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The “sepsis bundle” has been central to the implementation of identification and appropriate immediate management in the
the Surviving Sepsis Campaign (SSC) from the first publication initial hours after development of sepsis improves outcomes
of its evidence-based guidelines in 2004 through subsequent (7−11, 14, 16−21). The guidelines state that these patients need
editions (1−6). Developed separately from the guidelines pub- urgent assessment and treatment, including initial fluid resus-
lication by the SSC, the bundles have been the cornerstone of citation while pursuing source control, obtaining further lab-
sepsis quality improvement since 2005 (7−11). As noted when oratory results, and attaining more precise measurements of
they were introduced, the bundle elements were designed to be hemodynamic status. A guiding principle is that these complex
updated as indicated by new evidence and have evolved patients need a detailed initial assessment and then ongoing re-
accordingly. In response to the publication of “Surviving Sepsis evaluation of their response to treatment. The elements of the
Campaign: International Guidelines for Management of Sepsis 2018 bundle, intended to be initiated within the first hour, are
and Septic Shock: 2016” (12, 13), a revised “hour-1 bundle” has listed in Table 1 and presented in the following. Consis-tent
been developed and is presented below (Fig. 1). with previous iterations of the SSC sepsis bundles, “time zero”
The compelling nature of the evidence in the literature, or “time of presentation” is defined as the time of triage in the
which has demonstrated an association between compliance emergency department or, if referred from another care location,
with bundles and improved survival in patients with sepsis from the earliest chart annotation consistent with all elements of
and septic shock, led to the adoption of the SSC measures by sepsis (formerly severe sepsis) or septic shock ascertained
the National Quality Forum (NQF) and subsequently both by through chart review. Because this new bundle is based on the
the New York State (NYS) Department of Health (14) and 2016 Guidelines publication, the guidelines them-selves should
the Centers for Medicare and Medicaid Services (CMS) (15) be referred to for further discussion and evidence related to each
in the USA for mandated public reporting. The important element and to sepsis management as a whole.
relation-ship between the bundles and survival was confirmed
in a pub-lication from this NYS initiative (16). HOUR-1 BUNDLE
Paramount in the management of patients with sep-sis is The most important change in the revision of the SSC bun-dles
the concept that sepsis is a medical emergency. As with is that the 3-h and 6-h bundles have been combined into a single
“hour-1 bundle” with the explicit intention of begin-ning
resuscitation and management immediately. We believe this
1Department of Medicine, Division of Pulmonary/Critical Care Medicine,
Alpert Medical School at Brown University, Providence, RI, USA. reflects the clinical reality at the bedside of these seriously ill
2New York University School of Medicine, New York, NY, USA. patients with sepsis and septic shock—that clinicians begin
3St. George’s University Hospitals NHS Foundation Trust and St treatment immediately, especially in patients with hypoten-sion,
George’s University of London, London, UK. rather than waiting or extending resuscitation measures over a
This article is being published simultaneously in Critical Care Medicine longer period. More than 1 hour may be required for
and Intensive Care Medicine (https://doi.org/10.1007/s00134-018-5085-0) resuscitation to be completed, but initiation of resuscitation and
in the June 2018 issue of both journals.
treatment, such as obtaining blood for measuring lactate and
Dr. Levy is a Member of the Surviving Sepsis Campaign Executive
Com-mittee and is a Surviving Sepsis Campaign Guidelines Author. blood cultures, administration of fluids and antibiotics, and in
Dr. Evans is a Member of the Surviving Sepsis Campaign Steering the case of life-threatening hypotension, initiation of vasopressor
Committee and is a Surviving Sepsis Campaign Guidelines Co-Chair. therapy, are all begun immediately. It is also impor-tant to note
Dr. Rhodes is a Member of the Surviving Sepsis Campaign Executive
Committee and is a Surviving Sepsis Campaign Guidelines Co-Chair. that there are no published studies that have evalu-ated the
For information regarding this article, Email: mitchell_levy@brown.edu efficacy in important subgroups, including burns and
Copyright © 2018 by the Society of Critical Care Medicine and the immunocompromised patients. This knowledge gap needs to be
Euro-pean Society of Intensive Medicine. All Rights Reserved. addressed in future studies specifically targeting these sub-
DOI: 10.1097/CCM.0000000000003119 groups. The elements included in the revised bundle are taken
Administer Broad-
Spectrum Antibiotics
Empiric broad-spectrum ther-
apy with one or more intrave-
nous antimicrobials to cover
all likely pathogens should be
started immediately (21) for
patients presenting with sepsis
or septic shock. Empiric anti-
microbial therapy should be
narrowed once pathogen iden-
Figure 1. Hour-1 Surviving Sepsis Campaign Bundle of Care.* tification and sensitivities are
established, or discontinued
from the Surviving Sepsis Campaign Guidelines, and the if a decision is made that the patient does not have infection.
