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The practice and science of natural medicine
Intolerance, MTHFR
and methylation:
dealing with
histamine
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Integrative Healthcare and Applied Nutrition Integrative Healthcare and Applied Nutrition Integrative Healthcare and Applied Nutrition Integrative Healthcare and Applied Nutrition Integrative Healthcare and Applied Nutrition
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Articles may not be scanned for use on personal or
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7NT www.magprint.co.uk. ©2017 Target Publishing for their impact Stunning admission on how medical research is routinely skewed, from the intriguing paper “Close
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our environment papers used in this publication are
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this publication. IHCAN’s contributors Our thanks this month to:
• Emily Blake, BA (Hons), MA, DipCNM, mBANT CNHC reg, Clinical Sophia Health Institute, developer of Autonomic Response
Nutrition Advisor at BioCare: www.biocare.co.uk. Testing, and an expert on Lyme disease and chronic illness:
• Contributing editor, naturopath Ben Brown, ND, author The www.klinghardtacademy.com.
Digestive Health Solution: www.timeforwellness.com. • Naturopathic physician Dr Ben Lynch, ND, our go-to authority on
• In Practice featured practitioner Rebecca Cotterall, DipCNM (Nutr MTHFR and methylation defects. President and CEO of Seeking
Ther): www.hellohealing.co.uk. Health Educational Institute (www.seekinghealth.org), www.mthfr.
• BANT’s supervision manager, Helen Monk, DipION, BSc (Hons): net and Strategene.
https://fullylivingme.com. • In Practice section editor Rebecca Smith, ASK, CMH, CHyp, PNLP,
• Dr Dietrich Klinghardt, MD, PhD, lead clinician at the SQHP: www.newportcomplementaryhealthclinic.co.uk.
in this issue
APRIL 2017
Features
44 “You’ll never recover…”
Lyme disease and chronic fatigue for
13 years put REBECCA COTTERALL
in a wheelchair, but now she IS
recovered and helping others to
do the same, as a CNM-trained NT.
24
Read her inspiring In Practice story
Intolerance, MTHFR
and methylation: Regulars
dealing with histamine
Conference favourite, naturopathic physician
5 News
•B vitamin supplements reduce
Dr BEN LYNCH, ND, intolerant to histamine epigenetic effects of air pollution
himself, explains the genetic links to a common • Naturopaths push Integrative
problem – and what to do about it Oncology
• Scottish hospitals spending just
94p per patient meal
8 Need support?
Join a supervision scheme
10
14
New releases
Psoriasis: cracking •S wiss phytotherapy brand
Dr.Dünner launching in UK
autoinflammation
• Prebiotic properties of
and autoimmunity mushroom nutrition
Drawing on the most up to date published • NattoPharma chief launches
research, naturopath BEN BROWN, an IHCAN new K2
contributing editor, explains the auto-immune and
autoinflammatory components of psoriasis, its links
with insulin resistance, metabolic syndrome, heart
12 Your CPD dates
30
antioxidant and vitamin C authority
Dr Thomas Levy, MD, JD
Chronic illness:
a structured
approach 36 Listings
“Integrative Oncology…is
not alternative medicine”
The Seattle unit makes that clear in a headline following goals: aid in delivery and efficacy of conventional
on its website, and explains: • Improve general health and optimize treatments, including radiation and
“Rather, integrative oncology combines wellness. chemotherapy.
both time-tested and scientifically based • Strengthen and support the various organ “Although many oncologists may not
complementary medicine therapies with systems, including the immune system, during discuss integrative care with their patients,
conventional, or standard cancer treatment and after conventional oncology treatment. the majority of Americans with cancer are
methods, including surgery, radiation, • Prevent and manage adverse effects or using some form or another of what might be
chemotherapy, hormonal and biological symptoms experienced during treatment. considered ‘complementary and alternative
therapies. At Seattle Integrative Oncology, • Incorporate a targeted nutritional and medicine’. There are thousands of ‘natural’
we not only bring you expert naturopathic supplement plan based on demonstrated products recommended as ‘good for cancer’,
cancer care, but we also strive to provide a anticancer effects. however they are of varying degrees of purity
comprehensive and holistic approach that is • Address those factors that may contribute to and potency. It is therefore critical that you use
seamlessly integrated with every aspect of your tumor cell development and activity; such as the guidance of a well-trained and experienced
health care. inflammation, oxidative stress, poor glucose/ natural medicine expert to ensure your safety
“Depending on each patient’s individual insulin control and immune dysfunction. and maximize the efficacy of your treatment.”
needs and desires, our approach combines the • When possible, provide strategies that may • http://seattlend.com.
