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1.

Which of the following is the most likely explanation for multiple drug resistance to
antibiotics that has increased from one type of bacteria to other type of bacteria?
a) Adaptation
b) Decreased bioavailability
c) Gene transfer
d) Mutation
e) Pharmacogenetic
ANSWER: C

2. Which property or action is shared by the penicillins, the cephalosporins and


amphotericin B?
a) Contraindicated in immunocompromised patients
b) Interact w many drugs by inducing their hepatic metabolism
c) Leukopenia is a common side effect
d) Nephrotoxicity precludes use in patients w impaired renal function
e) Act, though various mechanisms, on cell walls or membranes of susceptible
organisms
ANSWER: E
1. The results shown in the graph below were obtained in a comparision of drugs that
increase the force of cardiac contraction. Which of the following statements is MOST
correct?

B C
Increase in cardiac force

a. Drug A is most effective


b. Drug B is least potent
c. Drug C is most potent
d. Drug B is more potent than drug C and more effective than drug A
e. Drug A is more potent than drug B and more effective than drug C
2. Which of the following terms describes an antagonist that interact directly with the agonist
and not at all, or only incidentally, with the receptor?
a. Pharmacologic antagonist
b. Partial agonist
c. Physiologic antagonist
d. Chemical antagonist
e. Noncompatative antagonist

3. Which of the following provides information about the largest response a drug can
produce regardless of dose?
a. Drug potency
b. Maximal efficacy
c. Mechanisms of receptor action
d. Therapeutic index
e. Therapeutic window

4. Which of the following drugs has no antibacterial effect but use in combination with beta-
lactam antibiotics due to its penicillinase inhibitory effect
a. sulbactam
b. vankomycin
c. aztreonam
d. chloramphenicol
e. nafcillin
5. 1. Which of the following drugs is bactericidal?
6. a) Macrolides
7. b) Chloramphenicol
8. c) Sulphonamides
9. d) Ampicillin
10. e) Etambutol
11. 2. Please indicate the selective antimicrobial drug.
12. a) Inhibitors of protein synthesis
13. b) Antimicrobials that bind to 30s subunit
14. c) Folate synthesis inhibiting sulfonamides
15. d) Antimicrobials that bind to 50s subunit
16. e) Inhibitors of nucleic acid synthesis

5. Which of the following molecules is a fluoroquinolone antibiotic which blocks


bacterial DNA synthesis by inhibiting bacterial topoisomerase II?
a) Cefadroxil
b) Cloxacillin
c) Ciprofloxacin
d) Cefoxitin
e) Capreomycin

6. Indicate the drug that acts via H2 histamine receptors when used in the
treatment of gastroduedonal ulcers.
a) Omeprazole
b) Famotidine
c) Aluminum hydroxide
d) Sodium bicarbonate
e)Lansoprazole

15. The phenomenon that you observed when you administer a combination of
morphine and petidine to rats on analgesic threshold is called................
a) Addition b) Subtraction
c) Synergism d) Antagonism
e)Agonisnm

16. Which of the following is least likely to be a resistance mechanism against


penicillins?
a) Decreasing binding affinity to bacterial ribosomal 50S sub unit.
b) Inactivation by beta-lactamase enzymes.
c) Alteration in target penicillin binding protein (PBP).
d) Prevention of penetration into periplasmic space of bacteria.
e) Increased efflux of the by the efflux pumps

17. Death from opioid overdose is most often the result of


a) Respiratory depression
b) Convulsions
c) Cardiac arrest
d) Shock
e) Neuromuscular blockade

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18. Which of the following is a general (nonspecific) CNS depressant?

a) Morphine
b) Naloxone
c) Anesthetic gases and vapors
d) Meperidine
e) Codeine

19. Please choose the incorrect statement for morphine.

a) Depresses the cough reflex.


b) Causes histamine release and peripheral vasodilation.
c) Decreases propulsive peristaltic waves in the colon.
d) Decreases tone in the colon.
e) Causes miosis.

20. Which of the following is a specific opioid receptor antagonist?

a) Methadone
b) Codeine
c) Tebaine
d) Naloxone
e) Papaverine

? 21. Morphine interacts with which of the following subtype of opioid receptors?

a) κ
b) δ
c) μ
d) Є
e) All

22. Indicate the one that is not among clinical uses of H2 receptor antagonists.
a) Peptic duodenal ulcer
b) Erosive Esophagitis (GERD)
c) Allergic reactions
d) Gastric ulcer
e) Hypersecretory conditions

23. Which of the following receptors of Histamine is responsible for gastric acid
secretion?
a) H1 b) H2
c) H3 d) H4
e) H5

24. Which of the following is not among uses of the H2 Histamine antagonists?
a) Gastroesophageal reflux disease b) Heartburn
c) Dispepsia d) Peptic ulcer caused by H pylori
e) Nonulcerdispepsia
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25. Which of the following is not derived from opium poppy, papaver
somniferum?
a) Morphine
b) Codeine
c) Tebaine
d) Papaverine
e) Enkephalin

26. Which of the following best explains the mechanism of action of


antihistaminic drugs?
a) They reduce synthesis of histamine in the body
b) They combine with histamine and produce inactive complexes
c) They block histamine receptors
d) They stimulate endogenous histamine metabolism
e) They reduce affinity of histamine for its receptors

34. Which of the following inhibits the synthesis of ergosterol?


a) Nystatin b) Amphotericin B
c) Ketoconazole d) Amphotericin C
e) All

38. Choose the one that is not an opioid receptor.


a) μ b) δ
c) κ d) Є
e) α

37. Clarithromycin belongs to which of the following groups?


a) Antimicotics
b) Antifungals
c) Polymixins
d) Macrolides
e) Polyenes

39. Which of the following is not observed in an individual during the abstinence
syndrome of morphine dependence?
a) Ptosis b) Diarrhea
c) Sedation d) Sweating
e) Tremors

1. Choose the correct one for the mechanism of action for Amphotericin B.
a) Has greater affinity for mammalian plasma membrane cholesterol than
for fungal plasma membrane ergosterol
b) Has greater affinity for fungal plasma membrane ergosterol than for
mammalian cholesterol
c) Has equal affinity for fungal plasma membrane ergosterol as for
mammalian cholesterol
d) Inhibits protein synthesis in the 30s subunit of the ribosomes
e) Inhibits protein synthesis in the 50s subunit of the ribosomes

6. Which of the following drugs is bactericidal?


a) Macrolides
b) Chloramphenicol
c) Sulphonamides
d) Ampicillin
e) Etambutol

7. Please indicate the selective antimicrobial drug.


a) Inhibitors of protein synthesis
b) Antimicrobials that bind to 30s subunit
c) Folate synthesis inhibiting sulfonamides
d) Antimicrobials that bind to 50s subunit
e) Inhibitors of nucleic acid synthesis

7. Please choose the incorrect one.


a) Penicillins are inactivated in the stomach
b) Penicillin V is more resistant to acid hydrolysis
c) Food can interfere with the absorption of penicillins
d) Penicillin V is more effective than G on certain aneorobs
e) Penicillins should be taken either 30 minutes before or 2h
after meals
3. Which of the following drug interactions can be considered basically as pharmacodynamic
drug interaction which results in alteration at the receptor level?

A) Propranolol – Salbutamol
B) Tetracyclin – Calcium
C) Phenytoin – theophylline
D) Antacid – iron
E) Itraconazole – Verapamil