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Objective. To assess and compare the suitability of Moberg pickup test (MPUT) and button test (BT) as indicators for
functional impairment in patients with inflammatory joint diseases.
Methods. Measurements for 369 patients attending a rheumatology outpatient clinic were collected. In addition to MPUT
and BT, measurements collected were grip strength, tender and swollen joint counts, visual analog scales for pain and
disease activity, Health Assessment Questionnaire, C-reactive protein levels, and erythrocyte sedimentation rates.
Results. We found a significant relationship between MPUT and BT. Both tests show the same pattern of correlations
with the other parameters, although all correlations are higher for MPUT. There is a significant sex and learning effect
for the BT, which implies a confounding of hand function and motor abilities. A significantly higher proportion of patients
was unable to complete BT.
Conclusion. MPUT and BT measure comparable aspects of hand function. In several theoretical and practical aspects,
MPUT seems superior to BT in arthritis. It is necessary to evaluate its value in long-term followup.
626
Moberg Picking-Up Test in Arthritis 627
* MPUT ⫽ Moberg pickup test; BT ⫽ button test; 95% CI ⫽ 95% confidence interval.
GST was measured with a vigorimeter (16): Patients activity also on a 100-mm VAS (20). For HAQ, patients
were sitting, shoulder in neutral position, elbow 90° were asked to fill in a German HAQ score form (19). CRP
flexed, thumb upwards and outside of the fist. Patients levels were measured in mg/dl.
were tested 3 times on both hands and average values for
both hands were recorded. The middle sized rubber bulb
(diameter 43 mm) was used for all patients. Statistical analyses. The data were analyzed using ver-
Tender and swollen joint counts were performed for 32 sion 1.2.3 of the statistical package R (21). Mean, standard
joints (15) by the same trained joint assessor (TAS). Fur- deviation, median, interquartile range, and skewness were
thermore, patients were asked to assess their general level calculated for both MPUT and BT. Histograms and quan-
of pain and their disease activity on a 100-mm VAS. In tile-quantile plots clearly showed that the values of both
addition, the therapist had to assess the patients’ disease tests were strongly non-normally distributed. Therefore,
Figure 2. Histogram of population Moberg pickup test (MPUT) scores and boxplots of group
MPUT scores by diagnosis, gender, and age (clockwise from upper left to lower left panel).
RA ⫽ rheumatoid arthritis.
Moberg Picking-Up Test in Arthritis 629
Figure 3. Histogram of population button test (BT) scores and boxplots of group BT scores
by diagnosis, gender, and age (clockwise from upper left to lower left panel). RA ⫽ rheu-
matoid arthritis.
95% confidence intervals for mean, standard deviation, left panels of Figure 2 and Figure 3 show the correspond-
and skewness were calculated by bootstrapping the data, ing histograms of the values.
using the library boot of R (22). The difference in the
percentages between the MPUT and the BT were tested Group comparisons. The boxplots of MPUT values by
using Fisher’s exact test (23). diagnosis, age, and sex are shown in Figure 2. As can be
MPUT and BT values were compared by diagnosis, age, seen, the values in RA patients were higher than in
and sex of patients (Wilcoxon rank-sum test and the Kruskal- non-RA patients. In addition, there was an increase in
Wallis test). The possibility of interactions between the 3 values with age. The differences between diagnostic and
grouping factors was explored graphically, using condition- age groups were significant (P ⬍ 10⫺4 and P ⫽ 0.02, re-
ing plots; additionally, analysis of variance (ANOVA) models spectively). Differences between men and women were
were fitted to the transformed test values. unremarkable and nonsignificant. Figure 3 shows boxplots
Scatterplots showed that relationships between MPUT
of the BT values for the same groups. These exhibit the
and BT and all other tests were monotonous, but not
same significant influence of diagnosis and age (P ⫽ 0.01
linear. Therefore, Spearman rank correlation coefficients,
and P ⫽ 0.04, respectively) as MPUT, but additionally,
together with approximate confidence intervals based on
there was a highly significant (P ⫽ 0.005) sex effect. No
the Fisher z-score transform (23), were calculated. The
significant interactions between the demographic factors
linear relationships between MPUT and BT and between
repetitions of both tests were expressed using simple lin- in regard to the MPUT and BT values were found either by
ear regression. visual inspection or in the ANOVA models.
are slightly stronger for MPUT than for BT. The most
notable exception is GST on both hands, which correlates
clearly stronger with the MPUT values. This allows a more
consistent interpretation of the MPUT in relation to the
other parameters. MPUT provides additional information
compared with the BT. This notion is based on the follow-
ing grounds.
