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A ALIMENTARY TRACT & METABOLISM

A02 DRUGS FOR ACID RELATED DISORDERS
A02B DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX (GORD)
A02BA H2-RECEPTOR ANTAGONISTS
A02BA02 ranitidine
Ranitidine
Antiulcerant
INDICATIONS
Brand name INN
• Gastric ulcer
Ranitidine ranitidine hydrochloride • Duodenal ulcer
• Gastrooesophageal reflux disease (GORD)
ATC DDD Pregnancy • Erosive oesophagitis.
• Zollinger-Ellison syndrome and other related conditions
A02BA02 O, P 0,3 g B (systemic mastocytosis )
Form and package Lactation • Other conditions where is hyperacidity important
disturbance for patient
Film coated tablets 20 x 150 mg Unknown effects on infants • Bleeding from upper part of digestive tract (only for
eff. tablets 20 x 150 mg exposed. No evidence of
parenteral form)
inj. 5 x 50 mg/2 ml harmfulness. Excreted into milk.
A02BA03 famotidine
Famotidine
H2-receptor antagonist
INDICATIONS
Brand name INN
• Gastric and duodenal ulcers
Famotidine famotidine • Reflux oesophagitis
• Zollinger-Ellison syndrome
ATC DDD Pregnancy
• Non-ulcus dyspepsia
A02BA03 O, P 0,04 g B
Form and package Lactation
Film coated tablets 30 x 20 mg Caution, the lowest excretion

film coated tablets 30 x 40 mg of all H2-receptor antagonists
A02BC PROTON PUMP INHIBITORS

A02BC01 omeprazole
Omeprazol
proton pump inhibitor
• treatment of duodenal and peptic ulcers resulting from the

Brand name INN
use of NSAIDs
Omeprazol omeprazole • prevention of peptic and duodenal ulcers in patients on
NSAIDs who are at risk
ATC DDD Pregnancy
• treatment of reflux oesophagitis
A02BC01 O 20 mg C • long-term therapy in patients with healed reflux
oesophagitis
• treatment of symptomatic gastro-oesophageal reflux
gastroresistant capsules 14 x 20 mg It is excreted into disease
gastroresistant capsules 15 x 20 mg breast milk, avoid • treatment of Zollinger-Ellison syndrome
Children (over 1 year and BW ≥ 10 kg):
INDICATIONS • treatment of reflux oesophagitis
Omeprazole gastroresistant capsules are indicated for: • symptomatic treatment of heartburn and regurgitation of
Adults: acid in gastro-oesophageal reflux disease
• treatment of duodenal ulcer Children (over 4 years) and adolescents
• prevention of relapse of duodenal ulcers • In combination with antibiotic treatment of duodenal ulcers
• treatment of peptic ulcers caused by H. pylori
• prevention of relapse of peptic ulcers
• treatment of peptic ulcers caused by Helicobacter pylori (H.
pylori) in combination with an appropriate antibiotic
A02BC03 lansoprazole
Sabax
proton pump inhibitor
INDICATIONS
Brand name INN
• Gastrooesophageal reflux
Sabax lansoprazole • Benign gastric ulcus
• Duodenal ulcer
ATC DDD Pregnancy
• Dyspepsia with hyperacidity
A02BC03 O 30 mg B • Therapy and prophylaxis of ulcus associated with long
term use of NSAID
• Hypersecretory conditions including Zollinger-Ellison
capsules 28 x 15 mg Potential toxic. Possible syndrome
capsules 14 x 30 mg suppression of gastric • Reflux oesophagitis
secretion
• Helicobacter pylori eradication (in combination with
appropriate antibiotics)
Laktuloza
Osmotic laxative
INDICATIONS
Brand name INN
• Chronic constipation.
Laktuloza lactulose • Hepatic encephalopathy (portal encephalopathy);
hepatic coma.
ATC DDD Pregnancy
A06AD11 O 6,7 g B
Bottle with 200 ml syrup Can be used.

Bottle with 500 ml syrup
A10B ORAL ANTIDIABETICS (drugs which lowered glucose level in blood)

A10BA BIGUANIDE ANTIDIABETICS
A10BA02 metformin
Gluformin
oral antidiabetic
INDICATIONS
Brand name INN
• Noninsulin-dependent diabetes mellitus (type II,
Gluformin metformin hydrochloride NIDDM), especially in overweight patients, whose
ATC DDD Pregnancy glucose metabolism are not adequately controlled with
diet and exercise.
A10BA02 O2g B
• For treating noninsulin-dependent diabetes mellitus
Form and package Lactation (Type II) in combination with sulfonylureas; strictly take
care about contraindications.
tablets 30 x 500 mg Avoid
tablets 30 x 1000 mg In patients with normal body weight and NIDDM, Gluformin
can used like monotherapy, or in combination with
sulphonylurea antidiabetics, and on this way is possible
to avoid use of insulin. Gluformin also might be combined
with insulin. It is very important that through therapy with
Gluformin, body weight not enlarged; in some cases body
weight can to fall off.
A10BB SULPHONYLUREA ANTIDIABETICS

A10BB09 gliclazide
Diprian
oral antidiabetic
INDICATIONS
Brand name INN
• Noninsulin-dependent diabetes mellitus (type II,
Diprian gliclazide NIDDM) in adults, whose glucose metabolism are not
adequately controlled with diet.
ATC DDD Pregnancy
A10BB09 O 0,16 g C
Reguly
oral antidiabetic
INDICATIONS
Brand name INN
Repaglinide is indicated in patients with type II diabetes
Reguly repaglinide (insulin-independent diabetes mellitus) whose hyperglycaemia
can no longer satisfactorily controlled regime of diet, weight
ATC DDD Pregnancy
loss and physical activity.
A10BX02 O 4 mg C Repaglinide in combination with metformin, is also indicated
in patients with type II diabetes whose blood glucose is not
properly regulated using only metformin.
tbl. 30 x 0,5 mg Begin therapy in addition to diet and physical activity, and
tbl. 30 x 1 mg No data, avoid adjust to meal.
tbl. 30 x 2 mg
B BLOOD AND FORMING ORGANS, DRUGS FOR TREATMENT OF DISEASES OF BLOOD AND FORMING ORGANS
B01 ANTITHROMBOTIC DRUGS (ANTICOAGULANTS)
B01A ANTITHROMBOTIC DRUGS (ANTICOAGULANTS) B01AC INHIBITORS OF THROMBOCYTES AGGREGATION, EXCLUDING HEPARINE
B01AC04 clopidogrel
Clopidix
Inhibitor of thrombocytes aggregation
INDICATIONS
Brand name INN
Clopidogrel is used in adults for the prevention
Clopidix clopidogrel atherotrombotic events:
- Patients who have had a myocardial infarction (from a few up
ATC DDD Pregnancy
to 35 days), ischemic stroke (between 7 days to a maximum of
B01AC04 O 75 mg B 6 months) or have a confirmed peripheral artery disease.
- In patients with acute coronary syndrome:
- Acute coronary syndrome without ST-segment elevation
film-coated tablets 28 x75mg Avoid (unstable angina or nonQ myocardial infarction), including
patients with stents after percutaneous coronary intervention,
in combination with acetylsalicylic acid.
- Acute myocardial infarction with ST-segment elevation, in
combination with aspirin in patients who have conditions for
treatment with thrombolytics.
B01AC05 ticlopidine
Ticlodix
Inhibitor of thrombocytes aggregation
Brand name INN

INDICATIONS
Ticlodix tablets used in the secondary prophylaxis of
Ticlodix ticlopidine thromboembolic complications:
ATC DDD Pregnancy • Cerebrovascular disease,
B01AC05 O 0,5 g B • Ischemic heart disease,
• Peripheral arterial disease with claudication,
• After coronary artery bypass
film tablets 30 x 250 mg Avoid • In patients on hemodialysis with arteriovenous cannula,
• Surgical procedures using the extracorporeal circulation.
Ticlodix should be used in patients who can not use aspirin
(Ticlodix use is related to the manifestation of life-threatening
side effects of blood dyscrasia, including thrombotic
thrombocytopenic purpura – TTP).
B03 ANTI-ANAEMIC PREPARATIONS • Treatment of severe anaemia of renal origin accompanied by clinical
B03X OTHER ANTI-ANAEMIC PRODUCTS symptoms in adult patients with renal insufficiency not yet undergoing
B03XA OTHER ANTI-ANAEMIC PRODUCTS dialysis.
B03XA01 epoetinum zeta
• Treatment of anaemia and reduction of transfusion requirements in
adult patients receiving chemotherapy for solid tumours, malignant
Eqralys lymphoma or multiple myeloma, and at risk of transfusion as assessed
Epoetinum zeta by the patient’s general status (e.g. cardiovascular status, pre-existing
anaemia at the start of chemotherapy).
Brand name INN
• Eqralys can be used to increase the yield of autologous blood from
Eqralys epoetinum zeta patients in a predonation programme. Its use in this indication must
ATC DDD Pregnancy be balanced against the reported risk of thromboembolic events.
Treatment should only be given to patients with moderate anaemia
B03XA01 P 1000 I.U. C No data available (haemoglobin (Hb) 10-13 g/dl [6.2-8.1 mmol/l], no iron deficiency),
Form and package Lactation if blood saving procedures are not available or insufficient when the
scheduled major elective surgery requires a large volume of blood (4 or
solution for injection 10000 I.U./1ml more units of blood for females or 5 or more units for males).
solution for injection 20000 I.U./0,5ml
solution for injection 30000 I.U./0,75ml Avoid,
solution for injection 6 x 1000 I.U./0,3ml no data available • Eqralys can be used to reduce exposure to allogenic blood transfusions
solution for injection 6 x 2000 I.U./0,6ml in adult non iron deficient patients prior to major elective orthopaedic
solution for injection 6 x 4000 I.U./0,4ml surgery, having a high perceived risk for transfusion complications.
Use should be restricted to patients with moderate anaemia (e.g. Hb
INDICATIONS 10 - 13 g/dl) who do not have an autologous predonation programme
available and with an expected blood loss of 900 to 1800 ml.
• Treatment of anaemia associated with chronic renal
failure in adult and paediatric patients on haemodialysis
and adult patients on peritoneal dialysis.
B05 SOLUTION FOR BLOOD SUBSTITUTE AND PERFUSION SOLUTIONS

B05A BLOOD AND KRV I SIMILAR SOLUTION
B05AA07 hydroxyethyl starch, sodium chloride

Hetasorb 6%
Hetasorb10%
plasma expander
INDICATIONS
Brand name INN
• Treatment and prevention of hypovolemia and shock after
Hetasorb 6% operations, injuries, infections and burns.
HAES , NaCl
Hetasorb 10 % • Normovolemic hemodilution.
ATC DDD Pregnancy • To compensate for the volume of cerebral disorders,
retinal and cochlear blood flow.
B05AA07 Not recomended
Inf.solution 500 ml Caution, Not

Inf. solution 500 ml enough data
B05B I.V. SOLUTIONS

B05BA SOLUTIONS FOR PARENTERAL NUTRITION
B05BA01 amino acids
Aminosol 10%
infusion solution
INDICATIONS
Brand name INN
Aminosol 10% infusion solution used together with fat
Aminosol 10% amino acids emulsions, electrolytes and carbohydrates as a part of partial
or total parenteral nutrition; for prophylaxis and therapy of
ATC DDD Pregnancy
protein and water loss in cases when the inability of enteral
B05BA01 C nutrition is present.
Infusion solution is indicated in severe gastroinestinal
diseases (ileus, peritonitis, malapsorption, bowel inflammation,
bottle 500 ml Avoid pancreatitis, enterocutaneous phystulas), hypercatabolic
status (traumas, burns, sepsis) and other diseases
(anorexia nervosa, malignant diseases), in preoperative and
postoperative period.
B05BA10 aminoacids, minerals
Aminosol 15%
infusion solution
INDICATIONS
Brand name INN
Aminosol 15% infusion solution used together with fat
Aminosol 15% amino acids emulsions, electrolytes and carbohydrates as a part of partial
ATC DDD Pregnancy
Aminosol 10% E
infusion solution
INDICATIONS
Brand name INN
Aminosol 10% E infusion solution used together with fat
Aminosol 10% E amino acids emulsions, electrolytes and carbohydrates as a part of partial
ATC DDD Pregnancy
B05BA.01 alanine, arginine, cysteine, phenilalanine, glycine, histidine, isoleucine, leucine, lysine, methionin, proline, serine,
acetate acid, threonine, triptophan, valine
Hepasol 8%
infusion solution
Brand name INN INDICATIONS

• Liver insufficiance with or without disturbances of
alanine, arginine, cysteine, phenilalanine,
glycine, histidine, isoleucine, leucine, cerebral functions (encephalopathy)
Hepasol 8 % • Hepatic coma or precomatous conditions.
lysine, methionin, proline, serine, acetate
acid, threonine, triptophan, valine
ATC DDD Pregnancy
B05A01 C
bottle 1 x 500 ml Avoid
B05BC SOLUTIONS PRODUCING OSMOTIC DIURESIS

B05BC01 mannitol
Mannitol
osmotic diuretic
INDICATIONS
Brand name INN
• Prevention of anuria after: incidental transfusion, large
Mannitol mannitol trauma, bleeding, surgery and burns
• Increased intracranial pressure: brain tumors, brain
ATC DDD Pregnancy
oedema, head injuries
B05BC01 P 40 g No data available • Increased intraocular pressure
• Poisoning with barbiturates and salicilates
• Heavy oedema, ascites caused by liver cirrhosys with
Mannitol 10 % bottle 500 ml Avoid use of saliuretics and aldosterone.
Mannitol 20 % bottle 250 ml • Hypoglicemic coma
B05C IRRIGATING SOLUTIONS

B05CX OTHER IRRIGATING SOLUTIONS
B05CX10 mannitol, sorbitol
Ispirol
For Flushing of the bladder
INDICATIONS
Brand name INN
• Ispirol is only used in urology to flush the bladder
Ispirol mannitol, sorbitol during transurethral resection of the prostate and other
transurethral procedures.
ATC DDD Pregnancy
B05CX10 C
Solution for external use (PVC bag) Caution

1 x 5000 ml (0,54%+2,70%)
C CARDIOVASCULAR SYSTEM
C01 CARDIAC THERAPY
C01B ANTI-ARRHYTHMICS, CLASS I AND III
C01BC Anti-arrythmics, group I C
C01BC03 propafenon
Propafen
anti-arrhythmic (class I C)

