1.

FNAC = clusters of cells with large, overlapping nuclei containing sparse, finely dispersed
Chromatin. Numerous Intranuclear Inclusion bodies and grooves = PAPILLARY CARCINOMA.
2. Pleomorphic cells, including irregular giant cells and biphasic spindle cells = Anaplastic Thyroid
Cancer.
3. Variable sizez thyroid follicles, colloid and Macrophage = Colloid nodules
4. Follicular Neoplasm= cannot be dermined by FNAC

LIVER

1. Panlobular mononuclear cell infiltration that cross into adjacent lobule = Acute viral Hepatitis.
2. Damaged cytokeratin filaments within hepatocytes= high eosinophilic intracytoplasmic
inclusions in Microscopy = Mallory bodies = Alcoholic hepatitis= fat deposition in hepatocytes =
centrilobular region.
3. Granulomatous inflammation in myocardium = RHD =Aschoff bodies
4. Cells that differentiate into Myofibroblast in response to injury = primary cells a/w liver fibrosis
= Stellete cells.
5. Liver Biopsy=LM=Large Hepatocyte filled with finely granular, homogenous, pale pink
cytoplasm(pale eosinophilic cytoplasma)=ground glass Hepatocytes= Hepatitis B infection
6. Lymphoid aggregates within portal tract and focal areas of macrovesicular steatosis = Hepatitis
C infection.

BRAIN

1. Microglial nodules ( Microglial cells in response to infection, inflammatory cytokines and HIV
derived proteins cause Microglial cells to form clusters around small areas of necrosis) their
fusion leads to Multinucleated giant cells = HIV on brain; this findings d/t Neurotoxic compounds
released by Activated monocytes.
2. Tissue destruction by Lysosomal enzymes = Liquefactive necrosis = cerebral infarct
3. Fibroblast proliferation in affected area = outside CNS to form granulation tissue; In CNS Tissue
repair and scar formation is by Astrocyte
4. Immune mediated focal demyelination = multiple periventricular lesions = Multiple Sclerosis
5. Necrosis of Rapidly dividing, Anaplastic astrocytes = Glioblastoma multiforme= can present with
cystic necrosis in gross examination. Heterogenous mass with midline shift.
6. Psammoma bodies in Brain biopsy  Arachnoid origin; Spindle cells, concentrically arranged in
whorled pattern; Psammoma bodies. Calcification.  meningioma.  Asymptomatic; may
present with seizures or Focal neurologic signs.
7. Kids with Suprasellar Tumor  cords/nests of palisading squamous epithelium with internal
areas of lamellar wet keratin under LM.
8. Medulloblastoma kid= Solid tumor on Brain stem = Small blue cells(homer wright rosette)
9. Astrocytoma kid= Cystic Tumor on Brain stem = elongate hairlike processes in LM ie Rosenthal
fibers.
CERVIX

1. Expansion of immature basal cells into epithelial layer = High grade CIN
2. Cells with nuclear atypia only in Basal epithelial layer = Low grade CIN.
3. Atypical glandular elements invading the basement membrane = Carcinoma
4. Perinuclear Vacuolization ( Koilocytic change) d/t viral protein = HPV infection.

LUNGS

1. Lung parenchyma = Macrophage rich giant cells and fibromyxoid connective tissue
2. IHC=All cases of Mesothelioma will stain positive for Cytokeratins; also for CalRetinin. EM =
Polygonal Tumor Cells with numerous long, slender microvilli and abundant TOnofilaments.
Histo = Mesothelioma can appear as Cuboidal or Flattened cells or Spindle cells(stromal like).