907515
1.831178222 0.96969697 25.1852256
0.194947934 1.09090909 24.4989254
29.76592122 1.21212121 23.8313269
127.5818865 1.33333333 23.1819205
136.5241225 1.45454545 22.5502105
604.6191546 1.57575758 21.9357147
4.428661714 1.6969697 21.337964
1.81818182 20.756502
1.93939394 20.190885
2.06060606 19.640681
2.18181818 19.1054702
2.3030303 18.584844
2.42424242 18.0784049
2.54545455 17.5857663
2.66666667 17.1065521
2.78787879 16.6403966
2.90909091 16.1869439
3.03030303 15.7458479
3.15151515 15.3167717
3.27272727 14.8993879
3.39393939 14.4933779
3.51515152 14.0984317
3.63636364 13.7142478
3.75757576 13.340533
3.87878788 12.977002
4 12.6233772
4.12121212 12.2793887
4.24242424 11.944774
4.36363636 11.6192775
4.48484848 11.3026509
4.60606061 10.9946523
4.72727273 10.6950468
4.84848485 10.4036056
4.96969697 10.1201061
5.09090909 9.84433208
5.21212121 9.5760729
5.33333333 9.31512382
5.45454545 9.06128564
5.57575758 8.81436457
5.6969697 8.57417213
5.81818182 8.34052496
5.93939394 8.1132447
6.06060606 7.89215786
6.18181818 7.67709565
6.3030303 7.46789392
6.42424242 7.26439296
6.54545455 7.06643742
6.66666667 6.87387619
6.78787879 6.68656228
6.90909091 6.5043527
7.03030303 6.32710834
7.15151515 6.15469392
7.27272727 5.98697781
7.39393939 5.82383198
7.51515152 5.66513189
7.63636364 5.5107564
7.75757576 5.36058766
7.87878788 5.21451103
8 5.07241501
8.12121212 4.93419112
8.24242424 4.79973385
8.36363636 4.66894056
8.48484848 4.54171139
8.60606061 4.41794924
8.72727273 4.29755962
8.84848485 4.18045063
8.96969697 4.06653287
9.09090909 3.95571939
9.21212121 3.84792558
9.33333333 3.74306917
9.45454545 3.64107011
9.57575758 3.54185053
9.6969697 3.4453347
9.81818182 3.35144894
9.93939394 3.26012157
10.0606061 3.17128289
10.1818182 3.08486506
10.3030303 3.00080214
10.4242424 2.91902994
10.5454545 2.83948604
10.6666667 2.76210972
10.7878788 2.68684192
10.9090909 2.61362517
11.030303 2.54240358
11.1515152 2.47312279
11.2727273 2.40572992
11.3939394 2.3401735
11.5151515 2.27640351
11.6363636 2.21437125
11.7575758 2.15402938
11.8787879 2.09533183
12 2.0382338
PKSolver 2.0 Compartmental Analysis of Plasma Data after Extravascular Input

Time Unit h
Conc Unit μg/ml Analyst lapcy
Dose 100 Date 2018-10-27
Dose Unit mg Time 22:21:33

Time Conc ln(Conc) Conc_pre Residual Weight Parameter Unit

1 18 2.89037176 18.3427274 -0.3427274 1 A μg/ml
2 20 2.99573227 19.3821499 0.61785006 1 ka 1/h
3 16 2.77258872 16.052271 -0.052271 1 k10 1/h
4 12 2.48490665 12.2827668 -0.2827668 1
5 9 2.19722458 9.1035386 -0.1035386 1 Parameter Unit
6 6.5 1.87180218 6.65416721 -0.1541672 1 t1/2ka h
7 4.8 1.56861592 4.83351003 -0.03351 1 t1/2k10 h
8 3.5 1.25276297 3.50099617 -0.0009962 1 V/F (mg)/(μg/ml)
9 2.55 0.93609336 2.53250632 0.01749368 1 CL/F (mg)/(μg/ml)/h
10 1.85 0.61518564 1.8308236 0.0191764 1 Tmax h
11 1.38 0.3220835 1.3231864 0.0568136 1 Cmax μg/ml
12 1 0 0.95617952 0.04382048 1 AUC 0-t μg/ml*h
15 1.68 0.51879379 0.36073417 1.31926583 1 AUC 0-inf μg/ml*h
18 0.65 -0.4307829 0.13608223 0.51391777 1 AUMC μg/ml*h^2
21 0.28 -1.2729657 0.05133484 0.22866516 1 MRT h
24 0.12 -2.1202635 0.01936523 0.10063477 1
Diagnostics Value
25 r obs-pre 0.9983472189
SS 2.6903124957
Observed WSS 2.6903124957
Predicted R^2 0.9979284686
20 WR^2 0.9979284686
SE 0.4549144041
AIC 21.834517701
Concentration (μg/ml)

