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MENINGITIS
Arranged by :
Supervisor :
NIP.
PEDIATRIC DEPARTMENT
FACULTY OF MEDICINE
MEDAN
2017
Case Report
MENINGITIS
Presentator : Diana Marlisa (130100069)
Day/date :
Introduction
Meningitis is an inflammation of the meningens (the covering of the brain and spinal
cord).1 Meningitis can be caused by infection from viruses and bacteria (germs), parasite and
fungal.2 But usually they develop the infection from viruses and bacteria. Meningitis virus (also
known as Aseptic Meningitis, Serous Meningitis) commonly caused by viruses called
“enteroviruses”.3 Before the effective immunisation was found, poliovirus was the most common
caused. But this time, the other enteroviruses (coxsackievirus and echovirus), California virus,
and Mumps virus are the most responsible for some cases of Aseptic meningitis during
summer.,4
In neonates and new born, some symptoms like letargy and decrease appetite with or
without seizures could be found.5 In infant, child and adult, the symptoms appeared suddenly,
with headache, vomiting, letargi and stiff neck.5 Sometimes fever, flu like syndrome, parotitis,
rash and adenopaty.6 Symptoms usually appear within 1- 2 weeks, after exposure to the virus.
There are no specific treatment for this. Some patient completely recovery from this disease.7
Meningitis bacterial is one of the most potentially serious infections occurring in infants
and older children.3 This infection is associated with acute complication and risk of long term
morbidity. The most common cause of bacterial meningitis in children 1 month to 12 years of
age in the USA is Neisseria meningitides.4 Bacterial meningitis caused by Streptococcus
pneumonia and Haemophilus influenza type b has become much less common in develop
countries since the introduction of universal immunization against these pathogens beginning at
2 month of age.4
Based on the pattern in Indonesia, meningitis is the cause of death ranked 17th with a
proportion of 0.8% Reflect the select nature of the type of patient studied or seasonal outbreak
of particular pathogens in the various regions of the world. Study inclusion criteria represented 2
categories of children: (1) children with seizure and fever, and (2) children with clinical
suspicion of invasive bacterial disease or meningitis.6 Almost all microbe that are pathogenic to
human beings have the potential to cause Meningitis, but relatively small number of pathogens
(group B streptococcus, Escherichia coli, Listeria monocytogenes, Haemophilus influenza type
b, S. pneumonia and Neisseria meningitis) account for most cases of bacterial meningitis in
neonates and children.4
Viral meningitis can occur at any age but is common in young children. In the largest
reported study, a 1996 birth cohort of 12.000 children in Finland, the annual incidence of
presumed viral meningitis was 219 per 100.000 in infants under 1 year and 27.8 per 100.000
overall in children under 14. In a smaller retrospective study, the incidence of aseptic meningitis
in people aged 16 and over lower at 7.6 per 100.000.7
Initial empiric theraphy for bacterial meningitis is based on the patient’s age, risk factors,
and clinical features. In patients with suspected bacterial meningitis, empiric theraphy should not
be delayed for more than one hour while awaiting diagnostic testing or transfers.8 Although no
prospective comparative trials have been perfomed, observational studies have found that
delayes in theraphy of as little as two to six hours are associated with adverse outcomes. Fluid
management includes treatment for possible dehydration or hyponatremia from the syndrome of
inappropriate antidiuretic hormone. After the results of the Gram stain, culture, and susceptibility
test are available, specific theraphy targeting the pathogen should be administered.9
Enteroviruses are the most common etiologic pathogens in persons with aseptic
meningitis and do not require specific antimoicrobial theraphy.10 HSV aseptic meningitis usually
a self limited infection that must be distinguished from HSV encephalitis based on clinical and
radiographic features; theraphy with acyclovir (Zovirax) can be lifesaving in patients with HSV
encephalitis. Varicella – zoster virus infection may cause aseptic meningitis in the absence of
cutaneous manifestation. Although it has not been studied in clinical trials, therapy with
acyclovir at 10 mg per kg every eight hours is suggested based on expert opinion. Central
nervous system Lyme disease is treated with ceftriaxone for 14 to 28 days, and central nervous
system syphilis is treated with intravenous penicillin for 10 to 14 days. 14
The mortality rate in adults with bacterial meningitis in develop countries is 21 percent; it
is higher in patients with pneumococcal disease than in those with meningococcal disease.