There is a significant linear relationship between MPUT
and BT; the measure of determination (R2 ⫽ 0.37) implies
that this relationship explains approximately 37% of the
variability of the values for both tests. We interpret this as
the amount of variability due to the common aspects of
functional ability that are measured by both tests, whereas
the rest is due to different aspects of functional ability and
random variation between patients. Under this assump-
tion, we have 1) regressed MPUT on BT and 2) regressed
BT on MPUT; the residuals from these regressions can be
seen as corrected test values for 1) MPUT and 2) BT, after
removal of the shared aspects of functional ability. Figure
5 shows the correlations of these corrected test values with
the other tests: the corrected BT values show no significant
Figure 4. Spearman rank correlations between Moberg pickup correlation with any of the other parameters, whereas the
test (MPUT; dark bars) and button test (BT; light bars) and all
corrected MPUT values are still significantly correlated
other tests. The thin error bars show approximate 95% confidence
intervals for the correlation coefficients. Note that for ease of with grip strength for the dominant hand and to a lesser
visual comparison, the absolute values of the correlations are degree also with ESR and CRP. From this we conclude that
shown. The direction of the relationship is indicated by the signs 1) MPUT measures specific aspects of functional ability
at the right border of the plot. HAQ ⫽ Health Assessment Ques- that are not described by BT, but that correlate negatively
tionnaire; GST.dom ⫽ grip strength dominant hand; GST.sub ⫽
nondominant hand; VAS.pat ⫽ visual analog scale; VAS.pain ⫽ with grip strength, CRP, and ESR; and 2) if BT measures
disease activity as assessed by patient; TE ⫽ tender joint count; any comparable specific aspects, these are not related to
VAS.ther ⫽ as assessed by therapist; SW ⫽ swollen joint count; the other parameters.
CRP ⫽ C-reactive protein; ESR ⫽ erythrocyte sedimentation rate. Both MPUT and BT values exhibit the population effects
dominant hand, while for the BT, the first attempt was that one would expect from clinical practice: a tendency
made with the dominant hand and the second attempt for slightly higher values for RA patients, and a slight
with the nondominant hand.
increase of values with the age of the patients. Addition- strated. Additionally, MPUT seems to have more relevance
ally, there is a strong sex effect for BT, which is completely to everyday life than grip strength and BT. Thus, we con-
absent from MPUT. A possible explanation is that the BT sider MPUT a possible alternative to GST and BT for
depends not only on functional ability, but also on skill, measuring functional ability of patients with inflammatory
because there is no connection between sex and degree of joint disease. Further research is needed to determine the
impairment, and the skills required for the BT are more usefulness of MPUT in monitoring RA patients over long-
traditionally associated with women. This sex effect com- term periods.
plicates test standardization for the BT.
Both MPUT and BT show a significant learning effect in
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22. Selvin S. Modern applied biostatistical methods using S-Plus. with any of these objects and was not allowed to do any
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recorded in seconds. Failures were recorded with 300
LA. An objective and standardized test of hand function. Arch seconds.
Phys Med Rehabil 1969;50:311–9. Patients were instructed as follows: “When I tell you so,
using 1 hand only, starting with the dominant hand, please
put these objects into the small container in front of you.
APPENDIX A: DESCRIPTION OF MPUT
You have to take 1 object at a time and you are not allowed
Moberg pickup test (MPUT) was performed according to a to slide these objects to the edge of the table. I will time
standard protocol with open eyes only (13). Patients were you while you are doing this.”