Beruflich Dokumente
Kultur Dokumente
Copyright © 2010
Hans Wu
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Disclaimer
Author's Note
The ideas explained and discussed in this book are by no means novel
discoveries. Most things have been discussed and researched in the
literature and online communities for many years now. This eBook is
just an explanation for what I have implemented in my life and
recommend for others. For more information visit my blog Beyond
Paleo. The url is: http://beyondpaleo.blogspot.com
Hans Wu (2010)
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Acknowledgements
There have been many resources online that I have used to discover
many of the issues discussed here, my home forum is the Immortality
Institute (http://www.imminst.org) where the participants have already
discussed the various ideas laid out in the book before I even had the
capability to understand them all, so I would like to thank all the users
there.
Last but not least I would like to thank my mother for entertaining these
crazy ideas that I have tried to implement in the household. Sounded
crazy at first but the results are undeniable.
Also thanks for reading the book, not the highest quality you will
ever see but hey it is free.
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About This Book
Everybody has their own idea of what healthy eating is. People
shun certain foods and eat others with gusto with nothing to base
their ideologies on other than the word of the “experts” and how
they feel. Over the years I have found that expert opinions are
usually conflicting and that how you feel is not a good barometer
for your health; the body adapts and the mind overpowers.
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Table of Contents
Introduction................................................................................7
6
Introduction
Take care of your body with steadfast fidelity. The soul must see
through these eyes alone, and if they are dim, the whole world is
clouded. ~Johann Wolfgang Von Goethe
Only recently has this “gap” come to the forefront. In the past
we suffered from infectious diseases, injuries, and starvation;
most of the world still does, but modern science has focused on
the new problem of chronic diseases (that is where the money
is). For those reading this book, you are probably more likely to
die of the diseases of civilization than the more “tropical”
diseases. Modern technology has rid us of many diseases that
would otherwise end our lives when we turn 40; instead we now
live until 80, a territory where evolution has not had a chance to
act upon. In return for our extended lifespan, technology has
made us stressed, out-of-shape, and overweight.
While we have doubled our lifespan in the last century (and will be
able to extend it in the next), people now suffer from diabetes, heart
disease, and dementia. It is not exactly my preferred way to live the
last half of my life. One extreme intervention for preventing this
suffering is Calorie Restriction with Optimal Nutrition (CRON).
This is a lifestyle where you consume less than you expend but
achieve all your required nutrients. The metabolic adaptation that
takes place extends maximum lifespan (probably your best bet to
achieve 120 years of age), but also keeps you younger at the older
age. The Okinawans probably
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went through some form of Calorie Restriction due to poverty
from World War II and they are the healthiest and longest
living population on earth for now.
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Chapter 1: The State of
Nutrition
It is no measure of health to be well adjusted to a profoundly
sick society. ~Krishnamurti
The modern food guide was not created until 1992. By this
measurement the science telling us what to eat is only 18 years
old, a science in its infancy stage. Nutrition and metabolism are
intertwined and metabolism is an incredibly complex topic.
While a lot of work has been done in the field what is right and
what is wrong is still under debate, despite what the “experts”
will tell you. To settle all this we should base our theories on
the results of Random Controlled Trials (RCTs) but this is very
hard to perform on humans
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The other problem is the data collected from rats, mice and
hamsters. Let’s say we used lions instead for our studies. We
feed it celery for 6 months and we are surprised it died of a heart
attack, we feed it beef for 6 months and they are perfectly
healthy with clean arteries. Then the newspapers can say that
celery causes heart disease, and then the researchers can use
their data and find a relationship between celery and heart
disease (I have seen weirder correlations). It’s too bad lions
don’t have a shorter life-span. Mice and rats do have a shorter
life, in that way we don’t have to wait decades for the results of
a study to come out. The problem is what do rats eat? They are
herbivores. Their natural diet is a bunch of plants with hardly
any cholesterol or saturated fat. If we feed it lots of fat no doubt
something bad happens.
One dietary regimen that I thought cut through all these problems
was the Paleolithic Diet. It is based on the principle that what helps
us maintain our health is what we evolved to eat. Just like a cow
eats grass and lions eat meat, in our natural environment we eat a
certain way. The problem is that the diversity of the human diet is
vast. Some are high-carbohydrate and some are low-carbohydrate,
but this is a recent phenomenon. Anthropology shows that we
evolved in the equatorial region of Africa for millions of years and
the diet present there is probably
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the diet we are adapted to consuming. Also, despite the variation in
diets, there are strong commonalities between them all.
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Chapter 2: The
Paleolithic Diet
Red meat is not bad for you. Now blue-green meat, that‟s bad for
you! ~Tommy Smothers
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To understand why this diet has so much appeal you would have
to understand evolution. Here’s a small refresher course that I
hope helps. I love Kent Hovind’s explanation of evolution:
“Twenty million years ago there was the big bang. 4.6 billion
Years ago the earth cooled down. It rained on the rocks for
millions of years and turned into soup, and the soup came alive
3 billion years ago. So your great great great great great great
grandpa was soup.”
This tells you what happened but not how it happened. Before
we start I want to say that this is a thought experiment, I
apologize for any inaccuracies portrayed here. So, imagine a
population of 10 primates living in the jungle. They all eat
leaves. One day a primate happens upon some meat (I don’t
know how) and eats some of it and dies. Its digestive tract hasn’t
evolved to consume raw meat. Soon the primate is replaced.
Another day another primate finds some meat and eats some, by
some quirk of the randomness of nature (mutations) this primate
has developed not only the digestive capability of digesting meat
but also has developed a taste for it. This primate then has
children who also have the same quirk, but this new primate also
utilizes the nutrients better (another mutation) and thus develops
bigger muscles and brains. This bigger muscled, more brained
primate is liked by more females thus also has more children
with the same quirks. So on and so forth until the meat eating
primates’ move somewhere else to find more meat. The
vegetarians stay behind to become chimpanzees and apes, the
omnivores move on to become us.
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However the thing about evolution is that it only acts up to the
point of reproduction (or maybe a little bit farther, grandmother
effect). So while it may provide us with big muscles in the short-
term it probably doesn’t extend it into the long-term. This is the
trade-off we see with CR. By restricting calories we signal to the
body that it is not a good time to reproduce (bring a child into the
world) so the body should try its best to preserve itself until
times are more plentiful. That is not to say we should ditch the
Paleolithic Diet (PD), but there are lessons we can learn from it.
Nature did not intend us to grow old and ill. We were designed
to die young, of old age, but free of disease. – Ernst L Wynder
and Marvin M Kristein
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By consuming large amounts of lectin (from grains, peanuts,
beans, etc…) you will be opening yourself up to the risk of
autoimmune disease:
Phytates (or phytic acid, or IP6) are a strong acid that binds to
divalent and trivalent heavy metal ions which then form
insoluble salts (not absorbable), for e.g. zinc, calcium,
magnesium and other trace minerals. Oxalic acid is another class
B anti-nutrient. There are doubts as to whether class B anti-
nutrients can cause deficiencies in the diets of western societies
considering the amount we eat, but if you’re not getting enough
minerals in the first place large amounts of the anti-nutrients will
probably be detrimental.
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in very good health. He wrote about his findings in a book titled,
“Nutrition and Physical Degeneration” published in 1939. Price
found that cultures who consumed grains or beans took great
effort to prepare them properly. They removed the bran, ground
the grains, soaked them and also fermented them. That seems to
be quite a bit of work but the benefits are numerous (and tasty).
Wheat
The wheat we know today traces back to a wild grass called
Triticeae. From what I’ve read it has a very pleasing flavor, so
that’s probably why it got utilized from the beginning. The
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modern wheat we consume today arose from a variety of wheat
called einkorn which had 14 chromosomes. Through artificial
breeding and selection we now utilize a variety of wheat that
contains 42 chromosomes. There are numerous reasons for this,
including easier seed collection as well as improved texture from
increased gluten content.
