Official Complete Biotic Ebook

Introduction
Move over probiotics, there is a new kid on the block! Butyrate, or

tributyrin, has been making headlines recently in the integrative
medicine community as the new superstar for
gut health. And no, butyrate is not a probiotic;
it’s not even a prebiotic. Butyrate is a short
chain fatty acid, and when it comes to your gut,
butyrate runs the show.
Recent studies have shown remarkable results

with the use of butyrate in a variety of diseases
and disorders. In brief Butyrate helps prevent
and manage the following conditions, which
this ebook will go over in more detail. (1)
• Inflammatory Bowel Disease • Diabetes

• Acid Reflux • Atherosclerosis
• IBS • High Cholesterol
• Candida • Hypertension
• Parasites • Autoimmune Disease
• Leaky Gut • Epstein Barr Virus
• Colon Cancer • Pancreatitis
• ADHD • Food Allergies
• Autism • Seasonal Allergies
• Anxiety • Weight Loss
• Depression • Muscle growth and strength
• Alzheimer's • Liver Damage
• Parkinsons • Cancer cell and tumor growth
• Huntington's Disease • Arthritis
In this ebook we’ll explore what butyrate is, and the many ways it
impacts your body. We’ll also discuss the best type of butyrate, in the
form of tributyrin, and reveal how our supplement, Complete Biotic,
can transform your health.
www.HealusHealth.com 2
“All diseases begin in the gut.” – Hippocrates
Understanding the Microbiome

In order to understand butyrate, we need to understand the
microbiome. You’ve most likely heard of this term, but may not fully
comprehend what the microbiome is or does. The microbiome simply
refers to a collection of bacteria that live in the gut. There are an
estimated 100 trillion microbial cells that make up this microbiome. Of
these bacteria, there are good guys and bad guys, and like any living
being they are all fighting for survival. Depending on your diet,
lifestyle, and medication use, you are either feeding the good guys, or
feeding the bad. Antibiotics, for example, while trying to go after
pathogenic bacteria, also end up destroying a lot of good bacteria in
the process. Over time with antibiotic use you can develop a ratio of
more bad bacteria to good. (2) This is a big problem, as the makeup of
your microbiome dictates not only the health of your gut, but the rest
of your body as well.
The microbiome is responsible for 80% of your immune system, has a

direct influence on your brain and nervous system, and is even involved
in hormone production. How do you know if the balance of your
microbiome is off? It’s simple, if you have any disease or disorder,
then you have something off balance with your microbiome.
In fact, researchers say that 90% of all disease can be linked back to the
gut in some way. There are of course other factors in your body that
contribute, but the microbiome definitely plays a major role. Digestive
disorders, cancer, autoimmune disease, arthritis, diabetes, weight gain,
and even depression can all be linked to the microbiome. (3) This is not
a comprehensive list, just an example of how many different conditions
your gut influences.
The Problem with Probiotics

As the microbiome becomes more understood in the medical
community, supplements claiming to help heal the gut have become
popular. Probiotics, in particular, are touted as the cure-all when it
comes to gut health. The problem with probiotics is that they just
aren’t getting the job done. There’s been a good 20 years of probiotic
praise, yet people are still sick, and new autoimmune conditions are
being labeled every year. Something is clearly not working here.
The idea behind probiotics was great. Beneficial bacteria are

important. But the “Let’s put a few strains in a capsule” method is
flawed. The problem with this is that we have over 5,600 different
strains of “good” bacteria in the gut that we know of. (4) In the grand
scheme of things, those 3-4 different strains that are in your probiotic
don’t have a huge impact, or they may even have the wrong kind of
impact.
For one, even the most expensive probiotics are not absorbed
completely. A probiotic has to make it through stomach acid and
digestive enzymes before it reaches your intestines. This is why you
see probiotics in high quantities such as 50 billion, because a good
portion of them are going to be lost along the way. Whatever you are
left with will be introduced into the microbiome, but this introduction
does not always go over very well.
“The researchers were looking to see where bacteria successfully

colonized and whether they led to any changes in the activity of
the gut. The results in the journal Cell, showed in half of the
cases the good bacteria went in the mouth and straight out the
other end. In the rest, they lingered briefly before being
crowded out by our existing microbes.” Probiotics Labeled
‘Quite Useless’
The microbiome is a delicate balance. All the beneficial bacteria in the

