Anacardic acids, the Anti Pituitary Adenomas

Bioactive Ingredient

By Kyle J. Norton

Scientists may have found a natural ingredient for the prevention and treatment
of pituitary adenomas with no side effects, according to studies.

Anacardic acids are phenolic lipids, phytochemicals of the organic acid found
abundantly in cashews, mangoes, etc.

Pituitary adenomas are noncancerous tumors occurred in the pituitary gland.

A pituitary tumor has a negative and strong implication of the production of the
thyroid-stimulating hormone, leading to a rare case of hyperthyroidism which
normally induces the unintentional weight loss.

Most cases of the pituitary adenomas start in the cell of the inner lining of the
tissue of the pituitary gland, due to the alternation of DNA. The tumor is well
contained in the gland with no tendency of spreading.

At the early stage, patients with benign tumor do not experience any symptoms.
However, when the tumor is growing larger, it may suppress the healthy tissue
in the gland or nearby nerve cells, leading to symptoms of a headache, vision
loss, and severe pain.

Epidemiological studies suggested that depending on the stage of the pituitary

tumor, patients can experience hormone overproduction and hormone
deficiency, leading to certain hormonal related diseases.

Depending on the size of the tumor and its effect on the patient's health, surgery
may be the only option, if the tumor is pressing on the optic nerves or
overproducing certain hormones.

In the concern of morbidity and complication of therapy in patients with

pituitary adenomas, researchers examined the effect of Anacardic acids, a
natural histone acetyltransferase inhibitor, on pituitary adenoma cells.
Epidemiological studies suggested that the progression of the benign pituitary
tumor, if not treated, is a prevalent risk factor of the onset of malignant tumor
pathogenesis.

Injection of anacardic acid exerted a significant anti antiproliferative and

cytotoxic effect on pituitary adenoma cells.

According to the flow cytometry and Western blotting assays, anacardic acid
inhibition of the tested cell line was associated with an increase the functions of
the protein involved in a number of cellular processes in programming cell
death and through cell cycle arrest on the G1 phase.

The marker used to detect cancer cell apoptosis, Annexin A5 (or annexin V), a
cellular protein in the annexin group also increased after injecting the cancer
cell with Anacardic acids.

In vitro and in vivo researchers found that administration of a pan-caspase

inhibitor that irreversibly inhibits enzymatic function and effective in blocking
apoptosis in a variety of cell types under normal condition has failed to reverse
anacardic acid-induced cell death.

These results suggested that the bioactive induced cancer cell apoptosis through
a possible nonclassical mechanism.

Furthermore, Anacardic acid the anti-cancer effect also suppressed the function
of the survivin protein functions to exhibit negative regulation of apoptosis or
programmed cell death and X-linked inhibitor of apoptosis protein (XIAP)
associated with the anti-apoptotic function.

More importantly, the bioactive compound was found to deactivate the

antiapoptotic proteins associated with cellular survival and radioresistance and
radiosensitized pituitary adenoma cells.

The findings indicated that the chemical compound inhibited the onset and
progression of pituitary adenomas through promoting cell cycle arrest, cancer
apoptosis, programming cell death through some known and unknown
mechanisms.

Taken all together, Anacardic acids may be used for the prevention and
treatment of pituitary adenomas with no side effects, pending to the result of
the larger sample size and multicenter human study.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers
have been written and published online, including worldwide health, ezine
articles, article base, health blog, self-growth, best before it's news, the karate
GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ
by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington
Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as
international journal Pharma and Bioscience, ISSN 0975-6299.
Reference
(1) Anacardic acid induces caspase-independent apoptosis and radiosensitizes
pituitary adenoma cells by Sukumari-Ramesh S, Singh N, Jensen MA,
Dhandapani KM, Vender JR.(PubMed)