Beruflich Dokumente
Kultur Dokumente
Elizabeth A. Toledo
17 May 2016
From the increasing and excessive use of technology, to the need to work both day and
night shifts to earn enough money for the family, to the unbearable traffic that eats up a chunk of
commuters’ time, millions of people have been sleeping less and less hours every day. This lack
of sleep phenomenon has been gradually compromising the health of people worldwide.
Particularly in adolescents, research suggests that sleep deprivation has been undermining teen
health, affecting day-to-day functioning in a wide variety of ways. It is an alarming danger that
Sleep is not a luxury but a necessity; it is a basic need. Most of people will sleep for
about 175,000 hours in our lifetimes (Pinel & Barnes, 2014, p. 366). This extraordinary amount
of time we devote on sleep implies how important it is to people’s well-being, even as vital as
the air we breathe and the food and water we eat and drink. Several researches, case studies, and
news about sleep deprivation clearly show that there are serious side effects from lack of sleep.
One famous case is the world record set by Peter Tripp, a famous DJ in New York who stayed
awake for 201 hours or 8.4 days. After 72 hours or 3 days, Tripp was reportedly becoming often
paranoid and confused, laughing hysterically without no reason, and hallucinating (Ingles-Arkell,
2014). Drowsiness and fatigue brought about by lack of sleep also cause more than 100,000
traffic accidents each year, as reported by the National Highway Traffic Safety Administration
(Carpenter, 2001). In extreme cases, there have even been several documented deaths about
excessive lack of sleep due to almost continuously playing of video games, ranging from 12
hours to 22 days (Hunt & Ng, 2015; Mccrum, 2015; Twomey, 2016).
These alarming consequences of sleep deprivation suggest how important sleep is. For
this reason, it is vital to research and study about the lack of sleep and its effects, especially on
adolescents. This research paper is a review of different literature and did not undergo
its causes and its effects, especially on adolescents. The researcher chose to narrow in on
adolescents because across postnatal development of human beings, adolescence is the period
wherein changes in the neural and cognitive, social and affect, and behavioral and sexual
The focus of this research paper is on the neurobiological causes of sleep deprivation
among adolescents. Circadian timing system and homeostatic system changes, and alterations in
brain activity, structure and organization changes that result to sleep deprivation will be
explored. Psychosocial causes will be tackled but will not be thoroughly discussed. Another
focus of this report is the impact of sleep deprivation on the school performance of adolescents.
This is discussed by looking at the different affective, behavioral, and cognitive effects
associated with the neurobiological causes of sleep deprivation among adolescents. It should also
be noted that terms such as lack of sleep, insufficient sleep and sleep deprivation are used
interchangeably in this report. They are only used as generic terms and do not refer to specific
during which your eyes are close and you become unconscious.” It is a widespread myth that
sleep is just a passive, dormant process. However, it is important to note that sleep is not just a
time when physical and mental activities shut down for a while. Rather, sleep is an active and
The research on the stages of sleep started with the invention of the
electroencephalogram (EEG) by German researcher Hans Begrer in the late 1920’s. The
discovery that brain waves change - as evident in EEG activities - as wakefulness shifted into
sleep paved the way for rapid expansion of sleep study. Since 1953, several researchers have
studies about the different stages of sleep, naming Rapid Eye Movement (REM) and non-REM
stages of sleep and showing that sleep consists of several repeating sleep stages. By 1968, the
stages of sleep had become standardized (Mastin, 2013). During sleep, we usually pass through
five phases of sleep: stages 1, 2, 3, 4, which consist the non-REM sleep, and the REM s leep.
These stages progress in a cycle from stage 1 to REM sleep, then the cycle starts over again with
stage 1.
Generally, there is a gradual increase in EEG voltage or amplitude and a decrease in EEG
frequency across the progression from stage 1 through stage 4. During the preparation to sleep,
alpha waves, which are bursts of 8- to 12-Hz EEG waves, begin to punctuate the low-voltage,
high-frequency waves of wakefulness. When fallen asleep, there is a sudden transition to stage 1
of sleep. At stage 1, sleep EEG is a low-voltage, high-frequency signal that is similar to, but is
slower than, that that of wakefulness. Our eyes move very slowly and muscle activity slows. At
stage 2, eye movements begin to stop and sleep EEG has a slightly higher amplitude and a lower
frequency, punctuated by two wave forms which are the K complexes, t he large negative wave
immediately followed by a single large positive wave, and the sleep spindles, t he 1- to 2-second
waxing and waning burst of 12- to 14-Hz waves. At stage 3, the largest and slowest brain waves
with a frequency of 1 to 2 Hz called delta waves b egin to appear occasionally, interspersed with
smaller, faster waves. At stage 4, delta waves are predominant and almost exclusive. These four
stages are non-REM sleep stages, and stages 3 and 4 are often called slow-wave sleep (SWS)
When switching into REM sleep, there is a low-amplitude, high-frequency sleep EEG.