15 SC 24.152283867

10

0
0 5 10 15 20 25 30
Time (h)

100

Observed
Predicted
ration (μg/ml)

10
 Observed
Predicted

Concentration (μg/ml)

10

1
0 5 10 15 20 25 30
Time (h)

Residual Plot
1.5

1
Residual (μg/ml)

0.5

0
0 5 10 15 20 25 30

-0.5
Time (h)
 Value Time Conc_Pre
47.22143208 0 0
1.096276004 0.24242424 7.44323163
0.324963492 0.48484848 12.5854943
0.72727273 16.0065042
Value 0.96969697 18.1474474
0.632274334 1.21212121 19.3435553
2.133000163 1.45454545 19.8490585
3.009888292 1.6969697 19.8563005
0.978103809 1.93939394 19.5103746
1.576483465 2.18181818 18.9203293
19.90493416 2.42424242 18.1677468
102.1790447 2.66666667 17.313305
102.2386367 2.90909091 16.4017979
407.8757048 3.15151515 15.4659728
3.989447804 3.39393939 14.5294626
3.63636364 13.6090244
3.87878788 12.7162472
4.12121212 11.8588532
4.36363636 11.0416884
4.60606061 10.2674752
4.84848485 9.5373831
5.09090909 8.85146067
5.33333333 8.20896145
5.57575758 7.60858881
5.81818182 7.04867924
6.06060606 6.52733868
6.3030303 6.04254321
6.54545455 5.59221269
6.78787879 5.1742639
7.03030303 4.78664829
7.27272727 4.42737808
7.51515152 4.09454369
7.75757576 3.78632474
8 3.50099617
8.24242424 3.23693104
8.48484848 2.99260064
8.72727273 2.7665729
8.96969697 2.55750954
9.21212121 2.36416243
9.45454545 2.18536932
9.6969697 2.02004941
9.93939394 1.86719869
10.1818182 1.72588533
10.4242424 1.5952451
10.6666667 1.47447697
10.9090909 1.36283882
11.1515152 1.25964341
11.3939394 1.16425455
11.6363636 1.07608343
11.8787879 0.99458526
12.1212121 0.91925604
12.3636364 0.84962961
12.6060606 0.78527485
12.8484848 0.72579309
13.0909091 0.67081569
13.3333333 0.62000182
13.5757576 0.57303638
13.8181818 0.52962808
14.0606061 0.48950761
14.3030303 0.45242604
14.5454545 0.41815326
14.7878788 0.38647659
15.030303 0.3571994
15.2727273 0.33013997
15.5151515 0.30513032
15.7575758 0.28201522
16 0.26065114
16.2424242 0.24090547
16.4848485 0.22265561
16.7272727 0.20578824
16.969697 0.19019866
17.2121212 0.17579006
17.4545455 0.16247297
17.6969697 0.15016473
17.9393939 0.1387889
18.1818182 0.12827485
18.4242424 0.11855729
18.6666667 0.10957589
18.9090909 0.10127489
19.1515152 0.09360273
19.3939394 0.08651178
19.6363636 0.07995801
19.8787879 0.07390072
20.1212121 0.06830231
20.3636364 0.06312801
20.6060606 0.0583457
20.8484848 0.05392567
21.0909091 0.04984048
21.3333333 0.04606478
21.5757576 0.0425751
21.8181818 0.03934979
22.0606061 0.03636881
22.3030303 0.03361366
22.5454545 0.03106723
22.7878788 0.0287137
23.030303 0.02653847
23.2727273 0.02452803
23.5151515 0.02266988
23.7575758 0.02095251
24 0.01936523
PKSolver 2.0 Compartmental Analysis of Plasma Data after Extravascular Input