• All form of ventricular and supraventricular
Propafen propafenon
extrasystolas
ATC DDD Pregnancy
• Ventricular and supraventricular tachicardias and
C01BC03 O, P 0,3 g C tachiarrhythmias
Form and package Lactation • Wolff-Parkinson-White syndrome (WPW).
Film coated tablets 50 x 150 mg Avoid
Film coated tablets 50 x 300 mg
inj. 10 x 35 mg/10 ml
C01D VASODILATATORS USED IN CARDIAC DISEASES

C01DA ORGANIC NITRATES
C01DA05 pentaerithrityltetranitrate (pentanitrole)
Dilcoran 80
antianginic with prolonged action

• Long term therapy of ischaemic heart disease
Dilcoran 80 pentaerithrityltetranitrate
(pentanitrole) • Prophylaxis of angina pectoris
• Additional therapy: chronic cor pulmonare and chronic
ATC DDD Pregnancy
heart failure
C01DA05 O 0,12 g C
retard tablets 20 x 80 mg Avoid
C01DA14 isosorbide mononitrate
Monizol
antianginic (vasodilatator)

• Prophylaxis of angina pectoris attack
Monizol Isosorbide mononitrate
• Coronary arteries spasm removal (Prinzmetal angina)
ATC DDD Pregnancy
• Chronic heart failure
C01DA14 O 0,04 g C
tablets 30 x 20 mg
Avoid
tablets 30 x 40 mg
C02 ANTIHYPERTENSIVES
C02A CENTRALY ACTING ANTIADRENERGICS
C02AB METHYLDOPA
C02AB02 methyldopa
Methyldopa
Antihypertensive

• Hypertension of different ethiology (except
Methyldopa methyldopa
phaeochromocythoma).
ATC DDD Pregnancy
C02AB02 O1g B
Film coated tablets 20 x 250 mg Caution
C03 DIURETICS
C03B WEAK DIURETICS, EXCLUDING THIAZIDES
C03BA MONOCOMPONENT SULPHONAMIDE DIURETICS
C03BA11 indapamide
Indapres
Diuretic

• Arterial hypertension (mild to moderate, like
Indapres indapamide
monotherapy, or in combination with other
ATC DDD Pregnancy
antihypertensives)
C03BA11 O 0,0025 g B • Water and electrolytes retention (oedema in congestive
Form and package Lactation heart diseases).
tablets 30 x 2,5 mg Avoid
Indapres SR
diuretic

• Therapy and control of essential hypertension.
Indapres® SR indapamide
ATC DDD Pregnancy
C03BA11 O 0,0025 g B
Film coated retard tablets 30 x 1,5 mg Avoid
C03E POTASSIUM-SPARING AGENTS WITH OTHER DIURETICS

C03EA THIAZIDES AND POTASSIUM-SPARING DIURETICS
C03EA01 PRODUCTS WHICH CONTENTS CORTICOSTEROIDS
C03EA01 hydrochlorothiazide, amiloride hydrochloride
Hemopres
diuretic combination

• Arterial hypertension
Hemopres hydrochlorothiazide,amiloride
hydrochloride • Congestive heart failure with hypokaliemia
• Liver cirrhosys with ascites
ATC DDD Pregnancy
C03EA01 O (0,05+0,005)g D
tablets 40 (50+5) mg Avoid
C04AE ERGOT ALCALOIDS

C04AE01 ergoloid mesilate (dihydroergotoxine)
Redizork
Vasodilatator

• Senile cerebral insufficiency
Redizork dihydroergotoxine
• Acute ischaemic stroke
ATC DDD Pregnancy
• Status after apoplectic stroke or traumatic brain
C04AE01 O, P 0,003 g X damage.
Form and package Lactation • Hypertension in older persons, in patients with
tablets 20 x 1,5 mg cerebrovascular insufficiency
Avoid
tablets 20 x 4,5 mg
C07 BETA-BLOCKING AGENTS

C07A BETA-BLOCKING AGENTS
C07AB SELECTIVE BETA-BLOCKING AGENTS
C07AB02 metoprolol
Presolol
beta1 receptors blocker
Brand name INN

INDICATIONS
Presolol metoprolol tartrate
• Hypertension
ATC DDD Pregnancy
• Angina pectoris
C07AB02 O, P 0,15g C, D in 2nd and 3rd trimester • Myocardial infarction and secondary prevention of
Form and package Lactation myocardial infarction
f. c. tablets 30 x 100 mg Caution • Arrhythmias (supraventricular tachiarrhytmias)
f. c. tablets 28 x 50 mg • Hyperthireoidism (like additional therapy)
f. c. tablets 56 x 50 mg • Prevention of migraines
inj. 5 x 5ml/5mg
• Chronic heart failure
Tensec
selective blocator beta adrenergic receptors
Brand name INN INDICATION

• Hipertension
Tensec bisoprolol
• Chronic stable angina pectoris.
ATC DDD Pregnancy
C07AB07 O 10 mg C
film tablets 30 x 5 mg Caution, excreted in
film tablets 30 x 10 mg milk
Tensec Plus
selective blocator beta adrenergic receptors with thiazides

• Essential hypertension
Tensec Plus Bisoprolol, HCTZ
• The fixed combination is indicated in patients in whom
ATC DDD Pregnancy
blood pressure is not adequately controlled by the individual
C07BB07 C components - bisoprolol and hydrochlorothiazide.
film tablets 30 x (5 mg+12,5 mg) Caution, excreted in milk
C07AG BLOCATORS OF ALPHA AND BETA ADRENERGIC RECEPTORS

C07AG02 carvedilol
Milenol
alpha and beta blocker
Brand name INN

INDICATIONS
Milenol carvedilol
• Mild to moderate arterial hypertension
ATC DDD Pregnancy
• Angina pectoris
C07AG02 O 0,0375 g C • Chronic heart failure
tablets 28 x 12,5 mg
Avoid
tablets 28 x 25 mg
C08 CALCIUM ANTAGONISTS

C08C SELECTIVE CALCIUM ANTAGONISTS WITH DIRECT ACTION ON HEART
C08CA DIHYDROPIRIDINE DERIVATES
C08CA01 amlodipine
Vazotal
calcium antagonist

Vazotal amlodipine
• Stable, chronic angina pectoris
ATC DDD Pregnancy
• Vasospastic angina Prinzmetal type
C08CA01 O 0,005 g C
tablets 20 x 5 mg
Avoid
tablets 20 x 10 mg
Cornelin
calcium antagonist

• Mild to moderate essential arterial hypertension
Cornelin lercanidipine
ATC DDD Pregnancy
C08CA13 10 mg O B
film tablets 28 po 10 mg Avoid, low concentration
film tablets 28 po 20 mg recorded in milk
C08D SELECTIVE CALCIUM ANTAGONISTS WITH DIRECT ACTION ON HEART

C08DA PHENYLALKILAMINE DERIVATES
C08DA01 verapamil
Verapamil
calcium antagonist

• Angina pectoris (all types)
Verapamil verapamil hydrochloride
• Arrythmias (chronic flutter and supraventricular
ATC DDD Pregnancy
fibrilation)
C08DA01 O 0,24 g C • Prophylaxis of paroxismal supraventricular tachycardias
Form and package Lactation • Essential hypertension
Film coated retard tablets 30 x 40 mg Caution, excretion in milk
film coated retard tablets 50 x 80 mg
Cortiazem retard
calcium antagonist

• Chronic treatment of arterial hypertension
Cortiazem retard diltiazem
• Chronic treatment of coronary artery disease
ATC DDD Pregnancy
• Prophylaxis of angina pectoris
C08DB01 O 0,24 g C • Vasospastic angina (Prinzmetal’s angina)
Form and package Lactation • Angina pectoris in the situation after myocardial
Retard tablets 30 x 90 mg Avoid infarction
• Non Q infarct
C09 AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM

C09A ACE INHIBITORS, PLAIN
C09AA ACE INHIBITORS, PLAIN
C09AA01 captopril
Zorkaptil
ACE inhibitor

• Arterial hypertension (monotherapy or in combination
Zorkaptil captopril
with thiazide diuretics)
ATC DDD Pregnancy
• Congestive heart failure (with cardiotonics and
C09AA01 O 0,05g D diuretics)
Form and package Lactation • Myocardial infarction
tablets 40 x 12,5 mg • Diabetic nephropathia.
tablets 40 x 25 mg Caution
tablets 40 x 50 mg
C09AA05 ramipril
Prilinda
ACE inhibitor
INDICATIONS
Brand name INN
• Essential hypertension (mild to moderate)
• Congestive heart failure
Prilinda ramipril
• Congestive heart failure after acute myocardial infarction
ATC DDD Pregnancy • Prophylaxis: reducing the risk of myocardial infarction,
stroke or cardiovascular death or need for revascularization
C09AA05 O 2,5 mg C, D in 2. and 3. trimester procedures in patients with clinically proven cardiovascular
disease (with or without previous MI), stroke or peripheral
Form and package Lactation vascular disease
• Prophylaxis: reducing the risk of myocardial infarction,
Tablets 28 x 2,5 mg Not enough data, it is stroke or cardiovascular death or need for revascularization
Tablets 28 x 5 mg probably in the milk
procedures in diabetic patients with clinically proven
previous cardiovascular disease
• The initial non-diabetic or diabetic nephropathy
• Manifest non-diabetic or diabetic nephropathy
C09AA02 enalapril
Prilenap
antihipertensive

Prilenap enalapril maleate
• Congestive heart failure.
ATC DDD Pregnancy
C09AA02 O 0,01 g D
tablets 20 x 20 mg
C09B ACE INHIBITORS, COMBINATION

C09BA ACE INHIBITORS AND DIURETICS
C09BA02 enalapril, hydrochlorothiazide
Prilenap HL, Prilenap H

antihipertensive

• All forms of essential hypertension, when combined
Prilenap HL, Prilenap H enalapril, hydrochlorothiazide
therapy is necessary
ATC DDD Pregnancy
C09BA02 D
tablets 20 x (10+12,5) mg Avoid
tablets 20 x (10 + 25) mg
C09AA06 quinapril
Hemokvin
ACE-ihibitor

Hemokvin quinapril
• Heart failure
ATC DDD Pregnancy
• Myocardial infarction
C09AA06 O, P, 0,015 g C (D in 2. and 3. trimester)
film tablets 20 po 10 mg
Caution
film tablets 20 po 20 mg
C09BA06 quinapril, hydrochlorothiazide
Hemokvin plus
quinapril, hydrochlorothiazide

Hemokvin Plus is indicated for the treatment of all forms of
quinapril,
Hemokvin plus essential hypertension, when needed combination therapy (for
hydrochlorothiazide
patients whose blood pressure was previously not normalized
ATC DDD Pregnancy
with individual ingredients of the preparation).
C (D in 2. and 3.
C09BA06 O 2,5 mg
trimester)
Film tabletas 20 x (20,0+12,5 mg) Caution
C09AA08 cilazapril
Zobox
ACE inhibitor

• Therapy of hypertension
Zobox cilazapril
• Therapy of congestive heart failure ( in combination with
ATC DDD Pregnancy
digitalis and/or diuretics).
C09AA08 O 2,5 mg D
Film coated tablets 30 x 2,5mg Avoid. Not enough data in
Film coated tablets 30 x 5mg literature
C09C ANGIOTENSIN II RECEPTOR ANTAGONISTS, PLAIN

C09CA ANGIOTENSIN II RECEPTOR ANTAGONISTS, PLAIN
C09CA01 losartan
Erynorm
angiotensin II receptor antagonist
INDICATIONS
Brand name INN
• Hypertension
Erynorm losartan • Hypertensive patients with left ventricular hypertrophy
(In hypertensive patients with left ventricular hypertrophy
ATC DDD Pregnancy
a reduced risk of stroke was demonstrated. The data do
C (D in 2nd and 3rd trimester). When not support the use of losartan for this indication in black
C09CA01 50 mg O pregnancy is detected, losartan should patients)
be discontinued as soon as possible.
• Renal protection in type 2 diabetic patients with
Form and Package Lactation nephropathy (macroalbuminuria)
(Losartan delays the progression of renal disease as measured
Because of the potential for adverse
Film coated tablets 28 x 50 mg by a reduction in the combined incidence of doubling of serum
effects on the nursing infant, losartan
should be avoided creatinine, end stage renal disease (need for dialysis or renal
transplantation) or death; and to reduce proteinuria)
Irbenida
angiotensin II receptor antagonist
INDICATIONS
Brand name INN
• Irbesartan is used in the treatment of
Irbenida irbesartan • essential hypertension
• diabetic nephropathy in patients with hypertension and
ATC DDD Pregnancy
type 2 diabetes as part of the antihypertensive regimen
C09CA04 O 0,15 g C (first trimester), D
Form and Package Lactation
f.c. tbl. 30x 150 mg

Avoid
f.c. tbl. 30 x 300 mg
C09DA01 losartan potassium + hydrochlorothiazide
Erynorm plus
angiotensin II receptor antagonist, hydrochlorothiazide
INDICATIONS
Brand name INN
• Erynorm plus tablets are indicated for the treatment of
Erynorm plus
losartan-potassium, hypertension in patients whose blood pressure can not
hydrochlorothiazide be adequately controlled individually applied losartan or
ATC DDD Pregnancy hydrochlorothiazide
C, D in the second and 3 trimester.

