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Arthritis & Rheumatism (Arthritis Care & Research)

Vol. 49, No. 5, October 15, 2003, pp 626 – 632


DOI 10.1002/art.11378
© 2003, American College of Rheumatology
ORIGINAL ARTICLE

Moberg Picking-Up Test in Patients With


Inflammatory Joint Diseases: A Survey of
Suitability in Comparison With Button Test and
Measures of Disease Activity
TANJA ALEXANDRA STAMM,1 ALEXANDER PLONER,2 KLAUS PETER MACHOLD,1 AND
JOSEF SMOLEN1

Objective. To assess and compare the suitability of Moberg pickup test (MPUT) and button test (BT) as indicators for
functional impairment in patients with inflammatory joint diseases.
Methods. Measurements for 369 patients attending a rheumatology outpatient clinic were collected. In addition to MPUT
and BT, measurements collected were grip strength, tender and swollen joint counts, visual analog scales for pain and
disease activity, Health Assessment Questionnaire, C-reactive protein levels, and erythrocyte sedimentation rates.
Results. We found a significant relationship between MPUT and BT. Both tests show the same pattern of correlations
with the other parameters, although all correlations are higher for MPUT. There is a significant sex and learning effect
for the BT, which implies a confounding of hand function and motor abilities. A significantly higher proportion of patients
was unable to complete BT.
Conclusion. MPUT and BT measure comparable aspects of hand function. In several theoretical and practical aspects,
MPUT seems superior to BT in arthritis. It is necessary to evaluate its value in long-term followup.

KEY WORDS. Moberg pickup test; Functional test; Arthritis.

INTRODUCTION measure (1). Quantitative assessment of functional status


in patients with RA has been approached through simple,
Quantitative assessments of functional status, such as grip rapidly completed physical measures of performance,
strength (GST) and walking time, have been widely used such as GST, walking time, and the BT (2). Those measures
for several decades in studies on rheumatoid arthritis (RA) have advantages compared with self-report question-
(1). These measures, as well as the button test (BT) (2) and naires: Some patients find it difficult to complete self-
questionnaires regarding activities of daily living (3,4), are report questionnaires, especially those with low formal
effective in documenting significant morbidity. Declines education levels who have an increased risk of developing
in functional status have been reported in most patients progressive RA (8). Furthermore, clinicians might find it
over the course of 9 years (5–7). problematic to rely only on self-reported data of functional
To evaluate patients with RA, quantitative assessment of
status as adjunct to clinical decisions (2).
functional status can provide valuable data on disability
Moreover, GST, walking time, and BT have been found
(7) and can be used as a long-term functional outcome
to be highly reproducible measures concerning their inter-
observer and intraobserver reliability when used accord-
1
Tanja Alexandra Stamm, MA, OTR, Klaus Peter Ma- ing to a standard protocol (2).
chold, MD, Josef Smolen, MD: Vienna University, Vienna, To assess hand function in patients with RA, GST is
Austria; 2Alexander Ploner, PhD: University for Agricul- widely used and BT is less often used (7,9 –11). Compared
tural Sciences, Vienna, Austria. with specific tests with a broad focus on different aspects
Address correspondence to Tanja Alexandra Stamm, MA,
OTR, Department of Internal Medicine III, Division of Rheu- of function, GST and BT values can be obtained quickly,
matology, Vienna University, Waehringer Guertel 18-20, which is especially important in busy clinic settings and
A-1090 Vienna, Austria. E-mail: Tanja.Stamm@akh-wien. long-term evaluations of RA patients.
ac.at. Nevertheless, these tests have serious drawbacks. Pa-
Submitted for publication October 17, 2001; accepted in
revised form September 15, 2002. tients with RA report pain when performing GST, which
has to be done 3 times with each hand according to the