W
hile UK practitioners who annual conference of OncANP. The roughly
are not medically-qualified $45,000 (35,000 GBP) costs of a resident for
have to tread carefully the year fall into five buckets: salary and taxes
around anything to do with ($41,047), administrative costs ($1,482),
cancer, naturopaths in the malpractice insurance ($682), continuing
US seem to be winning the battle to be formally education for the resident ($1478), and
recognised for their potential contribution to professional memberships (included in the
cancer treatment. $310). The average salary for an MD resident
At stake is not only freedom to practise for in Seattle in $61,000 (around 49,000 GBP).
the naturopathic physician profession, but also The Aschtgen-Joseph team noted that
access to government funding for residency Chad Aschtgen Erica Joseph the salary of a Medical Assistant is $38,539
positions in conventional hospitals. JOHN (around 31,000 GBP). The suggestion was
WEEKS, of The Integrator Blog News and 2006, the American Board of Naturopathic that it might be better to spend a few more
Reports explains (http://theintegratorblog. Oncology was created as the standards and thousand to fund a naturopathic resident.
com). credentialling programme through which The more intriguing data are in the
Most people are not aware of how a licensed naturopathic physician (ND) can breakdown of how many additional patient
significantly Medicare subsidises residencies become a Fellow (FABNO). Chad Aschtgen, ND, visits per week, via the resident, are needed
for medical doctors. An estimate in 2013 FABNO, SIO’s founder (pictured), is among the to make the programme cost out, and SIO’s
put the total at $10.1 billion annually. This roughly 100 naturopathic physicians who have actual experience. SIO’s average revenue per
is an average of $112,642 per resident. achieved Fellow status. visit is $156.26 (125 GBP). Notably, this does
Naturopathic physicians are among those who Meanwhile, on the educational side, the not include natural pharmacy. Product sales
would like to see this federal pie expanded or Council on Naturopathic Medical Education, are not part of the SIO business model. If the
shared with other professions. a federally-recognised accrediting body used resident works 46 weeks of the year, to return
The naturopathic profession hasn’t been by the eight North American colleges, created the $45,000, the team estimates that break-
sitting on their hands. It has slowly built a programme for accrediting residencies as
a network of 56 residencies, through the well as a Universal Naturopathic Residency
colleges, and from the ground up through application. The leaders of the Association
multiple strategies. The anatomy of one of Accredited Naturopathic Medical Colleges
successful bootstrapped residency programme (AANMC) established a process through
at Seattle Integrative Oncology (SIO) was which residency applicants apply via the
recently unveiled at the annual meeting of the “Naturopathic Postgraduate Association
American College of Naturopathic Oncology. Matching Program”. The SIO programme is
The Seattle Integrative Oncology accredited through an affiliation with Bastyr
programme rests on an evolving infrastructure University.
inside the naturopathic profession and In February 2017, Aschtgen and former
naturopathic medical education. The first step SIO resident Erica Joseph, ND, LAc, (pictured)
was the formation of the Oncology Association presented a poster of remarkable financial
of Naturopathic Physicians (OncANP). In transparency on the SIO residency at the 6th
{
This enabled BANT to design a supervision
scheme for members that met best practice “I just wanted to say thank you
across the health and caring professions, while for another great year of BANT
tailoring it to meet BANT’s members’ specific
supervision. I’m really grateful for
requirements. For example, as BANT members
the kind and caring support you give.
tend to be self-employed, supervision provides
the opportunity to review and learn from other
Starting out as an NT has huge
practitioner cases; this is something which challenges, and it has helped me
many employees in an NHS clinical setting have enormously to develop my business
integrated into their work structure. Supervision and know that I am doing it right.
also provides peer support, which helps reduce I would feel very isolated without
potential isolation, in absence of workplace it. Both the commercial and the
teams. technical help has been invaluable.”
– Sally W, Registered Nutritional Therapist.
Benefits of supervision
Membership of the supervision groups has
been stable, demonstrating that members find Secondly, BANT will be rolling out online
these groups useful and enjoyable. As well as supervision groups to more members, following
contributing to BANT’s aim to raise standards the popular pilot which started in November
in nutritional therapy, supervision has many 2016. These enable members, who are not
benefits for the practitioner. It helps with: able to travel to an in-person group, to access
• Resolving dilemmas that arise in day to day supervision and still benefit from the group
work. experience.
• Optimising skills for running a profitable and Thirdly, new modes of supervision will be
efficient practice. piloted, to give members the flexibility to
• Maintaining high standards, in line with choose supervision that works best for them.
policies such as the BANT Professional Practice Approaches that are being considered for future
handbook. development include one-to-one supervision,
• Facilitating successful relationships with clients among other formats.
and others in the wider professional community. This is an exciting time for BANT and the
• Growing relationships with peers. many projects and activities that are in progress
• Fully realising the individual’s potential. to support members and promote nutritional
• Setting career goals. therapy, including supervision.