C09DA01 1 tablets Discontinue drug if pregnancy is estab-
lished
Film-coated tablets
Potentially toxic to children. Avoid it.
28 x (50 mg+12,5 mg)
C09DA04 irbesartan+hidrohlorotiazid
Irbenida plus
angiotensin II receptor antagonist, hydrochlorothiazide
INDICATIONS
Brand name INN
• It is used in the treatment of essential hypertension.
Irbenida plus Irbesartan, hydrochlorothiazide • This fixed combination is intended for adults whose blood
pressure is not adequately regulated using only irbesartan
ATC DDD Pregnancy
or hydrochlorothiazide only.
C09DA04 C(first trimester), D
f.c. tbl. 30x (150 mg+12,5 mg)

Avoid
f.c. tbl. 30x (300 mg+12,5 mg)
C10 LIPID MODIFYING AGENTS (HYPOLIPEMICS)

C10A LIPID MODIFYING AGENTS, PLAIN
C10AA HMG CoA REDUCTASE INHIBITORS
C10AA01 simvastatin
Cholipam
Hypolipemic

• Hyperlipidemia Type IIa, IIb and III
Cholipam simvastatin
• Coronary heart disease (primary and secondary
ATC DDD Pregnancy
prevention).
C10AA01 O 0,015g X
Film coated tablets 20 x 10mg Avoid
film coated tablets 20 x 20mg
C10AA05 atorvastatin
Hipolip
Hypolipemic
Brand name INN 10 years with primary hypercholesterolemia, including family

hypercholesterolemia (heterozygous form) and combined (mixed)
Hipolip atorvastatin
hyperlipidaemia (corresponding types IIa and IIb according
ATC DDD Pregnancy
Fredrickson classification), when not achieved the desired
C10AA05 O 20 mg X response to diet and other non-pharmacological measures.
Form and Package Lactation In addition, atorvastatin is indicated for the reduction of elevated
F.c. tablets 30 x 10 mg Contraindicated. There are total cholesterol and LDL cholesterol in adults with homozygous
F.c. tablets 30 x 20 mg potentially serious adverse familiar hypercholesterolemia, in addition to other lipid-lowering
F.c. tablets 30 x 40 mg effects treatments (eg LDL apheresis) in situations where these
F.c. tablets 30 x 80 mg
treatments are not available.
Prevention of cardiovascular disease
Prevention of cardiovascular events in adult patients who have a
INDICATIONS high estimated risk of first cardiovascular events, with correction
Hypercholesterolemia of other risk factors.
Atorvastatin is indicated as an adjunct to diet to reduce
elevated total cholesterol, LDL-cholesterol, apolipoprotein B, and
triglyceride levels in adults, adolescents and children older than
G GENITO URINARY SYSTEM AND SEX HORMONES (DRUGS FOR THE TREATMENT OF GENITO
URINARY SYSTEM AND SEX HORMONES)
G02 OTHER GYNECOLOGICALS
G02A OXYOTOCICS
G02AB ERGOT ALKALOIDS
G02AB01 methylergometrine
Methylergometrine
Uterotonic

• Postpartum and postabortion haemorrhage,
Methylergometrine methylergometrine
haemorrhage after cesarean section, menorrhage,
ATC DDD Pregnancy
metrorrhage, uterine atony.
G02AB01 O, P 0,0002g D
drops 10 ml ( 0,25 % mg/ ml ) Avoid,
amp. 50 x 0,1 mg / 1 ml possible inhibitory effect on
amp. 50 x 0,2 mg / 1ml prolactin secretion
G04 UROLOGICALS
G04BE Drugs used for erectile dysfunction
G04BE03 sildenafil
Sildena
Drugs used in erectile dysfunction

• Treatment of erectile dysfunction, which is the inability
Sildena sildenafil
to achieve or maintain penile erection required for
ATC DDD Pregnancy
satisfactory sexual activity.
G04BE03 O 50 mg X For the effect of sildenafil is required sexual stimulation
film tablets 1 x 25 mg Contraindicated
film tablets 1 x 50 mg
G04C DRUGS USED IN BENIGN PROSTATIC HYPERTROPHY

GO4CA ANTAGONISTS OF ALPHA-ADRENERGIC RECEPTORS
G04CA02 tamsulosin
Betamsal
Therapy of BPH

• Treatment of functional symptoms caused by benign
Betamsal tamsulosin
prostatic hyperplasia (BPH).
ATC DDD Pregnancy
G04CA02 O 0,4mg tamsulosin is solely
intended for use in men.
Hard caps. with modified release 30 x 0,4 mg tamsulosin is solely
intended for use in men.
G04CB TESTOSTERONE-5-ALPHA REDUCTASE INHIBITORS

G04CB01 finasteride
Zerlon
androgen synthesis inhibitor

• The treatment and control of benign prostatic hyperplasia
Zerlon finasteride
(BPH) in men with an enlarged prostate.
ATC DDD Pregnancy
G04CB01 O 0,005 g X
Film coated tablets 30 x 5 mg Avoid
H SYSTEMIC HORMONAL PREPARATIONS EXCLUDING SEX HORMONES AND INSULINES

H02 CORTICOSTEROIDS FOR SYSTEMIC USE
H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
H02AB GLUCOCORTICOIDS
H02AB04 methylprednisolone
Lemod Depo
Corticosteroid
INDICATIONS
Brand name INN
• Rheumatoid arthritis and osteoarthritis
Lemod depo methylprednisolone • Bursitis, tendonitis, tenosynovitis, epicondylitis
• Localized neurodermatitis, hypertrophic lichen planus,
ATC DDD Pregnancy
necrobiosis lipoidica diabeticorum, lipoid necrosis,
H02AB04 O 0,0075 g; P 0,02 g B alopecia areata, systemic lupus erythematosus,
acute and chronic contact dermatitis and systemic
collagenosis
inj. depot 10 x 1 ml/40 mg Caution • Bronchial asthma and allergic rhinitis
tablets 20 x 4 mg • Acute exacerbations of multiple sclerosis
eff. tablets 20 x 16 mg
• Leukemias and lymphomas
Lemod Solu
Corticosteroid
INDICATIONS
Brand name INN • Severe or incapacitating allergic conditions
• Critical cardiovascular conditions (shock not responding to
Lemod Solu methylprednisolone standard treatment)
• Cerebral oedema, Tuberculous meningitis, acute
ATC DDD Pregnancy exacerbations of multiple sclerosis
• Endocrine and metabolic conditions (congenital adrenal
H02AB04 O 0,0075 g; P B hyperplasia, nonsuppurative thyroiditis, hypercalcemia
0,02 g associated with cancer)
• Rheumatic diseases, collagen disorders and ulcerative
Form and Package Lactation colitis
• Respiratory diseases (sarcoidosis, berylliosis, pulmonary
oedema, Loeffler’syndrome not manageable by other
inj. solu 15 x 20 mg with solvent
inj. solu 15 x 40 mg with solvent means).
Caution • Leukemias and lymphomas
inf. solu 1 x 125 mg with solvent
inf. solu 1 x 500 mg with solvent • Cytostatic-induced nausea and vomiting
• Acute severe exacerbations of lupus erythematosus,
exfoliative, contact dermatitis and generalized
neurodermatitis
• Organ transplant.
Lemod Solu – dabble-o-vial

Corticosteroid
Brand name INN • Dermatologic diseases - pemphigus, exfoliative dermatitis,

Lemod Solu – dabble-o-vial methylprednisolone bullous dermatitis herpetiformis, erythema multiforme, mycosis
ATC DDD Pregnancy fungoides, severe forms of psoriasis and seborrheic dermatitis
H02AB04 O 0,0075 g; P 0,02 g B • Gastrointestinal diseases - ulcerative colitis, Crohn’s disease
Form and Package Lactation • Respiratory tract diseases - fulminant or disseminated
lyophilisate for solution for injection with solvent for Caution tuberculosis (with appropriate antituberculous therapy),
parenteral use, 40 mg symptomatic sarcoidosis, Loeffler’s syndrome, diffuse
lyophilisate for solution for injection with solvent for
parenteral use, 125 mg
interstitial fibrosis
• Nervous system diseases - acute exacerbations of multiple
INDICATIONS sclerosis
Lemod- Solu is indicated for the treatment of conditions when • Inflammatory eye diseases - Uveitis, diffuse scleritis, deep
quick and intensive effect is needed, such as: parenchymatous keratitis, optic nerve neuritis, chorioretinitis,
• Allergic diseases and reactions - bronchial asthma, status sympathetic ophthalmia, herpes zoster ophthalmicus
asthmaticus, angioneurotic oedema, anaphylaxis, serum • Lymphomas and leukemias - As a component of complex
sickness, atopic dermatitis therapeutic protocols
• Rheumatic diseases - rheumatoid arthritis, posttraumatic • Renal diseases - Nephrotic syndrome without uremia,
osteoarthritis, bursitis, tendovaginitis, epicondilitis, fibrositis, idiopathic or in lupus erythematosus
psoriatic arthritis and gout, ankylosing spondylitis • Cerebral oedema - After injury, operation or as a consequence
• Collagenoses - systemic lupus erythematosus, acute of brain tumor
rheumatic carditis, systemic dermatomiositis • Organ transplant - Transplant rejection reactions
J ANTIINFECTIVES FOR SYSTEMIC USE

J01 ANTIBACTERIALS FOR SYSTEMIC USE
J01A TETRACYCLINES
J01AA TETRACYCLINES
J01AA02 doxycycline
Doksiciklin
Antibiotic
INDICATIONS
Brand name INN
• Acute and chronic gastrointestinal, respiratory and
Doksiciklin doxycycline urogenital tract, ENT and skin infections, caused by
strains susceptible to doxycycline
ATC DDD Pregnancy
• Rickettsial infections (typhus group, Q fever)
J01AA02 O 0,1g D • Chlamydial infections (limphogranuloma venerum,
nonspecific urethritis genitalne infections, pneumonia,
trachoma, inclusion conjunctivitis)
capsules 5 x 100 mg Avoid • Infections due to borrelia (borreliosis, recurrent fever)
• Infections due to mycoplasma (pneumonia, tularemia,
cholera)
• As an alternative drug in the treatment of gonorrhoea
and syphilis.
J01C BETA LACTAM ANTIBACTERIALS, PENICILLINS

J01CA PENICILLINS WITH EXTENDED SPECTRUM
J01CA04 amoxicillin
Amoksicilin
antibiotic

Amoxicillin is a broad spectrum antibiotic effect, which is
Amoksicilin amoxicillin
used in the treatment of infections (caused by susceptible
ATC DDD Pregnancy
microorganisms) upper respiratory tract, oral cavity, pharynx,
J01CA04 O1g B middle ear infections, lower respiratory tract, urinary tract
Form and Package Lactation infections (including gonorrhea), gastrointestinal tract
capsules 16 x 250 mg (including Salmonella infection), Lyme disease in children,
capsules 16 x 500 mg Caution infection of the skin and soft tissue infections, endocarditis
powder for syrup 100 ml (250 mg/5 ml) prophylaxis, eradication of Helicobacter pylori, as well as in
the treatment of other infections caused by microorganisms
sensitive to amoxicillin.
J01CE BETA LACTAMASE SENSITIVE PENICILLINS

J01CE30 benzylpenicillin, procaine benzylpenicillin
Pancillin
antibiotic
INDICATIONS
Brand name INN
PANCILLIN is indicated for the prophylaxis and treatment of
Pancillin benzylpenicillin, procaine infections caused by organisms susceptible to penicillin.
benzylpenicillin * Most commonly used for:
ATC DDD Pregnancy - Uncomplicated cases of pneumococcal pneumonia
- Streptococcal infections (tonsillitis, scarlet fever, sinusitis)
J01CE30 P 1,6 MIU B - diphtheria
Form and Package Lactation - gonorrhea
- syphilis
lio vial 50 x 800 000 i.u. Avoid For gonorrhea and syphilis cure only applies when the
sensitivity of the pathogen was confirmed.
* The prophylactic use before surgery on the head, neck,
mouth and on the cardiovascular system.
J01CR02 amoxicillin and clavulanic acid Infections of the upper-respiratory tract infections (sinusitis,
otitis media and recurrent tonsillitis). The most common causes
of these infections are Streptococcus pneumoniae, Haemophilus
Panklav influenzae, Moraxella catarrhalis and Streptococcus pyogenes.
Infection of the lower respiratory tract (especially in
Antibiotic
cases of acute exacerbation of chronic bronchitis and
bronchopneumonia). Common causes of these infections are
Brand name INN Streptococcus pneumoniae, Haemophilus influenzae, Moraxella
Panklav amoxicillin and clavulanic catarrhalis.
acid - Urogenital tract infections and abdomen, especially
ATC DDD Pregnancy cystitis (recurrent or complicated, but excluding
J01CR02 O1g B prostatitis), septic abortion, pelvic or puerperal sepsis and
Form and Package Lactation intraabdominal sepsis. Common causes of these infections
Film coated tablets 15 x (250+125) mg were Enterobacteriaceae (mostly Escherichia coli), and
Film coated tablets 20 x (500+125) mg Enterobacter species Staphylococcus saprophyticus.
powder for oral susp. 100 ml
Caution - Infections of skin and soft tissue infections (particularly
(125+31,25) mg/5 ml infections and cellulitis after bite animals and humans, as
powder for oral susp. 100 ml
well as severe dental abscesses with cellulitis). Common
(250+62,5) mg/5 ml
causes of these infections are Staphylococcus aureus,
Streptococcus pyogenes and Bacteroides species.
INDICATIONS
Panklav used in the short-term treatment of bacterial infections Mixed infections caused by organisms susceptible to amoxicillin,
in cases caused by bacteria that produce beta-lactamase and associated with microorganisms that produce beta-lactamase
are resistant to amoxicillin. In other cases, to consider the and who are sensitive to Panklav, can be treated with Panklav. In
application of amoxicillin. the treatment of such infections should not add some antibiotic
The combination of amoxicillin and clavulanic acid, beta- resistant to beta-lactamase.
lactamase inhibition has expanded spectrum activity and is
recommended in the treatment of:
J01CR02 amoxicillin and clavulanic acid
Panklav 2X
Antibiotic
INDICATIONS
Brand name INN
Panklav 2X is indicated for use in the treatment of infections in
Panklav 2X amoxicillin and adults and children:
clavulanic acid
• acute bacterial sinusitis (a certified diagnostic)
ATC DDD Pregnancy • acute inflammation of the middle ear (otitis media)
J01CR02 O1g B • acute exacerbation of chronic bronchitis (a certified diagnostic)
• community acquired pneumonia
• cystitis
Film coated tablets 14 x (875+125) mg
• pyelonephritis
powder for oral susp. 70 ml (400+57) mg/5 ml Caution
powder for oral susp. 140 ml (400+57) mg/5 ml • infections of the skin and soft tissues, particularly cellulitis,
animal bites, severe dental abscess with spreading cellulitis
• bone and joint infections, especially osteomyelitis.
It is necessary to take into account official recommendations on
the appropriate application of antibacterial drugs.
J01D OTHER BETA LACTAM ANTIBACTERIALS