626
Moberg Picking-Up Test in Arthritis 627

PATIENTS AND METHODS

Patients. We assessed 369 patients with inflammatory


joint disease attending a rheumatology outpatient clinic.
Inflammatory joint disease was classified as RA (n ⫽ 252)
and non-RA (n ⫽ 17). RA was classified according to the
American College of Rheumatology (ACR, formerly Amer-
ican Rheumatism Association) criteria (14). Non-RA in-
cluded patients with other inflammatory joint diseases,
such as psoriatic arthritis, connective tissue disease, or
undifferentiated oligoarthritis. Furthermore, patients with
early arthritis in each group, RA (n ⫽ 38) and non-RA (n ⫽
62), were analyzed separately. The term early is defined as
the presence of symptoms of inflammatory joint disease for
no longer than 3 months. Furthermore, for the analysis, the
patients were divided into groups according to demo-
graphic criteria, such as age and sex. Due to missing data,
only 366 patients were analyzed in the age groups. The
patients represent a heterogeneous population of patients,
as can be expected in a rheumatology outpatient clinic.
Inclusion criteria were as follows: 1) inflammatory joint
disease; 2) involvement of the upper extremity defined as
Figure 1. The 12 small objects of Moberg pickup test: These pain and/or soft tissue swelling in at least 1 joint (finger
objects have to be picked up and put into the small container joints, wrist, elbow, or shoulder) (15); and 3) no history of
while time is taken with a stopwatch. any neuromotor disease that could possibly affect motor
function.

Data collection. Every patient was assessed once. Data


standard protocol (2,7). In joint protection instructions in were gathered using a standardized assessment that con-
occupational therapy, patients with RA are told to avoid sisted of MPUT (13), BT (2), GST (16), and a core set of
maximum grip force and to respect their pain as an indi- parameters for assessing RA (17): tender and swollen joint
cator to stop (12). To use GST as a measurement in rheu- count (32 joints) (15), visual analog scales (VAS) for gen-
matology might be questionable under this perspective. eral pain and disease activity, Health Assessment Ques-
Some patients use these arguments or complain about pain tionnaire (HAQ) (18) in a validated German version (19),
and refuse to have GST assessed at all. In addition, GST C-reactive protein levels (CRP), and erythrocyte sedimen-
measures a single dimension of function whose impor- tation rate (ESR).
tance for performing everyday tasks may be limited and Not all variables could be obtained for every patient at
thus severely impairs the applicability of the test for long- the time of MPUT due to the survey character of the data
term observations. collection. MPUT was obtained for 333 patients, BT for
BT is less often used in clinical practice than GST. The 124 patients; 100 patients took both tests.
standard protocol requires a standardized button board (2) BT was administered to fewer patients than MPUT be-
that is difficult to obtain. Wear and tear, replacement, or cause of difficulties to obtain the standardized button board
repair of the board change the performance conditions for and because of the material weakness of the button board.
the patients.
The Moberg pickup test (MPUT) was considered a pos- Clinical tests. MPUT was performed according to a
sible alternative measure for assessment of functional sta- standard protocol once with open eyes only, instead of
tus of the hand in patients with RA. MPUT consists of 12 being performed 2 times, both blindfolded and with open
small objects that have to be picked up while time is taken eyes (13). For more detailed information on the standard
with a stop watch (Figure 1). A standard protocol has been protocol of MPUT, see Appendix A.
established and interrater reliability has been found to be Due to time constraints in a busy clinic setting, only the
good (13). When administered blindfolded, MPUT has dominant hand was tested, but 2 attempts were performed
been described to assess sensory function grip of the hand according to the protocol (13). Failures were recorded as
(13). When administered with open eyes, MPUT could be 300 seconds. For more detailed information, see Appendix
used to assess precision grip in patients with RA. MPUT A.
has not been used in RA patients so far. The aim of this The BT was administered according to the standard
study was to assess and compare the suitability of MPUT protocol as described in the literature (2). Both hands were
as an indicator of functional impairment in patients with tested, the patient always starting with the dominant hand.
inflammatory joint diseases. In this analysis, MPUT was Times were recorded (in seconds) separately for both
compared with BT as an already established test for quan- hands; for some analyses, times were averaged (according
titative assessment of functional status in patients with to the standard protocol). Failures were recorded as 300
inflammatory joint disease. seconds.
628 Stamm et al

Table 1. Statistical measures for the values of MPUT and BT*

MPUT value BT value


Statistic (95% CI) (95% CI)

Mean 14.5 (14.0–15.1) 28.3 (26.4–30.6)


Standard deviation 7.1 (5.81–9.54) 10.9 (9.02–15.3)
Skewness 3.0 (2.3–5.0) 1.4 (0.5–5.4)
Median (interquartile range) 12.0 (5.0) 26.3 (12.4)
Cases 333 124
Unable to perform, n 6 10
Unable to perform, % 1.8 (0.66–3.88) 8.1 (3.93–14.33)

* MPUT ⫽ Moberg pickup test; BT ⫽ button test; 95% CI ⫽ 95% confidence interval.

