MSCI AC ASIA HEALTH CARE INDEX (USD)

The MSCI AC Asia Health Care Index includes large and mid cap securities across 3 Developed Markets countries and 9 Emerging Markets
countries in Asia*. All securities in the index are classified in Health Care as per the Global Industry Classification Standard (GICS®).

CUMULATIVE INDEX PERFORMANCE - NET RETURNS (USD) (SEP 2003 – SEP 2018) ANNUAL PERFORMANCE (%)
MSCI AC Asia
400 Year MSCI AC Asia MSCI ACWI
Health Care
MSCI AC Asia Health Care
MSCI AC Asia 357.40 2017 24.08 33.41 23.97
MSCI ACWI
322.85 2016 -7.28 3.93 7.86
300 2015 26.92 -0.65 -2.36
279.81
2014 7.67 0.54 4.16
2013 17.30 13.43 22.80
200 2012 6.74 15.77 16.13
2011 -6.18 -15.93 -7.35
2010 11.68 17.55 12.67
2009 -1.32 31.73 34.63
100
2008 -10.11 -40.30 -42.19
50 2007 -4.26 12.11 11.66
Sep 03 Dec 04 Mar 06 Jun 07 Sep 08 Dec 09 Mar 11 Jun 12 Sep 13 Dec 14 Mar 16 Jun 17 Sep 18 2006 28.67 14.50 20.95
2005 7.89 24.55 10.84
2004 19.69 16.22 15.23

INDEX PERFORMANCE — NET RETURNS (%) ( SEP 28, 2018 ) FUNDAMENTALS ( SEP 28, 2018 )
ANNUALIZED
Since Div Yld (%) P/E P/E Fwd P/BV
1 Mo 3 Mo 1 Yr YTD 3 Yr 5 Yr 10 Yr
Dec 29, 2000

MSCI AC Asia Health Care 2.83 4.24 24.83 12.19 13.94 12.72 8.52 5.55 1.21 32.15 27.90 3.27

MSCI AC Asia 0.51 0.67 5.14 -2.96 12.74 6.69 7.02 5.18 2.34 13.53 12.45 1.51

MSCI ACWI 0.44 4.28 9.77 3.83 13.40 8.67 8.19 5.43 2.39 18.43 14.89 2.36

INDEX RISK AND RETURN CHARACTERISTICS ( SEP 28, 2018 )

ANNUALIZED STD DEV (%) 2 SHARPE RATIO 2 , 3 MAXIMUM DRAWDOWN
Turnover Since
3 Yr 5 Yr 10 Yr 3 Yr 5 Yr 10 Yr (%) Period YYYY-MM-DD
(%) 1 Dec 29, 2000
MSCI AC Asia Health Care 9.56 12.00 12.56 14.72 1.07 0.97 0.60 0.33 41.87 2007-10-02—2009-03-10
MSCI AC Asia 4.80 11.64 11.45 15.84 1.00 0.56 0.47 0.29 56.44 2007-11-01—2009-03-09
MSCI ACWI 2.61 9.37 9.79 15.83 1.28 0.83 0.54 0.31 58.38 2007-10-31—2009-03-09
1 2 3
Last 12 months Based on monthly net returns data Based on ICE LIBOR 1M

* Developed Markets countries in the index include: Hong Kong, Japan and Singapore. Emerging Markets countries include: China, India, Indonesia, Korea, Malaysia, Pakistan, the Philippines, Taiwan and Thailand.

The MSCI AC Asia Health Care Index was launched on Jan 01, 2001. Data prior to the launch date is back-tested data (i.e. calculations of how the index might have performed over that time period had the index
existed). There are frequently material differences between back-tested performance and actual results. Past performance -- whether actual or back-tested -- is no indication or guarantee of future performance.