J01DA CEPHALOSPORINS
J01DA01 cefalexin
Cefaleksin
Antibiotic

Cephalexin is indicated for the treatment of infections caused by
Cefaleksin cephalexin
susceptible bacteria:
ATC DDD Pregnancy
• Infections of the respiratory tract (tonsillitis, pharyngitis,
J01DA01 O2g B sinusitis, acute and chronic bronchitis, infections of
Form and Package Lactation • bronchiectasis)
capsules 16 x 250 mg • Otitis media
capsules 16 x 500 mg Caution • Infections of the skin, soft tissues, bones and joints
syrup 100 ml (250 mg/5 ml) • Infections of genito-urinary tract (acute prostatitis, cystitis,
pyelonephritis)
• Infection in the oral cavity.
respond to i.v. use of cefuroxime (750 mg) and metronidazole
(500 mg per 100 ml) for eight hours. In severe mixed infections
J01DC02 cefuroxime
may be indicated intravenous cefuroxime in larger doses (1500
mg) and metronidazole (500 mg per 100 ml) for eight hours.
Nilacef In the prophylaxis of postoperative infections (eg colorectal or
gynecological surgery) is indicated only a single dose of 1500 mg
Antibiotic
of cefuroxime and metronidazole (500 mg per 100 ml).
If necessary, they can be given two doses of 750 mg of
Brand name INN cefuroxime in combination with metronidazole.
Nilacef cefuroxime Na Indications include:
ATC DDD Pregnancy
J01DC02 O 0,5 g; P 3 g B • Respiratory infections (eg, acute and chronic bronchitis,
JKL Form and package Lactation bronchiectasis associated with infection, bacterial pneumonia,
0321971 inj. (powder for inj.) 1 x750 mg lung abscess, postoperative chest infection)
Compatible
0321972 inj. (powder for inj.) 1 x1500 mg • Infections of the ear, nose and throat (eg, sinusitis, tonsillitis,
pharyngitis)
INDICATIONS • Urinary tract infections (eg, acute and chronic pyelonephritis,
Cefuroxime is a bactericidal antibiotic of cephalosporin group, cystitis, asymptomatic bacteriuria)
which is resistant to most β lactamases and is active in a broad • soft tissue infections (eg, cellulitis, erysipelas, peritonitis and
spectrum of gram-positive and gram-negative microorganisms. It wound infections)
is used in the treatment of infections before identifying the cause, • bone and joint infections (eg, osteomyelitis, septic arthritis)
as well as infections caused by microorganisms sensitive to this • Gynaecological and obstetric infections (pelvic inflammatory
antibiotic. In addition, effective in the prophylaxis of postoperative disease)
infections in many operations. Cefuroxime may be used as • Gonorrhea (especially if they can not give penicillin)
monotherapy or, if necessary, together with aminoglycosides and • Other infections, including septicemia and meningitis
metronidazole, orally, parenterally or as a suppository. • Surgical prophylaxis (operations of abdomen, pelvis, heart and
In the case of the presence or suspected presence of mixed blood vessels, lung, esophageal, orthopedic procedures, in
aerobic and anaerobic infections (eg, peritonitis, aspiration which there is an increased risk of infection).
pneumonia, abscesses of lung, pelvic or brain), or if it is likely to
occur (eg colorectal or gynecological surgery) cefuroxime use in
combination with metronidazole . Most of these infections will
J01DD02 ceftazidime
Forcas
Antibiotic
• Gastrointestinal, biliary and abdominal infections
Brand name INN
• Infections of bones and joints
Forcas ceftazidime • Dialysis: infections associated with hemodialysis,
peritoneal dialysis and continuous ambulatory peritoneal
ATC DDD Pregnancy
dialysis (CAPD).
J01DD02 P4g B
JKL Form and package Lactation

In meningitis, before the ceftazidime monotherapy, to do
antibiogram. Ceftazidime may be used in the treatment of
0321600 inj. 1 x 1000 mg
Compatible infections with the pathogens resistant to other antibiotics,
0321601 inj. 1 x 500 mg including aminoglycosides and many cephalosporins. If
indicated, can be used in combination with aminoglycosides or
INDICATIONS other beta-lactam antibiotics, eg. with severe neutropenia or in
Ceftazidime is indicated in the treatment of infections caused combination with antianaerobe drugs if Bacteroides fragilis is
by a single cause, mixed infections caused by two or more suspected. Likewise, ceftazidime is indicated in perioperative
susceptible microorganisms and, generally, in the treatment of prophylaxis in transurethral prostatectomy.
serious infections, such as: In vitro combination of ceftazidime and aminoglycosides
• Respiratory infections showed additive effect, and in some strains tested and
• Infections of the ear, nose and throat synergy, which may be of importance in the treatment of
• Urinary tract infections patients with febrile neutropenia.
• Infections of skin and soft tissue
J01DA1 ceftriaxone
Azaran
Antibiotic

Ceftriaxone is indicated for the treatment of the following
Azaran ceftriaxone infections caused by susceptible microorganisms when
parenteral therapy is required:
ATC DDD Pregnancy • Pneumonia
• Septicemia
J01DA13 P2g B • Meningitis
• Infections of the bones, skin and soft tissue
Form and Package Lactation • infections in patients with neutropenia
• Perioperative prophylaxis of infections associated with surgical
powder for injections 50 x 1000 mg Caution procedures.
The treatment can be started before receiving confirmation of
infectious agents.
Adhere to the guidelines for the treatment of certain infections
and appropriate antibiotic
J01DE CEPHALOSPORINES IV GENERATION

J01DE01 cefepim
Cefim
IV generation cephalosporine
INDICATIONS
Brand name INN
Cefim is used in the treatment of moderate to severe and
severe infections caused by susceptible microorganisms. Here
Cefim cefepim
include:
ATC DDD Pregnancy • Lower respiratory tract infections including pneumonia and
bronchitis
J01DE01 2gP B • Uncomplicated and complicated urinary tract infections,
including pyelonephritis
Form and Package Lactation • Uncomplicated skin and soft tissue
• Complicated intra-abdominal infections, including
powder for injection or infusion 500 mg Allowed peritonitis and biliary tract infections (in combination with
powder for injection or infusion 1000 mg
metronidazole)
• Empirical therapy in patients with febrile neutropenia
Cefim used to prevent infections in intra-abdominal surgery (in
combination with metronidazole).
J01F MACROLIDES, LINCOSAMIDES AND STREPTOGRAMINS

J01FA MACROLIDES
J01FA01 erythromycin
Eritromicin
Antibiotic
• lower respiratory tract infections: tracheitis, acute and

Brand name INN chronic bronchitis, pneumonia (lobular pneumonia,
bronchopneumonia, primary atypical pneumonia),
Eritromicin erythromicin-ethylsuccinate bronchiectasis, Legionnaire’s disease.
ATC DDD Pregnancy • Ear infections: otitis media and external otitis, mastoiditis.
• Oral infections: gingivitis, Vincent angina.
J01FA01 O, P 1 g; O 2 g B • Eye infection: blepharitis.
Form and Package Lactation • Skin and soft tissue: ulcers and carbunculus, paronichia,
abscesses, pustules, impetigo, cellulitis, erysipelas.
Film coated tablets 20 x 250 mg Compatible • Gastrointestinal infections: cholecystitis, staphylococcal
enterocolitis.
• Prophylaxis: pre-and post-operative trauma, burns,
INDICATIONS rheumatic fever.
Therapy and prophylaxis of infections caused by bacteria • Other infections: osteomyelitis, urethritis, gonorrhea,
susceptible to erythromycin. syphilis, lymphogranuloma venerum, diphtheria,
• upper respiratory infections: tonsillitis, peritonsillar prostatitis, scarlet fever.
abscess, pharyngitis, laryngitis, sinusitis, bacterial
superinfection after influenza and the common cold.
against common and atypical respiratory pathogens.
Clarithromycin is indicated for the treatment of mild to
J01FA MACROLIDES moderately severe infections of the skin and soft tissues.
JO1FA09 clarithromycin Clarithromycin is recommended, along with a suppressor of acid
secretion omeprazole or lansoprazole in eradicating the bacteria
H. pylori in patients with duodenal ulcer.
Zymbaktar In vitro activity of clarithromycin showed the following organisms:
Antibiotic Gram-positive bacteria: Staphylococcus aureus (methicillin-
susceptible), Streptococcus pyogenes (Group A beta hemolytic
Brand name INN streptococcus), alpha hemolytic streptococci (viridans group);
Zymbaktar clarithromycin Streptococcus (diplococcus) pneumoniae; Streptococcus
ATC DDD Pregnancy
agalactiae; Listeria monocytogenes.
J01FA09 0,5 g O C, Avoid unless no alternative
Gram-negative bacteria: Haemophilus influenzae; Haemophilus
1gP present
Form and Package Lactation parainfluenzae; Moraxella (Branhamella) catarrhalis; Neisseria
Film coated tablets 14 x 250 mg Excreted in breast milk. Avoid gonorrhoeae; Legionella pneumophila; Bordetella pertussis;
Film coated tablets 14 x 500 mg Helicobacter pylori Campylobacter jejuni.
Granules for oral susp. 125 mg/100 ml Mycoplasma: Mycoplasma pneumoniae; Ureaplasma urealyticum.
Granules for oral susp. 250 mg/100 ml Other organisms: Chlamydia trachomatis; Mycobacterium avium;
Mycobacterium leprae.
INDICATIONS Anaerobes: Bacteroides fragilis sensitive to macrolides;
Clarithromycin film-coated tablets are indicated in adults and Clostridium perfringens; Peptococcus species
children older than 12 years. Peptostreptococcus species; Propionibacterium acnes.
Clarithromycin is indicated for the treatment of infections caused Clarithromycin is bactericidal against several bacterial
by susceptible micro-organisms. The indications include: strains. Among these organisms are Haemophilus influenzae;
Infection of the lower respiratory tract, eg acute and chronic Streptococcus pneumoniae; Streptococcus pyogenes;
bronchitis and pneumonia. Streptococcus agalactiae; Moraxella (Branhamella) catarrhalis;
-Infection of the upper respiratory tract, for example, sinusitis Neisseria gonorrhoeae; H. pylori and Campylobacter spp.
and pharyngitis. Clarithromycin is more active against H. pylori under conditions
Clarithromycin is appropriate to begin therapy community of neutral pH than at acidic pH.
acquired infections and it has been shown that in vitro active
J01FA10 azithromycin
Hemomycin
Antibiotic

Hemomycin azithromycin Azithromycin is indicated for the treatment of infections caused
ATC DDD Pregnancy by susceptible organisms:
J01FA10 O 0,3 g B • Upper respiratory tract infections: sinusitis, pharyngitis /
Form and package Lactation tonsillitis (as an alternative first line therapy) lower respiratory
capsules 6 x 250 mg tract infections: bacterial bronchitis, community acquired
powder for oral susp. 1 x 20 ml (200 mg/1 ml) pneumonia, if appropriate oral therapy
film coated tablets 3 x 500 mg • Acute otitis media
Avoid
powder for oral susp. 1 x 20 ml (100 mg/5 ml) • Uncomplicated skin and soft tissue (including erythema
powder for oral susp. 1 x 30 ml (200 mg/5 ml)
migrans)
inf. 500 mg
• uncomplicated urethritis and cervicitis caused by Chlamydia
trachomatis
• Genital ulcer (chancroid, ulcus molle) in men.
J01FF LINCOSAMIDES
J01FF01 clindamycin
Klindamicin
Antibiotic

Treatment of serious infections caused by organisms sensitive
Klindamicin clindamycin
to clindamycin.
ATC DDD Pregnancy
J01FF01 O 1,2 g; P 1,8 g B
inj. 10 x 2 ml/(150 mg/1 ml) Compatible
J01G AMINOGLYCOSIDE ANTIBACTERIALS

J01GB OTHER AMINOGLYCOSIDES
J01GB03 gentamicin
Gentamicin
Antibiotic
INDICATIONS
Brand name INN
• Urinary tract infections (complicated and recidive)
Gentamicin gentamicin • Respiratory tract infections
• Gastro-intestinal tract infections (including peritonitis)
ATC DDD Pregnancy
• Skin infections (including burns)
J01GB03 P 0,24 g D • Soft tissue and bone infection
• Septicemia (neonatal septicemia included)
• Serious bacterial infections due to unknown cause
inj. 10 x 80 mg/2 ml
Caution • Mixed infections
inj. 10 x 120 mg/2 ml
all the best :) hemofarm.com • Urinary tract Infections
• Gonococcal urethritis and cervicitis
• epididymis-orchitis including cases caused by the Neisseria
J01M QUINOLONE ANTIBACTERIALS gonorrhoeae
J01MA FLUOROQUINOLONES • Pelvic inflammatory disease, including those caused by the
J01MA02 ciprofloxacin Neisseria gonorrhoeae
Infections of the genital organs that are thought or known to be
Marocen caused by the Neisseria gonorrhoeae is very important to take into
account the local prevalence of resistance to ciprofloxacin and to
Antibiotic confirm susceptibility with appropriate microbiological tests.
Brand name INN
• Gastrointestinal infections (eg traveler’s diarrhea)
Marocen ciprofloxacin • Intra-abdominal infections
ATC DDD Pregnancy • Infections of the skin and soft tissue caused by Gram-negative
J01MA02 O 1 g; P 0,5 g C bacteria
Form and package Lactation • Necrotizing (malignant) otitis externa
Film coated tablets 10 x 250 mg • Infections of bones and joints
film coated tablets 10 x 500 mg Avoid • Treatment of infections in patients with neutropenia
inj. 5 x 100 mg/10 ml • Prophylaxis of infections in patients with neutropenia
• Prophylaxis of invasive infections due to Neisseria meningitidis
INDICATIONS • Pulmonary anthrax (after exposure prophylaxis and therapy)
Ciprofloxacin is indicated for the treatment of the following Children and adolescents
infections caused by susceptible bacteria. Before initiation of • Bronchopulmonary infections in cystic fibrosis caused by
therapy with ciprofloxacin should take into account available Pseudomonas aeruginosa
information on resistance to ciprofloxacin. • Complicated urinary tract infections and pyelonephritis
Adults • Pulmonary anthrax (after exposure prophylaxis and therapy)
• Infections of the lower respiratory tract caused by gram- If it is deemed necessary, ciprofloxacin can be used to treat
negative bacteria: exacerbation of chronic obstructive severe infections in children and adolescents.
pulmonary disease; broncho-pulmonary infections in cystic Treatment can start a physician experienced in the treatment of
fibrosis and bronchiectasis; pneumonia cystic fibrosis and / or severe infections in children and adolescents.
• Chronic suppurating otitis media
• Acute exacerbation of chronic sinusitis especially if it is caused
by gram-negative bacteria
J01MA12 levofloxacin
Forteca
Antibiotic
INDICATIONS
Brand name INN Levofloxacin is indicated for the treatment of adult patients with
mild to moderate infections caused by susceptible bacteria:
Forteca levofloxacin hemihydrate • Acute bacterial sinusitis (adequately diagnosed according
to national and /or local guidelines for the treatment of
ATC DDD Pregnancy respiratory infections)
• Acute bacterial exacerbation of chronic bronchitis
J01MA12 0,5 g O C (adequately diagnosed according to national and /or local
guidelines for the treatment of respiratory infections)
•community acquired pneumonia
•uncomplicated urinary tract infections
•Complicated urinary tract infections, including pyelonephritis
film tablets 10 x 250 mg Avoided, it excreted in milk
•Chronic bacterial prostatitis
•Infections of skin and soft tissue
Before prescribing levofloxacin to take into account the
recommendations of national and /or local guides on the
appropriate application of fluoroquinolones.
J01MB OTHER QUINOLONES