Neurologic sequelae include hearing loss in 14 percent of patients and hemiparesis in 4 percent.
Risk factors for adverse outcomes include advanced age, alteration of mental status on
admission, bacteremia, and a CSF white blood cell count of less than 1.000 per µL (1.00 × 10 9
per L). The mortality rate in children with bacterial meningitis is 3 percent; the incidence of
stroke in children with bacterial meningitis is 3 percent.7
In aseptic meningitis, motor incoordination, convulsive total or partial deafness, and
behavioral disturbances may follow viral Central Nervous System (CNS) infections. Most
children completely recover from viral infection CNS, although the prognosis depends on the
severity of the clinical illness, the specific cause and the age of the child. If the clinical illness is
severe, and the substantial parenchymal involvement is evident, the prognosis is poor, with
potential deficits being intellectual, motor, psychiatric, epileptic, visual or auditory in nature.14
Infection caused by S. pneumonia or H. influenza type b must be considered in
incompletely vaccinated individuals or those in developing countries. Those with certain
underlying immunologic (HIV infection, IgG subclass deficiency) or anatomic (splenic
dysfunction, cochlear defects or implants) disorders also may be at increased risk of infection
caused by these bacteria.9 The clinical picture of acute bacterial meningitis mainly depends on
the patient’s age. The classic manifestations (fever, chills,vomiting, photophobia, and severe
headache) noted in older children and adults are rarely present in infants. In general, the younger
the patient, the more subtle and atypical are the sign and symptoms. In general, meningitis
caused by a virus is less serious than meningitis caused by bacteria.3
The aim of this paper is to report the case of meningitis in a 5 months old boy.
CASE
PHYSICAL EXAMINATION
Physical examination
Presence Status: alertness : GCS 9 (E5V3M4) Temperature: 40 ⁰C
Body weight : 6630 gr Body length : 67 cm
Differential Diagnosis:
Meningitis
Meningoensefalitis
Ensefalitis
Working Diagnosis:
• Meningitis
Therapy :
• O2 1-2 l / min
• IVFD RL 36 gtt / min macro
• Ranitidine injection 5 mg / 8 hours// IV
• Paracetamol drips 70 mg / 8 hours
Plan:
- Head CT scan
- Complete blood count, AGDA, electrolyte
- Lumbal puncture
FOLLOW UP
June 2, 2017
Immunoserology
Virus
IgM Anti Dengue Negative
Anti Dengue IgG Negative
Autoimmune
Quantitative CRP 0.7 mg / dl <0.7
Another test
Extremities = pulse: 120x / bpm ,regular, P / V adequate, capillary refill time < 3
seconds
Meningoencephalitis
IVFD kaen 3B 32 cc / hr
June 5, 2017
Meningoencephalitis
IVFD Kaen 3B 32 cc / hr
June 6, 2017
Meningoencephalitis
IVFD Kaen 3B 32 cc / hr
The time to presentation (acute, subacute or chronic) and tempo of the illness differ based
on the etiology and guide appropriate initial management and treatment.9 The incidence of
bacterial meningitis in the first febrile seizures aged 6-18 months is still quite high, especially at
6-12 months of age, the seizure > 15 minutes is significantly associated with bacterial meningitis,
it is recommended to examine lumbar puncture in each child less than 18 months who suffered
first febrile seizures especially if the seizures more than 15 minutes. 12 Usually presents within
hours to days, whereas chronic meningitis is by definition longer than 4 weeks in duration. 9 A
wide range of bacteria cause purulent meningitis (bacterial mengitis). In the neonatal period,
which includes premature and term babies up to 3 months of life, group B streptococci cause
most bacterial meningitis in develop countries. Causes of bacterial meningitis in infants aged 2
months to 5 years of Streptococcus pneumonia, Neisseria meningitis, Haemophillus influenza. 13
Viral meningitis and bacterial meningitis are both characterized by acute onset of fever,
headache, photophobia, neck stiffness, and often accompanied by nausea and vomiting. To
distinguish bacterial and viral meningitis identified by lumbar puncture examination.14
Symptoms of meningitis include fever, headache, meningism with or without consciousness,
lethargy, malaise, seizures, and vomiting, for disease severity can be seen from the low GCS
(Glass Glow Coma Scale) value.13 The disturbance of consciousness experienced may be
decreased awareness or irritability. Also found prominent crowns, stiff neck, or meningeal
stimulation such as Bruzinski and Kernig, but in children aged less than 1 year may not
encounter signs of meningeal stimulation, and found seizures.13 There may also be an increase in
intracranial pressure.13
Obtain cloudy liquid or opalescence with None (-) (+) and Pandy (+) / (++).