gut are only beneficial if they are in the appropriate balance with one
another. Have too much of one, or too little of another, and the
equilibrium is thrown off. Think of your microbiome as an established
group or community. Newcomers are not always welcome into this
group, as the existing bacteria are defending their turf. Remember,
these microbial cells are living beings, and all living beings have the
desire to live and thrive. Anything that feels threatening to their
survival (even if it is good bacteria) is going to be met with some
resistance initially. So if it feels like there is a little war going on
inside your tummy at times, that’s because there actually is.
This is when taking a probiotic
can sometimes cause things to
be worse, especially if you take
the same one day after day.
You keep introducing the
same 4 strains into your
microbiome, while neglecting
the other 5,596 strains. You
may create an unhealthy
dominance of one “good”
bacteria over another. For
example, lactobacillus is a
popular strain included in
many probiotics due to its
benefits. When in balance, lactobacillus contributes to a healthy
microbiome. However, if you have too much lactobacillus, it can throw
off the balance of your microbiome and lead to such conditions as IBS,
diabetes, and weight gain. (5)
Does this mean that your probiotic consumption has been an entire
waste of time (and money)? Well…yes and no. Probiotics can help, but
only on a short-term basis, and only if you need the particular strain
that is in that probiotic to begin with. It is common for many people to
feel an improvement on probiotics initially, or temporarily.
Unfortunately, evidence has shown that it doesn’t do much in the long
run to change the balance of your microbiome, and it can even make it
worse.
If you feel like you’ve been scammed by this industry, don’t be.
Medical science is always evolving as our technology and knowledge
expands. Probiotics were a great start when it comes to gut health.
And this industry certainly provided a lot more education and
awareness concerning the microbiome. But as medicine evolves, it’s
best to evolve with it and not stay stuck in old ideologies. After all,
there was once a time that we thought bloodletting and using leeches
were a cutting edge healing therapy!
The Butyrate Discovery

It didn’t take long for Healus Co-founder Brian Yusem ND to realize that
probiotics weren’t working for his patients. With over 25 years in
practice he discovered very early on that probiotics did not produce the
results they promised. Not only were his patients’ symptoms not
improving, but neither were their lab tests. Dr. Yusem would run DNA-
based stool panels that would evaluate the microbial activity in the gut.
It didn’t seem to matter how many probiotics someone was taking, their
stool panel results would either remain the same, or sometimes they
would even get worse. Needless to say he was in search for a better
solution.
That solution came by chance (or perhaps fate) upon meeting an animal
feed developer from Spain. Brian learned that this man was utilizing
something called butyrate in the feed instead of antibiotics to prevent
bacterial infections in farm animals. They found that butyrate would
enhance the animals’ immune system, fight off infections, and increase
fertility rates. They even started bottling up butyrate for dogs in Spain,
as it seemed to enrich their health and expand their lifespan. Brian,
understanding the connection between the immune system and the
microbiome, asked if this product would work for humans. The
developer didn’t see why not, and agreed to work with Brian on
bringing this form of butyrate into America.
The first shipment of butyrate that Brian received from Spain was
actually made for dogs and even had pictures of German Shepherds on
the bottle (true story)! But that didn’t matter because the results spoke
for themselves. Chronic acid reflux gone in just one dose, IBS
symptoms disappeared within a few days, and autoimmune conditions
healed rapidly. Not to mention patients’ stool panel results were night
and day! The two men knew they were on to something big here and
continued to spend the next 16 years researching and developing
butyrate into the Complete Biotic supplement we have today.
Butyrate and Gut Health

You may not realize this, but you’ve definitely come face to face with
butyrate at one time or another in your past. You know that smell when
you throw up? That’s butyrate! Gross, I know. Butyrate lives in high
concentrations throughout your digestive system, which is why when
you throw up you can smell it. This is also why you see animals like
dogs and cats eat their own vomit. This isn’t a disgusting act, they are
instinctively trying to recapture the butyrate that they lost.
Butyrate is a short
chain fatty acid
produced in the gut
during the
fermentation process
of certain fibers. The
beneficial bacteria in
the gut produce
butyrate in the form of
tributyrin. In turn,
butyrate regulates the
microbiome and
creates a healthy
environment where
more good bacteria can thrive in harmony. The relationship between
beneficial bacteria and butyrate is very much cyclical. Butyrate has
antimicrobial properties, and helps keep pathogenic bacteria,
parasites, and candida in check. It is responsible for maintaining the
integrity of the gut lining, and is literally the fuel for colon cells
keeping them alive and healthy.
Without butyrate, there would be chaos in your microbiome,
colon cells would die, and the intestines would literally begin to
deteriorate. When it comes to maintaining a healthy gut, butyrate
is in charge.
Given the huge role that butyrate plays in the gut, it’s not surprising that
butyrate has such a positive impact on a variety of digestive disorders
and diseases.
Inflammatory Bowel Disease

