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The symptoms of the disease is usually clearly visible during the first 6 to 9 months of
age, but most of these can be apparent as late as 3 to 5 years of age. Each child may
experience a different type of symptoms but the most common ones are:

Sinusitis Sinus infection or

rhinosinusitis, is inflammation
of the sinuses resulting in
symptoms. Common
symptoms include thick nasal
mucus, a plugged nose, and
pain in the face.

Pyoderma skin infection with formation

of pus.

Conjunctivitis inflammation or swelling of

the conjunctiva.

Osteomyelitis infection in a bone. Infections

can reach a bone by traveling
through the bloodstream or
spreading from nearby

Meningitis rare infection that affects the

delicate membrane called
meninges that cover the
brain and spinal cord.

Sepsis life-threatening condition in

which the body is fighting a
severe infection that has
spread via the bloodstream.

Bronchitis inflammation of the bronchial

tubes, the airways that carry
air to your lungs. It causes a
cough that often brings up

Pneumonia Infection that inflames the air

sacs in one or both lungs.
The air sacs may fill with fluid
or pus (purulent material),
causing cough with phlegm
or pus, fever, chills, and
difficulty breathing.

Other symptoms also includes:

 Growth failure

 Absence of tonsils and adenoids

 Joint disease, primarily in the knees, similar to juvenile rheumatoid arthritis

 Autoimmune hemolytic anemia (red blood cell breakdown)

 Glomerulonephritis (kidney inflammation)

 Neutropenia (decreased neutrophils in the blood)

 Dermatomyositis (skin and muscle inflammation)

 Leukemia, Lymphoma, and colon cancer are also observed in small number of adults
with X-linked agammaglobulinemia.