J01MB04 pipemidic acid
Pipem
Uroantiseptic
Brand name INN

INDICATIONS
Pipemidic acid is a urinary antiseptic used for the treatment
Pipem pipemidic acid of infections caused by microorganisms sensitive to pipemidic
ATC DDD Pregnancy acid:
J01MB04 O 0,8 g No data available • Acute and chronic infections of the lower urinary tract,
• Prevention of recurrent lower urinary tract infection,
• Vaginal infections
capsules 20 x 200 mg Avoid
J01X OTHER ANTIBACTERIALS

J01XX OTHER ANTIBACTERIALS
J01XX08 linezolid
Zenix
Antibiotic
Brand name INN

• Complicated skin and skin structure infections.
Linezolid is to be used only if it is proven or suspected
Zenix linezolid that infection is due to gram-positive bacteria. In
ATC DDD Pregnancy patients with infection due to gram-positive and gram-
J01XX08 O, P 1,2 g C. No data available negative bacteria, linezolid can be used only when
other therapeutic methods are not available and in
combination with drugs for gram-negative bacteria.
inf. solution 10 x 600 mg No data available Before starting treatment with Zenix it is necessary to have
information about gram-positive bacteria resistance to
INDICATIONS antibacterial drugs or to do antibiogram. Linezolid does not
Zenix is indicated in treatment of the following infections effect gram-negative bacteria. If it is proven or suspected that
caused by susceptible gram-positive bacteria: infection is due to gram-positive bacteria as well as gram-
• Nosocomial pneumonia negative bacteria, combined treatment with antibacterials that
• Community-acquired pneumonia effect gram-negative bacteria is necessary.
J02 ANTIMYCOTICS FOR SYSTEMIC USE Candiduria, mucocutaneous candidiasis and chronic atrophic
J02A ANTIMYCOTICS FOR SYSTEMIC USE oral candidiasis (oral thrush). The persons with normal immune
J02AC TRIAZOLE DERIVATIVES systems can be treated, and immunocompromised patients
J02AC01 fluconazole also.
•Dermatomycosis including tinea pedis, tinea corporis, tinea
Fluconal cruris, tinea versicolor and dermal candidiasis only in those
states where there is resistance to first-line therapy or if this
Antimycotic infections occur in immunocompromised patients.
•Systemic candidiasis including candidaemia, disseminated
Brand name INN
Fluconal fluconazole
candidiasis and other forms of invasive Candida infections. This
ATC DDD Pregnancy refers to the infection of peritoneum, endocardium, lungs and
J02AC01 O, P 0,2 g C urinary tract. The safest and Candida infections in patients with
Form and package Lactation malignancy, in patients in intensive care, as well as in patients
capsules 7x50mg Excretion in breast milk. It can be used receiving cytotoxic or immunosuppressive therapy.
capsules 1x150mg during lactation period only in children •cryptococcal infections, including cryptococcal meningitis and
with disseminated candidiasis infections of other sites (eg, lung, skin). With Fluconal can treat
people with normal immune systems, patients with AIDS, organ
INDICATIONS transplants and immunosuppresion of other origin. Fluconal
Fluconal is indicated for the treatment of the following can be used as maintenance therapy for relapse prevention of
conditions: cryptococcal infection in patients with AIDS.
•Genital candidiasis. Vaginal candidiasis, acute or recurrent. •Prevention of fungal infections in patients with
Candida balanitis. It is necessary to consider the treatment of immunodeficiency, who are at risk of neutropenia after
partners. cytotoxic chemotherapy or radiation therapy, including patients
•Mucosal candidiasis (oropharyngeal and oesophageal with bone marrow transplantation.
candidiasis, non-invasive bronchopulmonary infections,
Fluconal
antimycotic for systemic use
Brand name INN • Repeated occurrence of oropharyngeal or esopharyngeal

candidiasis in patients infected with HIV who are at high risk
Fluconal fluconazole
for relapse.
ATC DDD Pregnancy
• Prophylaxis of Candida infections in patients with prolonged
J02AC01 O, P 0,2 g C neutropenia (such as patients with hematological malignancies
Form and package Lactation who are undergoing chemotherapy or patients who have had a
inf. solution 2 mg/ml 100 ml Excretion in breast milk. It can be used transplant of hematopoietic stem cells.
during lactation period only in children Fluconazole is indicated in term neonates, infants, children and
with disseminated candidiasis adolescents under the age of 17 years:
Fluconazole is used to treat mucosal candidiasis (oropharyngeal,
INDICATIONS esophageal), invasive candidiasis, cryptococcal meningitis and
Fluconazole is indicated in adults for the treatment of: prophylaxis of Candida infections in immunocompromised
• cryptococcal meningitis. patients.
• coccidioidomycosis. Fluconazole can be used as a preventive therapy of cryptococcal
• Invasive candidiasis meningitis in children with high risk of recurrence.
• mucosal candidiasis, including oropharyngeal, esophageal Therapy can be started before the results of cultures and other
candidiasis, candiduria and chronic mucocutaneous laboratory analysis to be known, but, once these results become
candidiasis. available, anti-infective therapy should be adjusted to the results
• Chronic atrophic oral candidiasis (with the use of dentures) if oral obtained.
hygiene and topical therapy does not demonstrate efficacy. Should be considered official guidance on the appropriate use of
Fluconazole is indicated in adults for the prophylaxis of: antifungal drugs.
• The reappearance of cryptococcal meningitis in patients at high
risk of recurrence.
L ANTINEOPLASTIC AND IMMUNOMODULATING Docetaxel in combination with trastuzumab is indicated for

AGENTS the treatment of patients with metastatic breast cancer whose
L01CD02 docetaxel tumors over-express HER2, who had not previously received
chemotherapy for metastatic disease.
Docetaxel in combination with capecitabine, is indicated for the
Docetaxel HF treatment of patients with locally advanced or metastatic breast
cancer after failure of cytotoxic chemotherapy. Previous therapy
Antineoplastic
should include anthracycline.
Non-small cell lung cancer
Brand name INN Docetaxel is indicated for the treatment of patients with locally
Docetaxel HF docetaxel advanced or metastatic non small cell lung cancer after failure of
ATC DDD Pregnancy prior chemotherapy.
In combination with cisplatin, docetaxel is indicated for the
L01CD02 D
treatment of patients with unresectable, locally advanced or
Form and Package Lactation metastatic non-small cell lung cancer, in patients who have not
Concentrate and solvent for solution Breastfeeding is not previously received chemotherapy for this disease.
infusion, 20 mg/0,5 ml recommended Prostate Cancer
Concentrate and solvent for solution Docetaxel in combination with prednisone or prednisolone is
infusion, 80 mg/2 ml indicated for the treatment of patients with hormone-refractory
metastatic prostate cancer.
INDICATIONS Adenocarcinoma of the stomach
Breast cancer Docetaxel in combination with cisplatin and 5-fluorouracil
Docetaxel in combination with doxorubicin and is indicated for the treatment of patients with metastatic
cyclophosphamide is indicated for the adjuvant treatment of gastric adenocarcinoma, including adenocarcinoma of the
patients with operable node positive breast cancer. gastroesophageal coupling, which had not previously received
Docetaxel in combination with doxorubicin is indicated for chemotherapy for metastatic disease.
the treatment of patients with locally advanced or metastatic Head and neck cancers
breast cancer who have not previously received treatment with Docetaxel, in combination with cisplatin and 5-fluorouracil is
cytotoxic drugs to treat this disease. indicated for the induction treatment of patients with locally
Docetaxel as a single agent, is indicated for the treatment of advanced squamous cell carcinoma of the head and neck.
patients with locally advanced or metastatic breast cancer after
failure of prior cytotoxic therapy applied. Previous chemotherapy
should include anthracycline or alkylation agent.
L01XA03 oxaliplatin
Oxaliplatin HF
Antineoplastic

Oxaliplatin in combination with 5-fluorouracil (5-FU) and folinic
Oxaliplatin HF oxaliplatin
acid (FA) is indicated for:
ATC DDD Pregnancy
- Adjuvant treatment of colorectal cancer in clinical stage III
L01XA03 D (Duke’s C) after radical surgery;
Form and package Lactation - Treatment of metastatic colorectal cancer.
Powder for solution infusion 50 mg Contraindicated
Powder for solution infusion 100 mg
L02AB01 megestrol acetate
O’Tentika
Progestagen

O’Tentika used to treat anorexia or weight loss that is
O’Tentika megestrol acetate
caused by malignant disease (cachexia), or acquired
ATC DDD Pregnancy
immunodeficiency syndrome (AIDS) patients of both sexes.
L02AB01 0,16 g O C
oral suspension 40 mg/ml, 240 ml Avoided
L02BG03 anastrozole
Altravesa
Selective aromatase inhibitor

Altravesa anastrozole • Treatment of hormone receptor-positive advanced breast
ATC DDD Pregnancy cancer in postmenopausal women
L02BG03 O 1 mg X • Adjuvant therapy of hormone receptor-positive early
Form and package Lactation invasive breast cancer in postmenopausal women
F.c.-tbl. 28 x 1 mg Contraindicated • Adjuvant treatment of early invasive hormone receptor
positive breast cancer in postmenopausal women who
received adjuvant tamoxifen therapy 2 to 3 years
M MUSCULO-SKELETAL SYSTEM
M01 ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
M01A ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
M01AB ACETIC ACID DERIVATIVES AND RELATED SUBSTANCES
M01AB05 diclofenac
Diclofenac
Rapten Duo
Rapten K
non-steroid antiinflammatory drug, analgesic

Diclofenac diclofenac sodium
• Inflammatory and degenerative articular and
Rapten Duo
Rapten K diclofenac potassium extraarticular rheumatism (rheumatoid arthritis,
ATC DDD Pregnancy osteorthritis, juvenile rheumatoid arthritis, ankylosing
M01AB05 O,P,R 0,1 g C (D in 3rd trimester and in time of spondylitis, arthrosis and spondiloarthrosis, spondylosis,
baby delivery) periarthritis, tendovaginitis, fibrositis, myositis)
• Primary dysmenorrhea
retard tablets 20 x 100 mg • Acute uric arthritis
inj. 5 x 75 mg / 3 ml
supp. 10 x 25 mg Caution • Renal and biliar colic (parenteral use)
supp. 10 x 50 mg
tablets 30 x 75 mg
dragee 10 x 50 mg
Zodol
NSAID, analgesic
INDICATIONS
Brand name INN
Zodol is indicated for short-term treatment of moderate
Zodol ketorolac
and severe acute pain and may replace opioid analgesics
ATC DDD Pregnancy (postoperative pain, renal colic, orthopedic trauma, cancer
related pain).
M01AB15 O, P 0,03 g C (D in 3rd trimester)
Ketorolac is not used for the treatment of chronic pain
Form and package Lactation conditions.
F.c.-tbl. 10 x10 mg
Avoid
inj..5x30 mg/ml
M04 ANTIGOUT PREPARATIONS

M04A ANTIGOUT PREPARATIONS
M04AA PREPARATIONS INHIBITING URIC ACID PRODUCTION
M04AA01 allopurinol
• Clinical conditions which may give rise to the formation

Alopurinol of deposits of urate and uric acid are idiopathic gout,
antiuric (uricostatic) urolithiasis, acute uricosuric nephropathy, neoplasms
and myeloproliferative diseases with intense cellular
metabolic turnover, in which high levels of uric acid occur
Brand name INN spontaneously or after cytotoxic therapy, certain enzyme
disorders lead to increased production of uric acid (a
Alopurinol allopurinol disorder hypoxanthine-guanine phosphoribosiltransferase,
ATC DDD Pregnancy including Lesch-Nyhan syndrome, a disorder of glucose-6-
phosphatase involvement of the accumulation of glycogen
M04AA01 O, P 0,4 g C synthase phosphoribosilpyrophosphate disorder, disorder
Form and package Lactation phosphoribosilpyrophosphate amidotransferase, adenine
phosphoribosiltransferase disorder).
• Allopurinol is used to treat 2,8-dihydroxiadenine (2,8-
DHA) renal calculi due to decreased activity of adenine
phosphoribosiltransferase.
INDICATIONS • Allopurinol is used to treat re-mixed oxalate renal calculi in the
• Allopurinol is used for the reduction of the urate and uric acid presence of hyperuricosuria in cases where diet, increased
in states that already have deposits of urate and uric acid fluid intake, and similar measures have no effect.
(gout, nephrolithiasis), or there is the risk of these deposits
(malignancy therapy that could potentially cause acute
uricosuric nephropathy).
M05BA04 alendronic acid (in form of sodium salt)
Bonap
Bisphosphonate

• Post-menopausal osteoporosis (alendronate reduces the
Bonap Alendronic acid
risk of vertebral and hip fractures).
ATC DDD Pregnancy
M05BA04 10 mg O C
JKL Form and package Lactation
1059079 tablets 4 x 70 mg Avoided
N NERVOUS SYSTEM
N02 ANALGESICS
N02A OPIOIDS
N02AX OTHER OPIOIDS
N02AX02 tramadol
Trodon
opioid analgesic

Trodon tramadol Treatment of moderate to severe pain.
ATC DDD Pregnancy
N02AX02 O,P 0,3g C
capsules 20 x 50 mg
injections 5 x 50 mg/ ml
injections 5 x 100 mg/ 2 ml Avoid
N02CC03 zolmitriptan
Zolmitriptan
anti-migraine drug
Trade mark INN INDICATIONS

Zolmitriptan zolmitriptan Zolmitriptan is indicated for acute treatment of migrain with or
ATC DDD Pregnancy without aura.
N02CC03 O, 2,5 mg C
Oral dispersible tablets 3 x 2,5 mg
Caution
Oral dispersible tablets 6 x 5 mg
N03 ANTIEPILEPTICS
N03A ANTIEPILEPTICS
Eftil
Eftil retard
antiepileptic

