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Effect of Cigarette Smoking on Blood Lipids A Study in Belgaum, Northern Karnataka, India
© 2012 Devaranavadgi B. B, Aski B.S, Kashinath R. T & Hundekari I. A. This is a research/review paper, distributed under the
terms of the Creative Commons Attribution-Noncommercial 3.0 Unported License http://creativecommons.org/licenses/by-
nc/3.0/), permitting all non commercial use, distribution, and reproduction in any medium, provided the original work is properly
cited.
Effect of Cigarette Smoking on Blood Lipids –
A Study in Belgaum, Northern Karnataka, India
σ
Devaranavadgi B. B α, Aski B.S α, Kashinath R. T & Hundekari I. A α
Abstract - Cigarette smoking is an important and independent tobacco in the world. About 550 million kgs of tobacco
risk factor of atherosclerosis, coronary artery disease and is grown in 4.2 lakh hectares of land and 250 million kgs
peripheral vascular disorders. Apart from active smokers, of tobacco is released for local consumption (8). In India
passive-smokers are also prone for the development of
337 million people above 10 years of age consume
Year 2012
smoking related disorders.
tobacco. Every year 1 million people die prematurely
Smoking adversely affects the concentration of the
plasma lipids and lipoprotein levels. The lipid profile was due to tobacco smoking related diseases (9).
measured from 100 selected smokers and nonsmokers and The mechanism by which smoking increases
the study shows that as the intensity and duration of smoking the cardiovascular diseases are unclear. Recently it has
increases a significant increase in the levels of very low density been suggested that smoking adversely affects the 57
lipoprotein -cholesterol, low density lipoprotein -cholesterol, concentration of plasma lipids and lipoprotein levels.
triglyceride and total cholesterol are noted in almost all groups
L
smoking.
ipids play an important role virtually in all aspects
of biological life. Some of these roles include II. Materials and Methods
and VLDL cholesterol were calculated by using VLDL-C in almost all the groups of cigarette smokers as
Friedewalds formula (15). compared to non smokers. Simultaneously a significant
reduction in level of HDL-C is observed in cigarette
LDL Cholesterol (mg%) = Total Cholesterol – (HDL smokers as compared to non-smokers and a parallel
cholesterol + TG/5) increase in these parameters with the increase in
VLDL Cholesterol (mg%) = TG/5 intensity and duration of smoking.
The significance level of different parameters
between the study groups were carried out using
students “t” test.
Table 1 : Table showing serum lipid profile in cigarette smokers and non-smokers in relation to duration and
intensity of smoking.
Global Journal of Medical Research
Values are expressed as Mean ± SD. All P values are in comparison with nonsmokers.
Graph 1 : Graph showing Lipid profile in cigarette smokers and non-smokers in relation to duration and intensity of
smoking.
214.13±26.98
202.78±20.56
196.38±18.54
191.16±35.45
250
171.57±32.42
167.78±25.41
155.28±24.09
143.87±24.32
200
133.5±21.76
124.01±18.12
121.2±32.70
Year 2012
150
84.08±24.42
Gr. I
Gr.II - A
100 Gr.II - B 59
38.63±3.06
46.9±6.71
35.46±3.50
34.35±6.53
33.78±4.91
38.627.34
31.64±2.56
Gr.II - C
24.24±6.54
0
Total TG (mg%) HDL-C (mg%) LDL-C (mg%) VLDL-C (mg%)
Cholesterol(mg%)
Majos O. D. et al. (21) in their study reported HDL-C assume a great significance since this has been
that there is significant decrease in HDL-C, but there is the pattern associated with CHD.
no change in total cholesterol and triglycerides in The low level of HDL-C in cigarette smokers and
cigarette smokers as compared to non-smokers. The the increased exposure of the vascular endothelium to
above findings, except for decrease in HDL-C are potentially atherogenic lipoproteins as a consequence
contradictory to our findings. of impaired clearance of triglyceride rich lipoproteins
Chart -1 : Chart showing a possible mechanism may provide a mechanism whereby smoking
by which nicotine absorbed from cigarette smoke may predisposes to greater risk of developing atherosclerotic
elevate plasma lipids and lipoproteins. plaques and CHD.
↓
1. D. A. Adedeji, M. H. Etukudo. (2006). “Lipid profile
of cigarette smokers in Calabar municipality”
Year 2012
↓
206 – 221.
2
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3. N. S. Neki. (2002). “Lipid profile in smokers – A
clinical study” JIACM. 3(1):51-54.
Volume XII Issue VI Version I
Secretion of catecholamines, cortisol and growth 4. David Pollock. (1996). “Forty years on a war to
hormones recognize and win.- How the tobacco industry has
↓
lipoprotein" Am. J. Cardiol. 52: 675-680.
11. Law M. R. N J. Wald, S. G. Thompson. (1994). “By
how much and how quickly does reduction in serum
Increased Plasma TG, VLDL-C cholesterol concentration lowers the risk of ischemic
Year 2012
121:141-147.
21. Majos O.D. et al. (1988) “Lipid effects of smoking”
Am Heart J. 115:272-275.
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