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FREQUENCY OF HYPERCHOLESTEROLEMIA
IN HYPOTHOROID PATIENTS ADMITTED IN
AYUB TEACHING HOSPITAL
CANDIDATE
DR.ADNAN IMRAN
SUPERVISOR
DR.NASIR HUSSAIN SHAH KAZMI
MBBS ( PESH), FCPS ( MEDICINE)
ASSOCIATE PROFESSOR OF MEDICINE
AYUB TEACHING HOSPITAL,
ABBOTTABAD.
INTRODUCTION:
Hypothyroidism is one of the common disease of thyroid gland and is common in
Pakistan.1 Hypothyroidism results from the deficiency of thyroid activity.2Thyroid
gland controls variety of metabolic processes of the body3. Thyroid hormone
effects lipid metabolism by influencing lipid and lipoproteins. Hypothyroid
patients have hypercholesterolemia as common finding. An essential risk factor for
hypertension and cardiovascular diseases is dyslipidemia.4 The mechanism of
hypercholesterolemia in hypothyroid patients is decreased number of LDL
receptors in liver resulting in decreased fractional clearance of LDL. The other
proposed mechanisms are slow removal of LDL from plasma and decreased
cholesterol conversion to bile acids in the liver.5 There are various experimental
studies showing potent effect of thyroid hormones on metabolism of cholesterol
and lipids. Increase in blood cholesterol levels are observed in myxedema.6 High
ratio of free to total serum cholesterol levels has been reported in cretinous
children while in adult patients with myxedema, an increase in cholesterol to
phospholipid ration is reported.7
OBJECTIVE:
To determine the frequency of hypercholesterolemia in hypothoroid patients
admitted in Medical Department of Ayub Teaching Hospital.
OPERATIONAL DEFINATIONS:
HYPERCHOLESTEROLEMIA:
HYPOTHYROIDISM:
MATERIALS AND METHODS:
Setting: Department of Medicine , Ayub Teaching Hospital.
Duration of Period: One year after the approval of synopsis.
Study Design : Cross sectional study.
Sample Size: Using the WHO software (sample size determination in health
studies), the formula to estimate the population proportion with specified absolute
precision , is used to calculate the sample size.