Breathing becomes more rapid, irregular, and shallow. The eyes jerk rapidly in various
directions. There is a loss in core-muscle tone and muscles become temporarily paralyzed.
Cerebral activities such as blood flow, oxygen consumption, and neural firing, increase to
wakefulness levels in several brain structures. There is also a general increase in the variability
of autonomic nervous system activities; heart rate increases and blood pressure rises (American
The several evidences of most adolescents’ chronical lack of sleep have raised questions,
one of which is about why most adolescents lack sleep. Researchers are curious about why there
For a variety of reasons, adolescents are particularly more prone to sleep deprivation.
school demands have directly or indirectly contributed to most adolescents’ lack of sleep. A
number of researches explored on how much impact school start times have on teenage students’
sleep cycle. These researches resulted in strikingly similar findings, such that students attending
school with a later or delayed start time were reported to have less daytime sleepiness, and better
attention, concentration and academic performance (Epstein et al., 1998 and Wolfson et al.,
2007). In addition, the pressure to stay awake to finish requirements for school also compel
students to drink more amounts of caffeine. Statistics show that adolescents are the fastest
growing group of caffeine users with an increase of 70% in the past 30 years (Temple, 2009).
generation of adolescents have grown up in an electronic age. It is not anymore surprising that
researches have shown that exposure to electronic devices late at night has been associated with
lack of sleep. As reported by the National Sleep Foundation’s 2006 Sleep in America Poll, most
teenagers have in their bedrooms devices such as televisions, music players, video game
consoles, computers, and phones. These teenagers were also reported to engage in an average of
four electronic activities after nine o’clock in the evening (Owens, 2014). Aside from that the use
of electronics displaces sleep, another possible mechanism how electronics lead to adolescents’
lack of sleep is that the light produced by devices is said to disrupt circadian rhythms by
suppressing melatonin, a hormone that regulates sleep-wake cycles (Cain & Gradisar, 2010).
A number of other psychosocial and external factors have been largely attributed to sleep
deprivation among adolescents. However, in recent years, researchers have discovered that
biology also plays big a role in the changing sleep patterns of adolescents. Several researchers
argue that psychosocial factors cannot completely account for the sleep deprivation among
adolescents.
social aspects. There are changes in self-identity, independence, emotional regulation, and
affiliations with parents and friends (Schulenberg et al., 2004). In addition to these, there are also
Researchers found that sleep deprivation particularly among adolescents is partly due to
pubertal alterations in the circadian timing system and the sleep-wake homeostatic system. The
changes in these two systems favor late timing of sleep among adolescents. In human beings, the
circadian timing system establishes and regulates normal sleep-wake cycles, while the
homeostatic system acts like a “sleep pressure” that increases the duration of wakefulness and
dissipates during sleep (Achermann, 2003; Hagenauer, Perryman, Lee & Carskadon, 2009;
The circadian timing system is controlled by the body’s “biological clock,” called the
suprachiasmatic nucleus (SCN), which rests in the hypothalamus. Signals from the SCN travel
to different brain structures, including the pineal gland, which responds to signals induced by
light, by switching off production of melatonin. The increase in melatonin level when darkness
falls makes people feel drowsy and sleepy (American Sleep Association, 2007). In adolescents,
however, growing evidence supports that light sensitivity of the circadian timing system is
altered during adolescence. Adolescents have a higher light sensitivity, having an advance phase
response to light exposure in the morning and an exaggerated delayed phase response to light
exposure in the evening (Crowley, 2009; Hagenauer, Perryman, Lee, & Carskadon, 2009).