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No Soy for the Boy
Besides the anti-nutrients found in soybeans, there are other
substances found in soy that probably have detrimental health
effects (this may be more applicable to males than females, but I
strongly caution against soy in either case). Soy is commonly
touted as a health food these days because it seems to be a good
source of protein (but the anti-nutrients interfere with that), low
in fat (just because it is low in fat doesn’t mean it is good for
you), and apparently the “healthy” Asians consume tons of it. If
you have ever been to some of the Asian countries it is true that
they consume tofu (which probably contributes to their shorter
stature) but it is not their main source of protein. It is almost
always a side dish, and most times it has been fermented (which
removes the anti-nutrients, but not the isoflavones). While there
are numerous speculative mechanisms by which soy could
provide health benefits to the consumer, I have yet to see solid
evidence that the isoflavones being consumed confer any
benefits; if anything all I see are risks.
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the soy isoflavon, approximately 30g of tofu per day (2mg of
isoflavones per 1g of tofu). This is really not a lot. While there
seems to be support for the aging effects of testosterone (eunuchs
live longer and castrated dogs also live longer), the decreased
testosterone may perhaps be a benefit for longevity. At the same
time, I do not think the trade-offs are very impressive.
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Vegetable Oils
If vegetables are healthy, shouldn’t vegetable oils be healthy? It
really depends. If you can press it out of the plant in question it
seems okay. If you must extract it with modern processing, that
is another question.
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inflammation. Short-term inflammation is necessary, its long-
term inflammation that can cause problem. If your blood vessels
are constantly inflamed something is bound to happen. With the
introduction of soybean oil, corn oil, and margarine to replace
our traditional fat sources, the n-6/n-3 ratio has been strongly
skewed towards n-6 with commonly known dietary ratios today
of 20:1. Compare this to our Paleolithic ancestors, who
probably had ratios closer to 1:1.
Saturated
Monounsaturated Polyunsaturated
The basis of the fatty acid names are descriptive of how many
double bonds each type has. The number of double bonds is
important because it determines how reactive it is in the
presence of oxygen or free radicals. It’s a tough concept to
explain so hopefully you have had some chemistry classes. All
you really need to know is that the more double bonds it has the
more chances there is for it to “break” (oxidize).
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The important thing to realize is that the type of fatty acids
you consume in your diet ends up being the type of fatty acids
your body utilizes. The more polyunsaturated fatty acids (the
ones more likely to go rancid) causes your body to go rancid
(the actual process is a bit more complicated).
Coconut Oil
Palm Oil
Avocado
Olive Oil (please see Appendix I)
Animal Fats
Vitamin D3
Vitamin K2
The Institute of Medicine has set an RDA for Vitamin K, but that is
for the plant form (phylloquinone) AKA Vitamin K1. What we are
interested in is the animal form K2. Sources for K2 usually come
from pastured butter, organ meats, dairy, and fermented products,
many of which we do not consume today. K2 is important not just
for bone health but for other reasons as well:
Japan has one of the lowest infant mortality rates in the world
(recently surpassed by Singapore and Sweden). I would not say
that their standard of care is better than everyone else’s or that
their technology is better. There may be some cultural issues
involved, but one difference that I have seen is that newborns in
Japan receive Vitamin K2 (the animal form) while most other
countries utilize Vitamin K1.
Vitamin A
Fructose/Sugar
Table sugar is half fructose and half glucose. You may know
fructose as the fruit sugar/”natural” sugar. It's commonly used as
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a sweetener as it is almost twice as sweet as glucose, but fructose
causes a very different metabolic response than glucose does:
Stanhope KL, Schwarz JM, Keim NL, Griffen SC, Bremer AA,
Graham JL, Hatcher B, Cox CL, Dyachenko A, Zhang W,
McGahan JP, Seibert A, Krauss RM, Chiu S, Schaefer EJ, Ai M,
Otokozawa S, Nakajima K, Nakano T, Beysen C, Hellerstein
MK, Berglund L, Havel PJ. Consuming fructose-sweetened, not
glucose-sweetened, beverages increases visceral adiposity and
lipids and decreases insulin sensitivity in overweight/obese
humans. J Clin Invest. 2009 May;119(5):1322-34.
What was found in this study was that the group consuming
fructose gained the same amount of weight as the glucose group;
however, the fructose group gained it all around their abdomen.
This is called visceral or central adiposity. Waist size is one of
the best predictors of metabolic syndrome because that huge
belly is a sign that your metabolism is damaged. Your body has
three main types of fat stores: intramuscular lipids,
subcutaneous/deep subcutaneous, and visceral/central adipose
tissue. The subcutaneous type is found under the skin, this is the
type that you measure when looking at skin folds. The visceral
type is the poisonous type.
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Fructose is commonly found in large amounts in sodas, candies,
and anything that has been sweetened. And yes, it is also found
in fruit.
This does not mean you shouldn't consume any fruit, as fruit has
a lot of beneficial factors in and of itself. It's just best not to
make fruit a central of your diet. Two servings of fruit a day
should be enough to get the benefits.
The problem with fructose is that the other parts of the body
don’t have the mechanisms necessary to deal with it, but the liver
does. So when it passes through the liver the body tries its best to
metabolize it. Nowadays most peoples’ glycogen liver stores are
constantly full so what happens is that fructose becomes
involved in lipogenesis (making of fat) which then leads to fatty
livers (like with alcohol).
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Chapter 3: Calories
and Nutrients
„Tis not the eating, nor „tis not the drinking that is to be blamed
but the excess. ~John Seldon
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Calories
The amount of energy your body burns in a day is represented by
the calorie. The resting metabolic rate (RMR) is a measurement
of how much energy your body requires in a day if you just sat
there for 24 hours.
Macronutrients
Protein, carbohydrate, and fat are the macronutrients. In terms
of calories this is how it breaks down:
1g of protein = 4 calories
1g of digestible carbohydrate = 4 calories
1g of fat = 9 calories
Others: 1g of fiber = 1-2 calories, 1g of alcohol =
7 calories
Protein
Protein is an essential nutrient, our bodies can make the fats and
carbohydrate we require but without protein we cannot survive.
While very low carbohydrate diets and very low fat diets are
possible, a very low protein diet is not; this would lead to protein
deficiency (Kwashiokor) and result in death. Consequently, when
designing a proper diet the first consideration should be protein
intake.
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Athletes regularly consume 2.2g/kg of protein per day to achieve
higher performance and muscle mass. This can be accomplished
via two important pathways: insulin-like growth factor-1 (IGF-1)
and the mammalian target of rapamycin (mTOR) pathway. Both
pathways are involved in causing growth. However, this may be
detrimental to long-term health. Calorie restriction inhibits these
pathways, and while they may not be the main mechanisms
through which CR acts, they are definitely important. Excess
calories and dietary protein (specifically leucine and methionine)
activate these pathways.
Osteoporosis
Most of the studies that the acid-base theory was based on did
not reflect reality (pure protein instead of whole food protein
sources, small sample size, and errors in the methods). It is
fairly clear now that adequate protein is required for calcium
homeostasis and hormonal support for the bones:
Carbohydrates
Many people blame excess sugar and carbohydrate intake for the
increase in chronic diseases today, and I would have to agree.
This is not to say that you should not eat any carbohydrates
whatsoever, but you should definitely eat within your body’s
ability to deal with the load.
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It is common belief that obese people eat a ton of food. While
that may have previously been true, they don’t eat 4000 calories
per day forever; if they did they would just gain more and more
weight. A lot of people claim they have a slow metabolism, but
in reality their metabolic rate divided by their lean body mass is
very similar to normal people, if anything it is a bit higher (fat
is metabolically active too). It’s not that their metabolism is
slow; instead, their body’s ability to defend the set-point in the
face of excess calories is not as effective as a lean person’s.
One way to avoid this fate is to ensure you glycogen stores are
low. If your glycogen stores are low your body has space to
store the incoming carbohydrate. This way if you ever do
consume junk-food high in sugar/carbohydrates (e.g. pasta) on
special occasions, your depleted glycogen stores can be utilized
to sidestep the excessive glucose intake (and maybe even offer a
margin of safety in caloric intake).
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Human glycogen stores are around 15g/kg of bodyweight. For a
70kg male that turns out to be 1050g of carbs (4200 calories).
That means 2200 calories over maintenance; this is a
considerably large margin of safety in case you cheat that day.
The important thing on that day would be to not consume any fat
because it would just get stored.