Butyrate helps to lower inflammation levels in the colon by driving anti-
inflammatory T cells to any damaged areas. This action has a huge
impact on inflammatory bowels diseases like ulcerative colitis and
Crohn's disease. Studies have shown significant improvement in both
conditions with butyrate supplementation. It has been discovered that
in fact, one of the underlying causes of inflammatory bowel disease to
begin with is insufficient butyrate. We now understand that butyrate is
essential to not only heal these disorders, but can help prevent them
from ever developing as well. (6)
“At present, treatment of Crohn’s Disease is limited to

aminosalicylates, corticosteroids, and immunosuppressants. The
anti-inflammatory properties of butyrate described in the present
study offer an interesting alternative approach for the treatment of
Crohn’s Disease. In our experimental model of Colitis, butyrate
treatment also improved inflammation and markedly reduced
NFκB activation.” Butyrate Inhibits Inflammatory Responses
through NFkB Inhibition
Acid Reflux/GERD
In truth, acid reflux and GERD have very little to do with stomach acid,
and instead are the result of an unbalanced microbiome.
Gastrointestinal pressure due to poor digestion, an overgrowth of
pathogenic bacteria in the small intestine, and too little stomach acid
are all direct causes of acid reflux and GERD. (7) To resolve this
condition for good, one needs to focus on healing the gut. Medications
to lower stomach acid are only masking the symptoms and actually
making the condition much worse. It is common for people to find relief
from acid reflux almost immediately with butyrate supplementation.
Butyrate will help lower inflammation in the gut, which reduces
gastrointestinal pressure and improves digestion. It will balance the
microbiome and fight off pathogenic bacteria in the small intestine.
Butyrate helps to repair damaged tissue in the esophageal lining due to
chronic GERD, which provides a tremendous amount of relief. (8) If you
are looking for a long term solution for acid reflux and GERD that
doesn’t involve taking an antacid for the rest of your life, butyrate is
your answer.
IBS
Irritable bowel syndrome is a condition that commonly presents as
alternating forms of constipation and diarrhea. It’s also the catch-all
diagnosis for digestive complaints that can’t otherwise be diagnosed. In
a nutshell, you have an imbalance of good to bad bacteria in your
microbiome. It’s not a surprise that countless studies on IBS have shown
significant improvement of symptoms with butyrate. By reducing
inflammation, improving digestion, and balancing the microbiome,
butyrate can make your IBS symptoms a thing of the past. (9)
Candida
This yeast that lives in the digestive tract might just be one of the
peskiest conditions out there. Anyone that’s been battling candida for a
long time can relate. Candida is behind a wide variety of symptoms
such as bloating, yeast infections, skin issues, depression, hormone
imbalance, and even toe fungus. Killing candida can seem futile at
times. There are different herbs and diets that can be very helpful in
managing candida, but they don’t always provide long term relief.
Butyrate, on the other hand, can keep candida in check. By regulating
the microbiome, butyrate creates an environment where candida can no
longer thrive. Long time candida sufferers can finally find the solution
they’ve been so desperately seeking. (10)
Parasites
It’s safe to say that if you are alive you have parasites. In fact, it’s
practically impossible not to. Some parasites are actually a fundamental
part of our microbiome to begin with. These little critters can vary in
size from
microscopic to foot-
long tape worms.
And while some may
be natural to our gut’s
ecosystem, others are
not. Even more
problematic is the
fact that parasites
breed and grow
rather quickly. If you
are not in the practice
of cleansing parasites
on an annual basis,
then there is a good
chance that you are walking around with your own village of critters that
are wreaking havoc on your body. From digestive disorders to joint pain
and arthritis, these little guys can cause some serious damage. Similar
to candida, butyrate helps to keep parasites in check and repair any
damage they’ve done. While it’s still important to cleanse out parasites
periodically, butyrate’s properties help reduce their numbers and keep
them in line. (11)
Leaky Gut
Leaky gut is a common condition that encompasses a wide array of
digestive, allergy, and immune issues. When there is chronic
inflammation in the gut, the lining of the intestines can become thin
and permeable, allowing contents inside to pass through, hence the
name leaky gut. A small molecule of food may escape through this
damaged area of the intestinal lining. Once outside, the immune
system does not recognize this molecule and sees it as a foreign
invader. Your immune system's response is to attack. This can result in a
wide variety of symptoms such as bloating, headaches, a stuffy nose,
and hives. Over time however, leaky gut can lead to more serious
autoimmune diseases as the body continues to attack itself. Whether
you are dealing with minor food allergies, or a full blown autoimmune
disease, you are really dealing with leaky gut. This is where butyrate
really shines. Butyrate is responsible for repairing and keeping the
integrity of the intestinal wall intact. Lack of butyrate will lead to
inflammation and tissue damage. Studies have shown butyrate provides
significant improvement to the gut barrier function and reduces
intestinal permeability. (12)
“Butyrate limits intestinal inflammation by promoting the

formation of the regulatory T cells (Tregs), a population of
adaptive immune cells that suppress inflammatory responses.”
Butyrate and Mucosal Inflammation
Colon Cancer
Perhaps one of the most exciting discoveries about butyrate is that it
can not only prevent, but reduce tumor cell growth in the colon. Studies
have shown for a while now that fiber reduces colon cancer risk. We are
discovering that the reason fiber helps in this case, is because fiber
produces butyrate. It is butyrate itself that has the ability to inhibit
tumor cell growth and prevent cancer to begin with. In a study
presented for the American Association for Cancer Research, mice were
fed either a low or high fiber diet, and some were given butyrate with
this fiber, while others were not. All of the mice were then given a
cancer-causing chemical so that they would develop colon tumors. The
number of tumors was 75% lower in mice that were fed a high fiber diet
and were given butyrate, compared with the other mice. However, the
high fiber diet by itself, without the butyrate did not protect against
colon cancer. Scott Bultman, an assistant professor at the University of
North Carolina School of Medicine concluded, “Our study showed that
it is not the high fiber itself that has a protective effect against cancer,
but it’s a combination of the fiber plus having the right types of
bacteria producing butyrate.” (13)
“Butyrate is recognized for its potential to act on secondary

