2016 TAJEV / Poster Presentation J Turk Ger Gynecol Assoc 2016; 17

S262

hours after PPROM (p=0.012 and p = 0.017, respectively). The opti- 4

mal cut-off values for the diagnosis of PPROM were >6.7 mg/dL for
urea and >0.12 mg/dL for creatinine. The optimal cut-off values for
the detection of delivery within 48 hours were >19.4 mg/dL for urea
and >0.23 mg/dL for creatinine.
Conclusion: Measurement of urea and creatinine levels in vaginal fluid
is a rapid and reliable test for diagnosing and also for predicting deliv-
ery interval after PPROM.
Keywords: Preterm premature rupture of membranes, vaginal fluid,
urea, creatitine, delivery interval
[PP-188]
Decreased maternal serum Netrin-1
levels as a new predictor of
preeclampsia
Yasemin Çekmez1, Sebnem Garip2, İpek Ulu1, Serdar Gülşen1,
Esra Tuştaş Haberal1, Yusuf Olgaç3, Eser Evrim Yoğurtçuoğlu1,
Simge Bağcı Türkmen1, Fatma Tutku Aksoy2, Gürkan Kıran4
1
Ümraniye Medical and Research Hospital, İstanbul, Turkey
2
Kemerburgaz University, İstanbul, Turkey
3
Florence Nightingale Hospital, İstanbul, Turkey
4
Bezm-i Alem University, İstanbul, Turkey
Department of Pathology, Acibadem Hospital, İstanbul,
Turkey
Introduction: Pena – Shokeir sydrome was first described in 1974
and is a fatal disease (1). İncidence is 1 per 12000 live births. It is
an autosomal recessive condition which has two types. Type 1 is
characterised with multiple joint contractures (arthrogryposis), facial
anomalies, polyhydramnios, fetal growth retardation and pulmonary
hypoplasia. This type is featured in “Fetal Akinesia Deformation Se-
quence(FADS)” that has similar phenotypic characteristics (2, 3). A
neuronal or muscular defect is evident, however etiology is not yet
clarified (1-4). Diagnosis can be made on 14th gestational week (5).
We have discussed a case of Pena – Shokeir type 1 sydrome, prenatal
ultrasound and postnatal autopsy findings.
Case: A 34 year old woman presented in our outpatient clinic with the
complaint of decreased fetal movements at 22nd week of gestation. It
was her first pregnancy. In ultrasonographic evaluation, lack of active
fetal body movements, multiple joint contractures in both upper and
lower extremities, facial anomalies, polyhydramnios and a septated
cystic hygroma were identified. Persistant flexion on arms, ulnar de-
viation of hands and claw-hand appearance were present on upper
extremities (Figure 1). Extansion deformity cross position of legs, pes
equinovarus and rocker-bottom feet were present on lower extremi-
ties. Micrognathia, flat bridge of nose and protruded eyes were pres-
ent as facial anomalies. Amniocentesis was performed for chrosomal

Objective: The aim of this study was to investigate whether the ne-
trin-1 levels in maternal serum was associated with presence of pre-
eclampsia.
Material and Methods: Total 72 patients, including 28 normal preg-
nant women and 44 patients with preeclampsia, were included in
this study. Maternal serum netrin-1 concentrations were measured by
ELISA.
Results: Levels of netrin-1 were detected statistically lower in pre-
eclamptic group than control group. Netrin-1 levels were also lower in
severe preclampsia group than mild preeclampsia group but this was
not detected statistically different.
Conclusion: Maternal serum Netrin-1 has a potential to be a new
marker for the detective of preeclampsia.
Keywords: Netrin-1, preeclampsia, placenta, vasculogenesis

[PP-189] Figure 1.

Pena – Shokeir Syndrome, prenatal

ultrasound and autopsy findings
Nermin Koç1, Osman Temizkan2, Oya Demirci3, Davut Şahin4,
Işıl Ayhan2
1
Department of Pathology Zeynep Kamil Training and
Research Hospital, İstanbul, Turkey
2
Department of Gynecology and Obstetrics, Şişli Etfal Training
and Research Hospital, İstanbul, Turkey
3
Department of Gynecology and Obstetrics, Zeynep Kamil
Training and Research Hospital, İstanbul, Turkey
Figure 2.
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permission.