The homeostatic system is said to be the sleep drive of human beings. One research on
adolescent homeostatic system showed that when compared to younger adolescents, older
adolescents are slower to fall asleep at critical times, after 14.5, 16.5, and 18.5 hours awake
(Taylor, Jenni, Acebo, & Carskadon, 2005). Another research showed that the buildup of sleep
drive is slower in older adolescents than young adolescents. This sleep drive was modeled as an
accumulation of slow wave activity (SWA), a marker of homeostatic system in response to sleep
system and homeostatic system may provide physiologically mediated “excuse” for later
Aside from the altered sleep-wake regulating systems of the body, several researchers
found that there are changes in the EEG of adolescents. Several analysis of sleep EEG have
provided a detailed description of the changes in sleep among adolescents, with emphasis on
alterations in the characteristics of delta waves or slow waves. These alterations in the
characteristics of delta waves include a dramatic decrease in SWA (Feinberg et al. 2006;
Gaudreau et al. 2001; Jenni and Carskadon 2004) among adolescents. Feinberg and his
colleagues (2006) also reported that the amplitude of slow waves increases until pre-puberty, and
then shows a marked decrease during adolescence. EEG studies also show a 50% reduction of
deep sleep, particularly stage 4 sleep, in adolescence (Dustman, Shearer, & Emmerson, 1999).
These findings suggest that because the adolescent brains have a slow wave or delta wave
activity, which is a major EEG characteristic of sleep stages 3 and 4, they physiologically have a
evidences from EEG, functional magnetic resonance imaging (fMRI), and postmortem studies
which show changes in the adolescent brain structure and organization. Adolescence is
associated with a changing balance between maturing limbic systems and later-maturing frontal
executive functions (Giedd, 2008), an ongoing myelination of neuronal axons, with an increase
in white matter (Courchesne et al. 2000; Reiss et al. 1996; Sowell et al. 2004), and a rapid
decline in the volume of cortical gray matter, which include brain regions involved in muscle
control, sensory perception, speech, memory, self-control, and decision-making (Giedd 2004;
Sowell et al. 2002; Steen et al. 1997). If this decrease gray matter volume reductions are partly
accounted for by decreases in synaptic density, it may be related to the EEG changes previously
discussed. This hypothesis was confirmed, such that curvilinear decrease in gray matter volume
of the frontal and parietal lobes were matched by similar curvilinear decrease in EEG amplitude
of the said regions, supporting the relationship between anatomical brain changes and EEG
These researches suggest that because the adolescent brains are not yet fully developed
and still undergo dramatic changes, they are more susceptible to the neurological consequences
Along with the neurobiological etiology of sleep deprivation among adolescents are its
affective, behavioral, and cognitive effects. Whitford and colleagues (2006) showed that
decrease in gray matter volume in frontal and parietal lobes were matched by a similar decrease
in EEG amplitude. Thus, it suggests that while these two brain structures are possible causes of
sleep deprivation, they are also the most affected areas when adolescents experience sleep
deprivation.
The frontal lobe is considered to be the emotional control center and the home to
personality (Kolb & Wishaw, 1990). It is also involved in problem solving, memory, language,
impulse control, decision making, social behavior, and motor function (Levin et. al., 1987). On
the other hand, the parietal lobe is involved in sensation and perception, and concerned with
integrating sensory input, primarily with the visual system (Kandel, Schwartz & Jessel, 1991).
With these functions of the two lobes, it is not surprising that several researches show that sleep
deprivation affect sleepiness and mood (Lo et al., 2016), attention, verbal learning (Drummond
et al, 2000), memory acquisition and retention (Chee & Chuah, 2007; Yoo et al., 2007), and
emotional memories and emotional processing (Sterpenich et al., 2007; Yoo et al., 2007).
Sleep restricted adolescents have been consistently found to be more sleepy and moody.
In their study, Lo and colleagues (2016) found that sleep deprived adolescents (in the
experimental group of their study) demonstrated increased sleepiness and decrease in positive
mood, and that subjective sleepiness did not return to baseline level even after two recovery
nights. Meanwhile, other adolescents (in the control group of their study) maintained baseline
levels of subjective sleepiness and mood the entire day. Other studies supported this claim and
revealed that shorter duration of sleep is associated with high levels of subjective sleepiness
(Wolfson & Carskadon, 1998) and elevated negative affect ratings (Talbot et al., 2010). Because
of sleep deprivation, students tend to sleep during class hours, thus missing class lectures.
In relation to decreased mood, the effects of sleep deprivation in the consolidation of
emotional memories and in emotional processing have been studies through fMRI, and these
studies found that sleep deprivation lead to deterioration in the recollection of neutral and
positive memories, but not of negative memories. Sterpenich and colleagues (2007) found that
recollecting of negative memories (but not positive memories) when sleep deprived lead to
eliciting of larger responses in the amygdala and occipital area. In addition, Yoo and colleagues
(2007) also demonstrated using an emotional stimulus viewing task, that there is enhanced neural
responses to negative stimuli in the amygdala. Thus, students’ negative mood and their tendency
to remember negative memories instead of positive ones, may also affect their relationship with
their classmates and teachers, and also their motivation and attitude toward school work.
