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Therapeutic class:
Thrombolytic enzyme.
Pharmacologic class:
Tissue Plasminogen Activator.
Pharmacology:
Converts plasminogen to the enzyme plasmin,
which aids in dissolution of blood clots.
Pregnancy category:
C
Available forms:
The only available form is powder for solution for
solution.
Administration:
1-IV ( intravenous route ).
2-IC ( intracoronary route ).
Action:
Dissolve clot that have formed in blood vessels.
Storage/Stability:
Store unopened vials at controlled room
temperature (59° to 86°F). Use reconstituted
solution immediately or within 8 h if stored at 36°
to 46°F. Discard any unused solution.
Pharmacokinetics
Metabolism:
No metabolites identified.
Elimination:
Streptokinase is cleared by the liver. The t ½ is
approximately 23 min (for activator complex).
Indications & usage:
1- AMI.
lysis of intracoronary thrombi → improvement of ventricular
function, and reduction of mortality associated with acute MI (IV or
intracoronary route); reduction of infarct size and CHF associated
with acute MI (IV).
2-Pulmonary Embolism.
(involving obstruction of blood flow to a lobe or multiple segments,
with or without unstable hemodynamics).
3-DVT.
acute, extensive thrombi of the deep veins (eg, those involving the
popliteal vessels); lysis of acute arterial thrombi and emboli;
alternative to surgical revision for clearing totally or partially
occluded arteriovenous cannula when acceptable flow cannot be
achieved.
Dosage and Administration
Acute MI (Adults):
IV infusion Administer ASA after symptom onset (greatest benefit
when administered within 4 h, but benefit has been reported up to
24 h). Infuse a total dose of 1,500,000 units within 60 min.
Intracoronary infusion Administer 20,000 units by bolus followed
by 2000 units/min for 60 min (total dose, 140,000 units).
1-Blurred Vision.
2-Dizziness.
3-Fever.
4-Sweating.
Antidote of Streptokinase:
Aminocaproic
acid.
Any question ?
References;
http://www.sfda.gov.sa/ar/drug/search/Pages/def
ault.aspx?tn=&gn=Streptokinase&mc=&an=®n
o=&sf=&sd=&PageIndex=1&sm=human
http://www.rxlist.com/streptase-drug/side-effects-
interactions.htm