Book
Ph arm
Practical Pharmaceutical Chemistry, third
edition-part II, A. H. Beckett and J. B.
Stenlake, The Athlone Press, University of
London, 4 Gower Street, London, WC 1,
Great Britain, 1976, 552 pages, $37.50.
Distributed in the U.S. by Humanities
Press, Atlantic Highlands, New Jersey.
Part II of this standard British text, now in
its third edition, provides a broad coverage
of physical and instrumental methods used
in the analysis of drugs and pharmaceutical
products. As in Part I, interpretation of phar-
maceutical analysis has been extended to
include the analysis of drugs and their distri-
bution characteristics in the human body.
New subjects covered in this revision include
high pressure liquid chromatography, circular
dichroism, the use of nonselective elec-
trodes, coulometry, atomic absorption
spectroscopy and radioimmunoassay.
Part I, concerned with general pharma-
ceutical chemistry, deals with basic parts of
the syllabus and all experiments are closely
linked to the requirements of the current
British and European Pharmacopoeias.
USAN and the USP Dictionary of Drug
Names, 1975 edition, Mary C. Griffiths, Marie
J. Dickerman and Lloyd C. Miller, editors,
USAN Division of USP Convention Inc.,
12601 Twinbrook Parkway, Rockville, MD
20852, 347 pages, $18.50. (softbound
in plastic).
This dictionary of United States Adopted
Names (USAN) is a primary reference source
for a single alphabetical list of 1,403 USAN
and other names for both marketed and in-
vestigational drugs. In addition, it includes
1, 739 investigational drug code designations,
USP XIX official names, NF XIV official
names, FDA-established names, brand
names, and abbreviations and trivial names.
Other features include a cross-index of
names by pharmacologic-therapeutic cate-
gories, guiding principles for coining U.S.
Adopted Names for drugs, molecular for-
mulas and corresponding USAN, names and
addresses of domestic firms concerned with
compounds for which USAN have been se-
lected, and a section on how to use the book.
Patient Dosage Instructions, third edition,
Steven Strauss, IMS America Ltd., Ambler,
PA 19002, 1975, 100 pages, paperback,
$7.95.
With a subtitle, "a guide for pharmacists,"
this book can serve as a useful tool for
pharmacists who provide instructions on
when and how to take medications. A list of
the most frequently prescribed and non-
prescribed drugs with generic names, man-
Vol. NS 16, No. 12, December 1976
i'i
.....-.~
ufacturers and dose instructions is included
in chart form. A unique feature of the book
are the figures illustrating how to use different
dosage forms such as ophthalmic prepara-
tions, otic drugs and nasal sprays. A total of
22 tables provides easily accessible infor-
mation often required when giving instruc-
tions to patients.
Catalog of Teratogenic Agents, second
edition, Thomas H. Shepard, The Johns
Hopkins University Press, Baltimore, MD
21218, 1976, 291_pages, $16.50.
This volume is a "catalog" in the true
sense of the word. It reproduces a computer
printout of teratogenic agents arranged al-
phabetically, each including a brief annota-
tion and reference. It is significant that an
attempt has been made to cover the foreign
literature since articles on teratogenic agents
are widely dispersed throughout the bio-
medical publications. According to the au-
thor, "the main purpose of this catalog is to
help link the information on experimental
teratogenic agents with the congenital de-
fects in man." Pharmacists receiving ques-
tions regarding possible teratogenic agents
will find the catalog a useful and exhaustive
key to the literature.
Antibiotics: A Critical Review, W.
Kurylowicz, editor, Polish Medical Publish-
ers, Warsaw, (Distributed in the United
States and Canada by the American Soci-
ety for Microbiology, 1913 Eye Street,
N.W., Washington, DC 20006), 1976, 204
pages, $6.00.