Valproic acid + Eftil retard is used in children and adults as monotherapy or in
Eftil
Eftil retard
sodium valproate combination with other antiepileptic drugs in the treatment of:
• Generalized seizures: clonic and tonic seizures, tonic-
ATC DDD Pregnancy
clonic seizures (grand mal epilepsy), absence seizures
(petit mal seizures) and myoclonic seizures or atonic
N03AG01 O, P, R 1,5 g D
and Lennox-Gastaut syndrome.
• Partial epilepsy: partial seizures with or without
syrup 150 ml/5,764 g Caution
secondary generalization.
retard film tablets 30 x(145 + 333) mg
N03AX09 lamotrigin
Solaban
Antiepileptic
Brand name INN • As a complementary therapy of epilepsy: partial

Solaban Lamotrigin seizures, generalized seizures (attacks the primary and
ATC DDD Pregnancy secondary tonic-clonic seizures) and seizures in the
N03AX09 O 0,3 g C -All antiepileptic drugs Lennox-Gastaut syndrome in case of failure of treatment
are teratogenic but the with other antiepileptic drugs.
benefit of application is Children older than 2 years:
greater than the risk for • As a complementary therapy of epilepsy: partial
the fetus.
seizures and seizures in the Lennox-Gastaut syndrome.
Tablets for oral suspen. 30 x 5 mg Present in milk, 2) Bipolar affective disorder:
Tablets for oral suspen. 30 x 25 mg potentially toxic to Adults (over 18)
Tablets for oral suspen. 30 x 50 mg children, avoiding • The prevention of depressive episodes in patients with
Tablets for oral suspen. 30 x 100 mg breastfeeding bipolar affective disorder.
INDICATIONS Suggested use: For the treatment administered by a

Lamotrigine is indicated in the treatment of: neurologist, pediatric neurologist or a psychiatrist or physician
1) epilepsy: who knows the treatment of epilepsy and is especially
Adults and adolescents: qualified to treat the mentally handicapped patients, the
• In the monotherapy epilepsy: partial seizures and treatment in the department of neurology, psychiatry and
generalized seizures (attacks the primary and secondary mental disorders.
tonic-clonic seizures)
N04 ANTI-PARKINSON DRUGS

NO4BC DOPAMINE AGONISTS
NO4BC05 pramipexole
Panarak
Antiparkinsonic
INDICATIONS
Brand name INN
Pramipexol is indicated in adults for the treatment of signs and
Panarak pramipexole symptoms of idiopathic Parkinson’s disease as monotherapy
(without levodopa) or in combination with levodopa, ie.
ATC DDD Pregnancy
throughout the period of the disease until the late stages
N04BC05 O, 2,5 mg C when the effect of levodopa begins to deteriorate or become
unstable, leading to fluctuations of the therapeutic effect
(“end of dose” phenomenon or “on-off” fluctuations).
30 tablets x 0,18 mg
Avoided Pramipexol is indicated in adults for the symptomatic
30 tablets x 0,7 mg treatment of moderate to severe idiopathic restless legs
syndrome in doses of less than 0.54 mg pramipexol base
(0.75 mg pramipexol salt)
N05 Psycholeptics
n05AH dIAZEPINs, OxAZEPINS and ThIAZEPINs
N05AH03 olanzapine
Treana
Antipsychotic

Olanzapine is primarily used to treat schizophrenia.
Treana olanzapine
In patients who achieved a good initial response to therapy,
ATC DDD Pregnancy
olanzapine has proven effective in maintenance therapy and
N05AH03 O, P 10 mg C – Studies have shown control of symptoms of schizophrenia.
toxic effects on the fetus
Olanzapine is also indicated in the treatment of moderate to
Form and package Lactation severe episodes of mania.
Film tablets 30 x 5 mg Avoided, it excreted in milk In patients with bipolar disorder who have shown good initial
Film tablets 30 x 10 mg response to therapy, during manic episodes, olanzapine is
used to prevent recurrence of manic phase of illness.
NO5AX OTHER ANTIPSYHOTICS Risperidone is effective for maintenance therapy in patients who
N05AX08 risperidone have responded to the initial use of risperidone.
Risperidone-monotherapy is indicated for the short treatment of
Risperidon manic or mixed episodes associated with bipolar disorder.

Combination therapy-concomitant use with lithium or valproic
Antipsychotic acid is indicated for the short treatment of manic or mixed
episodes associated with bipolar disorder, manifesting itself
Brand name INN
as elevated mood, euphoric or irritable, agitation, grandiosity,
Risperidon risperidon
ATC DDD Pregnancy exaggerated self-esteem, decreased need for sleep, rapid
N05AX08 O 5 mg C – applied only if the potential speech, accelerated thoughts, reduced attention or judgment,
benefit outweighs the risk including highly active or hostile behavior.
Form and package Lactation Risperidone is indicated for the treatment of severe behavioral
film tablets 20 x 1 mg avoid it, no reliable data disorders in patients with dementia, such as aggressiveness (the
film tablets 20 x 2 mg verbal performances, as well as in psychiatric manifestations),
film tablets 20 x 3 mg disturbances of body movement (agitation, movements without
goal) or psychotic symptoms that lead patients to a state of
suffering, uncertainty themselves and the potential dangers of
INDICATIONS
self-harm. Such patients should be monitored carefully and use
Risperidone is indicated for the treatment of a wide spectrum of
the drug Risperidone continue only if the benefit is greater than
patients with schizophrenia, including the first episode psychoses,
the risk to the patient.
acute schizophrenic exacerbations, chronic schizophrenia
Risperidone is also indicated as an adjuvant therapy to mood
and other psychotic states with prominent positive symptoms
stabilizers in treating acute manic episodes in bipolar disorder.
(such as hallucinations, delusions, thought disorders, hostility,
Risperidone is indicated in the treatment disruptive behavioral
suspiciousness) and / or negative symptoms (indifference,
disorders in adults with limited social, academic and work
emotional and social withdrawal, the scarcity of speech).
functioning, and which are expressed in behavioral disorders
Risperidone also facilitates and affective symptoms associated
such as aggressiveness, impulsiveness and self-mutilation.
with schizophrenia (depression, guilt, anxiety).
N05B ANXIOLYTICS
N05BA BENZODIAZEPINE DERIVATIVES
N05BA01 diazepam
Diazepam
Anxiolytic

• Anxiety states (endogenous or general anxiety due to social
Diazepam diazepam
conflicts).
ATC DDD Pregnancy
• Insomnia due to anxiety (benzodiazepines are indicated
N05BA01 O 0,01 g D for the treatment of insomnia only in severe cases when
Form and package Lactation the condition interferes with normal functioning and
tablets 30 x 2 mg performance of daily activities).
tablets 30 x 5 mg Avoid • acute alcohol abstinence syndrome.
tablets 30 x 10 mg • Preparation for endoscopic examination and surgical
procedures.
• muscle spasms (including spasms in cerebral spasticity)
and the treatment of epilepsy.
• Night fears and somnambulism in children.
N05BA06 lorazepam
Lorazepam
Anxiolytic

Lorazepam is indicated:
Lorazepam lorazepam
ATC DDD Pregnancy • for short-term treatment of anxiety conditions that
N05BA06 O 0,0025 g D
lead to disability, including anxiety associated with
psychosomatic, organic or psychotic illness
tablets 30 x 1 mg • for short-term treatment of insomnia (sleeplessness)
Avoid associated with anxiety
tablets 20 x 2,5 mg
• in premedication before surgery or more extensive
dental procedures
N05BA08 bromazepam
Bromazepam
Anxiolytic

Bromazepam bromazepam • Treatment of anxiety. The drug is designed to treat
ATC DDD Pregnancy
serious disorders that interfere with their daily activities
and create serious problems for the patient.
N05BA08 O 0,01 g D
tablets 30 x 1,5 mg
Avoid
tablets 30 x 3 mg
tablets 30 x 6 mg
N05BA11 prazepam
Demetrin
Anxiolytic

Demetrin prazepam
• Prazepam is indicated in the treatment of anxiety
ATC DDD Pregnancy
disorders
N05BA11 O 0,03 g D
N05C HYPNOTICS AND SEDATIVES

N05CF02 zolpidem
Belbien
Short-acting hypnotic

• Short-term treatment of insomnia.
Belbien zolpidem
• Benzodiazepines and related drugs benzodiazepines
ATC DDD Pregnancy
are indicated only for severe disorders that deplete or
N05CF02 10 mg O B-applied only if necessary incapacitate the patient
film tablets 20 x 10 mg low concentrations present
in milk, avoid it
N06AB SELECTIVE SEROTONIN REUPTAKE INHIBITORS

N06AB03 fluoxetine
Flunisan
Antidepressive

Flunisan fluoxetine • Adults
ATC DDD Pregnancy • Major depressive episodes
N06AB03 O 0,02 g B • Obsessive Compulsive Disorders
Form and package Lactation • Bulimia nervosa: Flunisan is indicated as a supplement to
tablets 30 x 20 mg Avoid psychotherapy to reduce food intake and increased bowel
movements.
• Children and adolescents aged 8 and over
• Moderate to severe, major depressive episode, if
there is no improvement after 4-6 sessions depression
psychotherapy. Antidepressant therapy in children and
young adults with moderate and severe depression should
always be combined with psychosocial therapy.
N06AB06 sertraline
Sidata
Antidepressive
Brand name INN prevention of initial episodes of depression relapse or

re-occurrence of depressive episodes, including the
Sidata sertraline
associated symptoms of anxiety.
ATC DDD Pregnancy
• treatment of obsessive compulsive disorder. After a
N06AB06 O 50 mg X satisfactory therapeutic response, efficiency, safety and
Form and package Lactation tolerability of sertraline application is held up to 2 years
Film coated tablets 28 x 50 mg contraindicated of therapy for this disorder.
Film coated tablets 28 x 100 mg • treatment of panic disorder, with or without
agoraphobia.
INDICATIONS • treatment of social phobia. Upon satisfactory treatment
The use of SIDATA film-coated tablet is indicated in the response, continuation with sertraline therapy achieves
following cases: efficiency in preventing relapse of initial episodes of
• treatment of symptoms of depression, including social phobia.
depression accompanied by anxiety symptoms. After • treatment of post-traumatic stress syndrome.
a satisfactory therapeutic response, continuation • treatment of obsessive compulsive disorder in children
sertraline treatment efficiency is achieved in the older than 6 years.
N06AB10 escitalopram
Lata
Antidepressive

Escitalopram is used to treat:
Lata escitalopram
• major depressive episodes
ATC DDD Pregnancy
• panic disorder with or without agoraphobia
N06AB10 O, 10 mg C • Social phobia
Form and package Lactation • Obsessive-Compulsive Disorder
film tablets 28 x10 mg Excreted in milk, avoid it
N06D DRUGS FOR DEMENTION THERAPY

N06DA ANTICHOLINERGICS
N06DA02 donepezil chloride
Tregona
Drug for demention therapy
Brand name INN INDIKACIJE

• Symptomatic treatment of mild to moderate dementia
Tregona donepezil
of the Alzheimer type.
ATC DDD Pregnancy
N06DA02 O 7,5 mg C-Studies have shown toxic
effects on the fetus
film tablets 28 x 5 mg Avoid
N07 OTHER NERVOUS SYSTEM DRUGS

N07B DRUGS USED IN ADDICTION DISORDERS
N07BC DRUGS USED IN OPIOID DEPENDENCE
N07BC02 methadone
Metadon
synthetic narcotic analgesic

• Methadone is used to treat opiate addiction, as a
Metadon methadone
means of preventing the appearance of abstinence
ATC DDD Pregnancy
syndrome.
N07BC02 O, P 0,025 g C
drops 1 x 10 ml (10 mg/ ml) Caution
R RESPIRATORY SYSTEM
R DRUGS FOR TRETAMENT OF RESPIRATORY DISEASES
R03 drugs used in obstructive lung disease
R03AC12 salmeterole xinafoate
Serevent Inhaler CFC-Free

Antiasthmatic

Serevent Inhaler CFC-Free salmeterole xinafoate • Regular additional symptomatic treatment of reversible
ATC DDD Pregnancy
airways obstruction in patients with asthma, including
patients with nighttime symptoms, which are not adequately
R03AC12 O 100 mcg C
controlled with inhaled corticosteroids in accordance with
Form and package Lactation current therapeutic guides.
inhaler with a pressurized dispenser, 120x25 No data • Serevent Inhaler CFC-Free is used in the treatment of
µg/dose
chronic obstructive pulmonary disease (COPD) in the
prevention of exercise-induced asthma attacks.
R03B Other drugs used in obstructive lung disease, for inhalation

R03BA Glucocorticoids
R03BA01 beclomethasone dipropionate
Becloforte CFC-Free Inhaler

antiasthmatic
Brand name INN Adults

Becloforte CFC-Free Inhaler beclomethasone dipropionate Prophylaxis in:
ATC DDD Pregnancy • Mild asthma (PEF values above 80% predicted baseline
R03BA01 800 mcg C values, with variations of less than 20%) patients who
Form and package Lactation occasionally require symptomatic treatment of asthma with
inhaler with a pressurized dispens- No data bronchodilators.
er, 1 x 200 dose (250 µg/1 dose) • Moderate asthma (PEF values 60-80% predicted basal values,
ranging from 20-30%) patients who require regular use of
INDICATIONS drugs to treat asthma and patients with unstable asthma is
Severe asthma is a disease that can be fatal and requires getting worse despite the implementation of prophylactic
regular medical monitoring. Patients with severe asthma have therapy or bronchodilator alone.
constant symptoms and frequent exacerbations, with limited • Asthma (PEF values below 60% predicted baseline values,
lung capacity and values of peak expiratory flow (PEF), less with variations of more than 30%) patients with severe chronic
than 60% predicted baseline values with a variation greater asthma.
than 30%, often do not return to normal after the use of Children
bronchodilators. These patients required high doses of inhaled All children that are needed drugs for the prevention of
or oral corticosteroid therapy. Sudden worsening of symptoms asthma.
may require increased doses of corticosteroids should be given
under medical supervision.
R03BA05 fluticasone propionate
Flixotide
antiasthmatic
INDICATIONS
Brand name INN
Fluticasone propionate applied with inhalation provides
Flixotide fluticasone propionate prophylactic treatment of asthma.
ATC Adults:
DDD Pregnancy
Mild asthma: patients who on a regular daily basis require
R03BA05 0,6 mg C intermittent bronchodilation therapy.
Moderately severe asthma: patients with unstable asthma or
asthma that worsens despite application prophylactic therapy
suspension for inhalation under pressure;50 No data or bronchodilator alone.
mcg/dose; pressurized container, 1x120 dose Severe asthma: Patients with severe chronic asthma and
suspension for inhalation under pressure; 125
those who are dependent on systemic corticosteroids applied
mcg/ dose; pressurized container, 1x60 dose
suspension for inhalation under pressure; 250 to adequately control symptoms. Upon the introduction of
mcg/ dose; pressurized container, 1x60 dose fluticasone propionate inhalation, many of these patients
can significantly reduce or eliminate the need for oral
corticosteroids.
R06 ANTIHISTAMINES FOR SYSTEMIC USE