Fiber
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fiber supplement. I prefer to get my fiber from non-grain sources
such as green-leafy vegetables, root vegetables, mushrooms, and
nuts. In total I get 30-40g of fiber a day. I’m not certain as to
what the optimal fiber intake is, but I have found that 30-40g of
fiber from fibrous vegetables is needed to help reach the RDA of
all the nutrients.
Fats
So far we have established that a 70kg man should be consuming
70g of protein, 100g of digestible carbohydrate and 30g of fiber.
This total caloric intake comes out to 740 calories. Considering
he probably requires 2000 calories a day to maintain his weight
that leaves 1260 calories for dietary fat, which turns out to be
140g. In reality, if he incorporates this lower-
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carbohydrate/moderate protein intake diet he will spontaneously
decrease his caloric intake. This would cause loss of body fat
(granted if he performs resistance exercise and watches his
nutrient timing). Some nuts, some cheese, some olive oil on
your salad, some fatty cuts of meat and some flax seed oil and
you’re there.
Micronutrients/Phytonutrients
Dr. Bruce Ames, who has done considerable research on Alpha
Lipoic Acid and Acetyl-L-Carnitine, has also established a
theory of aging: Triage Theory. Basically, without optimal
nutrition the body sacrifices short-term survival at the expense of
long-term survival. Each micronutrient your body uses is
involved in some important process to keep you alive, so if you
are missing one of them or some of them the mechanisms
involved in keeping you alive are not functioning optimally,
leading to DNA damage, cell damage, oxidative damage, etc.
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ancestors for millions of years as hunter-gatherers. There is an
interesting theory about xenohormesis which suggests that as
environment conditions worsen, plants alter their phytonutrient
content and thus mammals that consume these plants begin to
prepare their bodies for the tough times ahead.
Broccoli
Blueberries
Green Tea
Dark Chocolate
Olive Oil
Carninutrients
Taurine
Carnosine
Creatine
Vitamin B12
There are many more but these are just some of the important
ones. Take taurine as an example:
OxLDL is bad because the fatty acids get damaged then become
small. This leads to shrinkage in the size of the LDL particle and
a change in shape. When it changes shape, the body utilizes it
less effectively and thus it floats around, leaving time for the fat
to become oxidized in the blood. As it gets more and more
oxidized, the fat becomes sticky and attaches to the blood vessel.
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If you remember from chapter 2 on the Paleolithic Diet, the type
of fatty acid most likely to become oxidized is polyunsaturated
fatty acids (the one with lots of double bonds). Your
lipoproteins are in the contents of whatever you are eating; if
you eat tons of PUFAs you’ll get tons of PUFAs in your
lipoproteins. If you consume lots of saturated fats you get
saturated fats in your lipoproteins.
It’s true that the plaques (that block the blood vessels) are
made out of fat (and various other materials) but blaming it on
saturated fats is jumping the gun.
There is one thing that makes meat bad, namely its high fat and
protein content. This is due to the methods by which meat is
usually prepared these days. Cooking fats with protein at high
temperatures (grilling, baking, frying, etc.) is a very bad idea
because at these high temperatures, oxidation is rampant and
the formation of glycative-damaged products is very high. It’s
not that meat in and of itself is bad, it’s the way that it is
prepared that is bad. We all know consuming burnt material
isn’t good, but it doesn’t have to look charred for it to be burnt!
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Chapter 4: Weight
Loss/Gain
Don't dig your grave with your own knife and fork. ~English
Proverb
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The big problem here though is that our set-points are much more
likely to go up, than it is to go down. Set-point is by feedback to the
brain and in general I consider there to be two pathways: the
Reward pathway and the Fed pathway. The reward pathway has to
do with how happy you feel after eating. For example, if you have
ever been stressed or got dumped you are much more likely to eat
sweets and carbohydrates. The simple reason for this effect is that
these types of foods raise dopamine. Under these conditions the
reward pathway is below its natural set-point so the body tries to
raise it by any means necessary, thus eating. This pathway is usually
responsible for addiction to drugs such as cocaine and nicotine.
After smoking for months, your brain is used to a higher dopamine
level and when you try to stop smoking, it’s hard because your
dopamine levels drop, so most people begin to eat, but sooner or
later they start smoking again. One thing you see with addiction is
that, the person never “breaks” the addiction, they just use
“willpower” to overcome it, but they will always crave it under
similar circumstances. As you can see set-points usually go up, but
doesn’t come back down (just like weight gain), this is because on
the way up the body is adapting to stronger signals (more
dopamine), but on the way down it has nothing to adapt to because
if set point were to move lower, it has to adapt to a lack of signal.
The Fed pathway is where the body tells itself it is full. If you
eat and your stomach is full or your body knows it’s gotten
enough calories your appetite gets suppressed. If you ate an extra
1000 calories the day before and didn’t exercise it off, today
you’re not as hungry so you spontaneously eat less. Then why
do we get fat if the Fed pathway works. It stop workings because
of the reward pathway, that feeling of happiness overrides the
fed pathway, ever hear of the saying “there is always room for
desert.” So what happens is that one day you start consuming a
lot of junk food constantly stimulating the reward pathways
(which the body likes) and a few months later your 15lbs heavier
(freshman 15).
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Why would nature develop such a detrimental mechanism? In
our natural environment it is not detrimental at all; in nature we
do not have constant access to concentrated sugar, wheat, and
fats. Today we do have access to these supernormal stimuli. We
have existing mechanisms which are supposed to respond to
thing in nature like sweetness (sweet potato, occasional fruit,
rare access to honey), but today this response becomes
exaggerated because our access to it is exaggerated. Our bodies
did not evolve to be in the presence of donuts and cookies, it
evolved to be in the presence of berries and potatoes. It is the
supernormal stimulus that causes the reward pathway to short-
circuit our fed pathway, sooner or later our fed pathways get
damaged (leptin resistance, insulin resistance) and we suffer
the consequences (diabetes, heart disease, obesity).
This is why most diets never work, sure you can follow it for
a couple of months at best but sooner or later our body wants
to get back to set-point.
What can we do then? The first thing is not to gain the weight
in the first place. But if you have gained the weight there are
some things we can utilize that might fix the system a bit.
What the study found was that wrestlers who cycled their
weight up and down had a slower metabolism compared to
those who did not. This is commonly seen in those who diet and
then suddenly gain back more weight than they started with. It is
known as the rebound effect and is present in many systems in
the body.
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So we don’t want a short-term solution. A long-term solution has
two qualities that make it work:
So let’s say you are going to a big party where you know you can’t
resist. Why not just create a huge caloric deficit the day before or
on that day. If the party is on Friday, fast for 16 hours on
Wednesday and Thursday, after the fast eat a normal sized meal.
That way you just created a deficit of probably 2000 calories, and
then do your thing on Friday. If you throw in some resistance
training on Friday in the morning or before the party that’s even
better for calorie partitioning (more on this later too).
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low-blood sugar thing people experience when they are hungry.
What it leads to is consumption of sweets and constant grazing
throughout the day. I’m sorry but we are not cows or apes.
Humans probably went through periods of fasting, where they
hunted (exercised) and then consumed after a successful hunt.
Our bodies have adapted without the need for a constant infusion
of glucose. The reason people rely on snacks nowadays is
because this constant grazing has shut-down fat-burning
mechanisms.
It’s tasty
More satiety
Stable blood sugar
Breaks the supernormal addiction (at least gives you
the willpower)
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Carbohydrate loading is easy and also fun while we’re doing it.
Athletes and bodybuilders can easily consume over 3000 calories
of carbohydrate in a day. There’s something unsatiating about
carbohydrates. I could easily eat a whole box of cereal in one
sitting (depending on the box probably 2000 calories) but could
you eat 2000 calories of cheese? The funny thing is that I would
probably be hungry after the box of cereal (resulting low blood
sugar) but with the cheese I would be full and disgusted for the
day. By lowering your carbohydrate intake you not only stop
consuming the junk-food but it allows you to increase the fat
content of the diet which keeps your blood sugar level and
satiety centers satisfied.
Body Types
You probably heard of the term endomorph, mesomorph, and
ectomorph. It usually specifies the type of body that people have
naturally. The endomorph has a very easy time gaining weight as
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fat; their metabolism is less likely to compensate for the extra
calories they consume and they are more likely to gain fat
instead of protein. This ratio of fat and protein is called the P-
ratio (protein/fat).
