TandAb

TandAb (Tandem diabody) is a type of bispecific antibody fragments.

TandAb is a tetravalent bispecific molecule, 2+2 antigen-binding
valency, consisting solely of Fv domains. TandAb is expressed as a
monomeric subunit (single chain Diabody, scDb) with four variable
domains from two parental antibodies. In the subunit, the linkers are
too short to form intra-chain pairing, so the 2 polypeptides dimerize in
a head-to-tail fashion. TandAbs have been studied as BiTEs (bispecific
T cell engagers) or BiKEs (bispecific NK engagers) in tumor
immunotherapy.