Number of cells 100-10.000 / mm3 with predominant count of polymorphonuclear,
protein 200-500 mg / dl, glucose <40 mg / dl, gram staining, culture and resistance test.
In the early stages the number of cells can be normal with predominant lymphocytes.
When a previous antibiotic has been obtained, the picture may be nonspecific.13
Meningitis with negative CSS cultures will give the impression of having previous treatment
with antibiotics or enterovirus infection.15 CT scan with contrast or head MRI in severe cases or
suspected complications such as subdural empyema, hydrocephalus, and brain abscess). On
electroencephalography examination can be found general slowdown.13 The principle of
management is with empirical therapy, then adjusted to the results of culture and resistance
test.13 Antimicrobial therapy in bacterial meningitis should consist of ampicillin and cefotaxime
or ampicillin and gentamicin, unless it is likely to be staphylococcus, which is an indication for
vancomycin.15
Empirical antibiotic therapy:
Age 1 - 3 months:
Ampicillin 200-400 mg / kgBW / day IV divided into 4 doses + cefotaxime 200 - 300 mg
/ kgBW / day IV divided into 4 doses, or
Ceftriaxone 100 mg / kgBW / day IV divided into 2 doses
Age> 3 months:
If there is already a culture result then the antibiotic is adapted to the culture result.
Dexametasone 0.6 mg / kgBW / day IV divided into 4 doses for 4 days, dexametasone
injection was given 15 - 30 minutes before or at the time of administration of antibiotics.
The duration of treatment depends on the germs, generally for 10 - 14 days.13
Supportive:
The critical period of treatment of bacterial meningitis is day 3 and 4. Vital signs and
neurological evaluation should be done regularly. To prevent vomiting and aspiration,
the patient should be firstly empowered at the beginning of the illness.
Head circumference should be monitored daily in children with large open crown.
Increased intracranial pressure, seizures and fever should be well controlled. Fluid
restriction or higher head position is not always done in every child with bacterial
meningitis.13
To monitor the side effects of high-dose antibiotic use serial peripheral blood tests, liver
function tests and renal function tests if indicated. For the growth of the patient, for hearing loss
as a symptom of bacterial meningitis present in 30% of patients, therefore the auditory function
test should be done immediately after returning home.13 Other residual symptoms such as mental
retardation, epilepsy, blindness, spasticity, and hydrocephalus. 13
Summary
It has been reported the case of Meningitis in 5 months 23 days boys. The diagnosis was
established from history taking (anamnesis), physical examination and laboratory finding.
During hospitalization, patient got empiric antibiotic (ceftriaxone) and paracetamol for suportif
to decrease the fever, and diet to maintain the nutrition (SGM milk or breast milk)
REFFERENCE
12. Alam A. Kejadian Meningitis Bakterialis pada Anak Usia 6-18 bulan yang Menderita
13. Pudjiadi H.A, Hegar B, Handryastuti S, Idris SN., Gandaputra PE., Harmoniati DE.
Pedoman Pelayanan Medis Ikatan Dokter Anak Indonesia. Jilid 1. Jakarta :Pengurus Pusat
and St Thomas’ NHS Foundation Trust, London SE1 7EH; 2008. p. 1-5.
15.Wahab S.A. Nelson Ilmu Kesehatan Anak. Edisi 15. Jakarta ; Buku Kedokteran EGC;
2013. p.655-656.
Predictive model to distinguish bacterial from aseptic meningitis in children in the post