chemoprevention, by slowing growth and activating apoptosis in
colon cancer cells, but it can also act on primary chemoprevention.
The mechanism proposed is the transcriptional upregulation of
detoxifying enzymes, such as glutathione-S-transferases (GSTs).
This modulation of genes may protect cells from genotoxic
carcinogens.” Potential Beneficial Effects of Butyrate in Intestinal
and Extraintestinal Diseases
The Gut-Brain Connection – Butyrate and Brain

Health
As we’ve already
mentioned, the gut has
a huge impact on
nearly every system in
your body. The
connection between
the gut and the brain is
especially fascinating.
We’ve all had that

feeling in our gut
before when we know
something just isn’t quite right. Call it an intuitive hit in your solar
plexus. Or that punched in the gut feeling when you receive bad news.
And I think everyone has experienced “butterflies in the stomach”
before a nerve-racking event. These sensations are a very real
physiological event between the gut and the brain.
Scientists are referring to the gut as the “second brain” because like
the brain, the gut has its own nervous system. Just as the brain
operates within the central nervous system (CNS), the gut has the
enteric nervous system (ENS). Similar to the brain, the enteric nervous
system puts out more than 30 neurotransmitters. In fact 95 percent of
the body's serotonin is found in the gut. While your gut may not be
actively thinking thoughts, it is certainly influencing your mood and
emotions.
This connection goes even further as we now understand that certain

microbiota in the gut directly influence the production of
neurotransmitters. For example, certain digestive disorders such as IBS
are linked to higher rates of anxiety and depression due to their
microbiota makeup. There are similar correlations found in conditions
such as autism. Butyrate plays a large role in establishing a healthy
gut-brain relationship because of its influence on the microbiome. It’s
been discovered that butyrate helps protect the brain directly by
improving nerve cell adaptability and helping to regenerate nerve
tissue. Butyrate helps to protect nervous tissue from becoming injured
in the first place, and can even enhance the mitochondrial function of
the brain. With these discoveries it’s not a surprise that butyrate is
being used to treat different brain related diseases and disorders. (14)
ADHD and Autism

Researchers are starting to understand that the microbiome has an
influence on how the brain is developed. As a result, butyrate has
become one of the latest treatments for both ADHD and autism. Not
only does butyrate help alter the microbiome to aid in these conditions,
but it helps to reduce brain inflammation and improve mitochondrial
function. Studies have shown significant improvement in both ADHD
and autism with the use of butyrate. (15) (16)
Anxiety and Depression

Anxiety and depression are no longer all in your head. With the
understanding of the gut-brain relationship and the microbiome, we
know that the majority of neurotransmitter signaling is actually coming
from your gut. Butyrate has shown significant improvement in mood
and energy helping to alleviate chronic anxiety and depression. (17)
Neurodegenerative Disease
In Alzheimer’s studies we are finding that butyrate acts as a fuel source
for the brain, increasing mitochondrial function and aiding in tissue
repair. As one of the causes of Alzheimer’s is a reduction in energy
supply for the brain, having butyrate as fuel may just prevent this
disease to begin with. Studies suggest that butyrate’s action to
reduce brain cell damage and inflammation can help to prevent
Parkinson’s disease as well. Similar findings have been found in
reference to Huntington’s disease as butyrate protects against nerve
toxicity and improves muscle function. Butyrate also helps to improve
the learning and memory centers of the brain in all neurodegenerative
diseases. (18)
“Butyrate has also demonstrated a profound effect on improving

learning and memory, particularly in cases of disease-associated
or toxicity-induced dementia. These improvements in learning and
memory have also been demonstrated in models of memory
impairment from a toxic overload of metals, traumatic brain injury,
or neurological infections.” Butyrate, Neuroepigenetics and the Gut
Microbiome
Beyond the Gut