• If you are a nutritional therapist and interested in
Exciting future finding out more about opportunities to join BANT
supervision, email Helen Monk, BANT Supervision
2017 sees the start of BANT’s next strategic Manager at supervision@bant.org.uk.
five-year plan. Front and centre of the plan
is helping members increase the number of
consultations they deliver and improving the BANT’s supervision manager,
professional standing and standards of BANT Helen Monk, Dip ION, BSc
(Hons) Complementary Therapies
Members. Supervision is at the heart of these two – Nutritional Health (University
ambitions. of Greenwich), is a registered
BANT plans to create opportunities for many nutritional therapist who runs
Fully Living Me, a Hertfordshire-
more members to engage with supervision. based nutrition and lifestyle
Firstly, we’re extending the new student consultancy. She focuses on child
workshop programme. This programme has health, including concerns such
as eczema, ADHD and food intolerances, fussy eating and
been successfully piloting supervision taster issues with weaning; supporting women who want to get
workshops to final-year nutritional therapy pregnant; and support for men and women dealing with
students, and allows them to experience the health issues such as migraine, PMS, IBS, psoriasis and
fatigue. She holds clinics in Hitchin, Watford and London’s
support that supervision will give them when Victoria Dock.
setting up their new businesses upon graduation. • https://fullylivingme.com.
Visit www.kinesiology.co.uk OR
call 020 8391 5988 for more info.
Nutri stage new IFM event Grifola frondosa, Hericium erinaceus, Pleurotus eryngii,
Pleurotus ostreatus and Myrciaria dubia) to evaluate
Nutri Advanced are presenting a day the possible improvement in the quality of life of 169
of case-based training and patient- patients with aggressive metastasising colorectal cancer.
centred functional medicine as The company is also in the process of starting two
presented by the UK IFM Certified other clinical trials, which are EC-funded.
Practitioners Group.
This exclusive group of 13 UK-
based practitioners spans different Can vitamin D supplements
disciplines, meaning that they
are viewing functional medicine Presenting case histories: Pete Williams, in pregnancy prevent autism?
from many different angles giving M.Med.Sci, CSCS, IFMCP. Giving vitamin D supplements to mice during pregnancy
attendees different experiences and understanding of the foundational prevents autism traits in their offspring, University of
understanding of how the functional tools and resources used by seasoned Queensland researchers have discovered.
medicine model fits into clinical IFM Certified Practitioners (IFMCP). “Our study used the most widely accepted developmental
practice. This clinical and teaching team model of autism in which affected mice behave abnormally
and show deficits in social interaction, basic learning and
The event is the first independent comprises of Pete Williams, Jo
stereotyped behaviours”, said lead researcher Prof Darryl Eyles,
training day in the UK to be Gamble, and Robyn Puglia, who will
from UQ‘s Queensland Brain Institute.
recognised as an Institute for share their decades of knowledge and “We found that pregnant females treated with active
Functional Medicine educational experience as they model strategies vitamin D in the equivalent of the first trimester of pregnancy
event, say Nutri. of clinical implementation using the produced offspring that did not develop these deficits”.
“Through the process of case- Functional Medicine approach.” In human studies, QBI researchers recently found a link
based learning, those attending this • May 13, London. £149: www.nutriadvanced. between pregnant women with low vitamin D levels and the
day-long event will advance their co.uk/events. increased likelihood of having a child with autistic traits.
