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An important subgroup of VOCs is semi-volatile organic compounds or SVOCs which tend to have a higher
molecular weight and higher boiling point temperature than other VOCs. Examples include plasticizers, flame
retardants, and pesticides. All indoor VOCs are present partly as gaseous airborne chemicals and partly as
chemicals adsorbed on indoor surfaces and onto microscopic airborne and settled particles. SVOCs are often
present largely on surfaces and particles, with only a small fraction in the air unattached to particles.
The amount, or concentration, of VOC present in the indoor air is expressed in a variety of units. Commonly used
units are parts per billion (ppb), parts per million (ppm), and micrograms per cubic meter (µg/m3). A microgram is
one one-millionth of a gram. If the concentration is 1 ppb (or 1 ppm), for every billion (or million) molecules of air
there is one molecule of the VOC. If the concentration is 1 µg/m3, then for every cubic meter volume of air there
is 1 microgram of mass (weight) of the VOC.
A large number of VOCs are emitted into indoor air from building materials, furnishings, cleaning compounds,
office equipment, personal care products, air fresheners, pesticides, occupant activities, and unvented
combustion processes such as tobacco smoking, burning of wood or kerosene, or cooking with gas stoves [1-5].
Some of the key indoor sources of SVOCs are pesticides, building or decorating materials made of or containing
flexible plastics such as vinyl wallpaper or vinyl flooring, and building materials and furniture containing flame
retardants.
https://iaqscience.lbl.gov/voc-intro 1/3
28/05/2018 Introduction to VOCS and Health | Indoor Air Quality (IAQ) Scientific Findings Resource Bank (IAQ-SFRB)
VOCs are also produced indoors from chemical reactions of indoor ozone with other VOCs, SVOCs, or materials
(such as carpeting) [6]. Outdoor air is normally the major source of the indoor ozone, although ozone, ion, and
plasma generators (marketed as air cleaners), electronic air cleaners (that unintentionally produce ozone as a by-
product), and some types of office equipment can be additional sources of ozone. VOCs also enter buildings
along with outdoor air; however, for many VOCs and SVOCs for which the primary sources are indoors, indoor air
concentrations far exceed outdoor air concentrations [1, 2]. Most VOCs indoors are at low concentrations, but the
concentrations due to indoor sources are highly variable and depend on occupant behaviors. Some indoor VOCs
can be at high concentrations. For example in some homes ethanol concentrations are above 1000 µg/m3, and in
some homes 1,4-dichlorobenzene, alpha-pinene, and d-limonene concentrations have been measured at around
100 µg/m3 [7]. Information is available from representative U.S. population surveys on the distribution of
personal exposures to a variety of VOCs [8].
Researchers, and those who investigate indoor air quality problems, sometimes measure and report "total
volatile organic compound" or "TVOC" concentrations. The term TVOC refers to the total concentration of
multiple airborne VOCs present simultaneously in the air. TVOC methods do not measure all VOCs in the air, but
a subset of VOCs that are expected to be present. Measuring TVOC concentrations is less expensive than
measuring the concentrations of many individual VOCs. However, there are two main limitations to TVOC
measurements. First, different TVOC measurement methods can yield substantially different TVOC
concentrations and the differences between measurement methods will depend on the mixture of VOCs present.
Secondly, the toxicity and the odor thresholds of individual VOCs within the VOC mixture may differ by orders of
magnitude; therefore, the total concentration is not likely to provide a useful measure of total toxicity or total
odor level. In general, TVOC measurements in buildings have not been useful in predicting health effects,
Some VOCs and SVOCs are odorous and some are suspected causes of adverse health effects. The suspected
health effects cover a broad range including, but not limited to, sensory irritation symptoms, allergies and
asthma, neurological and liver toxicity, and cancer. While multiple VOCs present together may have effects
greater (or less) than the sum of their individual effects, little information is now available on such combined
effects. The following text briefly summarizes the current knowledge about the linkages of indoor VOCs with
sensory irritation, allergies, asthma, and related respiratory effects, and cancer. Additional sections briefly
summarize knowledge about potential health effects of VOCs in cleaning products, SVOCs, and VOCs produced
indoors from chemical reactions.
One common VOC, formaldehyde, is widely used in the manufacture of building materials and numerous
household products, and is also a by-product of combustion and other natural processes. Formaldehyde may be
present in substantial concentrations both indoors and outdoors. Due to its ubiquitous nature and significant
health effects, this website's section on "Indoor Volatile Organic Compounds and Health" often provides
discussions focused specifically on formaldehyde.
Various organizations have established guidelines or recommendations (none are legally enforceable limits) for
maximum formaldehyde concentrations, based on examinations of the scientific literature. Table 1 provides
examples of these guidelines, which are discussed again later in this document. It is evident in this table that,
despite differences in guidelines from different organizations, the longer exposure periods (longer than 8 hours)
consistently specify lower guideline concentrations of formaldehyde (7-40 ppb) relative to the guidelines for
periods of 8 hours or less (44-750 ppb). An exception is the relatively high chronic guideline of 100 ppb from the
World Health Organization (WHO). An alternate view of the evidence on chronic formaldehyde exposure and
sensory irritation, apparently underlying the WHO guideline, is provided by Wolkoff and Nielsen [9]. These
authors consider an indoor air quality guideline of 80 ppb, based on the available evidence, to be "protective
against both acute and chronic sensory irritation in the airways in the general population . . . [9]." Nielsen et al., in
2013 [10], who had provided the basis for the 2010 WHO formaldehyde guidelines, reviewed recent evidence that
they concluded strengthened support for the WHO guideline of 100 ppb as protective against all short- and long-
term health effects, including sensory irritation, cancer, and reproductive effects.
https://iaqscience.lbl.gov/voc-intro 2/3
28/05/2018 Introduction to VOCS and Health | Indoor Air Quality (IAQ) Scientific Findings Resource Bank (IAQ-SFRB)
https://iaqscience.lbl.gov/voc-intro 3/3