Time Unit h
Conc Unit μg/ml Analyst lapcy
Dose 400 Date 2018-10-27
Dose Unit mg Time 22:25:51

Time Conc ln(Conc) Conc_pre Residual Weight Parameter Unit

0.5 0.35 -1.0498221 0.35918636 -0.0091864 1 A μg/ml
1 0.69 -0.3710637 0.69397882 -0.0039788 1 ka 1/h
2 1.29 0.25464222 1.29603325 -0.0060332 1 k10 1/h
3 1.81 0.59332685 1.81667174 -0.0066717 1
4 2.26 0.81536481 2.26523173 -0.0052317 1 Parameter Unit
6 2.98 1.0919233 2.97837557 0.00162443 1 t1/2ka h
8 3.5 1.25276297 3.49133124 0.00866876 1 t1/2k10 h
12 4.1 1.41098697 4.08367243 0.01632757 1 V/F (mg)/(μg/ml)
24 4.11 1.41342303 4.13684813 -0.0268481 1 CL/F (mg)/(μg/ml)/h
48 2.71 0.99694863 2.69078396 0.01921604 1 Tmax h
72 1.61 0.47623418 1.60416797 0.00583203 1 Cmax μg/ml
96 0.94 -0.0618754 0.94843328 -0.0084333 1 AUC 0-t μg/ml*h
120 0.55 -0.597837 0.56027354 -0.0102735 1 AUC 0-inf μg/ml*h
AUMC μg/ml*h^2
MRT h

Diagnostics Value
r obs-pre 0.9999599733
SS 0.0018536359
WSS 0.0018536359
R^2 0.9999758015
WR^2 0.9999758015
SE 0.0136148297
5
AIC -75.77788107
4.5 Observed SC -74.08303299
Predicted
4

3.5
Concentration (μg/ml)

2.5

1.5

10
1

0.5 Observed
Predicted
0
0 20 40 60 80 100 120 140
Time (h)
Concentration (μg/ml)
Concentration (μg/ml)

1
0 20 40 60 80 100 120 140
Time (h)

Residual Plot
0.03

0.02

0.01
Residual (μg/ml)

0
0 20 40 60 80 100 120 140

-0.01

-0.02

-0.03
Time (h)
 Value Time Conc_Pre
7.791886343 0 0
0.117390495 1.21212121 0.82899516
0.021936688 2.42424242 1.52628691
3.63636364 2.10991405
Value 4.84848485 2.59550791
5.904627783 6.06060606 2.99661201
31.59762266 7.27272727 3.32495937
63.13309209 8.48484848 3.59071303
1.384930925 9.6969697 3.80267461
17.57232648 10.9090909 3.96846524
4.309150729 12.1212121 4.09468248
263.2823684 13.3333333 4.18703644
288.8230689 14.5454545 4.25046773
15626.57307 15.7575758 4.28924994
54.10431074 16.969697 4.30707833
18.1818182 4.3071469
19.3939394 4.29221512
20.6060606 4.26466588
21.8181818 4.22655569
23.030303 4.17965825
24.2424242 4.12550225
25.4545455 4.06540406
26.6666667 4.00049621
27.8787879 3.93175196
29.0909091 3.86000669
30.3030303 3.78597644
31.5151515 3.71027389
32.7272727 3.63342238
33.9393939 3.55586789
35.1515152 3.47798957
36.3636364 3.40010877
37.5757576 3.32249691
38.7878788 3.24538231
40 3.16895608
41.2121212 3.09337721
42.4242424 3.01877708
43.6363636 2.94526321
44.8484848 2.87292266
46.0606061 2.80182485
47.2727273 2.73202411
48.4848485 2.66356182
49.6969697 2.59646824
50.9090909 2.53076419
52.1212121 2.46646241
53.3333333 2.40356879
54.5454545 2.34208339
55.7575758 2.28200137
56.969697 2.22331376
58.1818182 2.16600811
59.3939394 2.11006912
60.6060606 2.05547909
61.8181818 2.00221841
63.030303 1.95026585
64.2424242 1.89959895
65.4545455 1.85019427
66.6666667 1.80202759
67.8787879 1.75507419
69.0909091 1.70930892
70.3030303 1.66470644
71.5151515 1.62124129
72.7272727 1.578888
73.9393939 1.53762119
75.1515152 1.49741566
76.3636364 1.45824642
77.5757576 1.42008874
78.7878788 1.38291824
80 1.34671089
81.2121212 1.31144301
82.4242424 1.27709138
83.6363636 1.24363315
84.8484848 1.21104595
86.0606061 1.17930784
87.2727273 1.14839732
88.4848485 1.11829338
89.6969697 1.08897545
90.9090909 1.06042341
92.1212121 1.03261763
93.3333333 1.0055389
94.5454545 0.9791685
95.7575758 0.95348813
96.969697 0.92847993
98.1818182 0.9041265
99.3939394 0.88041084
100.606061 0.85731637
101.818182 0.83482696
103.030303 0.81292684
104.242424 0.79160065
105.454545 0.77083345
106.666667 0.75061063
107.878788 0.73091799
109.090909 0.71174167
110.30303 0.69306818
111.515152 0.67488437
112.727273 0.65717744
113.939394 0.6399349
115.151515 0.6231446
116.363636 0.6067947
117.575758 0.59087366
118.787879 0.57537026
120 0.56027354
PKSolver 2.0 Compartmental Analysis of Plasma Data after Extravascular Input