Apart from the P-ratio there are two more components that
determine your body type: speed of your metabolism and how
effectively you unconsciously control calorie intake. Your
metabolism is actually made up of a couple of parts. There is
there basal metabolic rate (BMR) I mentioned in the beginning
of Chapter 3. There is the thermic effect of activity (the activity
factor you multiply by, the more you exercise the more you
burn), the thermic effect of food (it takes calories to digest food)
and the biggest factor, the non-exercise thermic effect of activity
(NEAT) which are movements outside of exercise such as
shaking your leg, fidgeting your hands, bouncing up and down
in your seat. NEAT can actually burn off up to 700 calories a day
depending on the person. While the movements may seem small
it adds up over the entire day.
The other component is how well you control your caloric intake
around your set point. Some people control it really well, some
people don’t.
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Endomorph
Low P-ratio
Low NEAT
Does not control caloric intake well
Ectomorph
High P-ratio
High NEAT
Controls caloric intake well
Mesomorph
In the middle
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Chapter 5:
Minimizing Damage
About the only thing that comes to us without effort is old age.
~Gloria Pitzer
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by the time you move along the line and get to the middle 50%
are alive, then at the bottom 0% is alive. So the lines can take
different paths. It can become more square, meaning less rats
die near the beginning, but then suddenly drop off at around the
same age (like humans), or that there is a very high death rate
throughout the lifespan creating the blue line (not accurate
because the blue line also shows a decrease in lifespan). The
other way it can move is parallel, the graphs could shift to the
right showing that at each time period the rat is living longer,
thus extending life span.
So in our example above with mice and AGE diets, the AGE-fed
mouse is the blue line and the controls were the black line (a CR-
mice would be the red line).
There are two sources for this type of damage: your blood sugar
levels and the damaged intermediates you consume in your diet.
Blood Sugar
High blood sugar is a dangerous thing. The body keeps blood
sugar regulated in a fairly narrow range through various
hormones (e.g. insulin, glucagon, glucocorticoids, epinephrine).
If your glucose levels are too low you die (the brain needs
glucose); if your glucose levels are too high, nothing acute
happens, but high glucose levels eventually lead to diabetes.
How well you body responds to your carbohydrate intake
depends on many factors such as source of carbohydrate, how
54
much fiber, protein, and fat you consume, how long since you
last ate, exercise, etc. However, the major factor is your insulin
sensitivity.
When you ingest a bowl of white rice (which is just starch and
water), the amylase (enzyme) in the mouth begins digesting the
starch molecules, which continue to be broken down in your
small intestine. It then gets broken up into tiny glucose
molecules, which are then absorbed through the hepatic portal
vein and released into blood for all the cells in your body. Your
body cannot really burn off all the carbohydrates at one time, so
now the muscles, adipose tissue, and liver suck it up from the
blood to prevent it from doing damage. This absorption of
glucose from the blood depends on a hormone called insulin,
which is released when you eat in preparation for storage. For
many reasons, consuming too many calories and excess
carbohydrates leads your muscles, adipose tissue and liver to
stop responding to insulin. This can lead to high blood sugar
levels (hyperglycemia) and then diabetes. Since your liver cannot
respond to insulin anymore, it believes that you don’t have
enough glucose in the blood, which then causes it to start
pumping out glucose into the blood, making matters even worse.
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Glucose may not sound damaging, but in large amounts it is. In
the picture above (on the left) you have a normal shaped protein.
Protein does its job because of its shape; if you change its shape
you change the protein. Usually for a protein to do its job it has
to fit into another protein that accepts its shape (like a key and
lock). If the protein’s shape is changed it will no longer work
properly (the key doesn’t fit). The picture on the right is the
same protein but with a glucose molecule attached to it (the
circle), by attaching a sugar to the protein it alters its shape, and
the shape is no longer allowed to do its job (it becomes
damaged). It becomes attached through a reaction known as the
Maillard reaction.
This may not seem like such a big deal since new protein can be
created and usually old protein can be broken down, but what
we are worried about are the proteins that stay with us forever,
such as the proteins that make up our arteries and the proteins
that make up our neurons. If they get damaged, they don’t get
removed or replaced.
Glycation doesn’t just end with the proteins. It can also cause
damage to fats. PUFAs are very reactive, and under high
temperatures they are reactive with sugars too. By damaging the
protein and lipids of the body, more and more damage occurs in
a vicious cycle. Glycative damage is actually one reason oxLDL
are produced. As the arteries get damaged by the excess sugar,
inflammation occurs and more macrophages are produced.
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To get this test go to your doctor and ask for it. You preferably
want a level between 4% and 6%, however if you are already
diabetic aiming for below 7% is good.
Glycemic Index
The glycemic index is a measurement for how different food
types spike your blood sugar level. This would be a useful tool
if everyone ate only one food at a time, but I consider it a moot
point considering people consume mixed meals. Sure, white rice
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has a high glycemic index, but when you eat it with a bunch
of broccoli, some meat, and fruit, what is the glycemic index
measuring exactly? The glycemic index diet probably works
because it tells you to eat more vegetables and less sugar.
Damaged Food-Products
Besides the glycation that occurs inside your body, you should
also be worried about the glycation in the food you digest
outside of your body. In the study I mentioned at the beginning
of the chapter, it showed that the AGEs in your diet matter. Fried
meat, bread crust, and evaporated milk are all processed at high
temperatures which lead to excessive glycative damage.
Food AGE
Pasteurized skimmed milk 0.35
Pasteurized whole milk 0.52
Evaporated whole milk 46.2
Butter 0.37
Cheese 5.80
Raw minced beef 0.72
Boiled miced beef 5.02
Fried minced beef 11.2
White bread crust 37.1
Another interesting point in the paper was that if you marinate your
meat in acidic vinegar the AGE content is reduced by 50%.
What we learn from all this is that high temperatures for long
periods of times are damaging. We should cook in moist heat
and lower temperatures. Between time and temperature, which
one is more important? Well, the rate of chemical reaction is
usually exponential with temperature and linear with time, so it
is better to cook at lower temperatures for longer, then higher
temperature for short periods.
Why don’t we just consume grains, breads, and legumes all the
time? Firstly, meat has carninutrients we should be getting, and
we must also be aware of balancing blood sugar and the
consumption of dietary AGEs. Diabetes is a disease due to high
blood sugar, so I think keeping your blood sugar under control is
more important.
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Iron Levels
Women have monthly cycles which cause them to lose ~30mg
of iron every month while males gain ~1mg of iron per day after
the end of their growth period. There may be many explanations
as to why women live longer than men (~7 years longer, e.g.
estrogen, disposition) but one interesting possible reason is that
men get overloaded with iron as they age and women do not
(until they hit menopause).
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discussed below) because it comes with substances that protect the
body from the damage (e.g. phytochemicals, carnosine, taurine).
Most multivitamins include the entire RDA for iron, so if you are
eating a wholesome diet you are getting 2x the RDA.
There are two types of iron: heme-iron (found in red meat) and
non-heme iron (found in vegetables, grains, legumes).
Absorption of non-heme iron really depends on the environment
where various fatty acids, proteins, and vitamins/minerals can
affect its absorption, but overall the absorption of non-heme iron
is not very good. Non-heme iron makes up ~85% of dietary
intake. Heme iron is absorbed very well thus while it only
contributes ~25%, it provides more iron to our bodies than non-
heme.
What was found in this study was that men who donated blood
were less likely to have heart attacks (which is a good thing).
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Donating at least twice a year is good. Not only do you
help others but you also help yourself in the process.
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Chapter 6: The Natural
and Supplements
Better to hunt in field, for health unbought, than fee the doctor
for a nauseous draft. ~John Dryden
Let’s take aspartame and stevia for example. Both are zero calorie
sweeteners commonly used in products today for those who do not
want to consume sugar. Aspartame is regularly blamed for causing
cancer, and stevia is championed as being all-natural, thus entirely
safe. I prefer my drinks with aspartame. While stevia has been
used by for generations by South American Natives, this type of
data doesn’t have any edge on
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clinical data (outcome trials, animal toxicity data, prospective
epidemiology). Just because it has been used historically doesn’t
mean that it’s safe. How is one generation supposed to link
cancer 40 years down the road to their ingestion of stevia leaves?
