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MOUSE DOSAGE CALCULATOR

for IACUC/LARC Preferred Anesthetics/Analgesics

Notes:
1) Follow step-by-step instructions below to calculate injection dosage
2) Label all solutions with Working Concentration (from this calculator) and expiration date (30 days from preparation date)
3) Calculator is write-protected, direct questions to <<daniel.ferguson@ucsf.edu>>

STEP 1) Select Drug From Drop-Down Menu: STEP 5) Prepare Solution:


ADD:
>> Meloxicam (5 mg/mL) 0.25 volume Meloxicam (mL)
(note: make sure your stock solution matches the concentration listed) N/A
N/A
TO:
STEP 2) Enter Average Mouse Weight (g): 2.75 dilutant volume (mL)

>> 25 TO GET
(note: the average adult B6 mouse weighs 25g) Working Concentrations:
0.41 [Meloxicam] (mg/mL)
N/A
STEP 3) Enter Number of Animals to Inject: N/A

>> 5
(note: used to calculate preparation amount, increase or decrease as advised in Steps 5 & 6) STEP 6) Administer Injection Volume (mL) to Mouse:

0.30 ---> Mouse ---> ^ ^


STEP 4) Enter Desired Dose Amount (mg/kg): (- -)
Suggested: Via Route: ( v v )~~~~~
>> 5 Meloxicam 5-10 mg/kg PO, IM, or SC note: mouse not to scale
10
2
Drug Name Purpose Route [Stock] (mg/mL)
Meloxicam NSAID PO/IM/SC 5

Carprofen NSAID SC 50

Ketoprofen NSAID SC 100

Atipamezole Reversal Agent SC/IP 5

Buprenorphine Analgesic SC/IP 0.3

Ketamine Anesthetic IP 100

Xylazine Sedative/Mild Analgesic (Reversed with IP 20


Atipamezole (5 mg/mL)

Acepromazine Sedative IP 10

Ketamine Cocktail 100


IP
Xylazine 20
Ketamine 100
Xylazine Cocktail IP 20
Acepromazine 10

Notes:
1) This table forms the basis for values in "Calculator" tab.
2) Columns F through K (colored gray) contain formulae output values, change with caution.
3) Worksheet is protected to prevent unwanted alterations to formatting.
4) Direct questions to <<daniel.ferguson@ucsf.edu>>

Meloxicam (5 mg/mL)
Carprofen (50 mg/mL)
Ketoprofen (100 mg/mL)
Atipamezole (5 mg/mL)
Buprenorphine (0.3 mg/mL)
Ketamine (100 mg/mL)
Xylazine (20 mg/mL)
Acepromazine (10 mg/mL)
Ketamine (100 mg/mL) Xylazine (20 mg/mL)
Ketamine (100 mg/mL) Xylazine (20 mg/mL)
Acepromazine (10 mg/mL)
Dose (mg/kg) Total Prep (mL) X factor Stock (mL) Dilutant (mL) [Working] (mg/mL)
5 3 9.9 0.25 2.75 0.41

5 5 16.5 Increase # of Animal N/A 0.41

5 5 16.5 Increase # of Animal N/A 0.41

1 5 16.5 0.08 4.92 0.08

0.1 5 16.5 0.14 4.86 0.01

100 5 16.5 0.41 4.59 8.25

10 5 16.5 0.21 4.79 0.83

3 5 16.5 0.12 4.88 0.25

100 0.41 8.25


5 16.5 4.38125
10 0.21 0.83
100 0.41 8.25
10 5 16.5 0.21 4.2575 0.83
3 0.12 0.25

1
Give (mL/mouse)
0.30

0.30

0.30

0.30

0.30

0.30

0.30

0.30

0.30

0.30