GST was measured with a vigorimeter (16): Patients activity also on a 100-mm VAS (20). For HAQ, patients
were sitting, shoulder in neutral position, elbow 90° were asked to fill in a German HAQ score form (19). CRP
flexed, thumb upwards and outside of the fist. Patients levels were measured in mg/dl.
were tested 3 times on both hands and average values for
both hands were recorded. The middle sized rubber bulb
(diameter 43 mm) was used for all patients. Statistical analyses. The data were analyzed using ver-
Tender and swollen joint counts were performed for 32 sion 1.2.3 of the statistical package R (21). Mean, standard
joints (15) by the same trained joint assessor (TAS). Fur- deviation, median, interquartile range, and skewness were
thermore, patients were asked to assess their general level calculated for both MPUT and BT. Histograms and quan-
of pain and their disease activity on a 100-mm VAS. In tile-quantile plots clearly showed that the values of both
addition, the therapist had to assess the patients’ disease tests were strongly non-normally distributed. Therefore,

Figure 2. Histogram of population Moberg pickup test (MPUT) scores and boxplots of group
MPUT scores by diagnosis, gender, and age (clockwise from upper left to lower left panel).
RA ⫽ rheumatoid arthritis.
Moberg Picking-Up Test in Arthritis 629

Figure 3. Histogram of population button test (BT) scores and boxplots of group BT scores
by diagnosis, gender, and age (clockwise from upper left to lower left panel). RA ⫽ rheu-
matoid arthritis.

95% confidence intervals for mean, standard deviation, left panels of Figure 2 and Figure 3 show the correspond-
and skewness were calculated by bootstrapping the data, ing histograms of the values.
using the library boot of R (22). The difference in the
percentages between the MPUT and the BT were tested Group comparisons. The boxplots of MPUT values by
using Fisher’s exact test (23). diagnosis, age, and sex are shown in Figure 2. As can be
MPUT and BT values were compared by diagnosis, age, seen, the values in RA patients were higher than in
and sex of patients (Wilcoxon rank-sum test and the Kruskal- non-RA patients. In addition, there was an increase in
Wallis test). The possibility of interactions between the 3 values with age. The differences between diagnostic and
grouping factors was explored graphically, using condition- age groups were significant (P ⬍ 10⫺4 and P ⫽ 0.02, re-
ing plots; additionally, analysis of variance (ANOVA) models spectively). Differences between men and women were
were fitted to the transformed test values. unremarkable and nonsignificant. Figure 3 shows boxplots
Scatterplots showed that relationships between MPUT
of the BT values for the same groups. These exhibit the
and BT and all other tests were monotonous, but not
same significant influence of diagnosis and age (P ⫽ 0.01
linear. Therefore, Spearman rank correlation coefficients,
and P ⫽ 0.04, respectively) as MPUT, but additionally,
together with approximate confidence intervals based on
there was a highly significant (P ⫽ 0.005) sex effect. No
the Fisher z-score transform (23), were calculated. The
significant interactions between the demographic factors
linear relationships between MPUT and BT and between
repetitions of both tests were expressed using simple lin- in regard to the MPUT and BT values were found either by
ear regression. visual inspection or in the ANOVA models.

Learning effect. The scatterplots (data not shown) show


RESULTS the strength of agreement between first and second at-
tempt, which is clearly stronger for the MPUT (R2 ⫽ 0.87
Descriptives. Descriptive statistics and confidence in- for the linear regression line) than for the BT (R2 ⫽ 0.38).
tervals for MPUT and BT are given in Table 1. The upper However, for the MPUT both attempts were made with the
630 Stamm et al