This unique publication, made possible by
the International Programs Division of the
National Library of Medicine, covers the en-
tire field of antibiotics. A separate monograph
on antibiotics as therapeutic agents includes
information on toxicity and side effects of
antibiotics, pharmacokinetic characterization
of antibiotics, survey of their use in medicine
and an outline of general principles for the
selection of antibiotics in therapy. Also, the
first chapter offers a concise orientation to
definitions and an historical interpretation
showing the number of antibiotics described
in the literature, 1939-1972.
Pills, Profits, and Politics, Milton Silver-
man and Philip R. Lee, University of Cali-
fornia Press, Berkeley, CA, 1974, 403
pages, paperback, $4.95.
Published in 1974 in hardback only, this
book, now in paperback edition, has been
referred to as " ... probably the most ex-
plosive book ever published on the modern
'wonder drug' era ... " For review, see the
August 1974 (page 427) issue of JAPhA.
The Pharmacology of Marihuana, 2 vol-
umes, M. C. Braude and S. Szara, Raven
Press, 1140 Avenue of the Americas, New
York, NY 10036, 1976, Volumes 1 and 2,
865 pages, $50.00.
This major work, sponsored by the Na-
tional Institute on Drug Abuse, brings together
the proceedings of a multidisciplinary inter-
national conference designed to review the
state of the art of current scientific research
on cannabis and its derivatives. The two
volumes cover every aspect of work done on
the effects of cannabis including chemical
and metabolic aspects, cellular, immuno-
logical and hormonal effects, autonomic ef-
fects, neuropharmacological effects, be-
havioral pharmacology and interactions,
long-term effect of marihuana, genetics and
reproduction, and therapeutic potentials.
Drug Treatment, Principles and Practice
of Clinical Pharmacology and Therapeu-
tics, Graeme S. Avery, editor-in-chief,
Australasian Drug Information Services,
Publishing Sciences Group, Inc., 162 Great
Road, Acton, MA 01720, 1976, 1,048
pages, $25.00.
More than 50 medical specialists from
throughout the world have contributed to this
volume which provides a valuable resource
for pharmacologists, physicians and phar-
macists practicing in the clinical setting. As
stated in the preface, "The aim of this book
is to discuss the use and effects of drugs
within a disease-oriented context and so
assist clinicians in an understanding of drug
response in disease states and in the selec-
tion of the most appropriate drug and dosage
for a patient."
To achieve this stated purpose, the book
covers the clinical pharmacological basis of
therapeutics with particular emphasis on
pharmacokinetics, rational selection and
individualized use of drugs, the influence of
associated disease or intercurrent illness on
drug response, diseases caused by drugs,
and summary tables and appendices to en-
able quick reference and correlation of data
on individual drugs and classes of drugs. Each
chapter begins with a synopsis of important
principles, making it easy to readily scan the
contents. Of special interest is the chapter
on "Geriatric Clinical Pharmacology and
Therapeutics" which includes sections on
determinants of altered drug responsiveness
in the elderly, principles of prescribing drugs
and drug treatment in the elderly. Appendices
include drug data information and guides to
adverse reactions, to clinically important drug
interactions and to the selection of a sys-
temic antibacterial agent.
647
The Drugging of the Americas, Milton Sil-
verman, University of California Press,
Berkeley, CA 94720, 1976, 161 pages,
$8.50.
This book, under the subtitle "How Multi-
national Drug Companies Say One Thing
About Their Products to Physicians in the
United States, and Another Thing to Physi-
cians in Latin America," reports on a study
which shows that drug promotion in Latin
America does not always disclose medica-
tion hazards. In contrast, U.S. drug com-
panies promoting their products to physicians
are required by law to limit their claims to
what they can prove and to make full dis-
closure of all known hazards.
In the study presented, the author surveyed
the published information presented to phy-
sicians and pharmacists on a number of im-
portant, widely used products marketed in
various countries. Twenty-eight drugs mar-
keted in Latin America under a variety of
brand or generic names by more than 20
multinational pharmaceutical companies
were chosen for the study. These included
drugs in seven major categories-antibiotics,
oral contraceptives, nonsteroid antiarthritics,
steroid hormones, antipsychotic tranquilizers,
antidepressants and anticonvulsants. Tables
covering each of the drugs show the infor-
mation provided in each of the countries for
indications for use, contraindications and
warnings, and adverse reactions.
