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PART I …2016

MCQs
PART I

MCQs

1. The epidermis is a cellular compartment. The relative amount of its different cells is

a). keratinocytes . 90% **

b). langerhans cells 15%

c). Merckel cells 10%

d). dendritic cells o2%

e) melanocytes 25%

2. The shape of the cells in the epidermis is as follows;

a). corneal layer………….oval.

b). granular…………………cribriform

c). suprabasal……………..polyhydral. **

d) basal………………………coloumner

e). melanocyte…………..polycyclic

3. Corneal layer cells are:

a). firmly attached to each other by desmosomes.

b). metabolically active.

c). surrounded by lamellated lipids **

d). have an outer protein envelope.

e). cytoplasm is filled with fibrillar keratin and reticulin

4. The major function of the corneal layer is

a). absorption of mechanical trauma.


b). prevention of water loss. **

c.) production of antibacterial peptides.

d). absorption of UV irradiation.

e). reflection of UV irradiation.

5. The granular layer is:

a). three cells thick.

b). fulfills an APC function.

c). synthesize envelope proteins. **

d). secrete ready ceremides for lamellar lipids.

e). the function of the granules is to absorb UV.

6. The suprabasal layer;

a). is capable of cell division.

b). expresses keratin 1-10 **

c). express keratin 5-14

d). participates in vit D synthesis.

e). expresses DNA synthases.

7. The hemidesmosome is a complex structure. Its anchoring filaments are made of;

a). collagen IV

b). collagen VII

c). keratin
d). laminin **

e). fibronectin

8. Adhesion molecules serve in the connection of cell to cell and cell to matrix in different tissues. Cell
to cell adhesion in epithelial tissue is mediated through:

a). integrins

b). E-selectins.

c). E-cadherins.

d). superglobulins

e). ICAM 1 **

9. Cell to cell adhesion in the epidermis is mainly maintained by:

a). desmosomes. **

b). gap junctions

c). tight junctions

d). ECM glycoproteins

e). hemidesmosomes

10. Gap junctions in the epidermis are connections between adjacent cells through;

a). Claudine

b). cadherins

c) connexins **

d). plakoglobins

e). plakophillins

11. The basement membrane that separates the epidermis from the dermis is:

a), porous and permeable to all substances.

b). mainly cellular in composition.


c). allows nutritional molecules regardless of the molecular size.

d). allows the passage of certain cells. **

e) end capillaries cross it to reach the lower side of basal cells.

12. The term dermo-epidermal junction designates a zone that includes:

a). the basement membrane and the papillary dermis.

b). the basement membrane, dermal papilla and outer plaque of BC.

c). the basement membrane,hemidesmosome, and lower part of the basal cells.
**

d). the basement membrane and the basal cell layer.

e). the hemidesmosome and basal ell layer.

13. The structures that compose the dermal papilla are:

a). type IV collagen.

b). anchoring fibrils and plaques.

c). anchoring fibrils , blood vessels and lymphatics. **

d). two different types of collagen, elastic mesh, blood vessels lymphatics and
nerves.

e). Elastic fibres, blood vessels and lymphatics.

14 . The regular cells inhibiting the dermis are:

a). T lymphocyte.

b). melanocytes.

c). mast cells. **

d). macrophages.

e). Merckle cells.

15. The inner plaque of the hemidesmosome contains:

a). fibronectin.
b). tenascin.

c). BP antigen. **

d). thrombpspondin

e) E selectin.

16, Which of these structures is not a regular component of the papillary dermis:

a). capillary.

b). venule.

c). blind ended lyphatics

d). elastic fine fibres.

e). reticulin fibres. **

17. The papillary dermis in contrast to the reticular dermis has:

a). thicker collagen fibres

b). blood vessels with two layers of smooth muscles.

c). tiny elastic fibers that run horizontally. **

d), eccrine sweat glands.

e). villous hair follicles

18. The functions of the extracellular matrix of the dermis are:

a). energy reserve.

b). thermogenesis.

c). promote cellular adhesion, movement and differentiation. **

d). wound repair.

e). regulation of blood pressure.

19. The proteoglycans of the dermis consist of a protein core and sugar side chains. Which of the
following statements is true about them:

a), the sugars In the side chains are glucose and fructose.

b). the point of attachment of side chain to the protein core is seriene **
c). the oligo chain at which synthesis of side chains starts is xylose
,glucose galactose.

d) side chains are repeated units of trisaccharides.

e). sugar chains undergo hydroxylation.

20. Small proline rich proteins operate in the dermis as:

a). water holding molecules.

b). promoters of cell-cell adhesion.

c). facilitators of molecular movement within ECM.

d) connector of collagen fibres into bundles. **

e) ensheath the elastic fibres core.

21. Which of these statements does not characterize the mast cell.

a). mesenchymal origin.

b). polychromatic.

c). immunopotent.

d). the mucosal type is larger than the dermal. *

e). secretory.

22, The mast cells holds the preformed histamine in granular form by:

a). binding it to a granular protein.

b), coating the molecule by a lipid layer,.


c). binding to heparin. **

d) binding to chondoroitin.

e). binding to uroconic acid

23. Stimulation of the mast cell is either immunological or direct. Direct stimulation mostly occurs
through

a). drugs. **

b). food,

c). physical trauma.

d). heat.

e) cold

24. The subcutaneous fat of the skin is conspicuously absent from:

a). mediastinum.

b). palms and soles.

c). scalp

d). male genitalia. **

e). retropleural space.

25. Select the correct statement about subcutaneous fat in a normal person;

a). is 20% of body weight.

b). gives 20 days reserve energy.

c). all adipocytes are active in thermogenesis.

d). brown fat is found in large quantities in adults.

e) brown fat has more mitochondria and multilocular cells. **

26. The adipocytes carry the following characterstics:

a). smallest connective tissue cell in the body.

b). capable of both synthesis and storage, **


c). polyhydral in shape.

d). have large round nuclei.

e). contains a number of small cytoplasmic vacuoles.

27. The sympathetic motor fibers of the skin do not feed in

a). apocrine sweat glands

b). eccrine sweat glands.

c). sebaceous glands.

d). Tyson’s gland. **

e). vascular smooth muscles

28. The following is true about free nerve endings of the skin;

a). pencillate free endings are common in papillary dermis **

b). papillary type is common in hairfollicle papillae

c). slowly adapt to pain and itch.

d). overlap is absent.

e). do not connect to Merckle cells.

29. Meissner’s corpuscle has:

a). a bulbar terminal. **

b). is located in dermal papillae all over the body.

c). has 10 axons inside the capsule.

d). has no potential for ramification.


e). oriented obliquely to the surface of the skin.

30. Passini.s corpuscle;

a) posseses a characteristic capsule but no lamellar wrapping.

b). capsule is arranged in 20 layers of cells.

c). slowly adapt to mechano stimuli.

d). subcapsular zone contains collagen and fibroblasts. *

e). capsule is wrapped in lamellated Schwan cells.

31. The vascular supply of the skin is achieved through the musculo-cutaneous arteries which:

a). break into lobar arteries that cross lobes into the reticular dermis.

b) pass directly to reticular dermis by crossing the connective tissue septa. **

c). after arriving in reticular dermis pass vertically with diminishing size to
papillary dermis.

d). Connecting arachades occur at the papillary dermis.

e) each papilla receives 2 capillaries

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