PATHOPHYSIOLOGY

Etiology: Risk factors:

 Hx of previous pre-eclampsia
 Unknown  Primagravidarum,
multigravidarum
 Family hx of pre-eclampsia
 Preexisting hypertension
 Diabetes
 Renal disease
 Obesity
 Pregnancy on > 35 years old
 Poor prenatal check up
 10 years gap of pregnancy

Spiral arteries don’t

widen

Less blood gets in placentaBRIEF DESCRIP

Hypo perfused placenta BRIEF DESCRIP

releases pro-inflammatory proteins

BRIEF DESCRIP
Pro-inflammatory proteins goes to
mother’s circulation

BRIEF DESCRIP
Pro-inflammatory proteins cause
Vasoconstriction
 Prolonged vasoconstriction
damages endothelial cell
BRIEF DESCRI

Endothelial cell injury BRIEF DESCRI

Blood vessels becomes
dysfunctional Formation of thrombi
(Body will use massive
amount of platelets)

BRIEF DESCRIPTION
BR
Causes general vasospasm
Narrowed passage of RBC

BRIEF DES
Narrowed renal BRIEF DESCRIPTION Intravascular
pressure
artery Narrowed
Ophthalmic
BR Narrowed hepatic
Artery increases
Blood clots blocks RBC

BRIEFBRIEF
BRIEF DESCRIPTIONartery
DES
DESCRIP Hypertension
Hypoperfusion
on the kidneys BR Hypoperfusion
on the liver
BRIEF DESCRIPTION RBC gets destroyed
(hemolysis)

BRIEFBRIEF DES
Reduced blood

BRIEF DESCRIPTION
Glomerular DESCRIP
flow to the retina
Severe liver injury
Nape pain,
dizziness
damage
BRIEF DESCRIPTION
Blurred vision

BRIEF DESCRIPTION
Proteinuria, BRIEF DESCRIP Elevated liver
Oliguria enzymes