CENTRO ESCOLAR UNIVERSITY

School of Medicine
Department of Pathology

Virtual Microscopy Lab Session

Cell Adaptation, Injury, Necrosis and Intracellular Accumulation

Instructions:
1. The following virtual slides demonstrates some of the pathologies associated with cell reaction
to injury
2. The slides are grouped into 1) cell adaptation 2) cell injury 3) necrosis and 4) intracellular
accumulation
3. Recognize and describe the essential histologic features of these entities
4. Predict the possible pathophysiologic effects of these lesions to the cells affected and/or the
immediate surrounding unaffected cells
5. List the more common causes of these pathologies.

Cell adaptation
1. 3687A1 – Hypertrophy, heart
2. uihc_s2 – Atrophy of skeletal muscle
3. 4048 – Hyperplasia of endometrium
4. 4922 – Metaplasia of esophageal epithelium

Cell injury
1. d2 – Fatty change, liver

Necrosis
1. 16b – Coagulative necrosis, heart
2. 4918a – Liquefactive necrosis, brain
3. au105 – Caseous necrosis, lung

Intracellular Accumulation
1. au167 – Anthracosis, bronchial lymph node