level of evidence in support of each element can be seen in The link between early administration of antibiotics for sus-
Table 1 (12, 13). We believe the new bundle is an accurate pected infection and antibiotic stewardship remains an essen-
reflection of actual clinical care. tial aspect of high-quality sepsis management. If infection is
subsequently proven not to exist, then antimicrobials should
Measure Lactate Level be discontinued.
While serum lactate is not a direct measure of tissue perfu-
sion (22), it can serve as a surrogate, as increases may repre- Administer IV Fluid
sent tissue hypoxia, accelerated aerobic glycolysis driven by Early effective fluid resuscitation is crucial for the stabilization of
excess beta-adrenergic stimulation, or other causes associated sepsis-induced tissue hypoperfusion or septic shock. Given the
with worse outcomes (23). Randomized controlled trials have urgent nature of this medical emergency, initial fluid resuscita-tion
demonstrated a significant reduction in mortality with lactate- should begin immediately upon recognizing a patient with sepsis
guided resuscitation (24−28). and/or hypotension and elevated lactate, and completed within 3
hours of recognition. The guidelines recommend this should
If initial lactate is elevated (> 2mmol/L), it should be
comprise a minimum of 30 mL/kg of intravenous crystalloid fluid.
remeasured within 2−4 h to guide resuscitation to normalize
Although little literature includes controlled data to support this
lactate in patients with elevated lactate levels as a marker of
volume, recent interventional studies have described this as usual
tissue hypoperfusion (24).
practice in the early stages of resuscitation, and observational
evidence is supportive (7, 8). The absence of any clear benefit
Obtain Blood Cultures Prior to Antibiotics
following the administration of colloid com-pared with crystalloid
Sterilization of cultures can occur within minutes of the first solutions in the combined subgroups of sepsis, in conjunction with
dose of an appropriate antimicrobial (29, 30), so cultures the expense of albumin, supports a strong recommendation for the
must be obtained before antibiotic administration to opti-mize use of crystalloid solutions in the initial resuscitation of patients
the identification of pathogens and improve outcomes (31, with sepsis and septic shock. Because some evidence indicates that a
32). Appropriate blood cultures include at least two sets sustained positive fluid balance during ICU stay is harmful (33−37),
(aerobic and anaerobic). Administration of appropriate anti- fluid administra-tion beyond initial resuscitation requires careful
biotic therapy should not be delayed in order to obtain blood assessment of the likelihood that the patient remains fluid
cultures. responsive.
Measure lactate level. Re-measure if initial lactate is Weak recommendation, low quality of evidence
> 2 mmol/L
Obtain blood cultures prior to administration of antibiotics Best practice statement
Administer broad-spectrum antibiotics Strong recommendation, moderate quality of evidence
Rapidly administer 30 mL/kg crystalloid for hypotension or Strong recommendation, low quality of evidence
lactate ≥ 4 mmol/L
Apply vasopressors if patient is hypotensive during or after Strong recommendation, moderate quality of evidence
fluid resuscitation to maintain mean arterial pressure
≥ 65 mm Hg
Copyright © 2018 by the Society of Critical Care Medicine and the European Society of Intensive Medicine. All Rights Reserved.
Special Article
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Copyright © 2018 by the Society of Critical Care Medicine and the European Society of Intensive Medicine. All Rights Reserved.