If stevia caused diarrhea I can see how they would make the
connection. To determine what is safe and effective we must turn
to the scientific method, and so far aspartame, sucrolose, splenda
all have this type of data behind it while stevia does not.:
Magnuson BA, Burdock GA, Doull J, Kroes RM, Marsh GM, Pariza
MW, Spencer PS, Waddell WJ, Walker R, Williams GM.
Aspartame: a safety evaluation based on current use levels,
regulations, and toxicological and epidemiological studies. Crit
Rev Toxicol. 2007;37(8):629-727.
The most convincing study is this one that has life-span data:
What they show in the study is that the rat fed aspartame and the
control rats had the same lifespan. In other words aspartame did
not cause more deaths despite what the conclusion of the study
states (the data was probably due to chance because the
researches were just really bad at taking care of the rats, many
rats died prematurely). If anything, the female group seemed
live longer when fed aspartame. So for the occasional treat I see
no reason why I would choose regular soda over diet-soda (30
grams of sugar or couple 180mg of aspartame).
Supplements
Propylene Glycol
Artificial Colorings
Sweeteners
Sodium Benzoate
Aluminum Silicate
Magnesium Stearate
Gelatin
Stearic Acid
Lecithin
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Cellulose
Di-Calcium Phosphate
Glycerin
These lists are by no means extensive but just keep an eye out
for how other ingredients there are. I have found some very
pricey supplements with 8-10 other ingredients.
Which supplements should you be taking then? Well there iss the
Weston A. Price nutrients, vitamins A, D3, and K2 (MK-7 or
MK-4) and maybe some magnesium and a source of omega-3s,
because modern diets are usually deficient in these nutrients.
Vitamin D3
This is not actually a vitamin but a hormone that our bodies require
to function optimally. Back near the equatorial region of Africa we
probably produced tons of Vitamin D3 due to exposure from the
sun. In 20 minutes our bodies have the capacity to produce
20,000IU of Vitamin D3, yet for most of us, when we go outside
we cover ourselves up, stay in the shade, and slap on sunscreen.
These are actually fairly smart things to do considering that UV
light causes skin aging, damage, and maybe cancer, but doesn’t do
much for our Vitamin D status. So the first thing you should be
supplementing with is at least 2000IU of Vitamin D3. What should
optimally be done is to supplement with 25IU/lb of bodyweight
then get blood tests performed measuring your levels to ensure that
you are in the optimal range >30ng/ml and less than 50ng/ml. You
can read more about Vitamin D and the Vitamin D Council
website.
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Vitamin K2
Cancer
Neuroprotection
Cardiovascular health
Dental health
There are two forms: MK-7 and MK-4. MK-7 comes from
fermented soybeans while MK-4 is the endogenous animal form.
If you take MK-7 take 45mcg a day, if MK-4 take 1mg a day.
Also ensure that it is in a softgel form.
Magnesium
Basically what has been found is that species with more long
chain PUFAs in their membranes live a shorter life than those
with less PUFAs. It is interesting to note that CR also reduces
the incorporation of long chain PUFAs into the membranes.
Common arguments against this are that flax seed oil conversion
into animal form omega 3 fatty acids are inefficient (~10%), but
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just because it is inefficient doesn’t mean it doesn’t happen at
all. Research has placed optimal amounts of omega-3 intake at
around 250mg (which comes out to 3 servings of fish per week).
One tablespoon of flax seed oil is enough to make 250mg.
It’s preferable if you get the rest of your nutrients from food, but
if you find it hard I suggest topping it up with a multi-vitamin.
The only good brand of multivitamins out there is AOR. Don’t
take the full-dose, a partial dose will do.
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Chapter 7: Maintaining
the Body
Fasting is the greatest remedy, the physician within. ~Philippus
Paracelsus
As we all know, exercise is good for you, but too much leads to
overtraining and down the road your body is going to
breakdown. There is evidence to show that alcohol intake
probably leads to better cardiovascular health (20g or so a day),
perhaps through the production of hydroxytyrosol (which is also
found in large amounts from high quality olive oil).
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Hormesis probably played a role in our evolutionary history by
selecting those who had mechanisms in place that could be up-
regulated when exposed to stress, thus preparing them for
larger stresses in the future. Those without the gene that leads
to up-regulation probably died off when those large stresses
came about.
In this study:
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considering the damage we do to it by the crap we eat and the
stress we experience, it is a surprise we don’t age faster. While
our body does have mechanisms by which to deal with some of
it, we never get into the optimal state to remove the garbage.
Today we are taught to eat 3 square meals a day and maybe even
have some snacks when hungry. We are constantly in a fed state,
and never have a chance to enter the fasted state. We are always
trying to build and store nutrients instead of breaking them
down. The only times that we may be in the fasted state is when
we are asleep but that doesn't take into account the fact that lots
of people eat very late night snacks.
So let’s say you don't eat for 24 hours (fasting). During the 24
hours your body still needs to run on something so it taps into
your body’s own energy stores. It requires glucose for the brain,
which the body can produce by breaking down liver glucose
stores. If your liver glucose stores are low, the body tries to leave
the glucose for the brain and instead breaks down fatty acids into
ketones. This allows other tissues to use ketones while the all-
important brain can still get its glucose. Another source of
glucose would also be amino acids. But this isn't amino acids
from your muscles, its most likely the crap that doesn't work and
instead is floating around in your cells and body. Basically, by
not eating your body decides to recycle the garbage. So as you
can see, if you never fast, or never eat below maintenance (i.e.
calorie restriction), you never get to take out the garbage. Also
there's the added benefit of ketones (if your liver glycogen stores
are depleted, which we will do with resistance training, Chapter
6, and low-carb diets).
There are some common myths associated with not eating and I
will address the two important ones here:
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bodyweight, body composition and energy metabolism. Am J
Clin Nutr. 2005 Jan; 81(1):69-73
What this study shows is that the metabolic rate did not slow
down. It also showed that the use of fats as energy increased
(as it should).
A 24 hour fast would work like this. On Monday, finish your last
meal at 6pm then don't eat until 6pm the next day. Then choose
another day to do that. I've actually included my fasting schedule
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into a larger scheme combining calorie cycling and
resistance exercise.
Fasting and calorie restriction are not the same thing, and I am
not recommending you consume all the calories you didn’t eat
one day in the day after. While IF may not provide the life
extending benefits of CR, there are benefits and it is better than
not doing anything at all.
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Chapter 8: Biometric
Measurements
Friend to Groucho Marx: “Life is difficult!” Marx to Friend:
“Compared to what?”
Vitamin D3
Lipid Profile
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The LDL number is not actually measured, instead it is
estimated from the Friedewald equation which estimates LDL
based on TC, HDL, TG. It is actually inaccurate when TG are as
low as mine are, and as low as most low-carbohydrate dieters
are, there has been a new equation for low TG created:
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Diet, micronutrients, and exercise determine your lipid profile.
If you consume the American Heart Association (AHA) low-fat
diet you will inevitably end up with Pattern B (ironic eh?), if
you consume low-carbohydrate high saturated fat you will end
up with Pattern A. The triglycerides are very representative of
your carbohydrate intake. If you consume lots of carbohydrates,
your triglycerides are high, the high carbohydrate intake also
somehow decreases HDL (by somehow increasing an enzyme
that breaks down HDL). Saturated fat also helps boost HDL.
After knowing this, it definitely seems like the whole lipid
profile thing was just a measurement of your carbohydrate
intake, which represented your intake of processed junk foods.
After a couple years they found that total cholesterol didn’t tell
much so they then focused on LDL, then LDL didn’t tell much
and now its TG/HDL, but the TG/HDL ratio is low only when
you are consuming saturated fat and low carbohydrate (with an
exception, which is calorie restriction).
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By depleting your body of cholesterol you may not be able to
build the plaque (controversial still), but at the same time your
body requires the cholesterol for other functions, and if you don’t
have enough you are more likely to die. Doesn’t seem like a very
good trade-off to me.
There are two tests in this category you should get if you can:
HbA1c and fasting glucose
My results (as of August 2010):
HbA1c: 4.3%
Fasting Glucose: 4.5mmol/L (81mg/dL)
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Body Fat
I wish there was an easy and inexpensive way to test your body
fat percentage but there is not. I also wish we had a test for
visceral adipose tissue but I do not know of one (CRP maybe?).