In the introduction, the author calls atten-
tion to points which deserve special em-
phasis, including the fact that the problem of
drug misuse is now receiving worldwide at-
tention, that the practices described in the
report are not limited to Latin America, that
nothing in the book is intended to approve or
condemn the drug labeling and promotional
regulations set by FDA, and finally, the
comments included are intended in no way
to pass judgment on the relative training, skill,
competence, or dedication of physicians or
pharmacists in the United States and Latin
America.
Pharmacy, Drugs and Medical Care, sec-
ond edition, Mickey C. Smith and David A.
Knapp, The Williams & Wilkins Company,
428 E. Preston Street, Baltimore, MD
21202, 1976, 322 pages, paperback,
$11.50.
As an introduction to pharmacy within the
context of the health care system in which it
is practiced, this book presents an overall
view of the profession. Nearly every facet of
pharmacy is covered including pharmaceu-
tical industry, ethics, functions and types of
648
pharmacies, social goals and the major
issues facing the profession . The book also
serves as a useful orientation to pharmacy
and as a source of information for data on
pharmacy practice and pharmacists. It also
gives a background on organizations asso-
ciated with pharmacy, as well as a briefing
on recent medical care legislation. Emphasis
is given to the growing importance of the
pharmacist's role on the health care team.
Extensive references, diagrams, tables and
a comprehensive index make this second
edition a valuable addition to any pharma-
cist's library.
Dispensing of Medication, eighth edition,
edited by John E. Hoover, Mack Publishing
Company, 20th & Northampton Streets,
Easton, PA 18042, 1976, 662 pages,
$22 .00.
Described as "a practical manual in the
formulation and dispensing of pharmaceutical
products," this eighth edition of a well-known
text has been completely redesigned and
updated. It is intended to aid the patient-ori-
ented pharmacist and provides compounding
and dispensing information on more than
1,400 drug entities and pharmaceutical
products. Thirteen chapters cover Medication
Orders, Bioavailability, Capsules, Powders,
Tablets and Pills, Dermatologicals, Sup-
positories, Liquid Medications, EENT Medi-
cations, Parenteral Medications, Aerosols,
Radiopharmaceuticals, and Compounding
and Dispensing Information.
In addition to the documentation included
for each chapter, there is a bibliography for
further reading on each subject. An editorial
board plus 22 authors, each a specialist in his
field, contributed to the volume, making it a
practical reference and an invaluable working
tool for pharmacy practitioners and students,
as well as for physicians, nurses and other
professionals who dispense medication.
Pharmacy Law Digest, Eugene L. Kaluzny,
Douglas McKay, Inc., P.O. Box 15565,
Dept. PLD, Milwaukee, WI 53215, 1975-
1976, 1,000 pages+, $24.95 including
1976 supplement service.
This provides an update of a law reference
used by pharmacists for more than a decade.
Compiled by a practicing pharmacist/attor-
ney, this looseleaf volume serves as a guide
and useful information resource for students,
practicing pharmacists and enforcement
agencies. Subjects covered in this 1975-76
edition include laws covering narcotics and
dangerous drugs, pharmacy inspection, FDA
drug control laws, civil liability, business law,
state pharmacy law and pharmacy court
cases.
Medical Pharmacology, Principles and
Concepts, eighth ·edition, Andres Goth, The
C. V. Mosby Company, 3301 Washington
Boulevard, St. Louis, MO 63103, 1976,
754 pages, $18.50.
