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POSTGRADUATE INSTITUTE OF MEDICINE UNIVERSITY OF COLOMBO MD (PAEDIATRICS) EXAMINATION — JULY/AUGUST 2018 Date: 24" July 2018 Time: 9. 00 a.m. — 12.00 noon PAPERI (STRUCTURED ESSAY QUESTIONS: " Answer all five questions. Answer each question in a separate book. .1. Give five (5) predisposing factors leading to the development of Bronchopulmonary Dysplasia. (15 marks) 1.2. List five (5) sequalae of chronic hypoxaemia in children. (15 marks) 13. 1.3.1, Define “long term oxygen therapy” in children. (20 marks) 1.3.2. List ten (10) paediatric conditions that may require long term oxygen therapy, (20 marks) 1.3.3. Outline briefly five (5) steps you would arrange when discharging a child on domiciliary oxygen therapy. (30 marks) 2 2.1. Define B° thalassemia major (10 marks) 2.2. Outline the pathophysiology of anaemia in B° thalassemia major. (30 marks) 2.3. Briefly outline the current and long term management plan for a child newly diagnosed to have B° thalassemia major . (50 marks) 2.4. Mention two (2) steps currently practiced in Sri Lanka to prevent B° thalassemia major. (10 marks) E} 3.1. List five clinical manifestations of congenital hyperthyroidism in neonates. (10 marks) 3.2. Briefly outline the pathophysiology of Graves ophthalmopathy. (30 marks) 3.3. Discuss the management options of Graves disease. (40 marks) 4. List three (03) adverse effects of each management option you mentioned in3.3 (20 marks) 4.1. List five (5) abnormalities associated with posterior urethral valves (PUV). (20 marks) 4.2. How do you establish the diagnosis of PUV in a neonate? (10 marks) 4.3. A polyethylene feeding tube is used in the bladder drainage in a neonate instead of a Foley catheter. Explain why. (10 marks) 4.4. List four (4) indications for initial vesicostomy prior to transurethral posterior urethral valve ablation. (30 marks) 4.5. List four (4) unfavourable prognostic factors in patients with PUV. (30 marks) 5. 5.1. “Deaths related to influenza are grossly underestimated”. Give 3 reasons to justify this statement. (15 marks) 5.2. ‘Globally, even if the attack rate of influenza is similar in young children in the low and high resource settings, mortality and morbidity of influenza are likely to be higher in the low resource settings’. Give 3 reasons for children in the resource poor setting to be more vulnerable. (15 marks) 5.3. What are the broad categories of seasonal influenza vaccines available for the use of children globally and their routes of administration and recommendation for 2017/2018. (25 marks) S -¥ 531Describe the following about influenza vaccine. 5-40 S

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