By now you are beginning to understand that the benefits of butyrate
go far beyond just gut health. Since virtually all disease begins with the
gut, we are finding that butyrate can help with a wide variety of
diseases and disorders.
Diabetes
In type 2 diabetes, butyrate helps to improve insulin sensitivity and
increase energy metabolism. (19) Studies have even found that butyrate
may help protect against the development of type 1 diabetes. (20)
Heart Disease
Butyrate can help to
prevent
arteriosclerosis by
reducing plaque
buildup in the arteries
and lowering
inflammation. (21)
Studies have shown a
reduction in high
cholesterol and
lowering of
triglycerides in
butyrate
supplementation. (22) In cases of critically high blood pressure, butyrate
is actually being used very successfully to stabilize and maintain a target
blood pressure rate. Not surprisingly, several studies have linked
hypertension to an unbalanced microbiome. (23)
“Butyrate lowered their blood cholesterol by approximately 25

percent, and their triglycerides by nearly 50 percent. It lowered
their fasting insulin by nearly 50 percent, and increased their
insulin sensitivity by nearly 300 percent. The investigators
concluded: Butyrate and its derivatives may have potential
application in the prevention and treatment of metabolic
syndrome in humans.” Butyric Acid: An Ancient Controller of
Metabolism, Inflammation, and Stress Resistance
Autoimmune Disease
As mentioned earlier, leaky gut can lead to a number of autoimmune
diseases. Since butyrate is the key to healing leaky gut, it would stand
to reason that it could have a beneficial effect on many autoimmune
conditions. However, butyrate goes beyond just healing the gut lining,
as it works directly with the immune system. In animal and in vitro
studies, butyrate causes a reduction of pro-inflammatory
cytokines and increases regulatory T cells (Tregs). Tregs help your
body distinguish between itself and everything else. Without enough
regulatory T cells, your immune system may attack your own organs,
which is what an autoimmune disease is. Butyrate’s ability to regulate
this immune process is essential to turning around autoimmune
disease. (24)
In addition, studies have shown that butyrate helps to inhibit the

Epstein-Barr virus (EBV) by increasing CD8 cells. These immune cells
help to inhibit EBV, which is believed to be an underlying cause of
many autoimmune diseases due to its ability to create antibodies
against your own organs. Butyrate is able to counteract the effects of
EBV and weaken the virus by supporting the production of CD8 cells.
(25)
Pancreas
Butyrate seems to have a protective function on the pancreas in
particular. Studies have shown butyrate’s positive effect in terms of
diabetes and pancreatic function. Findings show that butyrate serves to
protect the pancreas from tissue damage in cases of chronic
pancreatitis. (26) Butyrate can even cause the death of cancer cells
(apoptosis) in cases of pancreatic cancer. (27)
Allergies
When it comes to both food allergies and seasonal allergies, butyrate
has a very positive effect. Allergies are essentially an overactive immune
response to an irritant. As previously mentioned, butyrate helps to
reduce an inflammatory immune system reaction, thereby reducing the
body's allergic response. Studies have shown this to be effective in
cases of seasonal allergies. (28) When it comes to food allergies,
butyrate assists in healing the gut to prevent food allergies from
developing in the first place.
Weight Loss
Butyrate has become well known for its ability to help people lose
unwanted fat. Studies have shown that our makeup of microbiota in the
gut can directly contribute to weight gain. Butyrate helps to balance
and alter this composition, leading to weight loss in overweight people.
Butyrate helps to make the hormone leptin, which is responsible for
decreasing your appetite and helps to prevent overeating. Butyrate also
assists in the breakdown of fats and fatty acid synthesis, directing fat to
be used as fuel instead of stored. (29)
“Butyrate significantly inhibited food intake on the first two day,

leading to a 22% reduction in nine-day cumulative food intake
compared to control diet.” Butyrate and Propionate Protect Against
Diet Induced Obesity and Regulate Gut Hormones.
Muscle and Strength

In addition to reducing body fat, butyrate can aid in the production of
lean muscle mass. Butyrate increases absorption of amino acids
essential to muscle building and maintenance, as well as the synthesis
of nitric oxide for optimal muscle growth. (30)
Liver Function
Butyrate serves as damage control for organs like the liver by helping to
reverse alcohol damage. In animal studies, mice were given a high dose
of butyrate and then a high dose of ethanol. The mice with the butyrate
showed far less inflammation and damage in the control groups. As well
as preventing alcohol damage, butyrate can aid in liver lipogenesis,
regulating cholesterol. (31)
Cancer
As we established, butyrate can inhibit the growth of tumors in the
colon, but additional studies show that butyrate’s cancer fighting
benefits are far reaching. Butyrate is shown to promote cancer cell
death, and deprive tumors from being nourished and growing.
(32) This has proven to be so effective that butyrate is being used as a
component in certain anticancer drugs. (33) Butyrate helps to increase
the P53 tumor suppressor gene. This protein prevents cancer formation
and functions as a tumor suppressor. The P53 tumor suppressor gene
has been described as “the guardian of the genome,” given its crucial
role in maintaining genetic stability and the prevention of cancer
formation. This positive evidence has prompted further studies to be
done on butyrate and cancer. (34)
“The observed cancer-inhibitory activity of tributyrin has been

attributed to its ability to inhibit cell proliferation and induce
growth arrest and apoptosis.” The Chemopreventitive Activity of the
Butyric Acid Prodrug Tributyrin
Reduces Inflammation
Butyrate’s anti-inflammatory effect has a positive impact not just on the
gut, but on the rest of the body. It can reduce organ inflammation,
arthritis and joint pain. Butyrate’s ability suppress the activity of certain
proteins that produce inflammation make it a great pain fighter, as well
as reducing any tissue damage. (35)
Getting Enough Butyrate