P
soriasis, a chronic inflammatory (innate auto-inflammatory response) that to the management of psoriasis could include
multi-organ disorder with clinical initiates a Th17/Th22-dominated early T-cell individualised, patient-centred care (9), in
manifestation in the skin and infiltrate, to a Th1-dominated psoriasis plaque addition to addressing modifiable environmental
often the joints, is very common, (adaptive autoimmune response).(4) and nutritional factors, as these play an
with an estimated prevalence Comorbid illnesses are an important important role in the both the development and
of approximately 2%–5% of the consideration in psoriasis; it is associated perpetuation of the disease.(10)
population.(1) It is typically characterised by with several systemic disorders, including
raised, well-demarcated, erythematous oval Crohn’s disease, type-2 diabetes mellitus, Dysbiosis
plaques with adherent silvery scales, and is cardiovascular disease, metabolic syndrome, Research suggests that dysbiosis of gut bacteria
associated with significant comorbidity – depression and cancers, particularly lymphoma plays a primary role in the development and
including depressive illness, cardiovascular and skin cancer.(5) Notably, 6-42% of patients perpetuation of autoimmune diseases, and it
disease, psoriatic arthritis, and decreased with psoriasis have psoriatic arthritis.(6) is well established that the gut microbiota can
quality of life.(2) These associations suggest that psoriasis may influence the expression of specific lymphocyte
In contrast to autoimmunity, be the cutaneous manifestation of a systemic subsets involved in autoimmunity. See the
autoinflammation is characterised by systemic inflammatory state.(7) Imperial College paper from 2015 for more on
inflammation in the absence of high-titer Standard drug, topical and phototherapy this.(11) Psoriasis shares genetic and clinical
autoantibodies or autoreactive T lymphocytes treatments for psoriasis frequently have relationships with Cohn’s disease, which is
(3). This spectrum may help explain the adverse side-effects and are often ineffective; linked to gastrointestinal dysbiosis and loss
progression of psoriasis from an IL-1–TNF- safer and more effective management options of tolerance to intestinal microbes, and it
mediated, neutrophil-dominated inflammation are needed.(8) An improved clinical approach has been proposed that psoriasis is linked to
include significantly higher reactivity to acute Weight-loss diet Overweight and obesity can Dietary and lifestyle-based weight loss
stress (50), low cortisol (51), and evening contribute to disease severity regimes, including low-energy diets, can be
elevations in cortisol (52). Cortisol expression though increased low-grade considered as a component of nutritional
and HPA axis dysfunction have been shown inflammation and diet-induced management.
weight loss results in clinical
to correlate with psoriasis severity.(53, 54)
improvement.
There is some evidence that mind-body
interventions, especially cognitive behavioral Gluten-free diet There is a higher frequency of Confirmed coeliac disease must be
therapy, can improve quality of life and reduce coeliac disease and gluten sensitivity managed with a strict gluten-free diet,
in psoriasis, and gluten-free diets are however a gluten-free diet should be
feelings of stress as well as disease severity in
effective. considered even in the absence of
people with psoriasis.(55) histologically confirmed coeliac disease or
positive antibodies.
The power of a health-promoting
diet within six months.(59) The “before” and people with psoriasis have an approximately
Several factors associated with unhealthy “after” pictures tell the story (see page 16). three-fold increased risk of coeliac disease.
diets have been found to be common in people (66) Although most investigations have
suffering from psoriasis, including a higher Weight loss diet implemented gluten-free diets in antibody-
consumption of simple carbohydrates and fat, Overweight and obesity, especially central positive psoriasis patients, antibodies to
and lower intake of complex carbohydrates, obesity, may contribute to the development gliadin may be elevated in the absence of
omega-3 PUFAs and fibre, some of which and exacerbation of psoriasis.(60) Several biopsy-confirmed coeliac disease (67), and
have been correlated with disease severity. clinical studies have found that dietary and improvements in skin manifestations similar
(56) In an observational study of 62 patients lifestyle weight loss interventions reduce the to psoriasis have been observed in people
with mild-severe psoriasis, researchers at the severity of psoriasis in overweight or obese with NCGS after a gluten-free diet.(68) These
University Medical School of Naples found people.(61) observations suggest that the possibility of
that those who most consistently stuck to a A low-energy diet providing 800-1000 kcal gluten sensitivity should be considered even
traditional Mediterranean-style diet reported per for eight weeks to induce weight loss, in the absence of histologically confirmed
less severe symptoms – and less inflammation, followed by eight weeks of reintroduction coeliac disease or positive antibodies.
as assessed by CRP levels.(57 – 2015 Journal of normal food intake – reaching 1200 kcal Clinical studies and case reports have
of Translational Medicine paper free online.) per day – resulted in clinically important demonstrated important benefits of gluten-
In an intervention study from Brazil – “Pilot improvements in symptom and quality of free diets in psoriasis patients with gluten
study on which foods should be avoided by life in overweight patients with psoriasis, sensitivity.(69-71) In one such study, coeliac
patients with psoriasis”, most patients with according to a study published in JAMA screening in people with psoriasis revealed a
psoriasis (88.37%) reported reduced scaling Dermatology.(62) Another investigation found high prevalence (4.1%) compared to controls,
and erythema, milder outbreaks during the that a low-energy diet, providing 855 kcal per as assessed with anti-tissue transglutaminase
year, and improved quality of life when they day and mostly comprised of fresh and cooked antibodies and subsequently confirmed
cut down on foods such as black coffee, black vegetables, resulted in a significant reduction histologically. After a six-month gluten-free
tea, chocolate, pepper, smoked foods, beef, in serum lipids and clinical symptoms of diet there was a marked improvement of
monosodium glutamate, and alcoholic drinks, psoriasis after four weeks (63). In another skin lesions in seven out of eight people.(72)
and increased consumption of beta-carotene study, published in Clinical Nutrition, a Another report comparing the effects of a
containing foods, fruit, white meat and whole low-energy diet that was also designed to gluten-free diet in psoriasis patients with and
grains.(58) increase omega-3 (average 2.6 grams per day) without positive antibodies found that there
Well-known physician researcher Dr and reduce omega-6 fatty acids improved was a highly significant decrease in psoriasis
Matthias Rath and colleagues (www4.dr- metabolic profiles in 44 obese patients, symptoms scores, but only in those with
rath-foundation.org) have published a 2015 improved responses to immuno-modulating positive antibodies.(73) ihcan
nutritional therapy case report (free online) in therapy, and resulted in a significant clinical
Experimental and Therapeutic Medicine. Here, improvement over six months.(64) About the author
a woman with severe, treatment-resistant Ben Brown, ND, is a
psoriasis encouraged to increase vegetable Gluten-free diet naturopath, nutritionist,
intake, lower consumption of meat, avoid junk Both coeliac disease and non-coeliac gluten speaker, and science writer.