So I have opted for how you look in the mirror and calipers to
make sure you are not getting fatter. Cheap calipers may be
very inaccurate but it is useful to gauge relative change. If you
are getting fatter you should see it in the mirror and also on the
calipers.
Blood Pressure
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It definitely makes sense that by decreasing salt intake
blood pressure should go down:
The bottom half of the picture is your blood vessels. On the right
is a person without hypertension with normal amounts of salt.
On the right is someone with hypertension and for some reason
has more salt, thus water flows into the blood vessel, increasing
the volume and it pushes again the blood vessel (like filling a
balloon with water). The extra pressure causes the heart to work
harder than the heart on the left (this leads to left ventricular
hypertrophy, which is bad).
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Chapter 9: Perpetual
Leanness
The idler never attains great age. ~Thomas Easton
What the study found was that those from the Harvard Alumni who
remained active gained 1.5 years by age 90. However, exercise is
something everyone should still be doing; while it does not extend
life it does decrease your chances of dying prematurely. By
exercising you protect yourself from many chronic diseases such as
heart disease and diabetes. The improvement in strength and
endurance you achieve applies to all parts of the body: improved
heart function, increased bone strength and a more robust brain. It
lowers blood pressure, burns up fat, controls weight, and helps
improve your lipid profile. Finally, exercise not only makes you
feel good, but it also makes you look good which is what most
people are interested in.
How does one remain lean 24/7/365? We are all aware of the
cyclical dieting that many people go through. When summer is
over, they pack on the weight, pack on more weight at the
holidays, then try their best to cut down for the beach season
again (but most fail). As I mentioned in Chapter 4 on weight
loss, this up and down cycle is not very good for your
metabolism. It probably increases the likelihood of gaining
weight when you are older. What I am more interested in is
maintaining a lean state all year round. Now, each person’s
natural state of leanness is different, but this is mainly due to
genetics and the environment one grows up in (remember Set-
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Point). What I hope is that I have created is a regimen that helps
you maintain your muscle mass and helps cut body fat. Extra fat
is not good and loss of muscle is not good either (we need it as
we get older, and it also seems that loss of muscle leads to loss of
bone. We don’t want to die of a simple fracture due to tripping
over a tiny rock). My recommendation is that men achieve 15%
or lower, and women achieve 25% and lower (unless pregnant).
There are various ways to measure body fat (the accurate ways
are expensive) but to keep it simple let the mirror be your
friend. If you see more definition and fewer lumps you are
heading in the right direction.
The Schedule
Low Intensity High Volume High Intensity Low Volume
(LIHV) (HILV)
Total Duration: 30 30 min workout:
minutes 2-3 sets, 3-6 reps.
4-5 sets, 10-20 reps.
Alternating lower-body and
Alternating lower-body and upper-body.
upper-body. Weighted Squats -->
Squats --> Pushups --> Weighted Pushups --
Lunges --> Pull-ups --> > One-legged Squats
Ab Wheel on Knees --> --> One-armed
etc... Pushups -->
Weighted pull-ups or
One-arm Pull-ups -->
Ab Wheel on Toes --
> etc...
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Note: please see Appendix V for discussion of some
bodyweight principles.
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glycogen it leaves room for the extra carbohydrate days
that might come on Friday (for example if you cheat).
Exercise Supplements
If you walk into a supplement stores you find various
workout supplements. There are pre-workout, intra-workout,
post-workout, pre-sleep formulas and many more. Many of
the expensive brands contain 50 or more ingredients and the
amounts/dosages are all hidden under the term “proprietary
formula.” Most people continuously switch between various
products and brands because they just do not see the claimed
effects, so how proprietary can it really be? These claims
include:
These claims seem unlikely, and to tell you the truth they are.
They aren’t false but they aren’t true either. For example, by
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claiming an increase of lean muscle mass by 300%, are they
saying that if you have 100lbs of lean mass you will suddenly
have 300lbs of lean mass by taking their supplement, or do they
mean they found in some obscure study done on rats where the
circumference of their forelimb increased from 0.00001 to
0.00003 gain 6lbs of lean mass? Water is lean mass too; I can
drink 6 lbs of water pretty easily. Lose five inches? By not eating
for two days I can drop 2 inches (I just urinated it out). Don’t
waste your money on these products, because they just do not do
that much. If there are benefits they are incredibly small, and the
risks you’re taking are incredibly big. Remember our benefit to
risk ratio, well in these situations it is really low.
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The other widely sold product is branched chain amino acids. I
doubt we truly require these isolated. If you consume adequate
protein (especially in the form of whey) you are getting a large
amount of BCAAs already (whey is 25% BCAA while beef is
15%). BCAAs are expensive and useless if you are ingesting
adequate protein. However there are benefits, if you don’t ingest
adequate protein BCAAs will help with retaining muscle mass
and might also boost your immune system in times of sickness
when you cannot ingest enough food.
If you truly want to gain muscle, there are only three things you
need: whey protein, creatine monohydrate, and caffeine. (I won’t
go over all the forms of creatine but the monohydrate form is the
tried and tested one, sure the other ones don’t cause bloating, but
that is probably because it doesn’t work).
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first you may have tightness in your shoulder not allowing you
to flatten out completely but with practice you’ll get there.
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Chapter 10: Paleo Shoes,
Posture, and Sitting
In our natural state we did not have chairs to sit in, nor did we
have folk wisdom guiding our posture. Our ancestors most
likely all moved in an optimal state with optimal positioning.
This chapter will explore some of these issues.
Shoes
Running shoes are terrible. We did not evolve in the presence of
running shoes, or even shoes in general; we evolved with our
bare feet touching the dirt and rocks on the ground. We ran
barefoot, we walked barefoot and we stood and sat barefooted.
The mechanics of motion when wearing shoes and not-wearing
shoes are different. For example, go run on the grass with your
thick-soled, supported arch, raised heel running shoe, then try it
bare foot, it’s quite a different experience. With shoes we tend
to flex the foot and strike the heal, while bare feet our foot
position is more relaxed and its more of a front-mid foot strike.
Related to barefoot states, our feet have also been in contact with
the ground. The ground from before is not smooth and
homogenous like the floors we experience today. It’s much more
varied and for the uninitiated its also much more painful but
you’ll get used to it. By evolving barefoot our bodies have also
developed mechanisms that react to various stimulations of the
foot:
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Li F, Fisher KJ, Harmer P. Improving physical function and
blood pressure in older adults through cobblestone mat walking:
a randomized trial. J Am Geriatr Soc. 2005 Aug;53(8):1305-12.
Posture
The picture on the right is the posture
most people today are told is the
proper posture. Shoulder’s back head
up, which causes an excessive curve
in the lower back. But in reality
based on traditional populations the
posture on the right is more
“natural.” Hip back until you can
drop a straight line down from the
hip socket to the ankles. To
counteract the weight backwards we
must lean forward (think caveman
like) then we pull our head up and
back. This gives us a much straighter
spine. If you have children you will notice that this is how your
children stand.
Sitting
Today we sit on reclining chairs and stools, when we “do our
business” we sit on a toilet rather than squat over a hole. The
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back problems and hip problems commonly found among people
today may have roots in the lack of indigenous squatting done
today. What is the indigenous squat?
You keep your heels flat on the ground. Feet a bit wider than
shoulder width apart, then take your glutes straight to the floor.
Many people have problems with this at first, their behind cannot
pass parallel. This is tightness in your hips. If you have
problems, try holding onto something in front while squatting
down. If you can get all the way down, it is more of a stability
issue (not activating the right muscles). With practice you will
get there. Every day you should take some time to get down into
this position and open the hips and stretch the spine.
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If you watch Western people squat, to get their posterior down to
the ankles they have to lift their heels from the floor. Lifting the
heels defeats the purpose.
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with increased risk of heart disease, diabetes, obesity, and cancer.
Not only that, what has also been shown is that species who deviate
from the 24 hours the most also have decreased lifespan:
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Chapter 11: How
Much Life Left?