With all the benefits of butyrate, I’m sure at this point you are
wondering how you can raise your own levels. Butyrate is actually
made in the gut during the fermentation process of certain fibers. As
the fiber digests it makes butyrate. You can find butyrate in some
foods such as butter and ghee. However, this doesn’t mean you
should start eating a stick of butter every day! In fact you won’t get
near the amount of butyrate you need in a reasonable serving of
butter. Instead, you should focus on getting in the right types of fiber
and proper supplementation to fuel your butyrate production.
Fiber: The Key Ingredient

Diet trends tend to focus on getting in high amounts of protein and fat,
but not many of them are talking about fiber. If fiber is the key to a
balanced microbiome, and a balanced microbiome is the key to a
healthy body, then why aren’t we talking about fiber more? The average
American only gets in 5-10 grams of fiber a day, which is not nearly
enough to produce butyrate. In order to produce enough butyrate, you
need to take in 40-50 grams of fiber or more every day. Yes, that’s a lot
of fiber! But it is possible, as long as you focus on the right type of fiber.
(36)
Butyrate requires a combination of soluble and insoluble fiber to aid in

production. Soluble fiber attracts fluid in your digestive tract and forms
a slow-moving thick gel. This substance slows digestion, which gives
essential vitamins and minerals time to absorb through intestinal walls.
Examples of soluble fiber include nuts, seeds, fruits, and some grains
like oatmeal. Insoluble fiber stays relatively intact and sweeps through
your digestive tract, pushing out waste. This type of fiber adds bulk to
your stools and makes bowel movements easier to pass.
Examples of insoluble fiber include green veggies and legumes. Certain

fruits such as berries and apples with the skin on are good sources of
insoluble fiber as well. Resistant starches such as green bananas,
potatoes, and hi-maize flour can be very helpful in butyrate production.
The key to resistant starches is to make sure they are served cold. Cook
your potatoes, but be sure to let them cool before eating to maximize
butyrate. (37)
Supplementing Butyrate
The problem with relying on fiber alone, is that most people aren’t
going to be able to get in 40-50 grams on a daily basis. Even if we are
able to get in that much fiber, most people's guts are so compromised
at this point that we aren’t digesting food properly. It’s a bit of a catch
22. You need enough butyrate to properly break down fiber in order
to make more
butyrate. If you have
any sort of digestive
or immune
compromise, you’re
most likely caught in
this vicious cycle.
This is where
supplementing with
butyrate can be very
helpful. Butyrate
lowers inflammation
in the gut, supports digestion and absorption, and keeps the
microbiome in check. When you take in the right form of butyrate you
can break this cycle, heal your gut, and start making your own
butyrate.
Not All Butyrates Are the Same

Not all butyrates on the market are the same. If you don’t take the right
kind, you may be wasting your money. A qualified butyrate supplement
should be in the form of tributyrin. Not only is tributyrin the most
natural form, but it is also the most absorbed form in the intestines. (38)
Many butyrates on the market today are sodium or calcium magnesium
based. The problem with these forms is that they do not reach the small
and large intestines, which is where butyrate needs to get to in order to
work its magic.
Basic math of bioavailability tells you that you are lucky to get
approximately 30% delivery from sodium butyrate. Most supplements
with butyrate have only 60 mg to 100 mg per capsule. At 30%
absorption that is only 18 mg to 30 mg per two capsules. To put that
into perspective, our butyrate supplement Complete Biotic, in the form
of tributyrin, provides 500 mg per capsule. Our product also utilizes
an innovative encapsulation technique called Quantitative
Nitrogen Atmosphere (QNP ™). This specialized matrix keeps the
ingredients stable and active without refrigeration. It is encoded to be
gastro-resistant for 100% absorption in the small and large intestines.
To get close to that amount of butyrate into your system, you would
need to take 10-15 capsules of other brands compared to 1 capsule of
Complete Biotic. We’ve been developing this formula for the past 16
years, so we’ve definitely done our homework!
How to Take Complete Biotic

When you are supplementing
with our Complete Biotic we
recommend different dosing
depending on how much
butyrate your body needs. If
your digestive and immune
system are compromised you
will require more butyrate to
help repair in the beginning.
Suggested Starting Dosage

3 pills a day
To start, take 1 Complete

Biotic with food, 3 times a day. Complete Biotic can be taken with or
without food, but in the beginning we recommend taking it before
each meal.
Suggested Dosage for Advanced Disease
4-6 pills a day
If you have an inflammatory bowel disease, autoimmune disease, or

cancer we recommend that you work up to taking 4-6 pills a day, split
into 2-3 doses. This is a safe dose to stay on for a few months. In our
clinical studies most patients that started at a higher dosage were able
to back down to a maintenance dose as their condition subsided. The
time varies depending on the severity of the condition as well as the
overall health, diet, and lifestyle of the person. To figure out
approximately how much butyrate your body needs you can also do
the challenge test below. To figure out approximately how much
butyrate your body needs you can also do the challenge test below.
Challenge Test (Optional)

