BRAND MODE OF ADVERSE

GENERIC NAME CLASSIFICATION INDICATION CONTRAINDICATION SIDE EFFECTS NURSING RESPONSIBILITIES

NAMES ACTION EFFECTS
- Discourage swallowing in sublingual
administration
 Preventive and  Allergy to nitrates,  Increases
 Syncope, - Create a nitrate-free period to
long-term severe anemia, head supply of
 Dizziness, blurred vision, minimize tolerance
ISOSORBIDE treatment of trauma, cerebral oxygen to
light- persistent or - Give oral preparations on an empty
MONONITRATE angina pectoris/ hemorrhage, the heart by
 Antianginal / headedness, severe stomach, 1 hr before or 2 hrs after
(ISMN)  Imdur post myocardial hypertrophic dilating both
Nitrate / headache, headache, rash, meals; take with meals if severe
Durules, infarction angina; cardiomyopathy, the arteries
Vasodilator flushing of more persistent uncontrollable headache occurs
severe CHF; narrow-angle and veins
the neck or or more severe - Keep life support equipment readily
pulmonary HPN glaucoma, which supply
face angina attacks, available if overdose occurs
orthostatic the heart
fainting - Gradually reduce dose if angina
hypotension itself
treatment is being terminated to
prevent withdrawal
DRUG ANALYSIS OF IMDUR DURULES

 After reading many comments of patients who have been using Imdur Durules, I can’t assure that this should be the number one anti anginal drug. This medication will
not relieve chest pain once it occurs. Although unlikely, when this medication is used for a long time, it may not work as well and may require different dosing.
 DRUG ANALYSIS OF VASTAREL MR

BRAND MODE OF ADVERSE

GENERIC NAME CLASSIFICATION INDICATION CONTRAINDICATION SIDE EFFECTS NURSING RESPONSIBILITIES
NAMES ACTION EFFECTS
TRIMETAZIDINE Vastarel MR, Anti-ischemic / -  Ischemic heart  Hypersensitivity to  Improves  GI  Parkinsonism, - Assess location, duration and
Anti-anginal disease (angina Trimetazidine, myocardial discomfort, gait disorders, intensity of anginal pain
pectoris, sequelae pregnancy glucose nausea, tremors, visual - Monitor BP and PR before and
of infarction utilization vomiting, hallucinations after administering the drug
- Adjuvant through headache, - Notify prescribing signs of
symptomatic inhibition of vertigo heart failure such as swelling
treatment of fatty acid of the hands and feet or
vertigo and metabolism shortness of breath
tinnitus - Instruct to avoid strenuous or
- Adjuvant hazardous activities requiring
treatment of alertness to prevent risks of
decreased visual falls and injury
acuity

 It is interesting how Vastaral MR works in your body. It shouldn’t be happening but when your heart starts to fail, the metabolism in the heart muscles or myocardium shifts
towards increased oxidation of free fatty acids which consumes a lot of energy. Ideally what ought to be happening in the myocardium is glucose oxidation and this is
precisely what Vastaral MR ensures. So Vastaral MR prevents destructive fatty acid oxidation in the myocardium and restores glucose oxidation which is beneficial. Let’s say
that Vastaral MR optimizes cardiac energy metabolism and gives a cardio protective effect to your heart, which is not quite the same as how the other medications used for
treating angina go about doing their business.