Storing your car in New York is safer than entering it in a
demolition derby. But not much. ~Daniel S. Greenberg
Life Span
It may seem like we have extended our lifespan in the last 1000
years. The ancient Greeks, Romans, and Egyptians had a life
expectancy of 30, now we can expect to live up to 80 (Japanese
women can expect to live up to 86.44). Its seems we easily doubled
our life span and if you plot it, it looks like we are gaining a solid
2.5 years every decade in a straight line with no plateau in sight. If
you plot human survival curves it definitely seems very square, but
the squaring effect stopped at about 1950 (figure 3 in the study
below) and seems to be shifting parallel:
Remember Chapter 5?
In 1950 we reached the black line and now the survival curve
seems to be moving like the red one. As I said in the beginning
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of the chapter, maximum lifespan seems to be 125 years and I
suspect that this has always been the case for thousands of years.
Health Span
Even if we took the pessimistic view of 90, I would still
implement the lifestyle described in this book. Healthy life
expectancy is the number of years one can live with minimal
morbidity. For example, let’s say you live until 90 but have
diabetes for 15 years, then cancer for 10. Your healthy life
expectancy from birth is only 75.
From all the research, health span and life span are closely
correlated, healthier people just tend to live longer. But as
lifespan begins to reach the maximum (outside of anti-aging
interventions) morbidity will be compressed as people get
healthier. Even if I were to only achieve 86.44 (not saying I’m a
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Japanese woman, just that this is a number for the healthy) I
would be glad that I gained 10 years of healthy lifespan where I
am not suffering from cancer, diabetes, heart disease, and
Alzheimer’s.
I have volunteered at a care home for over 4 years and had the
chance to work at a hospital for 1 year, the way that seniors
spend the rest of their lives in these situations is not something I
want to go through.
Where to Now?
Research in the field of aging is exploding. Of course, there has
been some resistance (hey, death is “natural”) but sooner or later
we will have interventions that will expand both our health span
and our life span. The common interpretation of anti-aging
interventions is that you will be 120 years old but be more
decrepit than a 90 year old (which is really bad), but this is not
how these interventions will work. The new technologies being
developed will not make you “older,” instead it will extend you
lifespan by making you younger. The first development that will
come will probably be CR-mimetics. These are pharmacological
interventions that will mimic the metabolic altering effects of
CR, after that it will be Strategies for Engineered Negligible
Senescence (SENS) (read Aubrey De Grey’s book on this matter,
“Ending Aging”). SENS isn’t about trying to mimic the effects of
CR, it goes beyond that in that it is trying to go into our bodies
and fix/reverse/remove the damage that happens. If the damage
is gone then the cause of aging is diminished. This seems like a
tall order but it is definitely possible.
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It is because of SENS that I have put serious thought into
adopting CRON (please donate to SENS). It is the only way of
ensuring maximally robust lifespan, and this is important
because of the speed at which science advances. Less than 20
years ago we did not have the internet, and now it permeates
almost every facet of our world. Science and technology build
upon themselves and with each new block they reach farther
heights than ever before. To take advantage of these new
discoveries from SENS one has to have a body that is robust
enough to deal with the effects of these new drugs/interventions.
If you reach the age of 70 but can hardly move and have
dementia, you will not be able to survive the application of the
new technologies. However, if you are 70 years old with robust
health (like with CRON) then you can. Let’s say the intervention
extends your life by 10 years, because of that one discovery,
more will come and within those 10 years another intervention
will come along extending life another 20 years, and so on and
so forth, until immortality is reached (this is by no means far-
fetched). I am not saying that these interventions will be created
in my lifespan or yours, but the thing is that you never know, and
it would be best to not only live as healthily as possible, but to
live as long as possible. The only way to achieve the maximum
is through caloric restriction (this speeding up of technology is
known as the Singularity, read Ray Kurzweil’s book, “The
Singularity is Near”).
I think that I have taken this lifestyle as far as it can go, the only
other place to enter now is the world of the extreme, calorie
restriction with optimal nutrition. Will I enter that realm, I don’t
know yet, but it is best to decide sooner rather than later.
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Concluding Thoughts
My goal when I started researching all this was to try my best to
prevent the chronic illnesses. I saw how much pain they can
cause to everyone. Just take Alzheimer’s for example: lifeless
eyes with no sense of self, time, or place, a dreadful disease with
a slow progression that places strain on yourself as you lose your
soul as well as strain on your family, friends and society. Even if
you wanted to end it you couldn’t because you have basically
disappeared. Everyone’s goal in this life is different, but I am
certain that no one wants to end up in such decrepitude. The
regimens laid out in the book will help with preventing this,
screw the USDA Food Guide and the American Diabetes
Associate Diet, throw out common “wisdom” and rely instead
on hard science. The basic principle of this book is: eat the right
foods, but not too much; allow the body to take out the garbage;
be conscious of what you put in your body; and exercise.
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Appendix I: Olive Oil
There has been a Slow Food movement in our Western culture.
The idea that we can access authentic traditional cuisine through
local food, as well as the proliferation of extra virgin olive oil
(EVOO) are both prime examples of this movement. Today, the
best selling brands are the ones with the name of countries like
Italy, Spain, and Greece plastered on the front signaling the
source of the oil and providing a connection between the
consumer and the country of origin. However, large producers
have taken advantage of our love of olive oil and many of your
purchases today are not as high a quality as you would think. In
terms of olive oil, quality is very important, because without it
you are just consuming another plain old oil without the flavor,
aroma, or the health benefits of olive oil that has been used for
hundreds of years.
Is it the monounsaturated fat and low saturated fat in the olive oil
that provides the health benefits? Well, after learning about the
Paleolithic diet and looking at the research, saturated fat does not
seem to be a problem. Comparing the monounsaturated fat intake
of the U.S:
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It was probably not the monounsaturated fat so that left the
polyphenols:
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thus necessitating the need to create ways to detect them, which
there are many of now, but regulatory bodies do not have the
capacity to test all oils so it is left up to the consumer to be able
to determine what is real extra virgin olive oil.
Tasting
Why is the label “extra virgin” important? This is a term from
the International Olive Oil Council that signifies that the oil
must have passed certain chemical tests, be fault free, and passed
rigid taste tests. However, these tests aren’t exactly in place to
ensure quality, but are just there to ensure that the oils are
deemed edible.
If there is a defect
the oil is labeled
as virgin, and if it
is inedible it is
labeled as lamp oil
(scary thought that
lots of people may
be consuming
lamp oil grade).
Thus we either
have to pay
independent labs
to test our oils,
which can get
expensive, ask
the producer to
provide us with
independent tests they have performed (and not all companies
are happy to oblige) or we try our best to use our senses to taste
for extra virgin olive oil qualities.
The first thing is that the oil has to lack defects. On the picture
you can see the various defects; I have had experiences with oils
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that have tasted rancid, sour, and metallic, but were labeled
as extra virgin.
Defects
Fusty: Brined olives, lactic acid.
Musty-Humid: Mouldy
Muddy: Stale muddy water, baby vomit, wet soil.
Sour: Vinegar
Metallic: Metal on teeth (try some Epsom salts).
Rancid: stale oil (try leaving raw walnuts in a room for a couple
of days)
Positive Attributes
Fruity: Grass, orange, lemon, apple, nutty, leafy, almond,
eucaplyptus, perfumy, buttery. Bitter: grapefruit rind,
tonic water.
Pungent: chili, makes you cough, hot, pepper.
Always check for a date on the product you are buying, making
sure it is not too old (also taste for rancidity, it is a very bad
sign).
There is a process to tasting olive oil (just like wine) and this is
due to the fact that our noses and our tongues are connected
(oil should be at around room temperature):
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1. One tablespoon in small container with lid
2. Swirl: releases aroma
3. Smell it: you should have a fruity smell
4. Slurp: this brings in air which spreads the flavor/aroma
5. Swallow: it should sting and last for a bit.
Chemical Tests
Some producers do have certificates of authenticity (COAs) on
hand that might show the free fatty acid level and peroxide
levels. These are important because it tells you how well the oil
is stored and how “fresh” it is.
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Appendix II: Acne
and Balding
There are a couple disorders that affect our self-esteem today
that our ancestors probably did not have to experience, obesity,
acne, and balding. By setting up a lifestyle that can prevent
metabolic syndrome we can prevent the damaging
psychological effects these disorders have and hopefully be on
our way to achieve a healthy body image.