Time Unit h
Conc Unit μg/ml Analyst lapcy
Dose 100 Date 2018-10-27
Dose Unit mg Time 22:28:42

Time Conc ln(Conc) Conc_pre Residual Weight Parameter Unit

0.25 0.79 -0.2357223 0.78397192 0.00602808 1 A μg/ml
0.5 1.39 0.32930375 1.39083733 -0.0008373 1 ka 1/h
0.75 1.86 0.62057649 1.85323226 0.00676774 1 k10 1/h
1 2.2 0.78845736 2.19808579 0.00191421 1
1.5 2.6 0.95551145 2.62007578 -0.0200758 1 Parameter Unit
2 2.8 1.02961942 2.7914475 0.0085525 1 t1/2ka h
3 2.72 1.00063188 2.71667337 0.00332663 1 t1/2k10 h
4 2.4 0.87546874 2.39811622 0.00188378 1 V/F (mg)/(μg/ml)
6 1.66 0.5068176 1.66381391 -0.0038139 1 CL/F (mg)/(μg/ml)/h
8 1.09 0.0861777 1.08883328 0.00116672 1 Tmax h
Cmax μg/ml
AUC 0-t μg/ml*h
AUC 0-inf μg/ml*h
AUMC μg/ml*h^2
MRT h

Diagnostics Value
r obs-pre 0.9999364983
SS 0.0005932098
WSS 0.0005932098
R^2 0.9999860611
WR^2 0.9999860611
3 SE 0.0092056646
AIC -68.29962375
Observed SC -67.39186847
2.5 Predicted

2
Concentration (μg/ml)

1.5

10
1
Observed
Predicted
0.5
Concentration (μg/ml)

0
0 1 2 3 4 5 6 7 8 9
Time (h)
Concentration (μ

1
0 1 2 3 4 5 6 7 8 9
Time (h)