R06A ANTIHISTAMINES FOR SYSTEMIC USE
R06AX OTHER ANTIHISTAMINES FOR SYSTEMIC USE
R06AX13 loratadine
Pressing
non-sedating antihistamines

• Seasonal allergic rhinits
Pressing loratadine
• Allergic conjunctivitis
ATC DDD Pregnancy
• Non-seasonal chronic idiopatic rhinits
R06AX13 O 0,01 g B • Chronic urticaria and other allergic dermatosis
Form and package Lactation • Additional therapy in treatment of bronchial asthma
tablets 10 x 10 mg Caution with higher doses
syrup 1 x 120 ml (5 mg/5 ml)
S SENSORY ORGANS
S01 OPHTHALMOLOGICALS
S01A ANTIINFECTIVES
S01AA ANTIBIOTICS
S01AA01 chloramphenicol
Hloramkol
Antibiotic
Brand name INN

INDICATIONS
Hloramkol chloramphenicol
Hloramkol eye ointment 1% is used for the treatment of
ATC DDD Pregnancy
anterior segment of eye infections (caused by bacteria that
S01AA01 C are sensitive to chloramphenicol, when other antibiotics have
Form and package Lactation no effect or are contraindicated), such as:
eye ointment 1 x 5 g 1 % Caution • blepharitis and blepharoconjunctivitis
0,5% eye drops, solution • Bacterial conjunctivitis
• Bacterial keratitis
• expository, neuroparalitic and neurotrophic keratitis in the
case of secondary bacterial infections
Hloramkol eye drops are applied for treatment
• Acute bacterial conjunctivitis

S01AA11 gentamicin
Gentokulin
Antibiotic
INDICATIONS
Brand name INN
Gentokulin is intended to:
Gentokulin gentamicin
• treatment of superficial eye infections and ear infections
ATC DDD Pregnancy caused by susceptible microorganisms
S01AA11 C • for the prophylaxis of infections in trauma to the eye or ear.
eye drops 10 ml 0,3 % Avoid
S01AX OTHER ANTIINFECTIVES

S01AX13 ciprofloxacin
Marocen 0,3%
eye drops
Marocen ciprofloxacin Ciprofloxacin is indicated for the treatment of corneal ulcers
ATC DDD Pregnancy
and superficial infection of the eye and adnexa, caused by
susceptible microorganisms.
S01AX13 C
It is necessary to keep the official guide on the rational use of
Form and package Lactation antibiotic.
eye drops 1 x 5 ml 0,3% Avoid
S01B ANTIINFLAMMATORY AGENTS

S01BA CORTICOSTEROIDS, PLAIN
S01BA04 prednisolone
Oftalmol
Corticosteroid
INDICATIONS
Brand name INN
• Oftalmol is intended for the treatment of inflammation
Oftalmol prednisolone
of the anterior segment of the eye without the presence
ATC DDD Pregnancy of bacterial, viral or fungal infections: blepharitis,
S01BA04 B conjunctivitis, keratitis, keratoconjunctivitis, uveitis.
eye drops 5 ml 0,5 % Compatible
S01C Corticosteroids and anti-infectives in combination

S01CA Corticosteroids and anti-infectives in combination
S01CA01 dexamethasone, neomycin
• Chronic anterior uveitis

Neodeksacin • Corneal injury (burns resulting from the effects of chemical,
eye drops radiation or thermal means, or penetration of foreign
bodies).
Brand name INN The combined use of anti-infective component of the drug
Neodeksacin dexamethasone, neomycin is indicated in case of high risk or in situations which are
ATC DDD Pregnancy
expected to bacterial superinfection of the eye.
Anti-infective component of this drug is active according to
S01CA01 C
the following bacterial strains:
Form and package Lactation • Staphylococcus aureus
eye drops 10 ml (0,5 % + 0,1) Avoid • Escherichia coli
• Haemophilus influenzae
INDICATIONS • Klebsiella / species
Neodeksacin used in conditions that require corticosteroid • Neisseria species
therapy, such as inflammation of the eye, bacterial infection Neodeksacin not provide adequate protection against the
and the presence of risk of bacterial eye infections. following microorganisms:
Neodeksacin is indicated in the following conditions: • Pseudomonas aeruginosa
• Inflammation of the anterior segment of the eye • Serratia marcescens
• conjunctivitis • Streptococcus spp. (including Streptococcus pneumoniae)
• Inflammation of the cornea
S01E ANTIGLAUCOMA PREPARATIONS AND MIOTICS

S01EB PARASYMPATHOMIMETICS
S01EB01 pilocarpine
Miokarpin
miotic
INDICATIONS
Brand name INN
• Miokarpin as miotic applied in the treatment of:
Miokarpin pilocarpine • reduction of elevated intraocular pressure in patients with
open-angle glaucoma or ocular hypertension acute closed
ATC DDD Pregnancy
angle glaucoma
S01EB01 LOC 0,4 ml C • Prevention of postoperative elevated intraocular pressure
associated with the laser operation
• to induce miosis.
eye drops 1 x 10 ml 2% Caution
S01EE Prostaglandin analogues

S01EE01 latanoprost

Visus
latanoprost

Visus latanoprost • Reduction of elevated intraocular pressure in patients
ATC DDD Pregnancy
with open-angle glaucoma and intraocular hypertension
S01EE01 C
Eye drops, 50 µg/ml Caution
S01G DECONGESTANTS AND ANTIALLERGICS

S01GA SYMPATHOMIMETICS USED AS DECONGESTANTS
S01GA01 naphazoline
Hemokulin
Vasoconstrictor

Hemokulin naphazoline Hemokulin, eye drops are used for temporary symptomatic
ATC DDD Pregnancy
remove redness caused by minor irritation.
S01GA01 C
eye drops 10 ml 0,03 % Caution
S01GA02 tetryzoline
Montevizin
Vasoconstrictor

Hyperemia and / or edema of the conjunctiva caused by a
Montevizin tetryzoline
variety of non-specific causes, such as tonometry, placing and
ATC DDD Pregnancy
fitting of contact lenses, dust, smoke, smog, sun, cold, wind,
S01GA02 C allergies, swimming, reading, driving, watching television, etc.
eye drops 10 ml 0,05 % Avoid
eye drops 15 ml 0,05 %
DRUGS SOLD WITHOUT A PRESCRIPTION (OTC)

A ALIMENTARY TRACT & METABOLISM

A01 DENTAL PREPARATIONS
A01A DENTAL PREPARATIONS
A01AB Anti-infectives and antiseptics for local therapy of oral cavity
A01AB12 hexetidine
Hexoral
INDICATIONS
Brand name Generic name
Hexetidine as a local antiseptic is recommended for the treatment
Hexoral hexetidine of superficial oropharyngeal infections, including ulcers and their
prevention (eg, recurrent aphthous ulcers). It helps in the prevention
ATC DDD Pregnancy and treatment of gingivitis. It is also used for preoperative performance
of dental and surgical procedures in the oral cavity. Also, the use of
A01AB12 heksetidina recommended for bad breath from the mouth (foetor ex ore).
Form and Package Breastfeeding
Sol.for mouth rinsing 200 ml

A02 DRUGS FOR ACID RELATED DISORDERS

A02A ANTACIDS
A02AD05 Aluminium magnesium silicate hydrate
Gelusil Lac
Antacid
INDICATIONS
Brand name INN
• Relieve the symptoms of hyperacidity.
Gelusil Lac Aluminium magnesium silicate hydrate
ATC DDD Pregnancy
A02AD05 No data
Tbl. 40 x 500 mg Excreted into human breast milk.

Problems have not been documented
in humans.
A06 DRUGS FOR CONSTIPATION

A06A Drugs for constipation
A06AB Contact laxatives
A06AB02 bisacodyl
Panlax
Contact laxative
INDICATIONS
Brand name INN
Short-term symptomatic treatment of constipation.
Panlax bisacodyl
As recommended by physicians to prepare for radiology, diagnostic and
ATC DDD Pregnancy surgical procedures that require the bowel emptying.
A06AB02 O, R 10 mg B
gastroresistant tablets 6 x 10 mg Although not excreted into breast milk,

suppositories 6 x 10 mg it's not recommended in breast feeding
A07 ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS

A07A INTESTINAL ANTIINFECTIVES
A07AA Antibiotics
A07AA02 nystatin
Nystatin
Antimycotic
INDICATIONS
Brand name INN Nystatin powder for oral suspension is used in the prevention and treat-
Nystatin nystatin ment of fungal infections of the mouth, esophagus and intestinal tract
caused by fungi of the genus Candida spp. It is used in the prevention of
ATC DDD Pregnancy oral candidiasis in newborns whose mothers had vaginal candidiasis.
NYSTATIN tablets are intended for the treatment of gastrointestinal can-
A07AA02 O 1,5 MU C didiasis.
10 coated tablets x 500.000 i.u.

Not excreted into milk.
24 ml oral susp. 100.000 i.u/ml
A11 VITAMINS
A11H OTHER PLAIN VITAMIN PREPARATIONS
A11HA OTHER PLAIN VITAMIN PREPARATIONS
A11HA30 dexpanthenol
Panthenol
Vitamin
INDICATIONS
• Relieve symptoms of Inflammation of oral mucosa, throat, tongue
Panthenol dexpanthenol and gingiva (stomatitis, aphtous ulcers, glossitis, pharyngitis,
laryngitis).
ATC DDD Pregnancy
A11HA30 No data available
lozenges 20 x 120 mg No data available

B BLOOD AND BLOOD FORMING ORGANS

B01A ANTITHROMBOTIC DRUGS
B01AC INHIBITORS OF PLATELET AGGREGATION, EXCL. HEPARIN
B01AC06 acetylsalicylic acid
Midol 100
inhibitor of platelet aggregation
Brand name Generic name • To reduce the risk of morbidity and mortality in patients who have had
previously a myocardial infarction;
Midol 100 acetylsalicylic acid • For secondary prevention of stroke;
ATC DDD Pregnancy • To reduce the risk of transient ischemic attack (TIA) and stroke in
patients suffering from TIA
B01AC06 O3g C (1,2) D (3)
• To reduce the risk of morbidity and death in patients with stable and
Form and Package Breastfeeding unstable angina pectoris;
Tablets 20 x 100 mg Avoid usage during breastfeeding. • For the prevention of thromboembolism after surgery or vascular
Possible appearance of Rey syndrome. surgery, for example. PTCA, CABG, carotidendarterectomy,
Frequent usage of high doses can arteriovenous shunts in dialysis patients;
damage thrombocyte function and cause • For prophylaxis of deep vein thrombosis and pulmonary embolism
hypoprothrombinemia at breastfed infant. after prolonged immobilization, such as after a major surgical
procedures;
INDICATIONS • To reduce the risk of first myocardial infarction in people with risk
factors for development of cardiovascular disease, for example
• Acetylsalicylic acid tablets are indicated for use in the following cases, diabetes mellitus, hyperlipidemia, hypertension, obesity, smoking and
based on their properties of inhibition of platelet aggregation: age.
• To reduce the risk of mortality in patients with suspected acute
myocardial infarction;
C CARDIOVASCULAR SYSTEM
C05 VASOPROTECTIVES
C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
C05AA CORTICOSTEROIDS
C05AA04 heparin, prednisolone, polidocanol
Hepathrombin H
antihemorrhoidal preparation

In the symptomatic treatment of hemorrhoids and itching in the perianal
Hepathrombin H heparin, prednisolone, region in the short period of time.
polidocanol
ATC DDD Pregnancy
C05AA04 C

ointment 20 g (65 i.u.+2,233 mg+30 mg)/g No excretion into breast
suppositories 10 x (120 i.u.+1,675 mg+30 mg) milk, save use during
breastfeeding.
C05 VASOPROTECTIVES
C05B ANTIVARICOSE THERAPY
C05BA HEPARINS OR HEPARINOIDS FOR TOPICAL USE
C05BA53 heparin, combinations
Hepathrombin
antivaricose therapy
INDICATIONS
Brand name INN
Hepathrombin heparin, dexpanthenol, alantoin • Surface thrombophlebitis

• Relief of symptoms in superficial bruising and hematoma
ATC DDD Pregnancy
C05BA53 C
gel 30000 40 g No excretion into breast milk, save

cream 30000 40 g use during breastfeeding.
gel 50000 40 g
cream 50000 40 g
C05 VASOPROTECTIVES
C05B ANTIVARICOSE THERAPY
C05BA HEPARINS OR HEPARINOIDS FOR TOPICAL USE
C05BA53 heparin, combinations
Sinedol Gel
antivaricouse therapy
INDICATIONS
Sinedol gel heparin, dimethyl sulfoxide, Sinedol gel is a combination of active substances intended for the
dexpanthenol treatment of sports injuries and other injuries of muscles, tendons,
synovias and ligaments of the joints caused by bluntforce: contusions,
ATC DDD Pregnancy hematomas, distortion,tennis elbow, tendons and synovial inflammation,
bursitis. Also indicated in the treatment of peripheral venopathy, acute
C05BA53 C neuralgia, and humero-scapular periarthritis.
gel 40 g (500 i.u.+150 mg+25 mg)/g No excretion into breast milk, safe
usage during breastfeeding.
D DERMATOLOGICALS
D01 ANTIFUNGALS FOR DERMATOLOGICAL USE
D01A ANTIFUNGALS FOR TOPICAL USE
D01AA Antibiotics
D01AA01 nystatin
Nystatin
Antimycotic
INDICATIONS
Nystatin ointment for the treatment of cutaneous and mucocutane-
Nystatin nystatin ous infections caused by Candida (Monilia) albicans and other Candida
strains.
ATC DDD Pregnancy
D01AA01 C
Ointment 5 g 100.000 i.u./g Not excreted into milk.