MSCI AC ASIA HEALTH CARE INDEX

SEP 28, 2018

INDEX CHARACTERISTICS TOP 10 CONSTITUENTS

MSCI AC Asia Health Care Country Float Adj Mkt Cap Index
( USD Billions) Wt. (%)
Number of 83
Constituents ASTELLAS PHARMA JP 32.82 7.55
Mkt Cap ( USD Millions) TAKEDA PHARMACEUTICAL JP 30.61 7.04
Index 434,486.99 DAIICHI SANKYO CO JP 24.59 5.66
Largest 32,819.55 EISAI CO JP 24.55 5.65
Smallest 53.74 HOYA CORP JP 22.67 5.22
CELLTRION KR 21.82 5.02
Average 5,234.78
OTSUKA HOLDINGS CO JP 19.69 4.53
Median 2,493.76
SHIONOGI & CO JP 18.01 4.14
TERUMO CORP JP 18.00 4.14
SYSMEX CORP JP 14.39 3.31
Total 227.15 52.28

SUB-INDUSTRY WEIGHTS COUNTRY WEIGHTS

8.24% 12.13%
10.27% 11.57%
6.58%

5.35%
5.68%
3.28% 1.62%

2.98% 1.87%

1.89%

0.03%
67.13%
61.38%

Pharmaceuticals 61.38% Health Care Equipment 10.27% Biotechnology 8.24% Japan 67.13% China 12.13% South Korea 11.57% India 5.68%
Health Care Supplies 6.58% Health Care Distributors 5.35% Malaysia 1.62% Other 1.87%
Life Sciences Tools & Services 3.28% Health Care Technology 2.98%

Health Care Facilities 1.89% Health Care Services 0.03%

INDEX METHODOLOGY
The index is based on the MSCI Global Investable Market Indexes (GIMI) Methodology—a comprehensive and consistent approach to index
construction that allows for meaningful global views and cross regional comparisons across all market capitalization size, sector and style
segments and combinations. This methodology aims to provide exhaustive coverage of the relevant investment opportunity set with a strong
emphasis on index liquidity, investability and replicability. The index is reviewed quarterly—in February, May, August and November—with
the objective of reflecting change in the underlying equity markets in a timely manner, while limiting undue index turnover. During the May
and November semi-annual index reviews, the index is rebalanced and the large and mid capitalization cutoff points are recalculated.

ABOUT MSCI
For more than 40 years, MSCI' research-based indexes and analytics have helped the world' leading investors build and manage better portfolios. Clients rely on our offerings for deeper insights into the drivers
of performance and risk in their portfolios, broad asset class coverage and innovative research. Our line of products and services includes indexes, analytical models, data, real estate benchmarks and ESG
research. MSCI serves 99 of the top 100 largest money managers, according to the most recent P&I ranking. For more information, visit us at www.msci.com.

The information contained herein (the "Information") may not be reproduced or redisseminated in whole or in part without prior written permission from MSCI. The Information may not be used to verify or
correct other data, to create indexes, risk models, or analytics, or in connection with issuing, offering, sponsoring, managing or marketing any securities, portfolios, financial products or other investment vehicles.
Historical data and analysis should not be taken as an indication or guarantee of any future performance, analysis, forecast or prediction. None of the Information or MSCI index or other product or service
constitutes an offer to buy or sell, or a promotion or recommendation of, any security, financial instrument or product or trading strategy. Further, none of the Information or any. MSCI index is intended to
constitute investment advice or a recommendation to make (or refrain from making) any kind of investment decision and may not be relied on as such. The Information is provided "as is" and the user of the
Information assumes the entire risk of any use it may make or permit to be made of the Information. NONE OF MSCI INC. OR ANY OF ITS SUBSIDIARIES OR ITS OR THEIR DIRECT OR INDIRECT SUPPLIERS OR
ANY THIRD PARTY INVOLVED IN THE MAKING OR COMPILING OF THE INFORMATION (EACH, AN "MSCI PARTY") MAKES ANY WARRANTIES OR REPRESENTATIONS AND, TO THE MAXIMUM EXTENT PERMITTED BY
LAW, EACH MSCI PARTY HEREBY EXPRESSLY DISCLAIMS ALL IMPLIED WARRANTIES, INCLUDING WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE. WITHOUT LIMITING ANY OF
THE FOREGOING AND TO THE MAXIMUM EXTENT PERMITTED BY LAW, IN NO EVENT SHALL ANY OF THE MSCI PARTIES HAVE ANY LIABILITY REGARDING ANY OF THE INFORMATION FOR ANY DIRECT, INDIRECT,
SPECIAL, PUNITIVE, CONSEQUENTIAL (INCLUDING LOST PROFITS) OR ANY OTHER DAMAGES EVEN IF NOTIFIED OF THE POSSIBILITY OF SUCH DAMAGES. The foregoing shall not exclude or limit any liability that
may not by applicable law be excluded or limited.

© 2018 MSCI Inc. All rights reserved.

MSCI AC ASIA HEALTH CARE INDEX