are slightly stronger for MPUT than for BT. The most
notable exception is GST on both hands, which correlates
clearly stronger with the MPUT values. This allows a more
consistent interpretation of the MPUT in relation to the
other parameters. MPUT provides additional information
compared with the BT. This notion is based on the follow-
ing grounds.
There is a significant linear relationship between MPUT
and BT; the measure of determination (R2 ⫽ 0.37) implies
that this relationship explains approximately 37% of the
variability of the values for both tests. We interpret this as
the amount of variability due to the common aspects of
functional ability that are measured by both tests, whereas
the rest is due to different aspects of functional ability and
random variation between patients. Under this assump-
tion, we have 1) regressed MPUT on BT and 2) regressed
BT on MPUT; the residuals from these regressions can be
seen as corrected test values for 1) MPUT and 2) BT, after
removal of the shared aspects of functional ability. Figure
5 shows the correlations of these corrected test values with
the other tests: the corrected BT values show no significant
Figure 4. Spearman rank correlations between Moberg pickup correlation with any of the other parameters, whereas the
test (MPUT; dark bars) and button test (BT; light bars) and all
corrected MPUT values are still significantly correlated
other tests. The thin error bars show approximate 95% confidence
intervals for the correlation coefficients. Note that for ease of with grip strength for the dominant hand and to a lesser
visual comparison, the absolute values of the correlations are degree also with ESR and CRP. From this we conclude that
shown. The direction of the relationship is indicated by the signs 1) MPUT measures specific aspects of functional ability
at the right border of the plot. HAQ ⫽ Health Assessment Ques- that are not described by BT, but that correlate negatively
tionnaire; GST.dom ⫽ grip strength dominant hand; GST.sub ⫽
nondominant hand; VAS.pat ⫽ visual analog scale; VAS.pain ⫽ with grip strength, CRP, and ESR; and 2) if BT measures
disease activity as assessed by patient; TE ⫽ tender joint count; any comparable specific aspects, these are not related to
VAS.ther ⫽ as assessed by therapist; SW ⫽ swollen joint count; the other parameters.
CRP ⫽ C-reactive protein; ESR ⫽ erythrocyte sedimentation rate. Both MPUT and BT values exhibit the population effects
dominant hand, while for the BT, the first attempt was that one would expect from clinical practice: a tendency
made with the dominant hand and the second attempt for slightly higher values for RA patients, and a slight
with the nondominant hand.

Correlations. Figure 4 shows the Spearman rank corre-


lations between MPUT and BT and the other tests, together
with 95% confidence intervals. Correlations with CRP and
ESR measurements and the swollen joint count are not
significant at a 95% level for both MPUT and BT, whereas
the VAS score by the therapist is significant for MPUT, but
not for BT. All other tests correlate significantly with both
MPUT and BT at a 95% error level. The highest correlation
for both MPUT and BT was with the HAQ values. Overall,
the correlations with the other tests follow the same pat-
tern for MPUT and BT, with the MPUT correlations always
slightly higher than the BT correlations. The exceptions
are the GST subtests, which correlate clearly stronger with
MPUT than with BT.

Test comparison. A significantly higher percentage of


patients were unable to finish the BT as compared with the
MPUT (P ⫽ 0.004). For those patients who completed both
tests (n ⫽ 100), the Spearman rank correlation coefficient
between MPUT and BT values is 0.52, with a 95% confi-
dence interval of 0.35– 0.64. Figure 5. Spearman rank correlations between the residuals of 1)
regressing Moberg pickup test (MPUT) on button test (BT; dark
bars) and 2) regressing BT on MPUT (light bars). The thin error
DISCUSSION bars show approximate 95% confidence intervals for the correla-
tion coefficients, and the direction of the correlations is indicated
In general, MPUT and BT show the same pattern of corre- by the signs at the right border of the plot. See Figure 4 for
lation with the other parameters, though the correlations definitions.
Moberg Picking-Up Test in Arthritis 631

increase of values with the age of the patients. Addition- strated. Additionally, MPUT seems to have more relevance
ally, there is a strong sex effect for BT, which is completely to everyday life than grip strength and BT. Thus, we con-
absent from MPUT. A possible explanation is that the BT sider MPUT a possible alternative to GST and BT for
depends not only on functional ability, but also on skill, measuring functional ability of patients with inflammatory
because there is no connection between sex and degree of joint disease. Further research is needed to determine the
impairment, and the skills required for the BT are more usefulness of MPUT in monitoring RA patients over long-
traditionally associated with women. This sex effect com- term periods.
plicates test standardization for the BT.
Both MPUT and BT show a significant learning effect in
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APPENDIX A: DESCRIPTION OF MPUT
You have to take 1 object at a time and you are not allowed
Moberg pickup test (MPUT) was performed according to a to slide these objects to the edge of the table. I will time
standard protocol with open eyes only (13). Patients were you while you are doing this.”

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