Beruflich Dokumente
Kultur Dokumente
org/wiki/Sensory_neuron
Sensory neuron
Sensory neurons also known as afferent neurons are
neurons that convert a specific type of stimulus, via their
receptors, into action potentials or graded potentials.[1]
This process is called sensory transduction. The cell
bodies of the sensory neurons are located in the dorsal
ganglia of the spinal cord.[2]
Contents
Types and function
External
Smell
Taste
Vision
Auditory
Temperature
Mechanoreceptors
Internal
Blood
Nociceptors
Drugs
Neuroplasticity
Other animals
Additional images
See also
1 of 8 2019-02-19, 3:18
Sensory neuron - Wikipedia https://en.wikipedia.org/wiki/Sensory_neuron
References
External links
External
Smell
The sensory neurons involved in smell are called olfactory sensory neurons. These neurons contain receptors,
called olfactory receptors, that are activated by odor molecules in the air.
Taste
Similarly to Olfactory receptors, taste receptors (gustatory receptors) in taste buds interact with chemicals in food
to produce an action potential.
Vision
Photoreceptor cells are capable of phototransduction, a process which converts light (electromagnetic radiation)
into electrical signals. These signals are refined and controlled by the interactions with other types of neurons in
the retina.
The five basic classes of neurons within the retina are photoreceptor cells, bipolar cells, ganglion cells, horizontal
cells, and amacrine cells.
The basic circuitry of the retina incorporates a three-neuron chain consisting of the photoreceptor (either a rod or
cone), bipolar cell, and the ganglion cell.
The first action potential occurs in the retinal ganglion cell. This pathway is the most direct way for transmitting
visual information to the brain.
There are three primary types of photoreceptors: Cones are photoreceptors that respond significantly to color. In
humans the three different types of cones correspond with a primary response to short wavelength (blue), medium
wavelength (green), and long wavelength (yellow/red).[3] Rods are photoreceptors that are very sensitive to the
intensity of light, allowing for vision in dim lighting. The concentrations and ratio of rods to cones is strongly
correlated with whether an animal is diurnal or nocturnal. In humans, rods outnumber cones by approximately
20:1, while in nocturnal animals, such as the tawny owl, the ratio is closer to 1000:1.[3] Retinal ganglion cells are
involved in the sympathetic response. Of the ~1.3 million ganglion cells present in the retina, 1-2% are believed to
be photosensitive.[4]
Problems and decay of sensory neurons associated with vision lead to disorders such as:
Macular degeneration – degeneration of the central visual field due to either cellular debris or blood vessels
accumulating between the retina and the choroid, thereby disturbing and/or destroying the complex interplay
of neurons that are present there.[5]
Glaucoma – loss of retinal ganglion cells which causes some loss of vision to blindness.[6]
Diabetic retinopathy – poor blood sugar control due to diabetes damages the tiny blood vessels in the retina.[7]
2 of 8 2019-02-19, 3:18
Sensory neuron - Wikipedia https://en.wikipedia.org/wiki/Sensory_neuron
Auditory
The auditory system is responsible for converting pressure waves generated by vibrating air molecules or sound
into signals that can be interpreted by the brain.
This mechanoelectrical transduction is mediated with hair cells within the ear. Depending on the movement, the
hair cell can either hyperpolarize or depolarize. When the movement is towards the tallest stereocilia, the Na+
cation channels open allowing Na+ to flow into cell and the resulting depolarization causes the Ca++ channels to
open, thus releasing its neurotransmitter into the afferent auditory nerve. There are two types of hair cells: inner
and outer. The inner hair cells are the sensory receptors .[8]
Problems with sensory neurons associated with the auditory system leads to disorders such as:
Auditory processing disorder – Auditory information in the brain is processed in an abnormal way. Patients
with auditory processing disorder can usually gain the information normally, but their brain cannot process it
properly, leading to hearing disability.[9]
Auditory verbal agnosia – Comprehension of speech is lost but hearing, speaking, reading, and writing ability
is retained. This is caused by damage to the posterior superior temporal lobes, again not allowing the brain to
process auditory input correctly.[10]
Temperature
Thermoreceptors are sensory receptors, which respond to varying [temperature]s. While the mechanisms through
which these receptors operate is unclear, recent discoveries have shown that mammals have at least two distinct
types of thermoreceptors.[11] The bulboid corpuscle, is a cutaneous receptor a cold-sensitive receptor, that detects
cold temperatures. The other type is a warmth-sensitive receptor.