Acne
In western populations acne affects up to 95% of adolescents and
50% over the age of 25. The economic and psychological effects
are undeniable and best avoided. However in hunter-
gatherer/traditional populations there have been no reports of
acne in the anthropological reports:
Our skins should not have evolved so that everyone gets acne, it
should only occur to signal to the other sex that something is
wrong with the metabolism. The metabolism goes awry because
of your hormones and hormones depend on diet (and genetics
but only in special cases). Polycystic ovary syndrome (PCOS)
affects women and is characterized by excess androgen (male
hormones), too much insulin, and insulin resistance. PCOS
patients often struggle with acne. These hormonal profiles are
associated with acne in “healthy” people and by correcting the
hormone levels acne lesions decrease:
Smith RN, Braue A, Varigos GA, Mann NJ. The effect of a low
glycemic load diet on acne vulgaris and the fatty acid
composition of skin surface triglycerides. J Dermatol Sci. 2008
Apr;50(1):41-52.
The diet is a very important factor that determines insulin levels.
By elevating insulin with a high carbohydrate diet, it activates
pathways which then results in increased androgen production.
This leads to elevated insulin-like growth factor 1 (IGF-1) and
decrease insulin-like growth factor binding protein 3 (IGFBP-3)
[which bind IGF-1, thus resulting in more free IGF-1]. Somehow
this leads to low amounts of retinoids in the skin which is
responsible for keeping cell proliferation at proper levels (thus
the use of retinoids to treat acne). So to stop this progression we
have to lower insulin and we lower insulin through a low-
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carbohydrate diet (like the one espoused in this book). By
lowering insulin we prevent the hyperkeratinization, excess
sebum production and even lower inflammation. Without the
environment of excess growth (caused by IGF-1, insulin, and
androgens) the bacteria is not allowed to grow excessively.
I briefly discussed the glycemic index in chapter 4. Many
studies on acne these days utilize the glycemic index instead of
actually controlling total digestible carbohydrate intake. This is
probably the reason why the studies are equivocal. One low
glycemic index diet can lead to an overall high carbohydrate
intake (grains), while another will lead to a low carbohydrate
intake (mostly vegetables). So just make sure to keep you blood
sugar and insulin levels under control and your acne will soon
go away.
Note: Foods like milk and chocolate have also been implicated
in causing acne. I suspect that milk might be a problem because
of the growth factors present in the milk (which also raises IGF-
1, possibly so if you are trying to get rid of acne you should
probably stop the milk intake). Chocolate is not a problem
unless you are consuming milk chocolate. Milk chocolate is not
“real” chocolate in the sense that most of it is sugar and milk. If
you like chocolate go for 90% and above dark chocolate and the
acne problem should go away.
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Su LH, Chen TH. Association of androgenetic
alopecia with metabolic syndrome in men: a
community-based survey. Br J Dermatol. 2010
Aug;163(2):371-7. Epub 2010 Apr 23
This connection has only recently been studied and there are many
issues to tease out. Some studies show that those with MPB have
higher levels of testosterone but metabolic syndrome decreases
total testosterone and sex-hormone binding globulin. The way
most hormones work is that they are created by cells but also
present in the blood stream is a binding factor that inactivates the
hormone. This is done so that there are always hormones in the
blood but when needed the binding factor can be broken down to
release more hormone instead of making more hormone from
scratch. Treatments such as DHT lowering agents do seem to work
so it does have an effect but for all I know it is preventing the
damaging effects of high insulin, glucose, and inflammatory
levels. Metabolic syndrome may decrease total testosterone but
free testosterone could be higher or the conversion to DHT could
be higher or sensitivity of the
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hair follicles to DHT is higher. But one thing for sure is that if
you want to keep your hair, do not use steroids and do not get
metabolic syndrome.
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Appendix III: Skinny
Fat Body Type
The skinny fat body type has become a problem
over the years, not only for those trying to gain
muscle but also as a health policy subject. We are
not surprised when someone says that the United
States is suffering from a diabetes epidemic, but
most are surprised that China is also suffering an
epidemic. It is true diabetes is usually associated
with obesity, but obesity describes body fat, and
thin people can be fat too. There are two types of
ectomorphs, the ones that stay “ripped” while
consuming 8000 calories and another softer
ectomorph: these are the skinny types.
The brain gets what it wants, and when it doesn’t, other tissues
are not allowed to develop properly such as the muscle tissue.
This also stresses the body probably priming your neural
circuitry for a less stress-robust personality (leading to
overproduction of cortisol which is a hard environment to build
muscle in and also decreases anabolic hormones). For some
reason, this body type leads to tall and long bone structures that
stretch the muscle, decreasing the amount of tension you can
place on the muscle. There is also a decrease in fast-twitch
muscle fiber, which leads to the soft look many skinny-fat types
have.
Skinny fat types are not just a problem for Asians; I have seen
them from all cultures. I suspect they have very high amounts
of visceral adipose tissue.
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Appendix IV: Riskier
Supplements
Some other supplements that I personally take that I think are
worthwhile are:
Lithium
Phytate (IP6)
Beta-alanine
Taurine
Acetyl-L-Carnitine and Alpha Lipoic Acid
Lithium [1.25mg/day]
This mineral is not on the Institute of Medicines official list of
essential vitamins and minerals but there is convincing evidence
that humans do require it and consumed it in times past:
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Lithium is interesting because of the neuroprotective properties
is can confer at higher dosages but there is speculation that this
also occurs at lower dosages:
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Beta-alanine [2g/day]
This altered amino acid is a precursor to the dipeptide carnosine.
Carnosine prevents cell damage and aging, it also prevents
glycation end-products:
Taurine [250mg/day]
The reason for supplementing with taurine is a paleolithic one.
Taurine is found in high concentrations from seafood and organ
meats. Cooking also destroys about half of it from the meat we
commonly consume today. While some mammals produce taurine
by themselves, other mammals such as cats and humans rely on
dietary ingestion. Taurine is involved in many activities:
preventing atherosclerosis, modulating intracellular calcium,
osmoregulation, preventing glycation, and possibly even
preventing the transfer of diabetes from the mother to the fetus:
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Acetyl-L-Carnitine (250mg) and Alpha Lipoic
Acid (150mg)
These two are in my opinion the riskiest of them all. The data on
the long-term safety of these supplements are lacking but the
benefits sure seem impressive.
The data regarding ALCAR in humans also shows its safety. Most
studies are done in humans regarding Alzheimer’s disease and
weight loss. While the positive effects seem very weak, I use it as a
preventative measure to keep my mitochondria healthy.
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Mittermayer F, Pleiner J, Francesconi M, Wolzt M. Treatment
with alpha-lipoic acid reduces asymmetric dimethylarginine in
patients with type 2 diabetes mellitus. Transl Res. 2010
Jan;155(1):6-9.
There are two forms of Alpha Lipoic Acid you can purchase:
racemic (normal) or the stabilized R form. We are interested
in the R form because the racemic (normal) form contains the
S-form, which is not found in nature.
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Appendix V:
Bodyweight Exercises
An important part of various exercises is to utilize the full-range
of motions. Sure, cutting the distance you have to move by a
couple inches makes it easier, but it would be better to activate as
many muscles as possible. Let’s take the pushup for example:
As you move
down your hips
should not sag
downwards.
Keep them up
by pushing the
glutes up. The
chest should
touch the floor
then when you
go up and reach
the very top,
and make sure
to activate the
various muscles
around your
shoulders and ribs, and also try to extend up as far as possible.
Most people just wait until their elbows lock and then head back
down, what we want to do is reach the top and try and reach
more. Hopefully you can feel the difference.
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Appendix VI: Soft Tissue
Therapy and Stretching
Beyond your muscles and bones there is connective tissue,
ligaments, tendons, etc. sitting in between everything else. These
can be injured just like your muscles can. I don’t know if hunter-
gatherer/traditional populations required soft tissue therapy and
stretching, but they didn’t sit in front of a computer in a chair,
using keyboards and mice, and playing console games with
controllers by contorting their body in weird positions then
keeping it there for hours on end.
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These three books are great in terms of helping you understand
where the pain comes from and also helping you solve it.
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