The 59 chapters of this long-established
text have been thoroughly revised with
greater emphasis on those principles and
concepts needed not only for good medical
practice, but also for an understanding of the
current clinical literature. At the same time,
the deletion of obsolete or trivial information
has made it possible to reduce the size of the
book. Careful documentation, along with a
listing of recent review articles for each
chapter, makes the book a valuable refer-
ence as well as a text for those wishing a
background in the current clinical litera-
ture.
Sections of the book are devoted to gen-
eral aspects of pharmacology, drug effects
on the nervous system and neuroeffectors,
psychopharmacology, depressants and
stimulants of the central nervous system,
anesthetics, drugs used in cardiovascular
disease, drug effects on the respiratory and
gastrointestinal tracts, drugs that influence
metabolic and endocrine functions, chemo-
therapy, principles of immunopharmacology,
poisons and antidotes, drug interactions,
prescription writing and drug compendia.
The Comprehensive Desk Reference of
Veterinary Pharmaceuticals & Biologicals
76177, Ronald A. LeClair, editor, Dudley
E. Johnston, consulting editor, F. A. Davis
Company, 1915 Arch Street, Philadelphia,
PA 19103, 460 pages, $24.95 .
This reference brings together a wealth of
data about drugs used in veterinary medicine,
with emphasis on the needs of the practi-
tioner. Sections include an alphabetical list
of products by name and manufacturer, a
cross-index of generic and proprietary
names, indexes of biologicals, drug classi-
fication, diets and nutritional supplements and
parasiticides, product information by drug
classes and a list of distributors of veterinary
products . The appendices are extensive,
including information ranging from manage-
ment of poisoning to normal laboratory
values for animals. Appendices providing
information regarding registration with the
Drug Enforcement Administration and fun-
damentals of prescription writing may have
special interest to pharmacists. Annual
supplements and periodic revisions will keep
this reference current. Pharmacists providing
prescription service for veterinarians will find
this volume useful.
(Continued on page 688)
Journal of the American Pharmaceutical Association
Ph?rmacy
Today
Pharmacy ''in the name of Dr. John J.
Sciarra,'' executive dean of college. Grant
was established specifically to honor special
achievements of Dean Sciarra in his role as
editor of Society's Journal. In April this year,
Dean Sciarra attended NASA meeting in
Houston as consultant in Life Science Lab-
oratory for Space Shuttle. In same month, he
delivered keynote address at International
Aerosol Conference in Johannesburg, South
Africa.
Pennsylvania-Newly appointed executive
director of Pennsylvania Pharmaceutical
Association is Stanley Singer .... 1976-77
officers of Kitsap Peninsula Pharmaceutical
Association are Richard Wagner, president;
Dee Rolfe, president-elect, and Renee Roa-
druck, secretary-treasurer .... PCPS dean
of faculty and Remington professor of phar-
macy, Daniel Hussar, is president-elect of
Drug Information Association for 1976-77.
Hussar was recently elected to three-year
term on APhA Board of Trustees.
Wisconsin- William Blockstein, professor
of pharmacy and clinical professor of pre-
ventive medicine at University pf Wiscon-
sin-Madison, has received Wisconsin Asso-
ciation of Nursing Homes Better Life Award.
APhA member Blockstein was one of four
persons cited by association for ''outstanding
service through un$elfish and effective efforts
that have resulted in lasting contributions in
improved health care for the elderly in Wis.,.
cons in. '' Association commended Blockstein
for his " outstanding leadership role" as
member of state Nursing Home Administrator
Examining Board.
National Scene
Associations-Association of Drug Detec-
tion Laboratories will present second annual
symposium, ''The Detection of Drugs in Bi-
ological Fluids,'' on Dec. 3-5 in New Orleans.
Book Pharm
(Continued from page 648)
Self-Assessment of Current Knowledge in
Pharmacy, Fotios. M. Plakogiannis and An-
thony C. Cutie, Medical Examination Pub-
lishing Company, Inc., 65-36 Fresh Mead-
ow Lane, Flushing, NY 11365, 1976, 201
pages, $7.50.