He is a contributing editor of
food and sugar, and was put on a personalised sensitivity (NCGS) have been associated with Integrative Healthcare and Applied Nutrition,
nutritional supplement regime, particularly psoriasis, and a gluten-free diet has been board member and lecturer at BCNH College
of Nutrition and Health, Technical Director
high in various forms of vitamin C. She shown to reduce symptom severity in some at Viridian Nutrition and author of The
experienced complete resolution of symptoms cases.(65) Some researchers estimate that Digestive Health Solution. Visit www.timeforwellness.org.
IT K
ED N
SP OW
AC
ES
“Living legend” confirmed
for April conference
We are delighted to announce that Professor Emeritus Stig Bengmark,
MD, PhD, FRACS (hon), FRCPS (hon), will be joining us at the “Inflammation
and Antioxidants” IHCAN Conference in collaboration with BANT on Saturday April 22.
T
ravelling from human health – the role of pre-, step outside his usual round of academic
Sweden, Prof pro- and synbiotics” (Clinical medical conferences and agree to appear
Bengmark will join and Translational Medicine, with us and BANT.
us at the Cavendish December 2012). Dr Thomas Levy is a board certified
Conference Centre Stig is one of medicine’s cardiologist who became a campaigner for
in London to present a two- best-kept secrets. The paper that vitamin C after working with pioneering
parter: “Choosing Health brought him to our attention dentist Dr Hal Huggins and seeing incredible
– Honour your intestinal is an inspirational must-read, clinical results.
microflora, so that you may whether you can get one of the Vitamin C is an “old fashioned” nutrient
live long”. few remaining tickets to see that is making
Addressing the antioxidant him present in person or not. a comeback,
theme of the conference, we Free to access online, and an helped by new,
welcome one of the world’s easy read, the paper is “Obesity, highly absorbable
leading experts on vitamin C, Professor Emeritus Stig Bengmark the deadly quartet and the liposomal
Dr Thomas Levy, MD, JD. contribution of the neglected daily organ supplement
After a long successful career as a surgeon, rest – a new dimension of un-health and its forms and surge
professor and clinic director, Prof Bengmark prevention” (online at https://www.ncbi. in research. (See
has become an acknowledged world authority nlm.nih.gov/pmc/articles/PMC4526765). the latest study
on chronic inflammation and chronic diseases, In it he deals with food habits – including validating the
which he says the facts show are a result of insufficient “organ rest” between meals – as use of vitamin C
dysbiosis. the real threat to the health of the Western Dr Thomas Levy against cancer on
Stig received his MD and PhD in medicine world. He also warns that the early-warning Research update, page 40.)
from Lund University in Sweden and has held signs of impeding disease are often ignored in “A question that has been presented to
the position of Honorary Visiting Professor at orthodox treatment circles. me numerous times since the publication of
University College London since 1999. He is “The dysbiosis-induced low-grade my book, Curing the Incurable: Vitamin C,
a founding member of the editorial board of inflammation and malfunctioning immune Infectious Diseases, and Toxins, is ‘What kind
HepatoBiliary Surgery and Nutrition (HBSN), system induces early a series of various, of vitamin C should I take, and why?’” says Dr
who describe him as “a living legend” and say seemingly benign, manifestations in the body, Levy. “It is a very good question indeed,
he was “one of the three greatest European for which the sufferers often seek medical as the variable effects on both short-term
surgeons in recent history”. advice at their local general practitioner (GP, and long-term clinical outcomes can be
HBSN editor Prof Yilei Mao adds, “Stig family doctor), and often receive symptomatic dramatic” ihcan
has always had unlimited, unexpected, treatment. However, these minor, but
broad-spectrum, bright new ideas based irritating, symptoms should be taken
on his unique observations that ordinary seriously, as they are all signs of ongoing low
researchers would have ignored.” grade inflammation, which with time might
Prof Bengmark’s list of academic bring serious consequences – severe diseases
publications is almost 1,000-strong. His
long career at the top of the field of liver
and with time death.”