The butyrate challenge test is a way to gauge approximately how
much Complete Biotic your body needs at one sitting. You can remain
on the starting dosage for the first month, or, take the challenge test.
To do this test you will begin increasing your dosage from 1 capsule at
a time to 2 at a time, then 3, then 4 (do not exceed 4 capsules at a
time). During this test you are paying attention to any discomfort you
might feel such as a burning or slight nausea. For example, if you work
your way up to 3 capsules at a time and begin to feel a slight gnawing
feeling in your gut, then you know you’ve done too much. Go ahead
and back down to 2. You would remain on 2 capsules 3 times a day
until you feel the same sensation, then back down to 1.
Maintenance Dosage
1-2 pills a day
Once your condition or symptoms subside you can continue with the
maintenance dose of 1-2 pills a day. This dosage will supply your body
with enough Butyrate to maintain your overall health. If at any point
your health status changes you can begin to increase your dosage
again as needed.
What to Expect
When first taking the Complete Biotic you may notice that your stool
becomes firmer, this is a good sign. You may even experience a few
detox symptoms as your microbiome is worked over and the Complete
Biotic begins killing off pathogenic bacteria. This may consist of an
increase in bowel movements and slight discomfort or fatigue. Any
detox symptoms will be short lived. Mostly, you will find less bloating,
less inflammation, better digestion and improved immune health. Over
time you’ll find many ailments clearing up in your body.
How to Maximize Your Results

It should go without saying that adopting a healthy lifestyle will
maximize your results! The following principles will serve to enhance
Complete Biotic supplementation and accelerate your healing.
Eat Whole Foods
There is no right diet plan for everyone, but in general you want to
focus on eating whole, organic foods. If you are vegan, eat a whole,
plant-based diet with organic fruits and veggies, nuts, and seeds. If you
are paleo, still eat a mostly whole, plant-based diet with organic
veggies, and organic clean protein. Keep away from inflammatory foods
like gluten, dairy, and soy while you are healing.
Focus on Fiber
As previously stated, fiber makes butyrate, and butyrate thrives in a

high fiber diet. Focus on getting in a variety of soluble and insoluble
fiber, as well as resistant starches. You don’t have to count your protein,
trust me you’re getting enough. Instead, count your fiber! If you feel
like you need help increasing your fiber intake, Healus makes a hemp-
based protein powder that is not only delicious, but packed full of fiber.
Adding in 1 to 2 smoothies a day as breakfast or a snack is a great way
to increase your fiber. You can learn more about our protein powder at
www.HealusHealth.com.
Don’t Drink Water With Your Food
If you want a way to improve your digestion immediately, it would be

following this rule. Don’t drink water with your food, and for up to an
hour afterwards. When you drink any liquid with your food, you deplete
your enzyme production and your food will not digest as well. Take little
sips if needed, but no big gulps!
Chew Your Food
Your mother was right, chewing your food is a vital part of maintaining
a healthy body. You may have heard the expression, digestion starts in
the mouth, it’s true. When you thoroughly chew your food you activate
the necessary enzymes you need to properly break down your food.
This means that your body will not only absorb more nutrients and
vitamins, but it also means less bloating and digestive upset. To make
this easier try slowing down when you eat, and don’t dine distracted.
In other words don’t shovel food into your mouth at a rapid pace while
you are mindlessly watching tv. When you are present with your meal
you automatically slow down, chew more, and actually enjoy your
food! We understand that in a multitasking society, this isn’t always an
easy habit to adopt. But creating that space and time to properly eat
and digest your food can have a huge impact on your health and well
being.
Consider Cleansing
The Complete Biotic

alone will do great
things for your body.
Cleansing and taking
the Complete Biotic
together will do
wonders! At Healus
Health we offer a whole
cleansing system! Actively cleansing your body from things like toxic
waste, candida, parasites, and chemicals is the key to longevity and
will take your health to a whole new level. You can learn more about
our cleanses at www.HealusHealth.com.
Reduce Stress
Remember when we talked earlier about the gut-brain connection? As
much as the gut affects the thoughts you think, the thoughts you think
affect the gut. Stress really is a killer. You can take all the
supplements in the world and eat perfectly, but if you are highly
stressed all the time you are never going to heal completely. This
is why at Healus Health we focus on emotional health as well. Learning
stress reduction techniques such as meditation, journaling, yoga,
laughing, breathing, and even just taking a walk, can literally save your
life. For more stress reduction tips, follow our blog at
www.HealusHealth.com.
In Conclusion
If you can’t tell from this ebook, we are pretty passionate about
butyrate! Our formula has been 16 years in the making, and until
recently only available to a small patient grouping. We are beyond
thrilled to bring Complete Biotic to the public! Our passion goes
beyond just wanting people to feel better and be healthy. We want
people to think better! A healthy gut and body creates a happy, sound
mind, and our society could certainly use more of that. At Healus
Health our mission is to make the world a happier and healthier place,
one person at a time. We believe that sharing this product and
knowledge with you, is the start.
If you know this knowledge would benefit a friend or a loved one,