Attention also appears to be particularly sensitive to sleep loss. Sleep deprivation affects
attention, such that the lack of sleep result in poor attention. Several fMRI studies on tasks
involving attention and memory have investigated the effects of sleep deprivation on functioning
and the evidences from these fMRI studies are congruent to the effects of sleep deprivation on
decreased neural activity observed in PET studies. Drummond and colleagues (1999),
particularly, found decreased activation in several brain regions such as the frontal lobe
(prefrontal cortex and premotor cortex) and parietal lobe. In school, attention is absolutely
important. It is vital for different aspects of learning and memory storage. Encoding information
and recalling memory both require attention, thus attention is crucial for a student’s school
Sleep deprivation also impairs visual short-term memory, limiting its capacity, as evident
in fMRI scans. Chee and Chuah (2007) used fMRI and manipulated perceptual or memory load
in visual tasks. They found that the tasks showed reductions in parietal activation and declines in
behavioral performance after sleep deprivation. The lack of sleep reduced the linear relationship
between memory load and parietal activation. In addition, Yoo and colleagues (2007) also found
that sleep deprivation produced a significant decrease in hippocampal activity during encoding of
episodic memory, resulting in bad retention of memories. This finding suggest that lack of sleep
compromises both behavioral and neural capacity for encoding new experiences to memory,
positive mood, attention, and memory acquisition and retention, some studies found that verbal
learning is better after sleep deprivation. For instance, Drummond and colleagues (2000)
reported an increase in the activation of the prefrontal cortex and parietal lobe during a
performance of a verbal learning task after 35 hours of sleep deprivation. This increased
activation in the prefrontal cortex and parietal lobe was associated with better verbal memory
performance on the task. However, they also found that the greater activation in the said brain
regions only happened when the task was complex and involved difficult words. It is also
important to note that the task only demanded for rote learning and there was no comprehension
and understanding needed. This is not particularly helpful in school, because in most, if not all,
For a long time, external or psychosocial factors are mostly the reasons people pinpoint
as to why people, specifically adolescents, experience sleep deprivation. However, in the recent
years, several researches provide neurobiological evidences that explain why adolescents seem to
Adolescence is the period wherein changes in the neural and cognitive, social and affect,
and behavioral and sexual development are most dramatic. Pubertal alterations in the circadian
timing system and the sleep-wake homeostatic system lead to changes in adolescents’ sleeping
habits. Adolescents are more sensitive to light, thus just little exposure to light increases
melatonin levels. In addition, sleep drive is also slower in adolescents. Aside from these changes
in the systems related to sleep, adolescents also undergo developmental changes in brain activity,
in SWA and in slow wave amplitude, thus leading to 50% reduction of deep sleep, particularly
stage 4 sleep. In addition, the decrease in gray matter of the frontal and parietal lobes were
matched by similar decrease in EEG amplitude of the said regions, supporting the relationship
Along with these neurobiological etiology of sleep deprivation among adolescents are its
affective, behavioral, and cognitive effects. Several researches show that sleep deprivation lead
reduced attention, and deteriorated memory acquisition and retention. All these consequences of
sleep deprivation among adolescents affect school performance in a wide variety of ways, such
as decelerating or slowing down learning and ruining relationships with classmates and mentors.
suggest that developmental changes in the circadian timing system and homeostatic system and
the brain activity, structure and organization, may provide physiologically mediated “excuse” for
later sleeping times during adolescence. It seems like adolescents are “pre-programmed” to sleep
late and thus experience sleep deprivation. With these developmental changes that we cannot
avoid and change, what can we do to prevent or even get rid of sleep deprivation?
Several researches found that in some places, a later school start time lead to reported less
sleepiness and increased academic performance. Delayed school start times in Massachusetts
resulted in longer sleep times, improved academic performance, and reduced tardiness (Wolfson
et al., 2005) and in Minnesota, Colorado, and Wyoming public schools, starting school at 8:30am
or later allowed for more than 60% of students to obtain at least eight hours of sleep per school
night. Additional results included improved academic performance, reduced tardiness, and
improved performance on state and national achievement tests (Wahlstrom et al., 2014). Also,
based on the literature about adolescents’ increase sensitivity to light, it is suggested that
minimizing exposure to gadgets late at night should be done to help in reducing later sleeping
Just because there are evidences that show that adolescence pubertal and developmental
changes contribute to sleep deprivation, it does not mean that we cannot do our part in keeping
ourselves healthy, by sleeping at the right times and with enough hours.
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