A series of 1,208 multiple choice ques-
tions in pharmacy is designed as an aid in
self-assessment for pharmacists who wish
to assure themselves that their professional
knowledge is being kept up-to-date. Each
question is documented by specific refer-
688
Papers will include analytical areas of routine
screening in urine, therapeutic monitoring
and dosage form analysis, as well as labo-
ratory organization and quality control .....
Cosmetic, Toiletry and FragrancfJ Associa-
tion has launched Cosmetic Ingredient Re-
view, program designed to bring together all
worldwide scientific data on safety of cos-
metic ingredients for review and further
evaluation by independent panel of leading
scientists. Review, to continue over several
years, will be open, involving public partici-
pation in meetings and hearings and public
access to panel records, reports and safety
data.
Government-U.S. Consumer Product
Obituary
S. Morris Kupchan, a University of Virginia
chemistry professor who received a num-
ber of international awards for his re-
search for cancer-inhibiting compounds
from plants, died October 19. Kupchan had
twice been the recipient of the APhA
Academy of Pharmaceutical Science Ebert
Prize, and in 1975 won the Ernest Guen-
ther A ward of the American Chemical So-
ciety.
ences to textbooks and current pharmaceu-
tical journals. An answer key to the questions
makes it possible for the user to check his
work.
Clinical Pharmacy Sourcebook, American
Society of Hospital Pharmacists, Publish-
ing Sciences Group, Inc. Acton, MA
01720, 396 pages, $20.00.
This collection of articles on clinical
pharmacy, reproduced from the American
Journal of Hospital Pharmacy, does indeed
serve as a "sourcebook." Articles relating
to clinical pharmacy are classified under
At its 56th annual convention, Alpha Zeta Omega
pharmaceutical fraternity presented its 22nd Achieve-
ment Medal for long and distinguished meritorious
service to the profession of pharmcy to William S.
Apple (second from left),. APhA executive director.
Paul Pumpian (right) presented Dr. Apple to the con-
vention and spoke of his accomplishments as an edu-
cator, organizer, leader and executive. With Apple
and Pumpian are William Goldman (left), a past na-
tional AZO president, and David Weiss, national AZO
president. Fraternity 's Meritorious Award was pre-
sented to Co(eman Levin, a Philadelphia pharmacist
and APhA member.
Safety Commission has issued guidance to
public for filing petitions under Consumer
Product Safety Act. Under Section 10 of the
Act, any interested party may petition Com-
mission to issue, amend or revoke a con-
sumer product safety rule. The policy was
published in Sept. 29 issue of Federal Reg-
ister with comments being received until
Dec. 28 at which time Commission will
consider comments and decide upon final
rules for Section 10 petitions. Comments
and/or details on filing petitions are available
from U.S. Consumer Product Safety Com-
mission, Washington , DC 20207. CPSC
Chairman S. John Byington, in recent address
in which he reviewed his first 100 days as
chairman, stated reorganization of CPSC has
improved its management structure and fo-
cused its energies on people. ''The fact that
consumer precedes product in our title is not
accidental. We will be helping to protect and
inform people rather than continually looking
for engineering 'fixes'." Byington also said
the agency has devised a new tool, called a
product profile, to help CPSC "identify and
sort out the products which represent prob-
lems the Commission should address. ''
Product profiles will be prepared for about
100 products and will provide Commission
with coordinated body of information that
allows Commission to efficiently focus its
energies and resources.
Implementation and Administration, The
Hospitalized Patient, The Ambulatory Patient,
Therapeutic Considerations, Biopharma- .
ceutics and Pharmacokinetics, and Evalua-
tion.
Unfortunately, documentation of the orig-
inal source is not included. Of special note is
the first chapter entitled "Clinical Pharmacy: .
The Past, Present and Future" which provides
an historical perspective of clinical pharmacy
against the background of current trends. A
unique feature is the computer-generated
index which provides a "mini-abstract" for
each entry.
Journal of the American Pharmaceutical Association