Residual Plot
0.015

0.01

0.005
Residual (μg/ml)

0
0 1 2 3 4 5 6 7 8 9
-0.005

-0.01

-0.015

-0.02

-0.025
Time (h)
 Value Time Conc_Pre
6.769636302 0 0
0.74945621 0.08080808 0.27503911
0.226497598 0.16161616 0.52892742
0.24242424 0.76299833
Value 0.32323232 0.97850521
0.924866819 0.4040404 1.1766262
3.060284905 0.48484848 1.35846861
21.16964652 0.56565657 1.52507312
4.794874091 0.64646465 1.67741775
2.288161095 0.72727273 1.81642152
2.813245519 0.80808081 1.942948
15.99642181 0.88888889 2.05780856
20.85560499 0.96969697 2.16176547
119.9063525 1.05050505 2.25553482
5.749358629 1.13131313 2.33978925
1.21212121 2.41516052
1.29292929 2.48224197
1.37373737 2.54159076
1.45454545 2.59373005
1.53535354 2.639151
1.61616162 2.67831469
1.6969697 2.7116539
1.77777778 2.73957481
1.85858586 2.76245855
1.93939394 2.78066273
2.02020202 2.79452282
2.1010101 2.80435349
2.18181818 2.81044982
2.26262626 2.81308853
2.34343434 2.81252901
2.42424242 2.80901438
2.50505051 2.8027725
2.58585859 2.79401685
2.66666667 2.78294738
2.74747475 2.76975137
2.82828283 2.75460414
2.90909091 2.73766981
2.98989899 2.71910195
3.07070707 2.69904423
3.15151515 2.67763102
3.23232323 2.65498792
3.31313131 2.63123234
3.39393939 2.60647397
3.47474747 2.58081523
3.55555556 2.55435175
3.63636364 2.52717277
3.71717172 2.49936151
3.7979798 2.47099556
3.87878788 2.44214722
3.95959596 2.41288382
4.04040404 2.38326801
4.12121212 2.3533581
4.2020202 2.32320826
4.28282828 2.29286881
4.36363636 2.26238648
4.44444444 2.23180458
4.52525253 2.20116326
4.60606061 2.17049969
4.68686869 2.13984822
4.76767677 2.10924062
4.84848485 2.07870617
4.92929293 2.04827187
5.01010101 2.01796256
5.09090909 1.98780107
5.17171717 1.95780833
5.25252525 1.92800351
5.33333333 1.89840412
5.41414141 1.86902613
5.49494949 1.83988407
5.57575758 1.81099109
5.65656566 1.78235911
5.73737374 1.75399885
5.81818182 1.72591992
5.8989899 1.69813091
5.97979798 1.67063947
6.06060606 1.64345231
6.14141414 1.61657535
6.22222222 1.5900137
6.3030303 1.56377176
6.38383838 1.53785325
6.46464646 1.51226127
6.54545455 1.48699833
6.62626263 1.4620664
6.70707071 1.43746695
6.78787879 1.41320099
6.86868687 1.38926909
6.94949495 1.36567142
7.03030303 1.34240778
7.11111111 1.31947764
7.19191919 1.29688014
7.27272727 1.27461415
7.35353535 1.25267824
7.43434343 1.23107078
7.51515152 1.20978988
7.5959596 1.18883345
7.67676768 1.16819923
7.75757576 1.14788477
7.83838384 1.12788747
7.91919192 1.1082046
8 1.08883328
PKSolver 2.0 Compartmental Analysis of Plasma Data after Extravascular Input

Time Unit h
Conc Unit μg/ml Analyst lapcy
Dose 250 Date 2018-10-27
Dose Unit mg Time 22:31:05

Time Conc ln(Conc) Conc_pre Residual Weight Parameter Unit

0.25 1.95 0.66782937 4.55939873 -2.6093987 1 A μg/ml
0.5 3.5 1.25276297 8.09420108 -4.5942011 1 ka 1/h
1 10.5 2.35137526 12.7580024 -2.2580024 1 k10 1/h
1.25 19 2.94443898 14.1590772 4.84092284 1
1.5 18 2.89037176 15.0866808 2.91331922 1 Parameter Unit
2 16 2.77258872 15.863285 0.13671496 1 t1/2ka h
3 12.8 2.54944517 14.8124784 -2.0124784 1 t1/2k10 h
5 8.4 2.12823171 9.60378117 -1.2037812 1 V/F (mg)/(μg/ml)
7 5.5 1.70474809 5.2571516 0.2428484 1 CL/F (mg)/(μg/ml)/h
9 3.6 1.28093385 2.65612978 0.94387022 1 Tmax h
12 1.85 0.61518564 0.88039876 0.96960124 1 Cmax μg/ml
AUC 0-t μg/ml*h
AUC 0-inf μg/ml*h
AUMC μg/ml*h^2
MRT h