He also points up the huge differences Book now...
There is now limited availability
and gall bladder specialism has given him between modern Western-style eating
for this conference, so we
unique insights into chronic disease and and a more Paleo regime, and breaks this
recommend you secure your
inflammation. His investigations have led him down in terms of the liver and bile:
place as soon as possible.
to original publications on, for example, the long-chain fatty acids, significantly higher in
Standard tickets are priced at £95,
effect of Lactobacillus pre-treatment on the a Western diet, enter the body through the with significant discounts available for
function of macrophages in acute liver injury, thoracic duct – one of two “back door short- members of BANT, students and members
and to a review article on the antioxidant and cuts” into the body and remain in circulation of other associations. Book now at
anti-inflammatory properties of turmeric. for hours before finally being metabolised by www.ihcanconferences.co.uk or
He has addressed the inflammatory effect of the liver. telephone the team on 01279 810080.
endotoxins with “Integrative medicine and We’re privileged to have Prof Bengmark
IHCAN
in collaboration with
2017
conferences
Booking closed
Generous discounts available for for BANT members, students and members of other
associations, as well as a multiple booking discount for those booking more
than one conference at a time.
H
istamine intolerance is becoming intolerance. You have a bucket of histamine antihistamines (long-term))
more and more prevalent. and your body requires histamine in order to • Nutrient demands (stress, anxiety, lack of
I have it. function. sleep)
I also have MTHFR and am • Hormonal insufficiency (adrenal fatigue)
susceptible to methylation You need it • Hormonal excess (oestrogen)
deficiency. Given the prevalence of the MTHFR You need histamine to do a variety of things – • Lifestyle (excessive exercise, alcohol)
polymorphism, it only makes sense that the such as: • Diet (fermented foods, high protein intake,
general population is also very susceptible to • get blood, ie nutrients and oxygen, delivered aged foods, leftovers, citrus, fish)
histamine intolerance. to various areas • Environment (high pollen counts, dust
I wish I’d known I had histamine • pay attention mites)
intolerance 30 years ago. Now that I’ve • digest your food • Associated conditions (leaky gut, IBD, IBS)
addressed it, so many of my symptoms are • move your bowels There are four main genes which are central
gone – or are manageable. • enhance exercise to processing histamine:
The issue is that histamine intolerance can The ideal amount of histamine allows these • HNMT – which requires SAMe as a cofactor
rear its ugly head anytime, anywhere. You things to occur – and occur perfectly. (and this requires an effective MTHFR
have to be ready for it and know how to deal As histamine levels increase, your tolerance enzyme to help produce SAMe)
with it. for it goes down. You start to get too much • DAO – which requires vitamin B6 and copper
Identifying whether you have histamine blood flow, have too much attention, move • MAO – which requires vitamin B2 and iron
intolerance is not easy – and it is COMMONLY your bowels too often and your exercise is • NAT2 – which requires CoA (which stems
missed. now affected negatively. from vitamin B5)
The only true way to know if you have This translates into histamine INtolerance. If any one of these genes are slowed or
histamine intolerance or not is to go on a Your histamine bucket is overflowing. burdened, then the removal of histamine
low histamine diet for a period of time. Feel You need to get rid of some of it. Not easy, is slowed – and symptoms of histamine
better? You are then histamine intolerant. as there are many factors which increase intolerance occur.
Congratulations! You’ve joined the elite club histamine – and they should all be addressed. How can you see if these histamine-related
of folks who actually understand what is ailing The causative factors for histamine genes are slowed down due to genetic
them. intolerance are many: polymorphisms?
Now – my job is to help you beat it. • Genetic susceptibility (MTHFR, DAO, MAO, Order a 23andMe genetic test and then run
Before we do that, let’s get into what HNMT, PEMT…) your raw data through StrateGene (https://
histamine intolerance actually is. Imagine a • Pathogens (a number of which produce seekinghealth.org/product/strategene).
five- gallon bucket. You have a lot of things histamine or block methylation) I developed StrateGene with a team of
to put in there: soap, toys, screwdriver, • Nutrient deficiencies (B12, folate, B6, B2, B1, researchers. We have one section of the
watermelon, your favorite cat who doesn’t sit Zn, Cu, C, methionine) report specifically dedicated to histamine
still, a pound of sand and two gallons of water. • Nutrient excesses (histidine, protein excess metabolism. Here we show the genes
Obviously, you’re going to have issues. You in general) associated with histamine breakdown along
need to make some decisions. What stays? • Medications (antibiotics, antacids and even with the epigenetic controls and cofactors.
