Beruflich Dokumente
Kultur Dokumente
CELL NUMBER:9819042349
ABSTRACT
CASE REPORT : A 31 year old male diagnosed with FLT3 ITD Positive AML successfully underwent
haploidentical allogenic stem cell transplant with Fludarabine, Treosulfan and TBI as conditioning
regimen on 29.12.15. He received Cyclosporine, MMF and post transplant cyclophosphamide as
GVHD prophylaxis
On D+31 Post transplant his CMV titres were 857 copies . He was started on Oral leflunomide at
100mg OD for 3 days followed by 20mg OD. Ganciclovir was avoided considering his low counts. As
the CMV copies continued to raise ., His On D+49 the titres beingwere 4.9 log4. , He was started on
Injectable Artesunate on D+49 at 3.5mg/kg in two divided doses. He tolerated the drugs well except
nausea and dizziness , hence the dose of Aartesunate was reduced to OD. On D+56, his His CMV
titres reduced by 1 log and by 4 log on D+65. CMV titres were less than 150 on D+70. He received
Injectable Artesunate for a total of 30 days and Oral Leflunomide for 44 days showing . Hence
Leflunomide and Artesunate in combination proved to be beneficial in the treatment of CMV
reactivation in our patient. Hence we would like to conclude that the combination therapy could be a
promising and a safe alternative in treating CMV infections post transplant patients.
RESULTS