SRU 7718

D.M. CRITICAL CARE DEGREE EXAMINATION, DECEMBER 2007

PAPER-I

BASIC SCIENCES PERTAINING TO CRITICAL CARE

Time : 3 hours Maximum marks : 100

o Answer ALL questions

1. Discuss the types and mechanisms of hypoxia.

2. What are the effects of hypothermia on organ system function?

Discuss in detail how some of these effects may have therapeutic value in ICU
What clinical and laboratory parameters should be monitored while
a patient is hypotherrnic?

Give a brief account of:

3. Toll-like receptors in sepsis

4. Causes and mechanisms of metabolic alkalosis

5. Pharmacokinebc factors in antibiotic therapy with reference to

(i) peak concentration (ii) time above MIC
(iii) area under the curve (iv) postantibiotic effect

6. Nitric oxide
 SRU 8337

D .M. CRITICAL CARE DEGREE EXA-MINATION, JUNE 2008

PAPER-I

BASIC SCIENCES PERTAINING TO CRITICAL CARE

Time : 3 hours Maximum marks : 100

Answer ALL questions

1. Describe coaguiation pathway and ph,vsiological basis of

various tests of coagulation.

2. What are the determinants of oxygen supply and demand?

Discuss the significance of the central venous oxygen saturation and
its relationship to the mixed venous saturation.

3. Vasopressin receptors

4. PAOP

5. Extended spectrum beta-lactamases

6. Principles of :
a) ELISA (Enzyme linked immunosorbent assay)
b) PCR (Polymerase chain reaction)
 SRU 9546

D.M. CRITICAL CARE DEGREE EXAMINATION, JUNE 2009

PAPER-I

BASIC SCIENCES PERTAINING TO CRITICAL CARE

Time : 3 hours Maximum marks : 100

Answer ALL questions

1. Explain the applied anatomy and physiology of coronary circulation.

Elaborate the various methods for evaluation of myocardial ischaemia.

2. Discuss the mechanisms of antimicrobial resistance.

Write briefly on:

3. Glomerular filtration

4. Antiplatelet agents

5. Bronchodilators

6. Mechanisms and implications of lactic acidosis in critically ill patients

 SRU 10824

D.M. CRITICAL CARE DEGREE EXAMINATION, JUNE 2010

PAPER-I

BASIC SCIENCES PERTAINING TO CRITICAL CARE

Time : 3 hours Maximum marks : 100

Answer ALL questions

1. Discuss the pharmacokinetic factors that may help to

optimize antibiotic therapy in the ICU.
How are pharmacokinetics altered in patients with severe sepsis?

2. Discuss the pathogenesis of sepsis with specific reference to

(a) Inflammatory response systems
(b) Microcirculatory and mitochondria1 dysfunction
(c) Genetic factors

Write briefly on:

3. Procalcitonin

4. Amiodarone

5. Immunonutrition

6. Hyponatraemia