Mechanoreceptors
Mechanoreceptors are sensory receptors which respond to mechanical forces, such as pressure or distortion.[12]
Specialized sensory receptor cells called mechanoreceptors often encapsulate afferent fibers to help tune the
afferent fibers to the different types of somatic stimulation. Mechanoreceptors also help lower thresholds for action
potential generation in afferent fibers and thus make them more likely to fire in the presence of sensory
stimulation.[13]
Some types of mechanoreceptors fire action potentials when their membranes are physically stretched.
Proprioceptors are another type of mechanoreceptors which literally means "receptors for self". These receptors
provide spatial information about limbs and other body parts.[14]
Nociceptors are responsible for processing pain and temperature changes. The burning pain and irritation
experienced after eating a chili pepper (due to its main ingredient, capsaicin), the cold sensation experienced after
ingesting a chemical such as menthol or icillin, as well as the common sensation of pain are all a result of neurons
with these receptors.[15]
Neuropathic pain - a severe pain condition resulting from a damaged sensory nerve [15]
Hyperalgesia - an increased sensitivity to pain caused by sensory ion channel, TRPM8, which is typically
responds to temperatures between 23 and 26 degrees, and provides the cooling sensation associated with
menthol and icillin [15]
Phantom limb syndrome - a sensory system disorder where pain or movement is experienced in a limb that
does not exist [16]
3 of 8 2019-02-19, 3:18
Sensory neuron - Wikipedia https://en.wikipedia.org/wiki/Sensory_neuron
Internal
Internal receptors that respond to changes inside the body are known as interoceptors.
Blood
The aortic bodies and carotid bodies contain clusters of glomus cells – peripheral chemoreceptors that detect
changes in chemical properties in the blood such as oxygen concentration.[17] These receptors are polymodal
responding to a number of different stimuli.
Nociceptors
Nociceptors respond to potentially damaging stimuli by sending signals to the spinal cord and brain. This process,
called nociception, usually causes the perception of pain.[18] They are found in internal organs as well as on the
surface of the body. Nociceptors detect different kinds of damaging stimuli or actual damage. Those that only
respond when tissues are damaged are known as "sleeping" or "silent" nociceptors.
Classification
Adequate stimulus
A sensory receptor's adequate stimulus is the stimulus modality for which it possesses the adequate sensory
transduction apparatus. Adequate stimulus can be used to classify sensory receptors:
Ampullae of Lorenzini respond to electric fields, salinity, and to temperature, but function primarily as
electroreceptors
Hydroreceptors respond to changes in humidity
Magnetoreceptors respond to magnetic fields
Mechanoreceptors respond to mechanical stress or mechanical strain
4 of 8 2019-02-19, 3:18
Sensory neuron - Wikipedia https://en.wikipedia.org/wiki/Sensory_neuron
Nociceptors respond to damage, or threat of damage, to body tissues, leading (often but not always) to pain
perception
Osmoreceptors respond to the osmolarity of fluids (such as in the hypothalamus)
Proprioceptors provide the sense of position
Thermoreceptors respond to temperature, either heat, cold or both
Location
Sensory receptors can be classified by location:
Morphology
Somatic sensory receptors near the surface of the skin can usually be divided into two groups based on
morphology:
Free nerve endings characterize the nociceptors and thermoreceptors and are called thus because the
terminal branches of the neuron are unmyelinated and spread throughout the dermis and epidermis.
Encapsulated receptors consist of the remaining types of cutaneous receptors. Encapsulation exists for
specialized functioning.
Rate of adaptation
A tonic receptor is a sensory receptor that adapts slowly to a stimulus[22] and continues to produce action
potentials over the duration of the stimulus.[23] In this way it conveys information about the duration of the
stimulus. Some tonic receptors are permanently active and indicate a background level. Examples of such
tonic receptors are pain receptors, joint capsule, and muscle spindle.[24]
A phasic receptor is a sensory receptor that adapts rapidly to a stimulus. The response of the cell diminishes
very quickly and then stops.[25]It does not provide information on the duration of the stimulus;[23] instead some
of them convey information on rapid changes in stimulus intensity and rate.[24] An example of a phasic
receptor is the Pacinian corpuscle.
Drugs
There are many drugs currently on the market that are used to manipulate or treat sensory system disorders. For
instance, Gabapentin is a drug that is used to treat neuropathic pain by interacting with one of the voltage-
dependent calcium channels present on non-receptive neurons.[15] Some drugs may be used to combat other health
problems, but can have unintended side effects on the sensory system. Ototoxic drugs are drugs which affect the
cochlea through the use of a toxin like aminoglycoside antibiotics, which poison hair cells. Through the use of these
toxins, the K+ pumping hair cells cease their function. Thus, the energy generated by the endocochlear potential
which drives the auditory signal transduction process is lost, leading to hearing loss.[26]
Neuroplasticity
Ever since scientists observed cortical remapping in the brain of Taub's Silver Spring monkeys, there has been a lot
of research into sensory system plasticity. Huge strides have been made in treating disorders of the sensory system.