What goes? The cat must stay. You’d Very cool seeing it graphically.
love the water to stay, but your
favorite cat told you otherwise. Sand What are symptoms of
is chosen, as is the soap, because you histamine intolerance?
know your favorite cat is going to do I want to share with you one of
something to the sand. my favorite research papers of
The rest stays behind and off you all time – as it is so beautifully
go with your cat, sand and soap. done: “Histamine and histamine
This is the same thing as histamine http://seekinghealth.org/product/methylation-and-clinical-nutrigenomics-part-i-video-course. intolerance”, by Laura Maintz and
IHCAN
book by Dr Marilyn Glenville PhD.
Delivering the latest research
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n Oxygenation: Work, be outside and sleep adaptogens. If tired upon waking and hard
with your window open at least a crack. to get out of bed in the morning – and a
Get rid of the stale air and bring in fresh night owl – then you may need something
Chronic illness: a
structured approach
A tide of chronic illness is not being stemmed by orthodox medicine, and patients are
increasingly turning to integrative practitioners as a last resort. Dr DIETRICH KLINGHARDT,
MD, PhD, has developed an insightful approach to the challenge of unravelling complex
ill-health conditions over the course of his 42 years in medical practice.
I
n acute illness, patients come to the results hint at a success rate of 33% and a burden is ever-increasing. Current estimates
clinic because they have one significant failure rate of 66%. Meanwhile the numbers suggest that every one of us has upwards of
symptom. In chronic illness, patients of those suffering from severe neurological 20,000 different toxic chemicals in our body,
present with a long list of symptoms: some illnesses are increasing by the day. Over the mostly stored in the matrix of the connective
of them may be life-threatening, some last 20 years the number of women dying tissue, where our intelligent system carefully
appear insignificant (but to the client they from neurological illness in the US (80% from attempts to separate these molecules so that
are not). Most medical diagnoses are based Alzheimer’s disease) has increased by 663%. they cannot synergistically interact with each
on using Latin words to describe the outward Most other neurological illnesses are also other. The tests available to practitioners to
appearance of a symptom (ie arthritis = increasing dramatically – autism, Parkinson’s, identify these pollutants in our organisms are
inflammation of the joint), but fail to address MS, ALS and others. Among serious scientists woefully inadequate. It is a losing battle. What
the underlying cause. Conventional medicine there is a consensus that most illnesses of do we do? If (mostly) undetectable chemicals
has largely avoided dealing with the growing the brain and nervous system are caused by are closely interlinked with chronic illness, as is
evidence that chronic illness is affecting ever inflammation either due to toxicity (including so clear from the current literature, what chance
larger subsections of our population. Doctors fine particle pollution) or secondary to do we have of making a causal diagnosis?
learn little in medical school to prepare them bacterial infections/viruses. Many practical solutions have appeared in
for this unfolding worldwide crisis. Every therapeutic approach should be the pre-CAM environment in the 1950s,
Since the mid-‘90s, awareness has preceded by a clear diagnostic workup and a ‘60s and ‘70s: EAV (Electroacupuncture
increasingly grown of the presence of treatment plan based on the diagnostic results. according to Voll), Applied Kinesiology, VAS
Lyme spirochetes underlying many chronic But there is a major problem: every week an (vascular autonomic reflex), the Bi-digital
conditions. Treatment options with long- estimated 15,000 new chemicals are released O-Ring Test, and Autonomic Response Testing
term antibiotics emerged. The published into the environment worldwide. Our body (ART).
The exciting news from the Testing with ultrasonographic techniques invented of the human body.
Klinghardt Academy last and developed by Dr Ruggiero, validated by DNA The goal of the RK Protocol is to identify and
month was the publication of testing. “This represents a paradigm change with fight hidden pathogens, toxins and aberrant cells;
a groundbreaking new paper profound implications for diagnosis and treatment it aims at achieving accurate and early diagnosis,
by Dr Klinghardt and Dr Marco of chronic conditions ranging from silent infections at indicating the most appropriate therapeutic
Ruggiero, MD, PhD, in the peer- to neurodegenerative diseases, autism and intervention and at maximizing the efficacy of
reviewed American Journal of cancer”, says the Academy. specific therapeutic interventions.
Immunology. The RK Protocol is based on two phenomena The paper describing in full detail the RK
In it they describe an original procedure of resonance: the resonance between identical Protocol is an open-access publication, available
known as the “Ruggiero-Klinghardt Protocol” substances, and the resonance between free online at http://thescipub.com/PDF/
(RK Protocol) that merges Autonomic Response ultrasounds and cellular and molecular structures ofsp.11074.pdf.