please feel free to share this ebook. We would also love to hear from
you! If you would like to share your success story and results using
Complete Biotic, email us at Info@HealusHealth.com.
Resources
Website
www.HealusHealth.com
At Healus Health you can learn more about our additional products
that compliment the Complete Biotic, such as our fiber rich Protein
Powder and our 2 Week Digestive Cleanse. Stay up to date with the
latest health discoveries on our blog. And find food inspiration by
searching through our recipes.
Podcast
The Health Outliers (ITunes)
https://apple.co/2yfAa2T
If you want to dive deeper into the world of integrative health, join
Healus Health founders Lauren and Brian on their weekly podcast.
With a combined 30 years in the functional medicine world, these two
docs discuss a wide range of health topics, from parasites to
meditation and everything in between.
YouTube
https://bit.ly/2RJsZrW
Subscribe to our YouTube channel for a behind the scenes look on all
things Healus Health, as well as a variety of educational (and
entertaining) health and lifestyle videos.
Instagram
@HealusHealth
https://bit.ly/2NDQ0cG
Follow us on Instagram for additional helpful tips and to stay up to
date with the latest Healus Health developments.
Contact Us
Info@HealusHealth.com
Have a question about the Complete Biotic or any of our other

products? Reach out to us, we’re here to help! Want to request that we
cover a certain subject in either a blog, podcast, or video? Let us know,
we will gladly take suggestions and do our best to meet every request!
References
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Introduction

Move over probiotics, there is a new kid on the block! Butyrate, or

Recent studies have shown remarkable results

• Inflammatory Bowel Disease • Diabetes

Understanding the Microbiome

The microbiome is responsible for 80% of your immune system, has a

The Problem with Probiotics

The idea behind probiotics was great. Beneficial bacteria are

“The researchers were looking to see where bacteria successfully

The microbiome is a delicate balance. All the beneficial bacteria in the

The Butyrate Discovery

Butyrate and Gut Health

Inflammatory Bowel Disease

“At present, treatment of Crohn’s Disease is limited to

“Butyrate limits intestinal inflammation by promoting the

“Butyrate is recognized for its potential to act on secondary

The Gut-Brain Connection – Butyrate and Brain

We’ve all had that

This connection goes even further as we now understand that certain

ADHD and Autism

Anxiety and Depression

“Butyrate has also demonstrated a profound effect on improving

Beyond the Gut

“Butyrate lowered their blood cholesterol by approximately 25

In addition, studies have shown that butyrate helps to inhibit the

“Butyrate significantly inhibited food intake on the first two day,

Muscle and Strength

“The observed cancer-inhibitory activity of tributyrin has been

Getting Enough Butyrate

Fiber: The Key Ingredient

Butyrate requires a combination of soluble and insoluble fiber to aid in

Examples of insoluble fiber include green veggies and legumes. Certain

Not All Butyrates Are the Same

How to Take Complete Biotic

Suggested Starting Dosage

To start, take 1 Complete

Suggested Dosage for Advanced Disease

4-6 pills a day

If you have an inflammatory bowel disease, autoimmune disease, or

Challenge Test (Optional)

How to Maximize Your Results

Eat Whole Foods

As previously stated, fiber makes butyrate, and butyrate thrives in a

If you want a way to improve your digestion immediately, it would be

Chew Your Food

The Complete Biotic

If you know this knowledge would benefit a friend or a loved one,

Have a question about the Complete Biotic or any of our other

(2) “One course of antibiotics can affect diversity of microorganisms in

(8) Peter Holzer, “Acid-sensing ion channels in gastrointestinal function”,

(10) Mairi C. Noverr and Gary B. Huffnagle, “Regulation of Candida albicans

(13) Dallas R. Donohoe, et al., “A Gnotobiotic Mouse Model Demonstrates that

(17) SS Valvassori, et al., “Sodium butyrate functions as an antidepressant and

(18) Megan W. Bourrassa, et al., “Butyrate, neuroepigenetics and the gut

(20) Jintian He, et al., “Dietary Tributyrin Supplementation Attenuates Insulin

(21) EM Quigley, “Gut bacteria in health and disease.”, PubMed.gov, September

(22) Stephan Guyenet, “Butyric Acid: an Ancient Controller of Metabolism,

(24) Renan Correa-Oliveira, et al., “Regulation of immune cell function by short-

(27) B. Farrow, et al., “Butyrate inhibits pancreatic cancer invasion.”, PubMed.gov,

(28) J Wang, et al., “Therapeutic Effect of Histone Deacetylase Inhibitor, Sodium

(30) Marco Aurelio Ramirez Vinolo, et al., “Tributyrin attenuates obesity-associated

(31) J Liu, et al., “Protective effect of butyrate against ethanol-induced gastric

(33) Lauri Toich, “Combination of Chemotherapy Drugs Could Target Breast