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New Insight into Losing Weight


Blood sugars may be key to optimizing weight loss approaches

By Erin Lewis
August 10, 2017

What if a simple blood test could help you determine the best strategy for weight loss, before you even
started? Additional analysis of a study conducted by researchers at the Jean Mayer USDA Human
Nutrition Research Center on Aging (HNRCA) at Tufts suggests that a person’s fasting glucose levels,
also called blood sugar levels, may be useful in figuring out the best type of diet for weight loss. The
study focused on a weight-loss program based on the “iDiet,” which emphasizes a high-fiber, low-
glycemic diet and includes behavioral support. reddit

Tufts researchers, in collaboration with scientists from


Gelesis, a biotechnology company, found that at the end
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of the six-month program, overweight and obese people
with high fasting blood sugar levels lost more weight (an
average of 9.4 percent of body weight) than those with
low fasting blood sugar levels (4.1 percent body weight).

Senior author Sai Krupa Das, a scientist in the Energy


Metabolism Laboratory at the HNRCA, explained that

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high fasting blood sugar levels are a sign of poor glucose “It might be time to consider glycemic status
when advising patients on the best strategy for
control, making people susceptible to blood glucose
weight loss,” said Susan B. Roberts. Oatmeal is
spikes when they eat, leading to hunger and overeating. A an example of a food for those on low-glycemic
low-glycemic diet is designed to minimize those spikes. index diets. Photo: Ingimage
“Fasting blood sugar is easily measured, and our findings
suggest that it could serve as a useful measure in advising
some patients on the type of diet that is most beneficial for their weight loss,” Das said.

Most guidelines for weight control recommend that people with obesity lose 5-10 percent of their body weight to improve health. After six
months, a greater proportion of subjects with high fasting blood sugar lost this recommended amount of weight, compared to those with low
fasting blood sugar.

Almost 80 percent of subjects with high fasting blood sugar levels lost 5 percent of their body weight, compared to only 50 percent of subjects
with low fasting blood sugar levels. In addition, 36 percent in the high group, vs. 8 percent in the low group, lost 10 percent of their body
weight.

“The difference in response among those with high fasting blood sugar and lower fasting blood sugar is important. It might be time to consider
glycemic status when advising patients on the best strategy for weight loss,” said study author Susan B. Roberts, senior scientist and director of
the Energy Metabolism Laboratory at the HNRCA.

The analysis was published as a poster (with first author Lorien Urban, F09) at the American Diabetes Association’s 77th Scientific Sessions, so
the data and conclusions should be considered preliminary until they have been published in a peer-reviewed journal.

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