Techniques such as constraint-induced movement therapy developed by Taub have helped patients with paralyzed
limbs regain use of their limbs by forcing the sensory system to grow new neural pathways.[27] Phantom limb
syndrome is a sensory system disorder in which amputees perceive that their amputated limb still exists and they
5 of 8 2019-02-19, 3:18
Sensory neuron - Wikipedia https://en.wikipedia.org/wiki/Sensory_neuron
may still be experiencing pain in it. The mirror box developed by V.S. Ramachandran, has enabled patients with
phantom limb syndrome to relieve the perception of paralyzed or painful phantom limbs. It is a simple device
which uses a mirror in a box to create an illusion in which the sensory system perceives that it is seeing two hands
instead of one, therefore allowing the sensory system to control the "phantom limb". By doing this, the sensory
system can gradually get acclimated to the amputated limb, and thus alleviate this syndrome.[28]
Other animals
Hydrodynamic reception is a form of mechanoreception used in a range of animal species.
Additional images
See also
Sensory nerves
Afferent nerve
Pseudounipolar neuron
Efferent nerve
Neural coding
Posterior column
Receptive field
Sensory system
References
1. Parsons, Richard (2018). CGP: A-Level Biology Complete Revision & Practice. Newcastle Upon Thynde:
6 of 8 2019-02-19, 3:18
Sensory neuron - Wikipedia https://en.wikipedia.org/wiki/Sensory_neuron
7 of 8 2019-02-19, 3:18
Sensory neuron - Wikipedia https://en.wikipedia.org/wiki/Sensory_neuron
21. http://medical-dictionary.thefreedictionary.com/Cutaneous+receptor
22. Binder, Marc D.; Hirokawa, Nobutaka; Windhorst, Uwe (2009). Encyclopedia of neuroscience ([Online-Ausg.].
ed.). Berlin: Springer. ISBN 978-3-540-29678-2.
23. mentor.lscf.ucsb.edu/course/fall/eemb157/lecture/Lectures%2016,%2017%2018.ppt
24. http://frank.mtsu.edu/~jshardo/bly2010/nervous/receptor.html Archived (https://web.archive.org
/web/20080803215836/http://frank.mtsu.edu/~jshardo/bly2010/nervous/receptor.html) August 3, 2008, at the
Wayback Machine
25. Sherwood, Lauralee; Klandorf, Hillar; Yancey, Paul (2012). Animal Physiology: From Genes to Organisms
(https://books.google.com/books?id=I6X8G8YPdv4C&pg=PA213&lpg=PA213&
dq=A+phasic+receptor+is+a+sensory+receptor+that+adapts+rapidly+to+a+stimulus.+The+response+of+the+c
ell+diminishes+very+quickly+and+then+stops.&source=bl&ots=O8lwP574nq&sig=V-
U1uXf4KziyrhYrQmqqrSLaNbk&hl=en&sa=X&
ved=0ahUKEwiy6_S85YfYAhUIGt8KHRUXCbEQ6AEIVTAI#v=onepage&
q=A%20phasic%20receptor%20is%20a%20sensory%20receptor%20that%20adapts%20rapidly%20to%20a%
20stimulus.%20The%20response%20of%20the%20cell%20diminishes%20very%20quickly%20and%20then%
20stops.&f=false). Cengage Learning. ISBN 0840068654. Retrieved 13 December 2017.
26. Priuska, E.M.; Schacht, J. (1997). "Mechanism and prevention of aminoglycoside ototoxicity: Outer hair cells
as targets and tools". Ear, Nose, & Throat Journal. 76: 164–171. PMID 9086645 (https://www.ncbi.nlm.nih.gov
/pubmed/9086645).
27. Schwartz and Begley 2002, p. 160; "Constraint-Induced Movement Therapy", excerpted from "A Rehab
Revolution," Stroke Connection Magazine, September/October 2004. Print.
28. Blakeslee, Sandra; Ramachandran, V. S. (1998). Phantoms in the brain : probing the mysteries of the human
mind (https://www.worldcat.org/oclc/43344396). William Morrow & Company, Inc. ISBN 0688152473.
OCLC 43344396 (https://www.worldcat.org/oclc/43344396).
External links
The major classes of somatic sensory receptors (https://www.ncbi.nlm.nih.gov/books/NBK11162/table
/A611/?report=objectonly)
Text is available under the Creative Commons Attribution-ShareAlike License; additional terms may apply. By
using this site, you agree to the Terms of Use and Privacy Policy. Wikipedia® is a registered trademark of the
Wikimedia Foundation, Inc., a non-profit organization.
8 of 8 2019-02-19, 3:18