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get 72% of their energy daytime being inactive. They live a subsistence
lifestyle that involves hunting, gathering,
from carbohydrates. fishing and farming, where men spend an
The fact that they have average of 6-7 hours of their day being
physically active and women spend
the best indicators of 4-6 hours.
University of Essex growing season.” weight, age, heart rate, blood pressure,
Their diet is largely carbohydrate- cholesterol, blood glucose and inflammation.
a significantly increased risk of developing diabetes, bacteria deal with dysbiotic bacteria can cause disease.
However, these studies generally follow
according to a University of Queensland study
published in Drugs and Ageing.
sugars a similar protocol that may impact on
Scientists have found that single the outcome: they transfer dysbiotic
UQ’s Dr Mark Jones said women over 75 faced a
microorganisms in the human gut have bacteria to axenic mice that do not have
33% higher chance of developing diabetes if they were
the ability to disassemble the most any microbiota. For example, axenic mice
taking statins; this increased to more than 50% for
women taking higher doses of statins.
complex of carbohydrates in our diet. that receive microbiota from the gut of
“We found that almost 50% of women in their late It is the first time such a discovery has obese mice would increase their total
70s and 80s in the study took statins, and 5% were been made and it is hoped that this may body fat, indicating that microbiota play
diagnosed with new-onset diabetes”, Dr Jones said. be used to one day identify new pre- and a causative role in the development of
“Statins are highly prescribed in this age group but pro-biotic products to help digestion. obesity.
there are very few clinical trials looking at their effects Led by Prof Harry Gilbert, from Serino and his colleagues reasoned
on older women. The vast majority of research is on the Institute for Cell and Molecular that axenic mice are ill-equipped to
40- to 70-year-old men”. Biosciences at Newcastle University, the deal with dysbiotic microbiota. Their
study is published in Nature. gut barrier is impaired, favoring
Bacteria in the large bowel have a an uncontrolled spread of bacteria
major impact on health and physiology throughout the body. In addition, their
as they help to disintegrate substances immune system is not well developed.
in food that we cannot digest, such as So instead of using axenic mice, the team
starches and fibre. The main source of used normal, healthy mice, which have
nutrients available to the gut bacteria not been treated with antibiotics before.
are carbohydrates from the human diet,
which the body is unable to metabolise. Protection against metabolic
The most complex of these disease
carbohydrates is the plant A high-fat diet increases the production
polysaccharide, rhamnogalacturonan of glucose by the liver and can eventually
STEM CELLS II (RG-II), which can also be found at lead to metabolic disease. However, when
Electroacupuncture elevated levels in red wine. Serino and his colleagues transplanted
n Is dysbiosis
the effects of electroacupuncture from the stimulus fat diet. Normally, a high-fat diet would
of the needle all the way to the brain. Depending lead to weight gain. However, the body
on the species, electroacupuncture led to activation healthy? Yes – mass of mice that had received dysbiotic
of the hypothalamus within nine to 22 minutes. if you’re on a microbiota did not change, and their
adipose tissue showed smaller fat cells,
Reparative mesenchymal stem cells (MSCs) were
released into the bloodstream within two hours. high-fat diet consistent with increased plasma free-
Electroacupuncture treatments resulted in An unhealthy diet changes the fatty acids.
higher thresholds for injury-induced pain, as well composition of the gut flora and In conclusion, dysbiosis after high-fat
as considerable increases in the presence of a type it is generally assumed that this diet may not all be detrimental. As long as
of collagen that promotes tendon repair, and anti- maladaptation called “dysbiosis” triggers the gut barrier is intact and the immune
inflammatory cells known to be predictors of faster disease. A study published in Molecular system is functional, dysbiosis may even
healing. Systems Biology by Matteo Serino and protect the body from metabolic effects
The horses used in the study had been injured his colleagues at the Université Paul of unhealthy diets. “Our observation may
during training for international dressage Sabatier in Toulouse now challenges this encourage a new debate on the role of
competitions, and the six people who took part were view. Using mice as a model organism, gut microbiota dysbiosis in the induction
healthy volunteers, who still showed activation of the researchers show that dysbiosis of metabolic diseases”, said Serino.
their hypothalamus through brain imaging.
The IHCAN Awards are hugely successful, but we’re aware they only reward and recognise a handful of practitioners and clinics each year. Meanwhile, we know
that CAM practitioners are quietly getting on with changing people’s lives, every day – and we want to celebrate and share the inspiration. So we’ve re-vamped our
popular In Practice series. It is coordinated by regular contributor Rebecca Smith, who runs a successful practice of her own, established 20 years ago. Contact her
direct to be part of the feature: rebecca@newportcomplementaryhealthclinic.co.uk, and follow her on Twitter: @NCHealthClinic.