Diagnostics Value
r obs-pre 0.9131508177
SS 72.344025447
20
WSS 72.344025447
18
R^2 0.9463456593
Observed
WR^2 0.9463456593
Predicted SE 3.0071586558
16
AIC 53.095761583
14 SC 54.289447402
Concentration (μg/ml)

12

10

100
2

0 Observed
0 2 4 6 8 10 Predicted
12 14
Time (h)
Concentration (μg/ml)

10
Concentration (μg/m
10

1
0 2 4 6 8 10 12 14
Time (h)

Residual Plot
6

2
Residual (μg/ml)

0
0 2 4 6 8 10 12 14

-2

-4

-6
Time (h)
 Value Time Conc_Pre
164.4941805 0 0
0.539705478 0.12121212 2.35067981
0.414790102 0.24242424 4.43723833
0.36363636 6.282053
Value 0.48484848 7.90580703
1.284306366 0.60606061 9.32761035
1.671079368 0.72727273 10.5651121
6.566446296 0.84848485 11.6346054
2.723696926 0.96969697 12.5511252
2.107434444 1.09090909 13.3285384
15.88452212 1.21212121 13.9796292
89.52321245 1.33333333 14.5161771
91.78701112 1.45454545 14.9490304
391.3541464 1.57575758 15.2881742
4.263720342 1.6969697 15.5427935
1.81818182 15.7213325
1.93939394 15.8315487
2.06060606 15.8805646
2.18181818 15.8749143
2.3030303 15.820588
2.42424242 15.7230724
2.54545455 15.5873888
2.66666667 15.4181287
2.78787879 15.219486
2.90909091 14.9952877
3.03030303 14.7490219
3.15151515 14.4838645
3.27272727 14.2027026
3.39393939 13.9081579
3.51515152 13.6026071
3.63636364 13.2882015
3.75757576 12.9668847
3.87878788 12.6404095
4 12.3103533
4.12121212 11.9781322
4.24242424 11.6450143
4.36363636 11.3121319
4.48484848 10.9804929
4.60606061 10.6509913
4.72727273 10.3244166
4.84848485 10.0014632
4.96969697 9.68273824
5.09090909 9.36876938
5.21212121 9.06001193
5.33333333 8.75685524
5.45454545 8.45962873
5.57575758 8.16860743
5.6969697 7.88401705
5.81818182 7.60603867
5.93939394 7.33481305
6.06060606 7.07044461
6.18181818 6.81300506
6.3030303 6.56253677
6.42424242 6.31905584
6.54545455 6.08255489
6.66666667 5.8530057
6.78787879 5.63036153
6.90909091 5.41455932
7.03030303 5.20552163
7.15151515 5.00315851
7.27272727 4.80736908
7.39393939 4.61804309
7.51515152 4.43506225
7.63636364 4.25830152
7.75757576 4.08763017
7.87878788 3.92291287
8 3.76401057
8.12121212 3.61078138
8.24242424 3.46308127
8.36363636 3.32076479
8.48484848 3.18368567
8.60606061 3.05169735
8.72727273 2.92465347
8.84848485 2.80240832
8.96969697 2.6848172
9.09090909 2.57173676
9.21212121 2.46302534
9.33333333 2.35854314
9.45454545 2.25815255
9.57575758 2.16171825
9.6969697 2.06910745
9.81818182 1.98018998
9.93939394 1.89483842
10.0606061 1.81292821
10.1818182 1.7343377
10.3030303 1.65894824
10.4242424 1.5866442
10.5454545 1.51731298
10.6666667 1.45084507
10.7878788 1.38713404
10.9090909 1.32607652
11.030303 1.26757218
11.1515152 1.21152374
11.2727273 1.15783693
11.3939394 1.10642042
11.5151515 1.05718584
11.6363636 1.01004767
11.7575758 0.96492324
11.8787879 0.92173266
12 0.88039876
 8.7
tiempo(h) Cp(mcg/mL
0.25 1.95
0.5 3.5
1 10.5
1.25 19
1.5 18
2 16
3 12.8
5 8.4
7 5.5
9 3.6
12 1.85