Ointment 20 g 100.000 i.u./g
D01AC IMIDAZOLE AND TRIAZOLE DERIVATIVES

D01AC08 ketoconazole
Mycoseb
antifungal
INDICATIONS
Mycoseb ketoconazole • Prevention and treatment of infections that are believed to be

caused by the yeast Malassezia (formerly Pityrosporum), such as
ATC DDD Pregnancy dandruff, seborrheic dermatitis and tinea (pityriasis) versicolor.
D01AC08 O 0,2 g C
shampoo 2% 1 x 100 ml Possible excretion into breast milk.

Avoid.
D03 PREPARATIONS FOR TREATMENT OF WOUNDS AND ULCERS

D03A CICATRIZANTS
D03AX OTHAR CICATRIZANTS
D03AX03 dexpanthenol
Panthenol
Vitamin
Brand name Generic name INDICATIONS

Panthenol dexpanthenol
• Burns of first and second degree,
ATC DDD Pregnancy • Irritation of skin caused by UV rays,
• Rash of gluteal parts of infants,
D03AX03 No data available • Fissures of breast nipples at women in breastfeeding period,
• Chronic skin ulcers,
Form and Package Breastfeeding • Decubitus ulcers,
• Skin transplants – in reciprocation with cortisone therapy,
ointment 30 g 5 % No data available • Treatment of dry, callously and aged skin.
D08 ANTISEPTICS AND DISINFECTANTS

D08A ANTISEPTICS AND DISINFECTANTS
D08AG IODINE PRODUCTS
D08AG02 povidone-iodine
Povidon jod
antiseptic, disinfectant
INDICATIONS
Povidone-iodine ointment
Povidon jod povidone-iodine • Povidone-iodine ointment is abroad spectrum antiseptic for topical
treatment or prevention of infection in minor cuts and abrasions,
ATC DDD Pregnancy simple surgical procedures and small burns.
• Povidone-iodine ointmentis intended also for the treatment of
D08AG02 Possible absorption of iodine and effect fungal and bacterial skin infections, pyoderma, treatment of
on thyroid gland of fetus decubitus infections and ulcus cruris.
Form and Package Breastfeeding Povidone-iodine solution
• Povidone iodine solution intended for disinfecting the skin and
ointment 1% 1 x 40 g mucous membranes before and after complex and simple surgery.
foam 5 l Povidone-iodine foam
foam 500 ml Avoid • Povidone iodine skin foam intended for hand disinfection of
solution 100 ml surgical staff and patient preoperative skin preparation
solution 500 ml
G GENITO URINARY SYSTEM AND SEX HORMONES
G01 GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS

G01A ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH
CORTICOSTEROIDS
G01AX OTHER ANTIINFECTIVES AND ANTISEPTICS
G01AX11 povidone-iodine
Povidon jod
anti-infective, antiseptic
INDICATIONS
• Treatment of vaginitis caused by Candida, Trichomonas, for the
Povidon jod povidone-iodine treatment of non-specific and mixed infection and preoperative
preparation of the vagina.
ATC DDD Pregnancy
G01AX11 Possible absorption of iodine and

effect on thyroid gland of fetus
vaginal tablets 14 x 20 mg Avoid

M01AE Propionic acid derivatives
M01AE01 ibuprofen
Ibuprofen
NSAID
INDICATIONS
Ibuprofen ibuprofen DL-lysinate • The drug is intended to eliminate mild to moderate pain such as
headache, back pain, rheumatic or muscle pain, dysmenorrhea,
ATC DDD Pregnancy toothache, lower fever and to relieve the symptoms colds and flu.
M01AE01 O 1,2 g C
20 eff.tablets x 200 mg Compatible with breast feeding

as minimal amounts excreted into
milk.
M02 TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN

M02A TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
M02AA ANTIINFLAMMATORY PREPARATIONS, NON-STEROIDS FOR TOPICAL USE
M02AA15 diclofenac
Diclofenac
NSAID
Brand name Generic name INDICATIONS

Diclofenac diclofenac
• Local symptomatic relief of pain and inflammation in:
ATC DDD Pregnancy
• injuries of tendons, ligaments, muscles and joints (expansions,
M02AA15 O,P,R 0,1 g C (D in 3 trimester and in time
rd dislocations and contusions)
of baby delivery)
• localized forms of soft tissue rheumatism
• To relieve pain in mild arthritic conditions.
gel 40 g 1% Caution
N NERVOUS SYSTEM
N02 ANALGESICS
N02B OTHER ANALGESICS AND ANTIPYRETICS
N02BA SALICYLIC ACID AND DERIVATIVES
N02BA01 acetylsalicylic acid
Midol
analgesic, antipyretic
INDICATIONS
Midol acetylsalicylic acid • The pain of mild and moderate intensity: headache, toothache,
neuralgia, arthralgia, muscle pain and similar painful conditions.
ATC DDD Pregnancy
• Fever in adults: influenza, the common cold or similar infectious
N02BA01 O3g C (1,2) D (3) conditions that are accompanied by fever.
Form and Package Breastfeeding • Secondary prevention of myocardial infarction.
tablets 500 x 300 mg Avoid usage during breastfeeding. • Unstable angina pectoris.
Possible appearance of Rey syndrome.
Frequent usage of high doses can
damage thrombocyte function and
cause hypoprothrombinemia at
breastfed infant.
N02BE01 paracetamol
Febricet
INDICATIONS
Brand name Generic name • FEBRICET a mild analgesic and antipyretic. It is recommended that
Febricet paracetamol its short-term use in the following states
• headaches
ATC DDD Pregnancy • musculoskeletal disorders
• menstrual pain
N02BE01 O3g No harmful effects to fetus have • toothache
been reported. • symptomatic treatment of colds and flu
• mild to moderate pain associated with osteoarthritis
• Syrup
syrup 100 ml (120 mg/5 ml) Safe to use. Rash has been • For the symptomatic treatment of mild upper respiratory tract
suppositories 5 x 200 mg reported in breastfed infants. infections caused by viruses
• fever after immunization
• weak to moderately severe pain (headache, toothache, menstrual pain)
• Suppositories
• Symptomatic treatment of mild to moderately severe pain and /or fever
N02BE01 paracetamol
Grippostad hot drink

INDICATIONS
Brand name Generic name Symptomatic treatment of mild to moderate pain (such as headache,
Grippostad hot drink paracetamol toothache, menstrual pain and / or fever).
It is used in children older than 10 years, adolescents and adults.
ATC DDD Pregnancy
N02BE01 O3g No harmful effects to fetus have

been reported.
Sachet 5x5 g/600 mg Safe to use. Rash has been

reported in breastfed infants.
N02BE ANILIDES
N02BE51 Paracetamol, combinations excl. psycholeptics
Caffebol
INDICATIONS
Brand name Generic name • Quickly relieve symptoms of pain. Caffebol is indicated for short
Caffebol paracetamol, caffeine, codeine term treatment of acute moderate pain that does not respond to
paracetamol, ibuprofen or aspirin monotherapy: headache, migraine,
ATC DDD Pregnancy menstrual pain, toothache, neuralgia and rheumatic pain (including
myalgia, and back pain).
N02BE51 C, D in long term use
tablets 500 x (460+50+10 mg) Not enough data available. Poten-

tially toxic for child.
N02BE51 Paracetamol, combinations excl. psycholeptics
Febricet C
INDICATIONS
Febricet C paracetamol, ascorbic acid • Symptomatic treatment of colds and influenza (high temperature,
chills, and fever), and relieve mild to moderately severe pain such
ATC DDD Pregnancy as headaches. Ascorbic acid is a supplement of vitamin C, in
deficient conditions such as the flu or a cold.
N02BE51 O3g No harmful effects to fetus have
been reported.
eff. tablets 10 x (330+200 mg) Safe to use. Rash has been report-
ed in breastfed infants.
R RESPIRATORY SYSTEM
R01 NASAL PREPARATIONS
R01A Decongestants and other nasal preparations for topical use
R01AA Sympathomimetics, plain
Nafazol 0,5‰, 1‰
Nasal decongestant
INDICATIONS
Symptomatic treatment of congestion of the nasal mucosa
Nafazol naphazoline
ATC DDD Pregnancy
R01AA08 N 0,4 mg C
Nasal drops, solution 10 ml Unknown excretion into breast

milk. No problems have been
documented in humans.
R01B NASAL DECONGESTANTS FOR SYSTEMIC USE

R01BA SYMPATHOMIMETICS
R01BA52 pseudoephedrine, combinations
∆Rinasek
Sympathomimetic
INDICATIONS
Brend name Generic name • Allergic rhinitis – seasonal and nonseasonal
Rinasek triprolidine, pseudoefedrine • Vasomotor (perennial) rhinitis
• Rhinitis, cold
ATC DDD Pregnancy
R01BA52 O, 0,24 g C, B
syrup 100 ml (5 ml/1,25+30 mg) safe in breast feeding

tablets 10 x (2,5+60 mg)
R02 THROAT PREPARATIONS

R02A THROAT PREPARATIONS
R02AA ANTISEPTICS
R02AA15 povidone-iodine
Povidon jod
antiseptic
INDICATIONS
• Acute infections of the mouth and throat mucosa, for example.
Povidon jod povidone-iodine gingivitis and mouth ulcers.
• Oral hygiene, before, during and after dental procedures and
ATC DDD Pregnancy interventions in the oral cavity.
R02AA15 Possible absorption of iodine and
effect on thyroid gland of fetus
solution 0.85% 1 x 50 ml Avoid

R05 COUGH AND COLD PREPARATIONS

R05C EXPECTORANTS, EXCL. COMBINATIONS WITH COUGH SUPPRESSANTS
R05CB MUCOLYTICS
R05CB06 ambroxol
Ambroksol
mucolytic
INDICATIONS
Ambroksol ambroxol Mucolytic therapy in acute and chronic bronchopulmonary diseases

associated with increased production and disorder formation and
ATC DDD Pregnancy transport of mucus.
R05CB06 O 0,12 g No data available
syrup 100 ml 15 mg/5 ml No data available

R05CB03 carbocisteine
Mucodyne
Mucolytic
INDICATIONS
Mucodyne Carbocisteine Carbocisteine is mucolytic, and he is indicated for the adjuvant

treatment of disorders of the respiratory tract caused by thick viscous
ATC DDD Pregnancy secretions, including obstruction of the airways.
R05CB03 O 1,5 g No data available. Avoid.
capsules 30 x 375 mg No data available.

syrup 100 ml (125 mg/5 ml) 2,5%
syrup 100 ml (250 mg/5 ml) 5%
R06AB54 paracetamol, ascorbic acid, caffeine, chlorphenamine
Grippostad C
INDICATIONS
Brand name Generic name Treatment of the symptoms of colds and flu infections, such
Grippostad C paracetamol, ascorbic as headache, muscle aches, nasal congestion and dry cough.
acid, caffeine, GRIPPOSTAD® C leads to the reduction of fever.
chlorphenamine Because of the fixed combination of active substances in drug
GRIPPOSTAD® C, the dose can be individually configured with respect to
ATC DDD Pregnancy the predominant symptom. In such cases you should take your medicine
of a different composition.
R06AB54 X
10 caps.x (200 mg + 150 mg +25 mg + 2,5 mg) Contraindicated

S SENSE ORGANS
S01 DRUGS FOR THE TREATMENT OF EYE AND EAR
S01KA02 hypromellose
Hemodrops
Viscoelastic substances
INDICATIONS
Brand name Generic name Hemodrops, eye drops are used locally, for the symptomatic treatment of
eye dryness (the syndrome of “dry eye “- keratoconjunctivitis sicca and
Hemodrops hypromellose xerophtalmia, eye irritation associated with insufficient tears production,
the reduced secretion of tears in the elderly, as well as neuroparalytic
ATC DDD Pregnancy tears hyposecretion).
Also, it is used to prevent damage to the cornea when wearing hard contact
S01KA02 No data lenses, while used as adjuvant therapy for disorders precorneal tear film
(staphylococcal blepharitis and keratoconjunctivitis, herpetic keratitis,
chemical and thermal eye injury).
Eye drops 0,5% 10 ml No data

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A ALIMENTARY TRACT & METABOLISM

Form and package Lactation

Film coated tablets 30 x 20 mg Caution, the lowest excretion

A02BC PROTON PUMP INHIBITORS

• treatment of duodenal and peptic ulcers resulting from the

Form and package Lactation

Bottle with 200 ml syrup Can be used.

A10B ORAL ANTIDIABETICS (drugs which lowered glucose level in blood)

A10BB SULPHONYLUREA ANTIDIABETICS

Form and package Lactation

Brand name INN

B05 SOLUTION FOR BLOOD SUBSTITUTE AND PERFUSION SOLUTIONS

Form and package Lactation

Inf.solution 500 ml Caution, Not

B05B I.V. SOLUTIONS

B05BA10 aminoacids, minerals

Brand name INN INDICATIONS

B05BC SOLUTIONS PRODUCING OSMOTIC DIURESIS

B05C IRRIGATING SOLUTIONS

Form and package Lactation

Solution for external use (PVC bag) Caution

Brand name INN INDICATIONS

C01D VASODILATATORS USED IN CARDIAC DISEASES

Brand name INN INDICATIONS

C01DA14 isosorbide mononitrate

Brand name INN INDICATIONS

Brand name INN INDICATIONS

Brand name INN INDICATIONS

Brand name INN INDICATIONS

C03E POTASSIUM-SPARING AGENTS WITH OTHER DIURETICS

Brand name INN INDICATIONS

C04AE ERGOT ALCALOIDS

Brand name INN INDICATIONS

C07 BETA-BLOCKING AGENTS

Brand name INN

Brand name INN INDICATION

Brand name INN INDICATIONS

C07AG BLOCATORS OF ALPHA AND BETA ADRENERGIC RECEPTORS

Brand name INN

C08 CALCIUM ANTAGONISTS

Brand name INN INDICATIONS

Brand name INN INDICATIONS

C08D SELECTIVE CALCIUM ANTAGONISTS WITH DIRECT ACTION ON HEART

Brand name INN INDICATIONS

Brand name INN INDICATIONS

C09 AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM

Brand name INN INDICATIONS

Brand name INN INDICATIONS

C09B ACE INHIBITORS, COMBINATION

Prilenap HL, Prilenap H

Brand name INN INDICATIONS

Brand name INN INDICATION

C09BA06 quinapril, hydrochlorothiazide

Brand name INN INDICATION

Brand name INN INDICATIONS

C09C ANGIOTENSIN II RECEPTOR ANTAGONISTS, PLAIN

Form and Package Lactation

f.c. tbl. 30x 150 mg

C09DA01 losartan potassium + hydrochlorothiazide

C, D in the second and 3 trimester.

Form and Package Lactation

Form and Package Lactation